Uses of embryonic stem. Medical search. Frequent questions

The U.S. Food and Drug Administration (FDA) has approved the world's first human clinical trial of a therapy involving embryonic stem cells, a move that has been condemned by the Vatican as "unacceptable. (womenofgrace.com)

Adult stem cells are sometimes referred to as somatic stem cells to differentiate them from human germ cells, sperm cells and egg cells. (erlc.com)

This is a time-sensitive RFI to determine how best to accelerate research directed toward targeted differentiation of human embryonic stem cells (hESCs) into specific neuronal and glial cell types. (nih.gov)
The ESCRO Committee's review shall be specific to the scientific and ethical issues presented by proposals to use human gametes, human embryos, human embryo models, and the development and study of human embryonic stem cells (hESCs) or human induced pluripotent stem cells (hIPSCs) and their pluripotent derivatives in covered research in particular research projects. (washington.edu)
The UW Institute for Stem Cell and Regenerative Medicine (ISCRM) has been established for the purpose of facilitating and encouraging basic research on hESCs to develop therapies and cures for human disease. (washington.edu)
Here, we use human embryonic stem cells (hESCs) to show that the Activin-SMAD2/3 signaling pathway cooperates with the core pluripotency factor NANOG to recruit the DPY30-COMPASS histone modifiers onto key developmental genes. (ox.ac.uk)
We studied human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) measuring the SNPs and CNVs with Affymetrix SNP 6 microarrays and expression values with Affymetrix Exon microarrays. (biomedcentral.com)
Cell replacement using human embryonic stem cells (hESCs) derivatives may offer new therapeutic opportunities to replace degenerated neurons and repair damaged circuits. (lu.se)

Embryonic stem cells (ESCs) are pluripotent stem cells derived from the inner cell mass of a blastocyst, an early-stage pre-implantation embryo. (wikipedia.org)
Stem cells derived from an early embryo. (yourgenome.org)
As stem cells within a developing human embryo differentiate within the cell, their capacity to diversify generally becomes more limited and their ability to generate many differentiated cell types also becomes more restricted. (erlc.com)
Embryonic stem cells (ESCs) are stem cells that have been taken from the inner cell mass of a blastocyst, an embryo of about 150 cells that has not yet implanted into a woman's uterus. (erlc.com)
The process of obtaining stem cells leads to the destruction of the embryo from which the cells are taken. (erlc.com)
Management of what is called the 'national embryo supply' in the UK involves new forms of governance at the 'IVF-Stem cell Interface', where questions about the provenance of donated embryos, including the ethics of their sourcing, are at a premium. (lse.ac.uk)
This article explores the question of embryo donation to stem cell research from the perspective of the increasing proximity of IVF and hES cell derivation, using a model of 'double reproductive value' to explore what forms of exchange and flow are occurring, and how these are defined and negotiated in the context of a national hES cell coordination network of practitioners. (lse.ac.uk)
Scientifically, for serious technical reasons - that of tumour formation and immune rejection - embryo stem cells are highly unlikely ever to be trialled in humans, while adult stem cells are already making dramatic advances in human trials even here in Australia - spinal injury (at Brisbane's Princess Alexandra Hospital), heart disease (Newcastle's John Hunter Institute), and in the months ahead, Parkinson's (Melbourne's Peter McCallum Institute). (catholicleader.com.au)
Embryonic stem cells are grown from cells found in the embryo when it is just a few days old. (eurostemcell.org)
Embryonic stem cells are pluripotent cells derived from embryonic tissue in a process that usually results in the destruction of the embryo. (biopharminternational.com)
Using human stem cells, scientists led by NYSCF - Robertson Stem Cell Investigator Jun Wu, PhD , of UT Southwestern Medical Center have developed an embryo model called 'peri-gastruloids' that can form many of the body's cell types. (nyscf.org)
In 2021, Dr. Wu's lab published the first stem cell derived integrated human embryo model , human blastoids, which contain both embryonic and extraembryonic cells. (nyscf.org)
Human Embryo and Embryonic. (washington.edu)
UW's policy governing human embryo and human embryonic stem cell research has been changed to include oversight of research involving human embryo models and human gametes. (washington.edu)
Finally, genetic studies in mice show that Dpy30 is also necessary to maintain pluripotency in the pregastrulation embryo, thereby confirming the existence of similar regulations in vivo during early embryonic development. (ox.ac.uk)
Embryonic development or embryogenesis is the process by which the embryo is formed and develops. (news-medical.net)
During the process of harvesting embryotic stem cells, the embryo is destroyed. (healthline.com)
In fact to get a embryonic stem cell a human embryo has to be disassembled. (ipl.org)
People who believe that an embryo should not be destroyed tend to say that embryonic stem cell research should not be conducted. (ipl.org)

