• Urocanic acid is an intermediate in the catabolism of L-histidine. (wikipedia.org)
  • Urocanic acid is found predominantly in the stratum corneum of the skin and it is likely that most of it is derived from filaggrin catabolism (a histidine-rich protein). (wikipedia.org)
  • Some studies attribute filaggrin an important role in keeping the skin surface slightly acidic, through a breaking down mechanism to form histidine and subsequently trans-urocanic acid, however others have shown that the filaggrin-histidine-urocanic acid cascade is not essential for skin acidification. (wikipedia.org)
  • Is the filaggrin-histidine-urocanic acid pathway essential for stratum corneum acidification? (wikipedia.org)
  • The Online Metabolic and Molecular Bases of Inherited Disease - Chapter 80 - An overview of disorders of histidine metabolism, including urocanic aciduria. (wikipedia.org)
  • Histidase breaks down histidine to a molecule called urocanic acid. (medlineplus.gov)
  • This molecule is an intermediate in the conversion of histidine, an amino acid, to glutamate, a neurotransmitter that promotes electrical signalling in the brain. (nature.com)
  • But in the liver and other peripheral tissues, the acid is also known to be an intermediate molecule generated in the metabolic pathway that converts histidine to glutamate. (the-scientist.com)
  • Histidine is a semi-essential amino acid which is formed in the breakdown of carnosine. (healthmatters.io)
  • The amino acid histadine becomes histamine via a vitamin B6- dependent enzyme called histidine decarboxylase. (healthmatters.io)
  • Factors controlling the expressed activity of histidine ammonia-lyase in the epidermis and the resulting accumulation of urocanic acid. (healthmatters.io)
  • Amino acid (Lysine/arginine/ornithine/histidine/octopine) ABC transporter periplasmic binding protein, component of Amino acid transporter, PA5152-PA5155. (lbl.gov)
  • Probably transports numerous amino acids including lysine, arginine, histidine, D-alanine and D-valine (Johnson et al. (lbl.gov)
  • D-histidine and the histidine degradation products, histamine, urocanic acid and imidazole do not bind. (lbl.gov)
  • This may impair digestion, since histamine binds to H2 receptors located on the surface of parietal cells to stimulate gastric acid secretion, necessary for protein breakdown. (healthmatters.io)
  • tyrosine/phenylalanine becomes dopamine, norepinephrine, thyroid hormones and more -tryptophan becomes serotonin (eventually melatonin) -histadine becomes histamine and urocanic acid so I can be better prepared, again, for stronger UV light. (farhey.com)
  • This UV-induced effect was prevented when the researchers inhibited activity of the enzyme urocanase, which converts urocanic acid to glutamate, indicating that the acid was indeed the mediator of the UV-induced boost in glutaminergic activity. (the-scientist.com)
  • Dilutions of goji berry juice between 1% and 10% dose-dependently protected against SSUV-induced immunosuppression, and against suppression induced by the mediator, cis-urocanic acid, measured by the contact hypersensitivity reaction. (nih.gov)
  • Für seine wissenschaftliche Arbeit "The impact of skin microbiome on the immunomodulatory effects of ultraviolet radiation and its mediator cis-urocanic acid" erhielt Vijaykumar Patra, Postdoctoral Researcher am Centre International de Recherche en Infectiologie, Lyon, Frankreich und an der Universitätsklinik für Dermatologie und Venerologie, Med Uni Graz, den Vichy Exposome Grant in der Region Europa & Nordamerika. (medunigraz.at)
  • MOL2-13-185-s002.xlsx (83K) GUID:?3750B82C-9E1B-45CD-8C52-A12703E7D2A9 Abstract The peritoneal fluid of ovarian carcinoma patients promotes cancer cell invasion and metastatic spread with lysophosphatidic acid (LPA) like a potentially crucial mediator. (ece-inhibitor.com)
  • The researchers found that moderate ultraviolet exposure in mice elevated levels of a molecule called urocanic acid in the brain, where it is not usually found. (nature.com)
  • Xiong and his colleagues were using a mass spectrometry technique they had recently developed for analyzing the molecular contents of single neurons, when their results revealed the unexpected presence of urocanic acid-a little-known molecule produced in the skin in response to UV light. (the-scientist.com)
