EpithelialPoorly differentiatedTumorsMucinousAdrenocorticalMetastasesMalignantUrinaryKIDNEYProstatePrimaryOccurVast majorityTissueCancerPatientSecondaryAntibodyOriginGradeCommonFormNormalFoundMetastaticAdenocarcinomaMicropapillaryMelanomaNeuroendocrineBladder carcinomaTransitionalSquamousEosinophilic cytoplasmNeoplasticDysplasiaUrinary TractHistologicOvarianDiagnosticCytologyUrotheliumPatientsTumor cellsCharacteristicsHigh-gradeUrinalysisUrethraInvasiveNestsInvasionEpithelial cellsPathologyProstaticAntigenNucleiEndothelialGlandsExaminationTherapeuticSmall rounGleasonSpecificRisk
Epithelial9
- Carcinoma of cervix is classified as per the WHO classification into primary tumors which are predominantly epithelial tumors, mesenchymal tumors and tumor like lesions, mixed epithelial stromal tumors, melanocytic, germ cell, and lymphoid tumors. (cytojournal.com)
- Squamous cell carcinoma (SCC) in various morphological forms needs to be separated from other epithelial tumors for treatment modality selection. (cytojournal.com)
- Most of the cervical epithelial neoplasms and their precursors occur at the squamocolumnar junction or within the transformation zone. (cytojournal.com)
- Strong GATA3 positivity in all epithelial cells. (ms-validatedantibodies.com)
- Moderate to strong GATA3 positivity of a epithelial cells. (ms-validatedantibodies.com)
- Variable (weak to strong) GATA3 positivity in squamous epithelial cells. (ms-validatedantibodies.com)
- Weak to moderate GATA3 positivity in epithelial cells including hair follicles. (ms-validatedantibodies.com)
- A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)
- It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
Poorly differentiated2
- This corresponds to a poorly differentiated carcinoma. (wikipedia.org)
- The dMMR colorectal cancers are often poorly differentiated and frequently show proximal colon predominance, mucinous, medullary, or signet ring histologic features and increased numbers of tumor-infiltrating lymphocytes. (roche.com)
Tumors4
- Choroid plexus neoplasms are rare, intraventricular, primary central nervous system (CNS) tumors derived from choroid plexus epithelium that are seen predominantly in children. (medscape.com)
- Choroid plexus tumors are graded based on the World Health Organization (WHO) classification scheme and include choroid plexus papilloma (CPP) (WHO grade I) (see the following image), atypical choroid plexus papilloma (WHO grade II), and choroid plexus carcinoma (CPC) (WHO grade III). (medscape.com)
- [ 2 , 3 ] In adults, they account for less than 1% of primary intracranial neoplasms, whereas choroid plexus tumors represent up to 5% of pediatric brain tumors, and up to 20% of those arising in children aged 1 year and younger. (medscape.com)
- Although the vast majority of choroid plexus tumors are sporadic, hereditary factors appear to play a role in the development of some choroid plexus papillomas and carcinomas. (medscape.com)
Mucinous1
- Weak GATA3 staining of glandular cells (mostly mucinous). (ms-validatedantibodies.com)
Adrenocortical1
- Oncocytic adrenocortical carcinoma--a rare pathological variant. (edu.in)
Metastases1
- Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. (lookformedical.com)
Malignant1
- Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. (lookformedical.com)
Urinary2
- Urinary bladder Carcinoma Late recurrence Survival After. (karger.com)
- Kalra S , Manikandan R, Dorairajan LN, Badhe B. Synchronously detected secondary signet ring cell urinary bladder malignancy from the stomach masquerading as genitourinary tuberculosis. (edu.in)
KIDNEY1
- Kidney: A moderate to strong nuclear staining reaction should be seen in a fraction of collecting duct cells and podocytes in glomeruli. (ms-validatedantibodies.com)
Prostate1
- For example, it is not recommended in signet-ring adenocarcinoma or urothelial carcinoma of the prostate, and the scoring should discount the foamy cytoplasms seen in foamy gland carcinoma. (wikipedia.org)
Primary1
- For example, if the primary tumor grade was 2 and the secondary tumor grade was 3 but some cells were found to be grade 4, the Gleason score would be 2+4=6. (wikipedia.org)
Occur1
- A weak cytoplasmic GATA3 staining can occur in goblet cells of respiratory epithelium (probably non-specific staining). (ms-validatedantibodies.com)
Vast majority2
- The vast majority of choroid plexus neoplasms arise within the ventricles. (medscape.com)