The hallmark of embryonic stem (ES) cells is their ability for self-renewal (capability of unlimited cell division without the loss of pluripotency) as well as for differentiation into all cell types of the adult organism. (uni-muenchen.de)
Specifically, we study the genetic, epigenetic and metabolic control of pluripotent and adult stem cells, and the molecular circuitries governing the decision between self-renewal and commitment to differentiation, both in physiology and disease. (cnr.it)
The expression of TIMP-1, TIMP-2 and TIMP-3 was unchanged following stem cells differentiation into neurons and glia. (uea.ac.uk)
Interestingly, TIMP-4 also differed from the other TIMPs in that it was cell- associated in the stem cells, where this fraction remained unchanged upon differentiation. (uea.ac.uk)
There is an immense functional heterogeneity among stem cell within a population, considering proliferative capacity and differentiation potential. (uni-heidelberg.de)
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We used in vitro differentiation of embryonic stem cells through embryoid bodies as a model to analyze chondrogenic and osteogenic differentiation because embryonic stem cells recapitulate early embryonic developmental phases during in vitro differentiation. (uni-luebeck.de)
Ten-Eleven Translocation Ablation Impairs Cardiac Differentiation of Mouse Embryonic Stem Cells. (bvsalud.org)
Ten-eleven Translocation (TET) dioxygenases mediated DNA methylation oxidation plays an important role in regulating the embryonic stem cells (ESCs) differentiation. (bvsalud.org)
the EST, which assesses the effects of compounds on the differentiation of mouse embryonic stem cells into contracting cardiomyocytes, can be used to rank the potency of chemicals within a series of alkoxyacetic acid metabolites formed from The implementation of the European REACH (Registration, glycol ethers. (cdc.gov)

Though not intended to be an exhaustive explanation of this important topic, we believe this will help to clarify and explain the questions most frequently asked about embryonic stem cell research. (erlc.com)

Researchers are currently focusing heavily on the therapeutic potential of embryonic stem cells, with clinical use being the goal for many laboratories. (wikipedia.org)
Our assays showed that the hybrid cells, unlike adult cells, showed the development potential of embryonic stem cells," said Eggan. (news-medical.net)

Embryonic stem cells (ESCs), derived from the blastocyst stage of early mammalian embryos, are distinguished by their ability to differentiate into any embryonic cell type and by their ability to self-renew. (wikipedia.org)
Human embryonic stem cells (ESCs) are pluripotent cells, meaning cells that can make any other cell in the body. (eurostemcell.org)
Many areas of science use mouse ESCs to study how blastocysts grow into adults and to study what signals direct stem cells to differentiate into specialised cells. (eurostemcell.org)
An immense amount has been learned about embryonic development and disease from creating 'chimera' mice with genetically modified ESCs. (eurostemcell.org)
Mouse ESCs are being used to learn about how the body develops, from early embryonic stages to the formation of complex organs. (eurostemcell.org)