  • Cis-urocanic acid (Cis-UCA), the active product ingredient of Cis-UCA Eye Drops, is an endogenous small molecule component of human and animal skin. (oraclinical.com)
  • Decreased serum essential and aromatic amino acids in patients with chronic pancreatitis. (healthmatters.io)
  • Urocanic Acid is an imidazole compound . (wellnessadvantage.com)
  • The enzyme breaks down urocanic acid, a natural constituent of skin and other tissues of the body, into the metabolite imidazole propionate. (lu.se)
  • Mixquic cultivar had the highest number of differential compounds (amino acids and carbohydrates), followed by Xochimilco and Cuautla cultivars, respectively. (bvsalud.org)
  • These moisturizers often contain compounds found in the Natural Moisturizing Factor (NMF) like urea, lactic acid, and/or pyrrolidone carboxylic acid (PCA) . (fryface.com)
  • Thirty-nine metabolites identified in the 1H NMR spectra of aerial parts of purslane, 5 sugars, 15 amino acids, 8 organic acids, 3 caffeoylquinic acids, as well as 2 alcohols and 3 nucleosides, choline, O-phosphocholine and trigonelline were also detected. (bvsalud.org)
  • In the liver, urocanic acid is transformed by urocanate hydratase (or urocanase) to 4-imidazolone-5-propionic acid and subsequently to glutamic acid. (wikipedia.org)
  • Interestingly, histadine can also be broken down to form urocanic acid in the liver and skin. (healthmatters.io)
  • Inherited deficiency of urocanase leads to elevated levels of urocanic acid in the urine, a condition known as urocanic aciduria. (wikipedia.org)
  • The ultraviolet-triggered jolt of urocanic acid thus set off a biochemical cascade that increased the release of glutamate in neuronal synapses and improved motor learning and long-term memory in the mice. (nature.com)
  • Given glutamate's role in the brain as an excitatory neurotransmitter, Xiong and his colleagues were interested to test whether the observed UV-dependent increase in urocanic acid in neurons might be coupled with increased glutamate production. (the-scientist.com)
  • Urocanic acid was detected in animal sweat and skin where, among other possible functions, it acts as an endogenous sunscreen or photoprotectant against UVB-induced DNA damage. (wikipedia.org)
  • In Vivo Evaluation of the Protective Capacity of Sunscreen by Monitoring Urocanic Acid Isomer in the Stratum Corneum using Raman Spectroscopy. (solarlight.com)
  • Urocanic acid absorbs UV light and is thought to act as a natural sunscreen. (healthmatters.io)
  • Thirty year academic research career focusing upon photochemistry of intrinsic and extrinsic epidermal chromophores (urocanic acid, UV filters, ROS sensitization) and epidermal environmental conditions (stratum corneum pH, ozone). (ucr.edu)
  • Histadine metabolizes to glutamic acid with FIGLU as an intermediary and tetrahydrofolate as a cofactor. (healthmatters.io)
  • MS = A single protein comprised of tandem repeats of the UBIQUITIN 78 amino acid sequence. (doctorinternet.com)
  • IGF II was released from the fusion protein produced by BM-N cells infected with the recombinant virus by CNBr treatment, purified by extraction with guanidine-HCl, column chromatography and HPLC and the correct amino-terminal amino acid sequence confirmed. (microbiologyresearch.org)
  • The sponsor cell plasma membrane can be a complex framework cis-Urocanic acid formed with a liquid and powerful lipid bilayer to which different proteins and ligands with different natural functions are connected [12]. (healthanddietblog.info)
  • Acrylates are derivatives of acrylic acid (the structural formula CH 2 =CHCO 2 H), including its salts and esters. (wellnessadvantage.com)
  • Urocanic acid is thought to be a significant attractant of the nematode parasite Strongyloides stercoralis, in part because of relatively high levels in the plantar surfaces of the feet, the site through which this parasite often enters the body. (wikipedia.org)
  • Since both plasma membrane and lysosomes collaborate in parasite invasion we made a cis-Urocanic acid decision to research the need for these membrane domains for cis-Urocanic acid lysosomal recruitment and fusion during invasion into sponsor cells. (healthanddietblog.info)
