• Serum carcinoembryonic antigen and cytokeratin 19 were abnormally highly expressed in non-Small cell lung cancer patients, which are useful for clinical diagnosing, treatment planning, efficacy monitoring, and prognosis evaluation. (ijpsonline.com)
  • Monoclonal antibodies are used to detect serum antigens associated with specific malignancies. (aafp.org)
  • Conclusions and Clinical Relevance -Serum calprotectin concentration may be a useful biomarker for the detection of inflammation in dogs, but the use of certain drugs (eg, glucocorticoids) appears to limit its clinical usefulness. (avma.org)
  • With the exception of prostate-specific antigen (PSA), tumor markers do not have sufficient sensitivity or specificity for use in screening. (aafp.org)
  • Cancer antigen (CA) 27.29 most frequently is used to follow response to therapy in patients with metastatic breast cancer. (aafp.org)
  • A raised pre-treatment carcinoembryonic antigen (CEA) level is frequently observed in colorectal cancer patients with metastatic disease and is thought to be a reflection of disease burden. (sgo-iasgo.com)
  • Current monitoring of recurrence is via a blood test for carcinoembryonic antigen (CEA), a well-described marker for gastrointestinal tract diseases, especially CRC, in combination with CT scans and other clinical assessments. (www.csiro.au)
  • SCC antigen is useful in the clinical management of advanced cervical cancer. (medscape.com)
  • Despite encouraging results, low positive predictive values limited the clinical usefulness of this panel as a screening tool in subjects aged 70-80 years or younger. (biomedcentral.com)
  • Comprehensive understanding of the altered molecular mechanisms and cellular processes underlying carcinogenesis or cancer hallmarks may link biomarkers of cancer with their clinical usefulness in patients with cancer. (lifepronow.com)
  • This prospective study in Yazd, Islamic Republic of Iran, assessed the value of the tumour markers carcinoembryonic antigen (CEA) and cancer antigen (CA) 15-3 in 159 patients with primary breast cancer. (who.int)
  • A research team from Czech Republic immunohistochemically examined the expression of cyclooxygenase-2 (COX-2) in pancreatic ductal adenocarcinoma using monoclonal and polyclonal antibodies to validate the potential usefulness of this marker in predictive oncology. (wordnik.com)
  • Sixty-eight patients (45 males, 23 females) were studied in order to assess the usefulness of mucosal tissue concentrations of both carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) in detecting patients at high risk for gastric cancer. (cnr.it)
  • Carcinoembryonic antigen is used to detect relapse of colorectal cancer, and CA 19-9 may be helpful in establishing the nature of pancreatic masses. (aafp.org)
  • Each tumor marker has a variable profile of usefulness for screening, determining diagnosis and prognosis, assessing response to therapy, and monitoring for cancer recurrence. (aafp.org)
  • Cancer antigen (CA) 27.29 is a monoclonal antibody to a glycoprotein (MUC1) that is present on the apical surface of normal epithelial cells. (aafp.org)
  • However, its usefulness is not clear given that many patients with a positive result are subjected to different tests that are more or less bothersome and with various adverse effects to conclude that there was no cancer (false positive). (instedwesmile.com)
  • Usefulness of examination of some tumor markers in diagnostics of liver cancer. (edu.pl)
  • This antibody has a high affinity for CEA and shows no detectable reactivity to nonspecific cross-reacting antigen (NCA), biliary glycoprotein (BGP) and human polymorphonuclear leucocytes. (samatashkhis.com)
  • Upon the detection of either type of the antigen preparation, the lowest concentration of the antigen detectable in buffer with pH 5.1 has been found to be approximately equal, amounting to ~10 -14 M. This value has been found to be similar upon the use of either type of molecular probes. (preprints.org)
  • The various tumor markers differ in their usefulness for screening, diagnosis, prognosis, assessing therapeutic response, and detecting recurrence. (medscape.com)
  • Usefulness of tumor markers CEA, NSE and SCC-Ag in bronchoalveolar lavage (BAL) for the diagnosis of lung carcinoma. (edu.pl)
  • We all try and investigate prognostic elements and also evaluate the function regarding carcinoembryonic antigen (CEA) along with carbs antigen 19-9 (CA19-9) inside local innovative anus most cancers (LARC) individuals which gotten neoadjuvant chemoradiotherapy (neo-CRT), significant surgical treatment and also postoperative radiation treatment. (deubiquitinase.com)
  • Many of these factors stem from the location of the epitope that can affect accessibility of the antibody to the epitope at a cellular or molecular level, direct inhibition of target antigen activity, conservation of function despite escape mutations, and even non-competitive inhibition sites. (preprints.org)
  • Through the incorporation of novel computational methods for predicting antigen changes to model-informed drug discovery and development, superior vaccines and antibody-based therapeutics or diagnostics can now be more easily designed to mitigate failures. (preprints.org)