Currently, embryos left over from infertility treatments are the only source of human embryonic stem cells. (sciencedaily.com)
The issue of research involving stem cells derived from human embryos is increasingly the subject of a national debate and dinner table discussions," said President George W. Bush in a 2001 speech announcing his policy on embryonic stem cell research. (erlc.com)
Where do the embryos for embryonic stem cells come from? (erlc.com)
Currently, all human embryonic stem cell lines in use today were created from embryos generated by IVF. (erlc.com)
Scientists announced this week that they have successfully produced embryonic stem cells by transferring the DNA of human skin cells into unfertilized human eggs to produce embryos, a technique the Church considers to be an abuse of human life. (womenofgrace.com)
But the embryonic fantasy will continue to be fermented of exclusive miracles just around the corner, for as long as biotech companies need to ensure access to human embryos for more practical research. (catholicleader.com.au)
A gene for a green fluorescent protein was inserted into the genomes of stem cells, which were then injected into macaque embryos grown for around four days in vitro. (planer.com)
As Wisconsin observed the 10-year anniversary of James Thomson's embryonic stem (ES) cell discovery, some wonder whether the ensuing controversy over the destruction of human embryos has been worthwhile. (wtnnews.com)
The cost seems to be small, experimentation with stem cells derived from "spare" embryos that are no longer needed or wanted for in vitro fertilization. (jcrelations.net)
Earlier this week, the British House of Commons voted by a large majority the amendments for Human Fertilization and Embryonic Research Act which allows scientists to produce human-animal hybrid embryos for stem cell research. (battlingforhealth.com)
Thanks to advances in stem cell technology since then, scientists are now able to create models of human embryos that can provide a rare insight into the earliest stages of life. (nyscf.org)
An article published in the journal Cell Stem Cell describes the first scientific study to develop blastoids - "synthetic embryos", as they were initially (and incorrectly) called - from bovine pluripotent stem cells (PSCs). (news-medical.net)
Embryonic stem cells come from human embryos that are three to five days old. (healthline.com)
Embryonic stem cell research "uses special cells found in three-to-five day old human embryos to seek cures for a host of chronic disease" (PRC). (ipl.org)

This knowledge can be used to model and understand developmental disorders or diseases that arise during early embryonic development. (nyscf.org)

This screen is capable of analyzing the expression of 48 genes simultaneously across dozens of different samples, and our gene list covers all three germ layers that arise during normal embryonic development, the trophectoderm, and epigenetic regulators of chromatin status. (utexas.edu)
Induced pluripotent stem cells (iPS cells) generated by reprogramming of somatic cells are also discussed and related to the pluripotent cell states which can be captured during normal embryonic development. (dundee.ac.uk)

Dr. Katherine High of the Center for Cellular and Molecular Therapeutics at the Children's Hospital of Philadelphia was the lone speaker supporting embryonic research. (pacatholic.org)

Embryonic stem cells of the inner cell mass are pluripotent, meaning they are able to differentiate to generate primitive ectoderm, which ultimately differentiates during gastrulation into all derivatives of the three primary germ layers: ectoderm, endoderm, and mesoderm. (wikipedia.org)
According to a 2002 article in PNAS, "Human embryonic stem cells have the potential to differentiate into various cell types, and, thus, may be useful as a source of cells for transplantation or tissue engineering. (wikipedia.org)
By learning how stem cells differentiate and become specialized, scientists hope to gain a better understanding of how cells in general work and what can go wrong. (erlc.com)
Stem cells can self-renew and differentiate into multiple cell types. (ox.ac.uk)
Adult stem cells can't differentiate into as many other types of cells as embryonic stem cells can. (healthline.com)
The breakthrough has created a way to "de-differentiate" the stem cells. (healthline.com)
In response to signals from the notochord , neural tube and surface ectoderm, the somites subdivide and differentiate to give rise to the embryonic structures of the dermomyotome , myotome and sclerotome . (lifemapsc.com)
Here, we show that embryonic stem cells differentiate into chondrocytes, which progressively develop into hypertrophic and calcifying cells. (uni-luebeck.de)