  • Consequently sponsor cell plasma membrane performs an important part in adhesion and cis-Urocanic acid internalization and modulates intracellular signaling occasions that are essential for an effective infection of sponsor cells from the parasite. (healthanddietblog.info)
  • Organic acids, especially citrate, malate, and oxalate, are the root exudates most frequently investigated with regard to P mobilization. (biomedcentral.com)
  • the reduced amount of organic acids in the P-deficient roots likely reflected exudation of organic acids from the root into the rhizosphere. (biomedcentral.com)
  • These observations suggest that organic acids are involved in P acquisition. (biomedcentral.com)
  • Different mechanisms have been proposed for the facilitation of P acquisition by organic acids. (biomedcentral.com)
  • MS = A highly conserved 76-amino acid peptide universally found in eukaryotic cells that functions as a marker for intracellular PROTEIN TRANSPORT and degradation. (doctorinternet.com)
  • Administering urocanic acid directly to animals not exposed to ultraviolet light also spurred similar learning and memory improvements to those achieved with UV exposure. (the-scientist.com)
  • Protective Effects of a Topical Antioxidant Mixture Containing Vitamin C, Ferulic Acid, and Phloretin Against Ultraviolet-Induced Photodamage in Human Skin. (solarlight.com)
  • An important role for the onset of atopic dermatitis and asthma has been attributed to filaggrin, a skin precursor of urocanic acid. (wikipedia.org)
  • Urocanic acid can absorb UV rays and, as a result, may be able to protect skin against the sun's harmful effects. (the-scientist.com)
  • It may activate other anti-inflammatory molecules in the skin like nitric oxide or urocanic acid, but further research is needed to confirm this, she says. (spiritofchange.org)
  • These results provide the first assignment of a biological function to citramalic acid of plant origin. (biomedcentral.com)
  • With little information to go on, Xiong and his colleagues decided to see whether UV light could also boost levels of urocanic acid in the brain. (the-scientist.com)
  • Sure enough, levels of urocanic acid increased in neurons of the animals exposed to the light, but not in those of control animals. (the-scientist.com)
  • Kawaguchi Y, Ogawa M, Ito H, Mine T. Alterations in plasma amino acid levels in alcoholic chronic pancreatitis in Japanese. (healthmatters.io)
  • Low levels of essential amino acids may indicate a poor-quality diet, or maldigestion due to deficient digestive peptidase activity or pancreatic dysfunction. (healthmatters.io)
  • Precocious lysosomal exocytosis in MβCompact disc cis-Urocanic acid treated cells resulted in a big change in lysosomal distribution with a decrease in the amount of these organelles in the cell periphery and most likely compromises the intracellular pool of lysosomes essential for invasion. (healthanddietblog.info)
  • The consequences of ethanol had been cis-Urocanic acid significant. (ece-inhibitor.com)
  • The kidneys actively reabsorb significant amounts of amino acids. (msdmanuals.com)
  • 5) Another brain chemical made up of 241 amino acids called POMC interacts with UVA light and can become a wide range of chemicals such as beta endorphin (which boosts my mood, lowers pain and makes me crave the sunlight), ACTH (which lowers inflammation) and other chemicals that regulate mood, libido, appetite, fat burning, etc. (farhey.com)
  • Root exudates of sugar beet contain salicylic acid and citramalic acid, the latter of which has rarely been detected in plants so far. (biomedcentral.com)
  • Cataracts [folic acid], and Dietary and supplemental vitamin B2, along with other nutrients is important for normal vision and prevention of cataracts (damage to the lens of the eye which can lead to cloudy vision). (healthyplace.com)
  • But, Fisher says, if the results do hold, the finding that urocanic acid alone can enhance learning and memory might suggest "a way to utilize this information to benefit people without exposing them to the damaging effects of UV. (the-scientist.com)
  • Among these signals, negative ions with an m/z of 137 and 147 were shown to originate from salicylic acid and citramalic acid. (biomedcentral.com)