Urinary bladder urothelium. Medical search. Frequent questions

Bladder neoplasms can arise from any of the four bladder wall layers. (rhodeislandchronicle.com)
Other types of bladder neoplasms, namely, squamous cell carcinoma, adenocarcinoma, small cell carcinoma, and sarcoma account for 2-5% of bladder neoplasms. (rhodeislandchronicle.com)

This study presents the prostaglandin receptor system as a potential therapeutic target for lower urinary tract dysfunction. (biomedcentral.com)
The inner surface of the urinary tract is lined with epithelial tissue, or urothelium, which functions as a barrier to bacteria, environmental carcinogens, toxins, and the numerous and variable waste products in urine. (nih.gov)
To explore the mechanism of action of hyaluronic acid in this setting, investigators in this study first induced IC in cells from the urothelium, or the tissue that lines the urinary tract. (ichelp.org)
Porcine small intestinal submucosa (SIS) is an established matrix well-suited to the urinary tract. (johnshopkins.edu)
Urothelial carcinoma (UC) is one the most common malignancies derived from the urothelium of the lower urinary tract. (medsci.org)
Lower urinary tract symptoms (LUTS) are common in all age groups and both sexes, resulting in tremendous personal suffering and a substantial burden to society. (nature.com)
EAU guidelines on the treatment and follow-up of non-neurogenic male lower urinary tract symptoms including benign prostatic obstruction. (nature.com)
Urinary tract stones form from mineral and salts. (treatmentisrael.com)
Now, we know that testosterone plays a role in prostate growth and helps prevent inflammation in the lower urinary tract. (militarymuscle.co)
It affects the prostate and the lower urinary tract differently than commonly assumed. (militarymuscle.co)
TCC can arise anywhere in the urinary tract, including the renal pelvis, ureter, bladder, and urethra, but it is usually found in the urinary bladder. (medscape.com)
of the literature to identify the frequency, lower urinary tract symptoms (LUTS), urodynamic findings, putative underlying pathology, and management of bladder dysfunction in patients with depression/anxiety. (chksignal.com)
Understanding the signalling pathways involved in the mechanosensation of the urinary bladder will improve the understanding of bladder function, both in health and pathology and ultimately lead to novel treatment options available to patients of lower urinary tract conditions such as overactive bladder syndrome.Mediator release experiments in the whole, isolated murine bladder depicted that ACh is released in a mechanosensitive manner from the urothelium. (shu.ac.uk)

Using a novel superfused mouse bladder-pelvic nerve preparation, we detected a release of ATP proportional to the extent of bladder distension in both P2X 3 +/+ and P2X 3 − /− mice, although P2X 3 − /− bladder had an increased capacity compared with that of the P2X 3 +/+ bladder. (jneurosci.org)
The activity of multifiber pelvic nerve afferents increased progressively during gradual bladder distension (at a rate of 0.1 ml/min). (jneurosci.org)
Bladder pain syndrome Interstitial cystitis Magnetic resonance imagery Pelvic pain Urinary bladder The definition of Bladder Pain Syndrome/Interstitial Cystitis (BPS/IC) was redefined. (karger.com)
Fourth International Consultation on Incontinence Recommendations of the International Scientific Committee: evaluation and treatment of urinary incontinence, pelvic organ prolapse, and fecal incontinence. (nature.com)

Confirmed bladder cancer either during diagnostic cystoscopy, previous pathology, or pathological examination of the biopsy specimens. (who.int)

If the human bladder works similarly, then loss of normal urothelium mechanosensory signals due to disease or injury may lead to some forms of urinary frequency, urinary urgency, and urinary incontinence in people, and treatments based on this knowledge may follow. (nih.gov)
Epithelial tumors with differentiation toward normal urothelium are urothelial/ urinary carcinoma (UC). (rhodeislandchronicle.com)
The primary aim of this work was to survey normal urothelium and transitional cell carcinoma (TCC) for the presence of T lymphocytes expressing the intraepithelial, CD103(+) phenotype. (ox.ac.uk)
Occasional T lymphocytes (CD3(+)) were seen in normal urothelium and lamina propria. (ox.ac.uk)
T lymphocytes of the CD103(+) phenotype are present in normal urothelium where they may play a role in immunosurveillance. (ox.ac.uk)