Due to their plasticity and potentially unlimited capacity for self-renewal, embryonic stem cell therapies have been proposed for regenerative medicine and tissue replacement after injury or disease. (wikipedia.org)
Ethical adult stem cell research is succeeding and yielding therapies that are healing people now. (pacatholic.org)
Dr. Gary Friedman of the New Jersey Stem Cell Research and Education Foundation explained how successful stem cell therapies will be more important as the aging American population puts a strain on our health care system. (pacatholic.org)
For example, stem cell therapies might help the people on the rapidly growing organ transplant list. (pacatholic.org)
This is a momentous day-not only for science, but for the hopes of thousands of patients and their families who are relying on NIH-funded scientists to pursue life-saving discoveries and therapies that could come from stem cell research. (biopharminternational.com)
It is the belief of many scientists, lawmakers, as well as patients that the key to future therapies that can cure diseases - from cardiovascular disorders to cancer - lie in stem cell research. (battlingforhealth.com)

Pluripotency distinguishes embryonic stem cells from adult stem cells, which are multipotent and can only produce a limited number of cell types. (wikipedia.org)
Pluripotency factors Oct4 and Nanog play a role in transcriptionally regulating the embryonic stem cell cycle. (wikipedia.org)
Writing in the journal Cell Stem Cell , the team reports that more than half of mouse epiblast stem cells treated with the drug reversed course within three days, and regained an embryonic "be anything" state, also called pluripotency. (sciencedaily.com)
Past attempts by other teams to restore pluripotency to mouse cells from the epiblast stem cell state have yielded far lower amounts, or non-viable cells. (sciencedaily.com)
The developmental progression of embryonic stem cells into specialist cell types involves the activation of lineage-specific programs of gene expression and the silencing of genes involved in maintaining pluripotency. (ca.gov)
These findings provide supporting evidence that enrichment for proteins involved in pluripotency is not restricted solely to malignant tumors as is suggested by the "stem cell theory of cancer", but additionally extends to common benign vascular tumors such as hemangiomas. (medscape.com)

