• By comparing the growth patterns of prototypical enteropathogenic, uropathogenic, and nonpathogenic Escherichia coli strains devoid of σ 54 , we uncovered that the absence of σ 54 results in two differently sized colonies that appear at different times specifically in the uropathogenic E. coli (UPEC) strain. (nih.gov)
  • Here, we report an efficient gene editing strategy based on direct delivery of Cas9 and gRNA into Uropathogenic E. coli (UPEC) isolate. (microbiologyresearch.org)
  • Production of extended-spectrum β-lactamase (ESBL) is one of the most important resistance mechanisms that hamper the antimicrobial treatment of infections caused by uropathogenic Escherichia coli (UPEC). (innspub.net)
  • Uropathogenic Escherichia coli (UPEC) is responsible for the majority of urinary tract infections (UTI). (pasteur.fr)
  • Here we demonstrate the interconnected nature of the YpdAB and BtsRS TCSs in uropathogenic Escherichia coli (UPEC). (vanderbilt.edu)
  • 1) Background: Uropathogenic E. coli (UPEC) is responsible for 70-90% of urinary tract infections. (ac.ir)
  • Urinary tract infections (UTIs), mostly caused by uropathogenic E. coli (UPEC), are important human infections. (clinmedjournals.org)
  • Uropathogenic E. coli (UPEC) are endowed with several virulence associated factors (VFs) that enable the organism to attach, invade, and injure the host. (clinmedjournals.org)
  • We previously identified ribonuclease 7 ( RNase 7) as a human antimicrobial peptide that has bactericidal activity against uropathogenic Escherichia coli (UPEC). (bvsalud.org)
  • Urinary tracts infection (UTI) caused by uropathogenic Escherichia coli (UPEC) is a common infectious disease. (uitm.edu.my)
  • Molecular Characteristics of Extraintestinal Pathogenic E. coli (ExPEC), Uropathogenic E. coli (UPEC), and Multidrug Resistant E. coli Isolated from Healthy Dogs in Spain. (preprints.org)
  • Under one-health perspective and the worldwide antimicrobial resistance concern, we investigate extraintestinal pathogenic Escherichia coli (ExPEC), uropathogenic E. coli (UPEC), and multidrug resistant (MDR) E. coli from 197 isolates recovered from healthy dogs in Spain between 2013 and 2017. (preprints.org)
  • All these findings suggest that dogs are reservoirs of ExPEC, UPEC and MDR E. coli isolates with zoonotic potential. (preprints.org)
  • Uropathogenic E coli (UPEC) has the ability to colonize the uroepithelium by means of surface fimbriae. (medscape.com)
  • Among the common uropathogens associated to UTIs development, UroPathogenic Escherichia coli (UPEC) is the primary cause. (scienceopen.com)
  • Cranberry-based supplements and/or juice are a welcome alternative for patients and health care providers alike, especially with growing concerns of antibiotic resistance against uropathogenic Escherichia coli strains (UPEC). (naturalmedicinejournal.com)
  • The increasing prevalence of antibiotic-resistant uropathogenic E. coli (UPEC) together with the recognition of UPEC as intracellular bacteria confront our current treatment regimens of urinary tract infections. (oru.se)
  • The human urinary tract is one of the most common sites of bacterial infection and most of them are caused by uropathogenic Escherichia coli (UPEC). (esrf.fr)
  • Uropathogenic Escherichia coli (UPEC) attach specifically to human bladder cells using surface structures known as type 1 pili. (esrf.fr)
  • Multidrug-resistant, chuA -positive E. coli H18 strains and R-FLIC2 (5-CTAACCCTGCAGCAGAGACA-3), are also frequently recovered from patients with urinary we obtained an internal fl iC amplicon from 105 (80.1%) tract infection. (cdc.gov)
  • A total of 100 E. coli strains, isolated from hospitalized patients were phenotypically screened for ESBL production using drug-inhibitor combination disks, namely, ceftazidime-clavulanate (30+10μg) and cefotaxime-clavulanate (30+10μg) following CLSI guidelines. (innspub.net)
  • Since these genes are plasmidal and can be transmitted between E. coli strains, it is likely that stx1 and stx2 genes are also found in the Uropathogenic E. coli. (ac.ir)
  • Also, the incidence of urinary tract infections caused by Verotoxigenic E. coli strains is increasing. (ac.ir)