Non-schistosomiasis-associated squamous cell carcinoma of the urinary bladder is less common in the Western world. (biomedcentral.com)
Investigations revealed a squamous cell carcinoma of the urinary bladder with marked leukocytosis. (biomedcentral.com)
Non-schistosomiasis-associated squamous cell carcinoma (NSA-SCC) accounts for 2% of all bladder cancers in the Western world [ 3 ]. (biomedcentral.com)
Cross-section through the bladder, uterus, and vagina with squamous cell carcinoma of the bladder infiltrating through the bladder wall into the vaginal wall. (medscape.com)

However, previous studies utilising exogenous prostaglandins have shown that these chemicals can alter contractility and micturition reflex in human bladders [ 7 ]. (biomedcentral.com)
The maximal voiding rate and the contractility of urinary bladder are decreased, and the uninhibited bladder contraction is frequently observed in aged people [2]. (scirp.org)
It has been hypothesized in previous studies, that the balance of inhibitory and excitatory mediators released from the urothelium modulates afferent nerve activity and therefore bladder contractility. (shu.ac.uk)
In further experiments it should be examined if mediator release and receptor distribution of the urothelium differs between the different regions of the bladder and between the genders.In summary it can be stated that the urothelium plays an important role in signalling processes and in detrusor contractility of the porcine and murine urinary bladder. (shu.ac.uk)
The solvents utilized had no influence on the contractility from the bladder throat arrangements. (nonamimaho.com)

titled "Review of the Clinical Approaches to the Use of Urine-based Tumor Markers in Bladder Cancer", stated that approximately 75% of newly diagnosed bladder cancer cases present as non-muscle-invasive bladder cancer (NMIBC) out of which 50-70% recur and 10-20% progress to muscle-invasive bladder cancer (MIBC). (rhodeislandchronicle.com)
The treatment of non-muscle-invasive bladder cancer (Ta, T1, carcinoma in situ [CIS]) begins with transurethral resection of bladder tumor (TURBT). (medscape.com)
Perform the first surveillance cystoscopy within 3 to 4 months after completion of the initial evaluation and treatment of patients with non-muscle-invasive bladder cancer (NMIBC). (medscape.com)
The fairly high rate of progression to muscle-invasive disease (30%) in patients with high-risk NMIBC require more frequent monitoring by urine cytology and cystoscopy, the gold standard for detection of bladder cancer recurrence. (medscape.com)

To evaluate whether these connexins are affected by changes in transmural urine pressure, we used a rat model of bladder outlet obstruction, in which a ligature is placed around the urethra. (unige.ch)
The storage and periodic evacuation of urine by the bladder is regulated by a complex neural control system that consists of the CNS and the afferent and efferent spinal nerves. (jneurosci.org)
The bladder is a balloon-shaped organ that stores and releases urine. (nih.gov)
The bladder muscle relaxes and stretches when it ills with urine, and it squeezes when it is time to urinate. (nih.gov)
As the bladder ills with urine, nerves carry signals about its change in shape and stretching-mechanosensory signals-to let the brain know when the bladder is full. (nih.gov)
Urinary incontinence (UI) is the unintentional leakage of urine. (nih.gov)
The computerized system performed by the TAS (QFIA) was applied to 96 urine samples from 43 patients with cancer and other urinary problems. (cdc.gov)
It is important to study the mechanism of urinary bladder dysfunctions such as urinary incontinence, pollakisuria (urinary frequency) and residual urine (incomeplete voiding), because these problems increase with aging and affect the quality of life in elderly people [1]. (scirp.org)
Microbiota in Urine and Urothelium Can be a Factor for Induction of Urinary Bladder Cancer. (who.int)
The Study Will Examine Urine and Bladder Cancer Tissues From Male Patients and Urine of Controls Using Whole Genomic Sequencing Techniques and 16S rRNA. (who.int)
Adult men above 18 years, - Diagnosed of carcinoma of the bladder with imaging ultrasonography and/ or computerized tomography, and urine cytology. (who.int)
It's believed that the main cause of bladder cancer is exposure to carcinogenic substances (aromatic amines, certain industrial chemicals and diesel fumes), which reach the bladder mucosa via urine. (treatmentisrael.com)