- Tonsil: The vast majority of T helper cells (Th2) in the T-zones should show a weak to moderate nuclear staining. (ms-validatedantibodies.com)
Tissue5
- Pattern 3 - The tissue still has recognizable glands, but the cells are darker. (wikipedia.org)
- At high magnification, some of these cells have left the glands and are beginning to invade the surrounding tissue or having an infiltrative pattern. (wikipedia.org)
- Many cells are invading the surrounding tissue in neoplastic clumps. (wikipedia.org)
- There are often just sheets of cells throughout the surrounding tissue. (wikipedia.org)
- Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. (lookformedical.com)
Cancer2
- Choroid plexus carcinomas occasionally arise in association with hereditary cancer predisposition syndromes, including the Li-Fraumeni and rhabdoid predisposition syndromes, with germline mutations of TP53 and hSNF5/INI1/SMARCB1, respectively. (medscape.com)
- Carcinoma cervix is not the only cancer caused by HPV. (cytojournal.com)
Patient2
- Irrespective of patient age, choroid plexus papillomas outnumber choroid plexus carcinomas by a 5:1 ratio. (medscape.com)
- The third ventricle is the least common intraventricular location for choroid plexus neoplasms, irrespective of patient age. (medscape.com)
Secondary1
- This is a slight change from the pre-2005 Gleason system where the second number was the secondary grade (i.e., the grade of the second-most common cell line pattern). (wikipedia.org)
Antibody2
- This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. (thermofisher.com)
- Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Background Information", "Value": "VENTANA anti-MSH2 (G219-1129) antibody is a mouse monoclonal antibody produced against a recombinant human MSH2 protein. (roche.com)
Origin1
- Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. (thermofisher.com)
Grade1
- A total score is calculated based on how cells look under a microscope, with the first half of the score based on the dominant, or most common cell morphology (scored 1 to 5), and the second half based on the non-dominant cell pattern with the highest grade (scored 1 to 5). (wikipedia.org)
Common2
- Choroid plexus carcinomas are also far more common in the pediatric population, with approximately 80% of choroid plexus carcinomas occurring in children. (medscape.com)
- Seeding of the CSF may be seen even in benign choroid plexus papillomas, but leptomeningeal dissemination is much more common in choroid plexus carcinomas. (medscape.com)
Form1
- The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. (lookformedical.com)
Normal2
- Choroid plexus neoplasms can produce hydrocephalus and increased intracranial pressure by a number of mechanisms, including obstruction of normal cerebrospinal fluid (CSF) flow, overproduction of CSF by the tumor itself, local expansion of the ventricles, or spontaneous hemorrhage. (medscape.com)
- In normal cells, the MLH1 protein forms a complex (heterodimer) with the PMS2 protein, while the MSH2 protein forms a complex with the MSH6 protein. (roche.com)
Found1
- The neoplasms may be histologically the same or different, and may be found in the same or different sites. (lookformedical.com)
Metastatic2
- Presence or history of histologically confirmed, muscle invasive, locally advanced, nonresectable, or metastatic urothelial carcinoma (that is, greater than and equal to T2). (who.int)
- Genomic landscape of locally advanced or metastatic urothelial carcinoma with squamous differentiation compared to pure urothelial carcinoma. (cdc.gov)
Adenocarcinoma4
- Acinar prostatic adenocarcinoma cells are cuboidal, with amphophilic to clear cytoplasm and prominent nucleoli. (cap.org)
- For example, it is not recommended in signet-ring adenocarcinoma or urothelial carcinoma of the prostate, and the scoring should discount the foamy cytoplasms seen in foamy gland carcinoma. (wikipedia.org)
- In the US, most BC is UC, and less than 5% are squamous cell carcinoma or adenocarcinoma. (nih.gov)
- The signet ring variant (>50% of the tumor comprises neoplastic cells containing mucin which peripheralizes the nucleus) is one of the most common subtypes of gastric adenocarcinoma in dogs. (davisthompsonfoundation.org)
Micropapillary1
Melanoma1
- multiple melanoma cells. (ijpsr.com)
Neuroendocrine1
- The molecular characteristics of high-grade gastroenteropancreatic neuroendocrine neoplasms. (cdc.gov)
Bladder carcinoma3
- 6. E-cadherin promotes intraepithelial expansion of bladder carcinoma cells in an in vitro model of carcinoma in situ. (nih.gov)
