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  • urate
  • 8 Isolated defects in the tubular transport of uric acid have been associated with increased renal clearance of urate, hypouricemia, hypercalciuria, and decreased bone density. (labcorp.com)
  • It forms ions and salts known as urates and acid urates, such as ammonium acid urate. (wikipedia.org)
  • Thus in strong alkali at high pH, it forms the dually-charged full urate ion, but at biological pH or in the presence of bicarbonate ions, it forms the singly-charged hydrogen urate or acid urate ion. (wikipedia.org)
  • In humans and higher primates, uric acid (actually hydrogen urate ion) is the final oxidation (breakdown) product of purine metabolism and is excreted in urine. (wikipedia.org)
  • The loss of uricase in higher primates parallels the similar loss of the ability to synthesize ascorbic acid, leading to the suggestion that urate may partially substitute for ascorbate in such species. (wikipedia.org)
  • The normal concentration range of uric acid (or hydrogen urate ion) in human blood is 25 to 80 mg/L for men and 15 to 60 mg/L for women (but see below for slightly different values). (wikipedia.org)
  • Acute uric acid nephropathy (AUAN, also acute urate nephropathy) is a rapidly worsening (decreasing) kidney function (renal insufficiency) that is caused by high levels of uric acid in the urine (hyperuricosuria). (wikipedia.org)
  • Patients at risk for acute uric acid nephropathy can be given allopurinol or rasburicase (a recombinant urate oxidase) prior to treatment with cytotoxic drugs. (wikipedia.org)
  • This can occur because of diet, genetic predisposition, or underexcretion of urate, the salts of uric acid. (wikipedia.org)
  • acute
  • In one country, Spain, uric acid is an investigational drug in a phase 3 trial studying its effects as an adjunct to alteplase in acute ischemic stroke. (drugbank.ca)
  • The potential therapeutic use for uric acid is as an adjunct in acute ischemic stroke. (drugbank.ca)
  • Chamorro A, Planas AM, Muner DS, Deulofeu R: Uric acid administration for neuroprotection in patients with acute brain ischemia. (drugbank.ca)
  • Acute uric acid nephropathy is usually seen as part of the acute tumour lysis syndrome in patients undergoing chemotherapy or radiation therapy for the treatment of malignancies with rapid cell turnover, such as leukemia and lymphoma. (wikipedia.org)
  • Once the acute attack subsides, levels of uric acid can be lowered via lifestyle changes and in those with frequent attacks, allopurinol or probenecid provides long-term prevention. (wikipedia.org)
  • excretion
  • Elevations of uric acid occur with increased purine synthesis, inherited metabolic disorders, excess dietary purine intake, increased nucleic acid turnover, malignancy, cytotoxic drugs, decreased excretion due to chronic renal failure, and increased renal reabsorption. (labcorp.com)
  • concentrations
  • High protein foods that do not significantly contribute to uric acid concentrations in the body are eggs, dairy products and certain nuts, reports HealthXc. (reference.com)
  • high
  • A diet low in fat, animal protein, alcohol and high fructose corn syrup is helpful for reducing uric acid in the body, states Mayo Clinic. (reference.com)
  • Beef has some uric acid content but not as high as pork. (ehow.co.uk)
  • Because beer is a yeast products, it is especially high in uric acid. (ehow.co.uk)
  • The five-membered ring also possesses a keto group (in the 8 position), flanked by two secondary amino groups (in the 7 and 9 positions), and deprotonation of one of these at high pH could explain the pK2 and behavior as a diprotic acid. (wikipedia.org)
  • breakdown
  • Today it is seen in a wider range of the population, as well as in women and children and is thought to be the result of eating habits where people consume excess animal protein and fats which contribute heavily to the formation of purine breakdown and uric acid. (livestrong.com)
  • Uric acid is a product of the metabolic breakdown of purine nucleotides, and it is a normal component of urine. (wikipedia.org)
  • metabolism
  • The metabolism of Uric Acid can be decreased when combined with 6-Deoxyerythronolide B. (drugbank.ca)
  • According to A. Halabe and O. Sperling of the Department of Metabolism, Beilinson Medical Center, Petah Tikva, Israel, 'uric acid is more soluble in a more alkaline pH. (livestrong.com)
  • amino
  • amino acid A class of organic compounds containing an amino group and a carboxylic acid group. (wikipedia.org)
  • End Products of Digestion: Irrespective of the type of animal, the end products of protein, carbohydrates and fats are amino acids, simple sugars, and fatty acids respectively. (wikipedia.org)
  • therapeutic
  • 3 The therapeutic goal for uric acid-lowering therapy is to promote crystal dissolution and prevent crystal formation. (labcorp.com)
  • As a therapeutic agent, it is known that uric acid is increased in response to oxidative stress, and as such, uric acid acts as an antioxidant. (drugbank.ca)
  • increase
  • The increase in the level of uric acid in the body can cause a lot of trouble. (articlealley.com)
  • Thus, while most organic acids are deprotonated by the ionization of a polar hydrogen-oxygen bond, usually accompanied by some form of resonance stabilization (resulting in a carboxylate ion), uric acid is deprotonated at a nitrogen atom and uses a tautomeric keto/hydroxy group as an electron-withdrawing group to increase the pK1 value. (wikipedia.org)
  • Raising the urinary pH to a level higher than 7 (alkalinization) is often difficult to attain, although sodium bicarbonate and/or acetazolamide are sometimes used in an attempt to increase uric acid solubility. (wikipedia.org)
  • uricase
  • In higher primates and humans, the enzyme, uricase, is absent, and thus uric acid is not further metabolized and is excreted. (drugbank.ca)
  • anti-inflammatory
  • However, most plant-based foods are relatively harmless in this category, and there are some plant foods that actually counteract uric acid and are anti-inflammatory in nature. (ehow.co.uk)