The inner mucosal lining keeps the urothelium moist and the urethra supple. (medscape.com)
1990. Urinary bladder, ureter, and urethra. (nih.gov)
Norepinephrine released from adrenergic nerve endings, relaxes bladder body by increasing intracellular cAMP via β-adrenergic receptors widely expressed in the bladder body, and contracts bladder base and proximal urethra via α-adrenergic receptors to prevent premature bladder emptying. (scirp.org)
Support of the urethra and bladder neck is thought to be important in the maintenance of continence during sudden increases in intra-abdominal pressure. (medscape.com)

He had cystolitholapaxy and transurethral resection of the bladder tumor. (biomedcentral.com)
Standard treatment for NMIBC is a complete transurethral resection of the bladder tumor (TURBT). (medscape.com)

Prostaglandin I 2 is the main prostaglandin synthesised in the human bladder, followed by PGE 2, PGF 2α and TXA 2 [ 14 , 15 ]. (biomedcentral.com)
We evaluated the ability of human embryonic germ (hEG) cell-derived stem cells to form a composite graft on SIS, grown alone or in combination with human bladder smooth muscle cells (SMCs) or urothelial (URO) cells. (johnshopkins.edu)
Comparison of hypoxia transcriptome in vitro with in vivo gene expression in human bladder cancer. (ox.ac.uk)
We investigated the hypoxia transcriptome in primary human bladder cancer using cDNA microarrays to compare genes induced by hypoxia in vitro in bladder cancer cell line EJ28 with genes upregulated in 39 bladder tumour specimens (27 superficial and 12 invasive). (ox.ac.uk)
Further characterisations of the studied pathways are now required to fully validate the data, most suitably in human tissue, as it is not clear if the same pathways are affected by age in the human bladder.Spontaneous contractions and carbachol-induced contractions were measured in male and female porcine bladder strips isolated from the dome, body and trigone region. (shu.ac.uk)

The urethral epithelium is composed of stratified squamous cells, which variably becomes transitional as the bladder is approached. (medscape.com)

Flexible cystoscopy showed solid-looking tumors at the bladder base and a calculus. (biomedcentral.com)
Eight of these had tumors already proven by bladder biopsy. (cdc.gov)