  • Microbial Susceptibility, Virulence Factors, and plasmid profile of uropathogenic Escherichia coli strains Isolated from children in Jahrom, Iran. (ac.ir)
  • Detection of Shiga Toxin-Producing Strains of Escherichia coli (O157: H7) isolated from specimens of urinary and stool by Multiplex-PCR method. (ac.ir)
  • We found 55 Escherichia coli and 19 Klebsiella pneumoniae strains confirmed uropathogenic following screening for the prevalence of UTI virulence genes including fimH, iutA, feoA/B/C, mrkD, and foc. (uncst.go.ug)
  • We identified 18 different sequence types in E. coli population while all K. pneumoniae strains belong to ST11. (uncst.go.ug)
  • Overall, 93% are multi-drug resistant in the E. coli collection while 100% of the K. pneumoniae strains contained genes that are associated with resistance to three or more antibiotic classes. (uncst.go.ug)
  • Hemolytic-uremic syndrome (HUS) is a potentially devastating consequence of enteric infection with specific E coli strains. (medscape.com)
  • 1] "Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach. (tcdb.org)
  • Yet, most of what we know about E. coli stems from the investigation of laboratory strains, which fail to capture the ecology and evolution of this key organism "in the wild" ( Hobman, Penn & Pallen, 2007 ). (peerj.com)
  • Extended-spectrum β-Lactamases in ceftazidime resistant Escherichia coli and Klebsiella pneumoniae isolates in Turkish hospitals. (innspub.net)
  • However, despite this staggering statistic, very few studies have investigated the relationship between biofilm production and host factors such age group and hospitalization status, and non-host factors, including recurrence of UTI, phylogenetic group distribution, and antibiotic susceptibility, among urinary E. coli isolates from reproductive age women. (clinmedjournals.org)
  • In contrast to the essential and beneficial role of most E coli isolates in the human intestine, pathogenic E coli are responsible for a broad spectrum of human disease. (medscape.com)
  • We isolated and whole-genome sequenced up to five colonies of faecal E. coli from 66 asymptomatic children aged three-to-five years in rural Gambia (n = 88 isolates from 21 positive stools). (peerj.com)
  • Several isolates encode putative virulence factors commonly found in Enteropathogenic and Enteroaggregative E. coli, and 53% of the isolates encode resistance to three or more classes of antimicrobials. (peerj.com)
  • ABSTRACT We investigated antimicrobial resistance patterns and plasmid profiles of uropathogenic Escher- ichia coli isolates from inpatients and outpatients at Jordan University Hospital in 2000 and 2001. (who.int)
  • E. coli accounted for 32.4% and 37.4% of all isolates respectively. (who.int)
  • A large, transferable R-plasmid of 28 kb was found in most E. coli isolates (67%) that were resistant to at least ampicillin, cotrimoxazole and tetracycline. (who.int)
  • Eight to 10 colonies of tance to fluoroquinolones among uropatho- each pure culture of E. coli were taken and genic E. coli isolates [ 1-14 ]. (who.int)
  • We included 53 multidrug-resistant E. munity and hospitalized patients at a major coli isolates that were susceptible to nalid- teaching hospital in Jordan. (who.int)
  • Uropathogenic Escherichia coli strain CFT073 disrupts NLRP3 inflammasome activation. (umm.de)
  • Although clinical microbiology typically relies on single-colony picks (which has the potential to underestimate species diversity and transmission events), within-host diversity of E. coli in the gut is crucial to our understanding of inter-strain competition and co-operation and also for accurate diagnosis and epidemiological analyses. (peerj.com)
  • Pregnant women are at a higher risk of colonization with the K1 capsular antigen strain of E coli . (medscape.com)
  • to which uropathogenic E. coli clonal group A belongs. (cdc.gov)
  • Title : Enteroaggregative Escherichia coli Related to Uropathogenic Clonal Group A Personal Author(s) : Wallace-Gadsden, Faith;Johnson, James R.;Wain, John;Okeke, Iruka N. (cdc.gov)