The scientists knew that if their studies were successful, it would provide the research community with a new option for producing reprogrammed cells using embryonic stem cells, which are more plentiful and easier to obtain than unfertilized human eggs. (news-medical.net)
An international collaboration of researchers from the RIKEN Center for Biosystems Dynamics Research (BDR) in Japan and Gladstone Institutes in the USA have generated 3D blastocyst-like structures from stem cells. (sciencedaily.com)
Why are stem cells so important to research? (erlc.com)
There are two main reasons stem cells are of interest to both scientific and medical research. (erlc.com)
Funding for stem cell research in two of the most liberal states in the nation - California and Maryland - appears to be shifting away from embryonic to adult stem cells. (womenofgrace.com)
Human Embryonic Stem (hES) cell research has met with a mixed reception internationally, but in the UK remains a significant national priority. (lse.ac.uk)
In July, President George Bush vetoed a bill that would have provided federal funding for embryonic stem cell research. (pacatholic.org)
Stephen Webster, CEO of Nureonyx, discussed the business opportunities of stem cell research. (pacatholic.org)
She contends that without state funding Pennsylvania might be a "follower" instead of a "leader" in stem cell research which could hurt the Commonwealth's economy. (pacatholic.org)
Ethical considerations of embryonic stem cell research were discussed by Fr. (pacatholic.org)
He reiterated that the Catholic Church does not oppose stem cell research, but advocates research on non-embryonic cells that does not destroy human life. (pacatholic.org)
Expect embryonic stem cell research to be on the agenda. (pacatholic.org)
29, 2011, a federal appeals court has lifted a ban on federal funding for embryonic stem cell (ESC) research. (biopharminternational.com)
The case began when a lawsuit was brought against the National Institutes of Health (NIH) by Dr. James Sherley and Dr. Theresa Deisher, scientists opposed to embryonic stem cell research. (biopharminternational.com)
The scientists also claimed that funding embryonic stem cell research hurt their ability to receive federal funding for their own research using adult stem cells. (biopharminternational.com)
In August 2010, a district court agreed with the plaintiffs that embryonic stem cell research violated federal law and blocked funding, but a three-judge appeals court temporarily lifted the ban in September. (biopharminternational.com)
The issue is whether that law's restrictions apply to research conducted on stem cell lines that had been developed without federal funding. (biopharminternational.com)
NIH has interpreted the law narrowly, and argued that creating embryonic stem cells is not the same as using lines created without federal funding for research purposes. (biopharminternational.com)
Researchers used stem cells obtained from the embryonic tissue of cynomolgus monkeys, a type of macaque commonly used in genetics research because of their similarity to humans. (planer.com)
Medical ethicists from my Roman Catholic religious tradition face a dilemma when investigating the morality of human embryonic stem cell research. (jcrelations.net)
This statement shows that, from a Roman Catholic point of view, the starting point for reflection on the ethics of embryonic stem cell research does not begin with stem cell research in itself nor even with the social good that comes about from the possible results of such research. (jcrelations.net)
Understood in this way, the moral context of embryonic stem cell research from a Roman Catholic point of view involves the acceptance of the idea that the benefits given to so many in society come through the destruction of the weakest and most vulnerable forms of life. (jcrelations.net)
Part of why NYSCF was founded was to offer scientists a private, philanthropy-driven funding source for stem cell research, which at the time could only be done using embryonic stem cells. (nyscf.org)
However, more research is needed to help understand the potential uses of amniotic fluid stem cells. (healthline.com)
STEM CELL RESEARCH is a very controversial topic in today's time. (ipl.org)
Stem cell research is not worth supporting. (ipl.org)
Advocates of stem cell research believe that the cells are not equivalent to human life because it is inside the womb even facing the fact that the start of a human life is in the moment of conception. (ipl.org)
In recent years, several competing viewpoints have emerged about embryonic stem cell research. (ipl.org)
All of this debate raises an important question, Should embryonic stem cell research be conducted for treatment of present and future diseases? (ipl.org)
On the other hand, people who believe that embryonic stem cell research creates means of curing diseases reply that the research should be conducted. (ipl.org)
Within this context, research involving stem cells are on the agenda of several academic articles and major newspapers and magazines around the world. (bvsalud.org)
We followed different mediators along their deviations, in order to produce a report based on the analysis of current bioethical controversies involving, specifically, embryonic stem cell research. (bvsalud.org)
5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (who.int)

The fusion causes the adult cells to undergo genetic reprogramming, which results in cells that have the developmental characteristics of human embryonic stem cells. (news-medical.net)
The interest of the Institute in developmental biology is rooted back at the time when IGB researchers pioneered mouse genetics using gene targeting techniques to study mammalian embryonic development. (cnr.it)
Human embryonic development is a critical component of human life, and is a stage during which many conditions - including developmental disorders, birth defects, genetic disorders, and many neurological disorders - can begin to take form. (nyscf.org)