Current clinical judgment in bladder cancer (BC) relies primarily on pathological stage and grade. (nih.gov)
Effective strategies are lacking for the management of urinary bladder cancer for which smoking is a potential risk factor. (nih.gov)
Herein, we evaluated chemoprevention of urinary bladder cancer by natural chemopreventive agents, silymarin and silibinin, in a preclinical animal (ICR mouse) model of bladder cancer induced by tobacco smoke carcinogen N-butyl-N-(4-hydroxybutyl) nitrosamine (OH-BBN). (nih.gov)
Research in this area conventionally involves in vitro models using resistant cell lines generated by continuous low dose drug exposure for many months, unlike the exposure experienced by residual superficial bladder cancer cells during chemotherapy adjuvant to resection. (soton.ac.uk)
Materials and methods: RT112 bladder cancer cells (Catalog No. ACC 418, Deutsche Sammlung von Mikroorganismen und Zellkulturen, Braunschweig, Germany) were exposed to a range of mitomycin C concentrations for 1 hour. (soton.ac.uk)
The expression of androgen and/or oestrogen receptors has been assessed in bladder cancer, leading to conflicting data of expression levels and their relationship to histopathological characteristics of the tumours. (urotoday.com)
Compared to benign bladders, a significant decrease in the expression of AR, ERα or ERβ in bladder cancer was seen. (urotoday.com)
Detection of DNA aneuploidy by quantitative fluorescence image analysis: potential in screening for occupational bladder cancer. (cdc.gov)
Of 545 chemical company workers exposed to the known bladder carcinogen 2-naphthylamine (91598), 14 cases of bladder cancer were detected, including three identified by ANFI. (cdc.gov)
The authors suggest that these techniques could be applied to screening asymptomatic workers who have been exposed to chemicals known to induce bladder cancer. (cdc.gov)
To characterize the microbiota in health and bladder cancer, and may lead to new prevention, diagnosis and treatment strategies for bladder cancer [Time Frame: Sample sollection 12 months, next generation sequencing ind bioinformatics 6 months, interpretation of data 6 months. (who.int)
These antigens were evaluated for both the degree of expression and prognostic value in cancer of the urothelium. (aacrjournals.org)
The secondary aim was to determine the pattern of distribution of CD103(+) lymphocytes in relation to E-cadherin expression in bladder cancer. (ox.ac.uk)
Bladder cancer is a common urologic cancer that has the highest recurrence rate of any malignancy. (medscape.com)
No blood tests are specific for bladder cancer, but a general evaluation is necessary prior to initiating therapy with intravesical bacillus Calmette-Guérin (BCG) vaccine. (medscape.com)
Bladder cancer is a common urologic cancer. (medscape.com)
Most cases of noninvasive bladder cancer remain clinically indolent with even a modicum of urologic intervention. (medscape.com)
Bladder cancer surveillance standards arose based primarily on expert opinion rather than as an evidence-based standard. (medscape.com)
TURBT is the initial treatment recommendation to help identify the stage of the bladder cancer. (medscape.com)
Treatment protocols for bladder cancer are provided below, including those for chemotherapy, immunotherapy, and systemic neoadjuvant and adjuvant therapy. (medscape.com)
NCCN Clinical Practice Guidelines in Oncology: Bladder Cancer. (medscape.com)

These are small myelinated (A δ ) and unmyelinated (C) fibers that convey impulses from bladder wall receptors. (jneurosci.org)
Burnstock (1999) recently put forward a hypothesis about purinergic mechanosensory transduction that proposed that in hollow organs, including the ureter and bladder, distension causes release of ATP from epithelial cells lining these organs and that ATP can then activate P2X 3 receptors on subepithelial sensory nerve terminals to evoke neural discharge. (jneurosci.org)
We simultaneously analyze three receptors in non-neoplastic bladder tissues as well as in primary and metastatic bladder tumour specimens. (urotoday.com)
To assess the expression of the androgen receptor (AR) and oestrogen receptors (ERs) in bladder tumours because recent studies have shown conflicting results and the prognostic significance of their expression remains unclear. (urotoday.com)
Materials and Methods: The bladders of 7 guinea pigs were stained for prostaglandin receptors type 1 and 2, and costained for vimentin and cyclooxygenase I. Results: Prostaglandin receptor type 1 staining was seen in urothelial cells and in the suburothelium. (maastrichtuniversity.nl)
Acetylcholine released from cholinergic nerve endings, contracts the smooth muscle of bladder body via activation of muscarinic receptors to cause voiding. (scirp.org)
Conclusions and implications 5-HT calm the pig urinary bladder throat through muscle tissue 5-HT7 receptors from the cAMP-PKA pathway. (nonamimaho.com)

Improperly operating signals can lead to one of several conditions, including urinary frequency, urinary urgency, and urinary incontinence. (nih.gov)
However, in contrast to normal mice, mice lacking β-1 integrin were found to have several abnormal bladder conditions that may reflect urinary incontinence, urinary frequency, and urinary urgency, and their bladders filled beyond normal limits before triggering urination. (nih.gov)
Future studies could explore whether people with urinary frequency, urinary urgency, and urinary incontinence also have abnormal integrin signaling in their urothelium. (nih.gov)
Loss of β1‑integrin from urothelium results in overactive bladder and incontinence in mice: a mechanosensory rather than structural phenotype. (nih.gov)
Global prevalence and economic burden of urgency urinary incontinence: a systematic review. (nature.com)
EAU guidelines on urinary incontinence. (nature.com)

abstract = "Purpose: Urothelium has 2 main functions. (maastrichtuniversity.nl)