- Bladder carcinoma (BC) is the most common neoplasm of the urinary system. (nih.gov)
- Identification of potential biomarkers and novel therapeutic targets through genomic analysis of small cell bladder carcinoma and associated clinical outcomes. (cdc.gov)
Transitional11
- 1. E-cadherin expression in urothelial carcinoma in situ, superficial papillary transitional cell carcinoma, and invasive transitional cell carcinoma. (nih.gov)
- 4. Differential expression of progression-related genes in the evolution of superficial to invasive transitional cell carcinoma of the bladder. (nih.gov)
- 7. Prostate stem cell antigen is overexpressed in human transitional cell carcinoma. (nih.gov)
- 8. Clinical implications of the expression of epidermal growth factor receptors in human transitional cell carcinoma. (nih.gov)
- 9. Highly invasive transitional cell carcinoma of the bladder in a simian virus 40 T-antigen transgenic mouse model. (nih.gov)
- 10. Urothelium-specific expression of an oncogene in transgenic mice induced the formation of carcinoma in situ and invasive transitional cell carcinoma. (nih.gov)
- 11. Expression of transforming growth factor beta1 and its receptors in normal human urothelium and human transitional cell carcinomas. (nih.gov)
- 12. E-cadherin expression in papillary transitional cell carcinoma of the urinary bladder. (nih.gov)
- 17. [Proliferative activity and p53 expression in transitional cell carcinoma of the urinary bladder]. (nih.gov)
- 18. Estrogen receptor expression in papillary urothelial carcinoma of the bladder and ovarian transitional cell carcinoma. (nih.gov)
- The WHO has replaced the old term transitional cell carcinoma with urothelial carcinoma. (nih.gov)
Squamous2
- Schistosoma haematobium ova embed in the bladder wall leading to irritation, chronic inflammation, squamous metaplasia, and dysplasia, with further progression leading to squamous cell carcinoma of the urinary bladder. (nih.gov)
- In developing countries, most BCs are squamous cell carcinoma and correlate with endemic schistosomiasis. (nih.gov)
Eosinophilic cytoplasm1
- Typical well-differentiated nests have cells with abundant eosinophilic cytoplasm. (patholines.org)
Neoplastic3
- Many cells are invading the surrounding tissue in neoplastic clumps. (wikipedia.org)
- The definition of UC is the invasion of the basement membrane or lamina propria or deeper by neoplastic cells of urothelial origin. (nih.gov)
- By current convention, all high-grade intra-acinar and intraductal neoplastic lesions of prostatic origin fall under the diagnostic umbrella term: prostatic intraepithelial neoplasm (PIN). (bmj.com)
Dysplasia2
Urinary Tract3
- It is the most common urinary tract neoplasm, with urothelial carcinoma (UC) being the most common histologic type. (nih.gov)
- Late pulmonary metastasis from urothelial carcinoma (UC) of the upper urinary tract is extremely rare. (springeropen.com)
- CASE PRESENTATION: In this case, a 55-year-old male patient presented with bothersome lower urinary tract symptoms and computed tomography findings demonstrating a urachal mass that was worrisome for urachal carcinoma. (bvsalud.org)
Histologic1
- Histologic examination shows glands with loss of surrounding basal cells. (cap.org)
Ovarian1
Diagnostic2
- 5. E-cadherin cell-adhesion molecule expression as a diagnostic adjunct in urothelial cytology. (nih.gov)
- Diagnostic laboratory evaluation for urothelial cancer may include urinalysis, cytology, and urinary tumor marker levels. (medscape.com)
Cytology2
- Conventional microscopic urine cytology may reveal tumor cells. (medscape.com)
- The false positive rate for urine cytology is approximately 1-12%, mostly due to urothelial atypia, inflammation, or changes associated with chemotherapy or radiation. (medscape.com)
Urothelium1
- Each of the three anatomically distinct zones of the prostate has its own set of periurethral main prostatic ducts lined by several layers of urothelial-like cells, reminiscent of the urothelium. (bmj.com)
Patients5
- The distinction between low-grade and high-grade urothelial disease has implications related to risk stratification and management of patients. (nih.gov)
- Mutation profile and its correlation with clinicopathology in Chinese hepatocellular carcinoma patients. (cdc.gov)
- Genomic profiling of Chinese patients with urothelial carcinoma. (cdc.gov)
- Cancer cell lines procured from patients who underwent aggressive cancers. (ijpsr.com)