  • The changing prevalence of drug-resistant Escherichia coli clonal groups in a community: evidence for community outbreaks of urinary tract infections. (innspub.net)
  • Our findings illustrate the abundant acquired resistome and virulome repertoire in uropathogenic E. coli and K. pneumoniae, which are mainly disseminated via clonal and horizontal transfer, circulating in the East African region. (uncst.go.ug)
  • In most UTI cases, E. coli is the causative pathogen, with over 80-90% of uncomplicated UTIs caused by this organism [ 3 ]. (clinmedjournals.org)
  • Escherichia coli is a versatile organism and very diverse. (intechopen.com)
  • E. coli has also been used as a model organism for most bacteria except a few. (intechopen.com)
  • Escherichia coli was the infecting organism in 83% of cases. (who.int)
  • Enteropathogenic E coli (EPEC) is a cause of childhood diarrhea. (medscape.com)
  • Enteroaggregative E coli (EAggEC) is primarily associated with persistent diarrhea in children in developing countries, and enteroadherent E coli (EAEC) is a cause of childhood diarrhea and traveler's diarrhea in Mexico and North Africa. (medscape.com)
  • Superficial infection with E. coli was associated with a reduced duration of hospital stay by −2.46 days and a reduced odds ratio of infectious diseases as main diagnosis of 0.04. (scienceopen.com)
  • Transcriptional alterations in bladder epithelial cells in response to infection with different morphological states of uropathogenic Escherichia coli. (oru.se)
  • Little is known about the genomic diversity of Escherichia coli in healthy children from sub-Saharan Africa, even though this is pertinent to understanding bacterial evolution and ecology and their role in infection. (peerj.com)
  • Escherichia coli is one of the most frequent causes of many common bacterial infections, including cholecystitis, bacteremia, cholangitis, urinary tract infection (UTI), and traveler's diarrhea, and other clinical infections such as neonatal meningitis and pneumonia. (medscape.com)
  • E coli bacteremia precedes pneumonia and is usually due to another focus of E coli infection in the urinary or GI tract. (medscape.com)
  • Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli. (kegg.jp)
  • First described in 1885, E coli has become recognized as both a harmless commensal and a versatile pathogen. (medscape.com)
  • Analysis of the variability of S fimbriae expression in an Escherichia coli pathogen. (uni-wuerzburg.de)
  • Prevalence and significance of fluoroquinolone resistant Escherichia coli in patients undergoing transrectal ultrasound guided prostate needle biopsy. (nature.com)
  • Escherichia coli could associate a specifi c H antigen with 10 of these RFLP patterns. (cdc.gov)
  • The characteristic serotype of this pathogenic E coli displays the K1 antigen, which is responsible for 40% of the cases of bacteremia and 80% of the cases of meningitis caused by E coli . (medscape.com)
  • 40% glycerol and then stored at -20 °C for terns and plasmid profiles of uropathogenic further investigation. (who.int)
  • Further, all of the mcr-positive genomes were identified as Escherichia coli and all contained a IncX4 plasmid replicon. (cdc.gov)
  • Of the seven σ factors in Escherichia coli and related bacteria, σ 54 exists in a class of its own. (nih.gov)
  • Filamentation is the anomalous growth of certain bacteria, such as Escherichia coli, in which cells continue to elongate but do not divide (no septa formation). (wikipedia.org)
  • It was demonstrated by itrtmunofluorescence microscopy that in noimal (wild-type) and hyperS- fimbriated E. coli populaiions non-fimbriated cells also · exist, and that the percentage of Sfinibrlated and non-fimbriated bacteria was roughly identica1 in either population. (uni-wuerzburg.de)
  • Characterization of different strategies used by uropathogenic bacteria to weaken or modulate the host immune response is one research area of major interest. (oru.se)
  • Escherichia coli, a facultatively anaerobic gram-negative bacillus, is a major component of the normal intestinal flora and is ubiquitous in the human environment. (medscape.com)
  • E coli is facultatively anaerobic with a type of metabolism that is both fermentative and respiratory. (medscape.com)