Mouse bladder afferents of P2X 3 +/+ , but not P2X 3 − /− , were rapidly activated by intravesical injections of P2X agonists (ATP or α,β-methylene ATP) and subsequently showed an augmented response to bladder distension. (jneurosci.org)
Valrubicin is indicated for intravesical therapy of BCG-refractory CIS of the urinary bladder in patients for whom immediate cystectomy would be associated with unacceptable morbidity or mortality. (medscape.com)

Materials and Methods: The study comprised a total of 578 patients from 9 centers worldwide with pT3N0 urothelial carcinoma of the bladder who underwent radical cystectomy without perioperative chemotherapy. (elsevierpure.com)
Alternatively, a bladder-sparing approach of TURBT followed by concurrent radiation therapy and systemic chemotherapy (trimodality therapy) may be used. (medscape.com)

Purpose: Patients with pathological T3N0 stage urothelial carcinoma of the bladder show a range of outcomes after radical cystectomy. (elsevierpure.com)
Given that nomograms have included heterogeneous groups of patients, we focused on and stratified patients with pT3N0 urothelial carcinoma of the bladder after radical cystectomy into prognostically different risk groups to facilitate the development of adjuvant therapy trials for those at high risk. (elsevierpure.com)
Conclusions: We constructed a user friendly prognostic risk model for patients with pT3N0 urothelial carcinoma of the bladder treated with radical cystectomy based on pT3 substage at radical cystectomy, lymphovascular invasion and margin status. (elsevierpure.com)
Urothelial Carcinoma starts when cells that make up the urinary bladder become cancerous. (rhodeislandchronicle.com)

Enclose the keywords in quotation marks e.g. 'overactive bladder syndrome' t o return results where the keywords appear next to each other and in the same order. (libguides.com)
Persistence and adherence in the treatment of overactive bladder syndrome with anticholinergic therapy: a systematic review of the literature. (nature.com)

The expression patterns of nine CTAs (NY-ESO-1, LAGE-1, MAGE-A1, MAGE-A3, MAGE-A4, MAGE-A10, CT7, CT10, and GAGE) were examined by immunohistochemistry and reverse transcription-PCR in a panel of high-grade urothelial carcinomas of the urinary bladder. (aacrjournals.org)

Inflammation is often associated with several bladder dysfunctions, including overactive bladder (OAB) and interstitial cystitis/bladder pain syndrome (IC/PBS). (biomedcentral.com)

In both the depression cohort and the psychogenic bladder dysfunction cohort (at a urology clinic), the most common LUTS was overactive bladder (OAB), followed by difficult urination and infrequent voiding. (chksignal.com)

Hypercalcemia-leukocytosis syndrome (HLS) as a paraneoplastic syndrome (PNS) of bladder cancers is rare, although it is documented in anaplastic thyroid, lung, and penile squamous cell carcinomas (SCCs) [ 1 , 2 ]. (biomedcentral.com)
Most bladder cancers develop in the urothelium (the bladder's innermost layer). (treatmentisrael.com)
Almost all bladder cancers originate in the urothelium, which is a 3- to 7-cell mucosal layer within the muscular bladder. (medscape.com)
it constitutes more than 90% of bladder cancers in those regions. (medscape.com)

Studies were carried out using isolated tissue baths, where strips of porcine bladder U&LP or detrusor were exposed to varying concentrations of prostaglandin agonists (1 μM and 10 μM). (biomedcentral.com)
Total radioactivity detected from urinary and faecal excretion and tissue residue levels accounted for 0.9% and 0.2% of the radioactivity at the low and high dose, respectively. (inchem.org)
After cholinergic stimulation the amplitude of denuded tissue strips was higher compared to the intact counterparts in all bladder regions and in both genders. (shu.ac.uk)
Components and Methods Human being bladder cells Using a genuine broker program of medical Sciences Tissue Loan company at College or university of Pittsburgh human being bladder tissues had been obtained after educated consent from another of kin of 3 body organ donors. (biotechnologyconsultinggroup.com)

Urinary urgency is the sudden, strong need to urinate immediately. (nih.gov)

The results revealed a selective and concentration-dependent desquamation effect of poly-L-lysine on superficial urothelial cells followed by quick regeneration of the urothelium, which functionally and structurally recovers in 2 to 3 h after poly-L-lysine-induced injury. (uni-lj.si)