  • Frequently used methods are based on, for example, antigen-antibody systems, nucleic acid hybridization techniques, and protein-ligand systems. (justia.com)
  • 13. Usefulness of Enhanced Liver Fibrosis, Glycosylation Isomer of Mac-2 Binding Protein, Galectin-3, and Soluble Suppression of Tumorigenicity 2 for Assessing Liver Fibrosis in Chronic Liver Diseases. (whocc.org.cn)
  • CEA has low sensitivity and is subject to false-positive results, limiting usefulness. (www.csiro.au)
  • The samples were deparaffinized with xylol and ethanol followed by heat induced antigen retrieval with 10 mM citrate buffer. (progen.com)
  • This importance is focussed on the target binding site - epitope, where epitope selection as a part of design thinking beyond traditional antigen selection using whole cell or whole protein immunisation can positively impact success. (preprints.org)
  • The specific labeling method chosen often dictates the usefulness and versatility of a particular system for detecting an analyte of interest. (justia.com)
  • 39. [Neuron-specific enolase (NSE) and squamous cell carcinoma antigen (SCC) as serum markers in the diagnosis of bronchial carcinoma]. (nih.gov)
  • 34. [Detection and diagnostic value of serum carcinoembryonic antigen and cytokeratin 19 fragment in lung cancer patients]. (nih.gov)
  • 40. [Clinical and prognostic significance of tumor markers cytokeratin 19 fragment, carcinoembryonic antigen, and neuron-specific enolase in lung cancer]. (nih.gov)
  • Increased preoperative serum Carcinoembryonic Antigen (CEA) and Cytokeratin-19 Fragment (CYFRA 21-1) levels are associated with a poor postoperative prognosis in early-stage Non-Small Cell Lung Cancer (NSCLC). (heraldopenaccess.us)
  • Carcinoembryonic Antigen (CEA) and Cytokeratin Fragment 19 (CYFRA 21-1) are two predictive markers that have been extensively studied in lung cancer[8]. (heraldopenaccess.us)
  • 35. Pro-gastrin-releasing peptide (ProGRP), neuron specific enolase (NSE), carcinoembryonic antigen (CEA) and cytokeratin 19-fragments (CYFRA 21-1) in patients with lung cancer in comparison to other lung diseases. (nih.gov)
  • The various tumor markers differ in their usefulness for screening, diagnosis, prognosis, assessing therapeutic response, and detecting recurrence. (medscape.com)
  • Each tumor marker has a variable profile of usefulness for screening, determining diagnosis and prognosis, assessing response to therapy, and monitoring for cancer recurrence. (aafp.org)
  • 26. Soluble Human Leukocyte Antigen-G in the Bronchoalveolar Lavage of Lung Cancer Patients. (nih.gov)
  • This prospective study in Yazd, Islamic Republic of Iran, assessed the value of the tumour markers carcinoembryonic antigen (CEA) and cancer antigen (CA) 15-3 in 159 patients with primary breast cancer. (who.int)
  • SCC antigen is useful in the clinical management of advanced cervical cancer. (medscape.com)
  • Cancer antigen (CA) 27.29 most frequently is used to follow response to therapy in patients with metastatic breast cancer. (aafp.org)
  • Carcinoembryonic antigen is used to detect relapse of colorectal cancer, and CA 19-9 may be helpful in establishing the nature of pancreatic masses. (aafp.org)
  • Cancer antigen (CA) 27.29 is a monoclonal antibody to a glycoprotein (MUC1) that is present on the apical surface of normal epithelial cells. (aafp.org)
  • The histological diagnosis was Skene adenocarcinoma based on the results of immunohistochemical staining showing positivity for PSA, P504S, and cancer antigen 125. (biomedcentral.com)
  • SCCA is an antigen present in the SCC subtype of cervical cancer. (healthline.com)
  • The aim of this study was to determine the usefulness of the carbohydrate antigen 19.9 (CA19.9)/carcinoembryonic antigen (CEA) ratio as a diagnostic tool. (medscape.com)
  • [ 9 ] Carbohydrate antigen 19.9 (CA19.9), also known as sialyl Lewis A, is the recommended TM in case of suspicion of malignancy of the gastrointestinal tract, with special relevance for a pancreatic orientation. (medscape.com)
  • The usefulness of adjuvant chemotherapy after curative resection or palliative chemotherapy for advanced or recurrent SBA remains unconfirmed because of the absence of a randomized control trial (RCT) for SBA [ 4 , 5 ]. (biomedcentral.com)
  • Carcinoembryonic antigen (CEA) Sample and study design years of follow-up. (who.int)
  • Isolated fractions were examined for their capacity to bind [125I]C1q as a measure of immune complex levels, and for their ability to bind soluble tumour-specific antigen as well as to react with antigens expressed at the surface of viable hepatoma cells. (nih.gov)
  • His blood tests revealed a white blood cell count of 11,900 cells/µL with 82% neutrophils, hemoglobin of 12.8 g/dL, platelet count 389,000 cells/µL, C-reactive protein 7.53 mg/dL (range, 1.0 to 0.8), and carcinoembryonic antigen 4.0 ng/mL (range, 0 to 5.0). (e-ce.org)
  • Induction of an effective anti-tumour response requires the active and integrated participation of host dendritic cells (DCs), taking up tumour-associated antigens (TAAgs) and generating Ag-specific T cells[ 1 ]. (biomedcentral.com)