Stem cells also provide a model system in which researchers can study the causes of genetic disease and the basis of embryonic development. (news-medical.net)
All specialized cells arise originally from stem cells, and ultimately form a small number of embryonic cells that appear during the first few days of development. (erlc.com)
A new study has revealed a link between indoor air pollution, stemming from both passive smoking and the use of unclean cooking fuels, and development delays in children. (medicaldaily.com)
SOX2 is an intronless gene encoding a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. (thermofisher.com)
Gastrulation is a critical step in embryonic development in which cells begin to organize themselves into layers that will contain the basic plan for a future organism, but there are few ways to study this process in depth. (nyscf.org)
Scientists have already established stem cell models of gastrulation - the process of human development in which cells reorganize from a single layer to a 3D structure - but these models have lacked the diversity of cell types needed to more fully model complex development. (nyscf.org)
Dermis is formed approximately at E11 of mouse embryonic development. (lifemapsc.com)
During the third week of human embryonic development, the paraxial mesoderm forms paired "balls" of mesoderm on either side of the neural groove. (lifemapsc.com)
We have generated several transgenic lines to explore how neuromasts are created after embryonic development (Development 144, 687-697), which are their cells of origin and which and how they integrate the signals from the environment to trigger organ formation. (uni-heidelberg.de)
Both methods have contributed extensively to our current knowledge on the lineage relation of differentiated cells during embryogenesis, the potential of stem cell populations to generate or re-generate missing cell types, and the cell autonomous or non cell autonomous effects of many genes during development and disease. (uni-heidelberg.de)
The fact that the DNA of a fully differentiated (adult) cell could be stimulated to revert to a condition comparable to that of a newly fertilized egg and to repeat the process of embryonic development demonstrates that all the genes in differentiated cells retain their functional capacity, although only a few are active. (who.int)
In vitro toxicity data of these metabolites derived in the development of validated and accepted in vitro and in silico embryonic stem cell test were used as input in the PBK model to extrapolate in vitro concentration-response curves to predicted approaches is urgently needed. (cdc.gov)

Furthermore, Eggan noted that genetic analyses of the fused cells revealed that the somatic cell genes characteristic of adult cells had all been switched off, while those characteristic of embryonic cells had been switched on. (news-medical.net)
With the exception of a few genes one way or the other -- which is perhaps because these cells are now tetraploid -- the hybrid cells are indistinguishable from human embryonic stem cells," he said. (news-medical.net)
We found that a large fraction of genes were differentially localized in human thymocytes derived from embryonic stem cells versus human myeloid cells. (ca.gov)
Chimeras can pass on genes from embryonic stem cells to their offspring. (eurostemcell.org)
A chimeric monkey has been created using embryonic stem cells with two different sets of genes, a new study has demonstrated. (planer.com)
Our results revealed that in the human pluripotent stem cells, the expression values of several genes, transcripts and exons were affected due to the genomic variation. (biomedcentral.com)

No end believed to be good, such as the use of [embryonic] stem cells for the preparation of other differentiated cells to be used in what look to be promising therapeutic procedures, can justify [the destruction of embryonic life]. (jcrelations.net)
Therapeutic cloning, which creates embryonic stem cells . (medlineplus.gov)

We portrayed the Notch system in embryonic stem cell (ESC)-derived embryoid bodies (EBs) differentiating under the standard protocols used to assess yolk sac (YS) hematopoiesis in vitro. (karger.com)
Comparison of toxicity of benzene metabolite hydroquinone in hematopoietic stem cells derived from murine embryonic yolk sac and adult bone marrow. (cdc.gov)

Based on this knowledge, IGB researchers are developing molecular and pharmacological tools to target progenitor/stem cells and their metabolism, paving the way for novel approaches to regenerative medicine and disease treatments. (cnr.it)
Recent studies have isolated distinct cell populations from infantile hemangiomas that display properties equivalent to aberrant progenitor cells, suggesting that, in addition to malignant tumors, benign tumors may also contain a stem cell-like component. (medscape.com)

In addition to their potential in regenerative medicine, embryonic stem cells provide a possible alternative source of tissue/organs which serves as a possible solution to the donor shortage dilemma. (wikipedia.org)
For that reason, many researchers believe stem cells offer promise for creating populations of specialized cells that can be used to rejuvenate organs, such as the pancreas or heart, that are damaged by disease or trauma. (news-medical.net)
This male macaque exhibited organs with a mixture of both sets of cells, including green eyes and fingertips, demonstrating tissues featuring a high proportion of cells derived from the injected stem cells. (planer.com)
These stem cells come from developed organs and tissues in the body. (healthline.com)
We are particularly interested in learning how organs can adapt to the changing organismal size , with a focus on the molecular mechanisms for stem cell coordination within and among organs. (uni-heidelberg.de)
We follow stem cell derived lineages in different organs to learn whether fish use the same stem cells to maintain homeostasis replacemente and to drive growth, or if they have dedicated populations for each feature. (uni-heidelberg.de)
Since fish grow during their entire post-embryonic life, their organs have to adapt to an increasing body size. (uni-heidelberg.de)