- Is a Single Nephrographic Phase Computed Tomography Sufficient for Detecting Urothelial Carcinoma in Patients with Visible Haematuria? (ous-research.no)
Tumor cells2
- The tumor cells are positive for pankeratin and NKX3.1 but negative for GATA3, synaptophysin, FLI1, and SOX10. (cap.org)
- ImmunoCyt is an immunocytochemistry assay that utilizes a mixture of 3 monoclonal antibodies that can detect bladder tumor cells in the urine. (medscape.com)
Characteristics1
- As cancer is not homogeneous it makes the treatment complicated because there may be three, four, five, or six different slight variations in the cancer cells as known cancer is the constellation of over two hundred diseases having similar characteristics but are different from each other in their mechanism. (ijpsr.com)
High-grade1
- Histologically confirmed initial diagnosis by local pathology (within 90 days of the initial signed informed consent) of high grade non-muscle invasive bladder cancer (HR-NMIBC) (high-grade Ta, any T1 or carcinoma in-situ [CIS]), in participants who are Bacillus Calmette Guérin (BCG)-naïve. (who.int)
Urinalysis1
- Urinalysis showed numerous red blood cells and revealed positive results for nitrites and leukocyte esterase. (bvsalud.org)
Urethra1
Invasive2
- 2. E-cadherin expression in invasive urothelial carcinoma. (nih.gov)
- The search for more sensitive and specific urothelial tumor markers with the goal of decreasing the need for invasive procedures has led to the development of multiple molecular biology-based tests. (medscape.com)
Nests1
- The tumor is composed of nests and sheets of epithelioid cells with prominent nucleoli. (cap.org)
Invasion1
Epithelial cells1
- 1) Monolayer (anchorage-dependent) culture: cells cultured from an organ or tissue such as epithelial cells and fibroblasts. (ijpsr.com)
Pathology1
- 16. P53 overexpression in bladder urothelial neoplasms: new aspect of World Health Organization/International Society of Urological Pathology classification. (nih.gov)
Prostatic2
- The tall columnar cells lining the larger ducts resemble the cells lining the smaller ducts and acini in their staining patterns with prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP). (bmj.com)
- 2 Thus, following this approach, prostatic ductal lesions are derived from the large periurethral ducts, and the lesional cells tend to share their tall columnar morphology. (bmj.com)
Antigen1
- BTA assays are based on an antibody-detectable tumor marker that is used to detect BTA, a basement membrane antigen released when cancer cells are invading and breaking down basement membrane. (medscape.com)
Nuclei1
- Nuclei of normal cells containing DNA made up of nucleotides gets damaged causing mutation. (ijpsr.com)
Endothelial2
- Bladder cancer cells produce vascular endothelial growth factor (VEGF) to support angiogenesis. (medscape.com)
- Primary hepatic angiosarcoma is a non-epithelial malignancy derived from sinusoidal endothelial cells, accounting for approximately 1.8% of primary hepatic malignancies. (springeropen.com)
Glands2
- Pattern 3 - The tissue still has recognizable glands, but the cells are darker. (wikipedia.org)
- At high magnification, some of these cells have left the glands and are beginning to invade the surrounding tissue or having an infiltrative pattern. (wikipedia.org)
Examination1
- Various parameters including B ultrasound, DAPK methylation in urinary sediment, examination of exfoliated cells in the urine, and cystoscopy were performed. (bvsalud.org)
Therapeutic1
- According to various experiments conducted at the laboratories and literature surveys exhibited, to examine the therapeutic efficacy of different FDA approved anticancer drugs on cell lines of Homo sapiens (human), Mus musculus (Mouse), Caviaporcellus (Guinea pig), Sarcophilus harrisii (Tasmanian devil) ( Sarcophilus laniarius ), Chlorocebus aethiops (Green monkey) were used 4 . (ijpsr.com)
Small roun1
- Extraskeletal Ewing sarcoma/Primitive neuroectodermal tumor (PNET) is an aggressive small round blue cell tumor seen primarily in adolescents and young adults. (cap.org)
Gleason2
- Gleason grade 5 includes solid growth, single infiltrative cells, cords of cells, or cases with comedonecrosis. (cap.org)
- For example, if the primary tumor grade was 2 and the secondary tumor grade was 3 but some cells were found to be grade 4, the Gleason score would be 2+4=6. (wikipedia.org)
Specific1
- increase in specific types of diets that cause quandaries in the cell cycle. (ijpsr.com)