  • Hence, we conclude that CQD-CRISPR-Cas9-gRNA could be a novel therapeutic strategy for the eradication or treatment of antibiotic resistant pathogenic E. coli -based pathologies. (microbiologyresearch.org)
  • His main research interest focuses on understanding the molecular mechanisms of bacterial pathogenesis with a specific focus on uropathogenic Escherichia coli. (dillard.edu)
  • UTI, although treatable, is now becoming increasingly tough to control because of rampant antimicrobial resistance in the Enterobacteriaceae family, particularly inEscherichia coli. (microbiologyresearch.org)
  • Rapid detection of cefotaxime-resistant Escherichia coli by LC-MS.Burrer A, Findeisen P, Jäger E, Ghebremedhin B, Grundt A, Ahmad-Nejad P, Miethke T, Neumaier M. Int J Med Microbiol. (umm.de)
  • Enterohemorrhagic E coli (EHEC) causes hemorrhagic colitis or hemolytic-uremic syndrome (HUS). (medscape.com)
  • Also, this study adds significantly to the number of commensal E. coli genomes, a group that has been traditionally underrepresented in the sequencing of this species. (peerj.com)
  • In addition, S fimbriae have been associated with many of the E coli of patients with CNS infections. (medscape.com)
  • Methods: Over a 5-year interval, patients in whom either E. coli or S. aureus was detected in superficial or primary sterile compartments were assessed for the primary endpoint death during hospital stay and the secondary endpoints duration of hospital stay and infectious disease as the main diagnosis. (scienceopen.com)
  • The hospital stay of patients with E. coli was increased due to third-generation cephalosporin and ciprofloxacin resistance, and in the case of patients with S. aureus due to tetracycline and fusidic acid resistance. (scienceopen.com)
  • However, E coli pneumonia may also be community-acquired in patients who have underlying disease such as diabetes mellitus, alcoholism, chronic obstructive pulmonary disease, and E coli UTI. (medscape.com)
  • Enteroinvasive E coli (EIEC) causes a Shigella -like dysentery. (medscape.com)
  • The role of caspase-1, caspase-4 and NLRP3 in regulating the host cell response evoked by uropathogenic Escherichia coli. (oru.se)
  • Systemic infections caused by E coli are frequently seen in neonates either by means of vertical or horizontal transmission. (medscape.com)
  • E coli O157:H7 is the most virulent of the EHEC. (medscape.com)
  • Enterotoxigenic E coli (ETEC) is a cause of traveler's diarrhea. (medscape.com)
  • EHEC, also known as Shiga-toxin producing E coli (STEC), induces an attaching and effacing (AE) lesion in the large bowel. (medscape.com)
  • Conclusions: Reduced disease severity of superficial infections due to both E. coli and S. aureus and resistance-driven prolonged stays in hospital were confirmed, while other outcome parameters were comparable. (scienceopen.com)
  • The book has been divided into four main sections representing the different facets of E. coli applications, which include disease, biotechnology, environmental engineering and innovative approaches to detection, and lastly its physiology and cell biology. (intechopen.com)
  • The vast majority of neonatal meningitis cases are caused by E coli and group B streptococcal infections (28.5% and 34.1% overall, respectively). (medscape.com)
  • In adults, E coli meningitis is rare but may occur following neurosurgical trauma or procedures or complicating Strongyloides stercoralis hyperinfection involving the CNS. (medscape.com)
  • A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli. (umm.de)
  • These were spread over 37 seven-allele sequence types and the E. coli phylogroups A, B1, B2, C, D, E, F and Escherichia cryptic clade I. Immigration events accounted for three-quarters of the diversity within our study population, while one-quarter of variants appeared to have arisen from within-host evolution. (peerj.com)
  • Escherichia organisms are gram-negative bacilli that exist singly or in pairs. (medscape.com)
  • When bile flow is obstructed, colonic organisms, including E coli, colonize the jejunum and duodenum. (medscape.com)