In collaboration with mathematicians, we focus on how many stem cells and stem cell types are required to setting up a functional organ during embryogenesis and in an already developed organism. (uni-heidelberg.de)

In a surprising new finding, scientists have shown that mouse stem cells treated with the drug reverted to an 'embryonic' state. (sciencedaily.com)
It's the first time that scientists have shown they can get stem cells to revert to their original state by erasing specific labels called epigenetic markers. (sciencedaily.com)
Scientists at Stanford University in California have been able to coax embryonic stem cells into becoming eggs and sperm, which could one day lead to the creation of children through entirely artificial means. (womenofgrace.com)
A recent open letter to all Australian parliaments from nine senior medical scientists tries to counter these fantasies, warning that 'undue expectations have been created in the community, particularly in those with various medical afflictions, as to the imminence and likely scope of embryonic stem cell therapy. (catholicleader.com.au)
Embryonic stem cells have captured the imagination of scientists and non-scientists alike. (eurostemcell.org)
Since stem cells have the ability to turn into various other types of cells, scientists believe that they can be useful for treating and understanding diseases. (healthline.com)
Scientists have recently discovered how to turn adult stem cells into pluripotent stem cells. (healthline.com)
To create iPSCs, scientists genetically reprogram the adult stem cells so they behave like embryonic stem cells. (healthline.com)

abstract = "Since their discovery more than 30 years ago, embryonic stem (ES) cells have been propelled from relative obscurity into the centre stage of international attention. (dundee.ac.uk)

It is more likely that the new technique will see immediate use in helping to accelerate understanding of how embryonic cells "reprogram" somatic cells to an embryonic state. (news-medical.net)

Activin/nodal signaling and NANOG orchestrate human embryonic stem cell fate decisions by controlling the H3K4me3 chromatin mark. (ox.ac.uk)

The researchers also performed fusion experiments using pelvic bone cells as the somatic cells and a different human embryonic cell line, to demonstrate that their technique was not restricted to one adult cell type or embryonic cell line. (news-medical.net)

These data indicate that the majority of the genome derived from that of human embryonic stem cells shows a similar pattern in chromatin folding as compared to that of iPS cells derived from human B cells but that they differ from each other in a subset of genomic regions. (ca.gov)

Researchers have developed a new technique for creating human embryonic stem cells by fusing adult somatic cells with embryonic stem cells. (news-medical.net)
In theory, researchers can induce embryonic stem cells to mature into a variety of specialized cells. (news-medical.net)
Eggan, Melton and their colleagues decided to pursue their alternative route after other researchers had shown that genetic reprogramming can occur when mouse somatic cells are fused to mouse embryonic stem cells. (news-medical.net)
In the studies published in Science, the researchers combined human fibroblast cells with human embryonic stem cells in the presence of a detergent-like substance that caused the two cell types to fuse. (news-medical.net)
The researchers demonstrated that they had achieved fusion of the two cell types by searching the fused cells for two distinctive genetic markers present in the somatic fibroblast and stem cells. (news-medical.net)
Researchers have generated 3D blastocyst-like structures from stem cells. (sciencedaily.com)

The surgical procedure for delivery of embryonic stem cell-derived endothelial cells to the ischemic hindlimb is demonstrated, with non-invasive tracking by bioluminescence imaging. (jove.com)
The use of stem cell-derived dopamine neurons or deep brain stimulation (DBS) represents two alternative approaches to treat Parkinson's Disease. (lu.se)
DBS is a widely used FDA-approved treatment and stem cell-derived dopamine neuron replacement has now evolved to the first in-human clinical trials. (lu.se)

Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)