Infusion of GSK1016790A into the bladders of TRPV4 +/+ mice induced bladder overactivity with no effect in TRPV4 −/− mice. (aspetjournals.org)
Figure 3: Functional organization of CB 1 expression in experimental models of bladder overactivity. (nature.com)
i.e. urodynamic findings were normal except for increased bladder sensation without detrusor overactivity for OAB (50% of all patients), followed by underactive detrusor without post-void residual for difficult urination. (chksignal.com)

The role of the urothelial mucosa in bladder mechanosensation. (shu.ac.uk)
Removed bladder cells had been held in ice-cold Krebs sodium solution before detrusor was separated through the bladder mucosa by microdissection under sterile circumstances. (biotechnologyconsultinggroup.com)
The word bladder mucosa identifies both suburothelial and urothelial structures like the lamina propria. (biotechnologyconsultinggroup.com)
For quantitative polymerase string response QPCR and Traditional western blot studies freezing detrusor and bladder mucosa examples had been split into 2 areas each. (biotechnologyconsultinggroup.com)

Induced desquamation of urinary bladder epithelial cells, also called urothelial cells, is frequently used in studies of bladder epithelial regeneration and also in treating recurrent bacterial cystitis. (uni-lj.si)

We investigated the expression of AR, ERα and ERβ in 188 bladder tumour specimens, as well as matched 141 non-neoplastic bladder and 14 lymph node metastasis tissues, by immunohistochemistry. (urotoday.com)

In patients with interstitial cystitis (IC), treatment with hyaluronic acid is able to replenish the glycosaminoglycan (GAG) layer, a barrier layer on the inner surface of the bladder. (ichelp.org)

AR/ERα/ERβ was positive in 80%/50%/89% of benign urothelium, 50%/67%/41% of benign stroma, 42%/27%/49% of primary tumours and 71%/64%/71% of metastatic tumours. (urotoday.com)

In order to elucidate the mechanism of functional changes in aged rat urinary bladder, we studied the influence of senescence on, 1) the α-adrenergic contractile response to phenylephrine in the urinary bladder body and trigone, 2) the muscarinic contractile response to carbachol in the body and trigone. (scirp.org)
We revealed that the muscarinic receptor-mediated response was not affected by aging, while the contractile response to α-adrenergic stimulation was significantly augmented in both bladder body and trigone. (scirp.org)

In response to stretch urothelium releases various substances that modulate afferent nerve activity. (maastrichtuniversity.nl)

Immunohistochemistry revealed abundant nerve fibers in a suburothelial plexus in the mouse bladder that are immunoreactive to anti-P2X 3 . (jneurosci.org)
In contrast, strong prostaglandin receptor type 2 staining was seen in the urothelium and in suburothelial cells. (maastrichtuniversity.nl)

Loss of the GAG layer results in increased permeability of the bladder wall, which can lead to pain and urinary dysfunction in patients with IC. (ichelp.org)
We aimed to delineate bladder dysfunction in patients with depression/anxiety by reviewing the literature. (chksignal.com)

This evidence-based text is an essential reference source for residents, physicians, and healthcare professionals involved in the diagnosis and management of neurogenic bladder patients. (chipsbooks.com)
Amelioration of bladder dysfunction is an important target in treating patients with depression/anxiety. (chksignal.com)

Ta are noninvasive papillary lesions confined to the urothelium and have not penetrated the basement membrane. (medscape.com)

The urinary bladder U&LP and detrusor respond to a variety of prostaglandin agonists, with their activation resulting in direct contractions, as well as increases to spontaneous contractile activity. (biomedcentral.com)
Thus, prostaglandin produced by urothelium may target prostaglandin receptor types 1 and 2 in the urothelium and suburothelium. (maastrichtuniversity.nl)
Therefore prostaglandin is hypothesized to have a role in signal regulation in the bladder wall. (maastrichtuniversity.nl)