For example, hematopoietic stem cells are a type of adult stem cell found in bone marrow. (healthline.com)
Doctors have been performing stem cell transplants, also known as bone marrow transplants, for decades using hematopoietic stem cells in order to treat certain types of cancer. (healthline.com)
The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)

Using an ensemble of computational strategies we found that the majority of genomic regions in iPS cells derived from human B cells was indistinguishable from that of human embryonic stem cells. (ca.gov)

Now, they're working to see if the MM-401 eraser technique works with human stem cells that bear some resemblance to mouse epiblast stem cells. (sciencedaily.com)
This approach could become an alternative to somatic cell nuclear transfer (SCNT), a method that is currently used to produce human stem cells. (news-medical.net)
Embryonic stem cell transplants have been an ethical, social, and legal controversy since the first successful transplant of human stem cells in 1998. (ipl.org)

Stem cells have two unique characteristics: (1) an almost unlimited capacity for self-renewal (they can theoretically divide without limit to replenish other cells for as long as the person is alive) and (2) they retain the potential to produce differentiated and specialized cell types. (erlc.com)

During the past three years we have identified the folding patterns of human embryonic stem cells to iPS cells derived from human B cells, differentiated progeny and mechanisms that orchestrate the folding patterns of genomes. (ca.gov)

Human embryonic stem cell (hESC)-derived MSCs are an alternative to adult MSCs that can circumvent issues regarding scalability and consistent quality due to their derivation from a renewable starting material. (nature.com)

Adult stem cells don't present any ethical problems. (healthline.com)

Their analyses showed that the hybrid cells were "tetraploid" - meaning they contained the combined chromosomes of both the somatic cells and the embryonic stem cells. (news-medical.net)

Published in the journal Stem Cell Reports , the study shows that the blastocyst-like structures very closely resemble actual blastocysts, and even induce proper changes in the uterus after being implanted in pseudo-pregnant mice. (sciencedaily.com)
These findings were important since they provide new insights as to how such regulatory elements find each other with great speed, selectivity and specificity to induce lineage specific patterns of gene expression both in embryonic stem cells and differentiated progeny. (ca.gov)

The following product was used in this experiment: SOX2 (Embryonic Stem Cell Marker) Recombinant Rabbit Monoclonal Antibody (SOX2/4267R) from Thermo Fisher Scientific, catalog # 6657-RBM7-P1. (thermofisher.com)

We are tackling functional heterogeneities on somatic stem cells by combining metabolic reporters in vivo with lineage progression. (uni-heidelberg.de)

Specificity Comments: SOX2 is required for stem cell maintenance in the central nervous system, and it also regulates gene expression in the stomach. (thermofisher.com)

An essential function of SOX2 is to stabilize embryonic stem cells in a pluripotent state by maintaining the requisite level of Oct 3/4 expression. (thermofisher.com)

Anatomy49

Organisms11

Diseases4

Chemicals and Drugs79

Analytical, Diagnostic and Therapeutic Techniques and Equipment52

Psychiatry and Psychology1

Phenomena and Processes61

Disciplines and Occupations5

Technology, Industry, Agriculture1

Information Science2

Involving embryonic stem1

Germ cells1

HESCs6

Embryo19

Differentiation20

Asked about embryonic stem cel1

Potential of embryonic stem2

ESCs5

Embryos14

Early embryonic development1

Normal embryonic development2

Supporting embryonic research1

Differentiate8

Therapies6

Pluripotency6

Research33

Developmental3

Development12

Genes6

Therapeutic2

Yolk sac2

Progenitor2

Organs7

Embryogenesis1

Scientists8

Abstract1

Reprogram1

Nanog1

Adult cell1

Chromatin1

Researchers6

Cell-derived3

Hematopoietic Stem Cell Trans1

Bone marrow3

Indistinguishable1

Human stem cells3

Capacity for self-renewal1

Mechanisms1

HESC1

Ethical1

Somatic cells1

Induce2

Scientific1

Lineage1

Gene expression1

SOX21