They are synthesised in the bladder by cyclooxygenase (COX) and then subsequently converted into five primary prostanoids via their respective synthases: PGE 2 , PGD 2 , PGF 2α , prostacyclin (PGI 2 ) and thromboxane (TXA 2 ) [ 9 ]. (biomedcentral.com)

The involvement of prostaglandins in bladder physiology was first recognised from their release after urinary bladder distension or injury to the urothelium [ 1 , 2 ]. (biomedcentral.com)
However, the bladder afferents from P2X 3 − /− mice showed an attenuated response to bladder distension. (jneurosci.org)
By contrast, P2X antagonists [2′,3′- O -(2,4,6-trinitrophenyl)-ATP and pyridoxal 5-phosphate 6-azophenyl-2′,4′-disulfonic acid] and capsaicin attenuated distension-induced discharges in bladder afferents. (jneurosci.org)
Spontaneous contractions were also measured in the whole, isolated murine bladder and showed a positive correlation to increasing distension levels. (shu.ac.uk)

This study assessed the actions of PGE 2 , PGF 2 , PGD 2 , TXA 2 , and PGI 2 on urinary bladder urothelium with lamina propria (U&LP), and detrusor smooth muscle. (biomedcentral.com)
Prostaglandins are synthesised in both the bladder urothelium with lamina propria (U&LP) and in detrusor smooth muscle in response to stretch, nerve stimulation, U&LP damage or other inflammatory mediators [ 10 , 11 ]. (biomedcentral.com)
Specifically, of interest is to determine how the actions of the prostaglandins affect urothelium with lamina propria that is separated from the detrusor smooth muscle. (biomedcentral.com)

Textbook of the Neurogenic Bladder covers all aspects of the neurogenic bladder from aetiology and pathophysiology to diagnosis and treatment of all associated problems. (chipsbooks.com)
Diagnosis and treatment of overactive bladder (non-neurogenic) in adults: AUA/SUFU guideline. (nature.com)

In the human urinary bladder, β-ARs expressed in ICs may play a role in bladder physiology. (chksignal.com)

Carbachol-induced contraction in aged rat bladder was identical to that obtained in young rat. (scirp.org)

Recent research has identified a protein, β1-integrin, as having an essential role in bladder control in mice. (nih.gov)

TRPV4 mRNA was detected in urinary bladder smooth muscle (UBSM) and urothelium of TRPV4 +/+ mouse bladders. (aspetjournals.org)
Further analysis revealed that these changes were accounted for by a fourfold increase in Cx43 mRNA of SMC but not urothelial cell and by a fivefold increase in Cx26 mRNA of urothelium. (unige.ch)

The urinary bladder is innervated and functionally regulated by the autonomic nervous system. (scirp.org)
The urinary bladder is innervated and functionally regulated by sympathetic and parasympathetic nerves. (scirp.org)

The augmentation of α-adrenoceptor-mediated contractions in aged bladder may induce urinary dysfunction such as voiding difficulty. (scirp.org)

Conclusions Species-specific variations had been noted in manifestation of HCN stations in bladder. (biotechnologyconsultinggroup.com)

Anatomy9

Organisms3

Diseases19

Chemicals and Drugs9

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes3

Disciplines and Occupations1

Neoplasms2

Tract13

Pelvic4

Pathology1

Normal urothelium5

Squamous cell carc4

Contractility5

Muscle-invasive4

Urine12

Urethra4

Transurethral Resection2

Human bladder5

Stratified squamous1

Tumors2

Cancer21

Receptors7

Incontinence6

Abstract1

Intravesical2

Chemotherapy2

Urothelial carcinoma4

Overactive bladder2

High-grade urothelial carcinomas1

Dysfunctions1

Urology1

Cancers4

Tissue4

Urgency1

Superficial1

Overactivity3

Mucosa4

Epithelial cells1

Tumour specimens1

Interstitial cystitis1

Metastatic1

Body and trigone2

Afferent1

Suburothelial2

Dysfunction in patients2

Patients2

Noninvasive1

Prostaglandin3

Cyclooxygenase1

Distension4

Lamina3

Diagnosis2

Physiology1

Contraction1

Role in bladder1

MRNA2

Functionally2

Contractions1

Conclusions1