Hydroxy-ureaHydrolysis of ureaAntimetaboliteAcute myelogenCapsulesTherapyOccursIncludePresenceUSAGEBloodComponentCellsTotalActiveDoses of hydroxyureaWARNINGS AND PRECAUTIONSSickleAntineoplasticBacterialEfficacyAcuteAntimetaboliteSiklosMalignanciesSerumPatientsLiverGastricRapidlyDrugsProteinTreatmentOralHighGreaterImportant
Hydroxy-urea2
- Monthly provision of Folic acid and Hydroxy urea capsules. (org.in)
- A unique automobile describing appliance is utilized in this case, as well as solutions utilized include man made hydroxy urea and acids acids. (ciencias.fun)
Hydrolysis of urea2
- These enzymes catalyze the hydrolysis of urea into carbon dioxide and ammonia: (NH2)2CO + H2O urease→ CO2 + 2NH3 The hydrolysis of urea occurs in two stages. (wikipedia.org)
- The Saccharomyces cerevisiae enzyme (but not that from green algae) CC also catalyzes the reaction of EC 6.3.4.6, thus bringing about the CC hydrolysis of urea to CO2 and NH3 in the presence of ATP and CC bicarbonate. (expasy.org)
Antimetabolite1
- A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. (blogspot.com)
Acute myelogen1
- Therapy-related acute myelogenous leukemia in a hydroxyurea-treated patient with sickle cell anemia. (ctsicn.org)
Capsules5
- These highlights do not include all the information needed to use HYDROXYUREA CAPSULES safely and effectively. (nih.gov)
- See full prescribing information for HYDROXYUREA CAPSULES. (nih.gov)
- HYDROXYUREA capsules, for oral use. (nih.gov)
- Live Vaccinations: Avoid live vaccine use in a patient taking hydroxyurea capsules. (nih.gov)
- discontinue hydroxyurea capsules and implement treatment. (nih.gov)
Therapy3
- Dermal Therapy Extra Strength Body Lotion ' s nourishing 10% urea formula helps relieve dry, rough, problem skin. (dermaltherapy.com)
- Hydroxyurea is used alone or in conjunction with other antitumor agents or radiation therapy to treat neoplastic diseases. (nih.gov)
- Monitor blood counts at least once a week during hydroxyurea therapy. (nih.gov)
Occurs1
- Vasculitic toxicities: Discontinue hydroxyurea and initiate treatment if this occurs. (nih.gov)
Include1
- The optimum pH is 7.4 and optimum temperature is 60 °C. Substrates include urea and hydroxyurea. (wikipedia.org)
Presence1
- Coculture of human bone marrow endothelial cells with erythroid progenitor cells also induced gamma-globin mRNA expression (2.4-fold) in the presence of hydroxyurea (40 mu M). Conclusion. (ac.rs)
USAGE1
- Recent reports on 1-(N-benzyloxycarbamoyl) benzotriazole revealed its crystal structure (10) and usage in the synthesis of hydroxyurea derivatives (11, 12). (moam.info)
Blood1
- He also worked closely with the Sickle Cell Disease Branch of the National Heart Lung and Blood Institute, serving on many panels including the Data Safety and Monitoring Board for the pivotal trial of hydroxyurea in babies (Baby HUG). (kidneyfund.org)
Component1
- In patients who have demonstrated a previous hypersensitivity to hydroxyurea or any other component of its formulation. (nih.gov)
Cells5
- Urea causes skin cells deep below the surface to attract, absorb and hold moisture better. (dermaltherapy.com)
- Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. (blogspot.com)
- However, preventing phosphorylation of SAMHD1 and/or lowering dNTP levels by adding hydroxyurea was not enough to restore restriction in cycling cells. (biomedcentral.com)
- We have previously shown that nitric oxide (NO) is involved in the hydroxyurea-induced increase of gamma-globin gene expression in cultured human erythroid progenitor cells and that hydroxyurea increases NO production in endothelial cells via endothelial NO synthase (NOS). (ac.rs)
- Interestingly, chemotherapy, including hydroxyurea, has been associated with acute leukemia in JAK2 V617F-negative stem cells in some PV patients. (basicmedicalkey.com)
Total1
- This graph shows the total number of publications written about "Hydroxyurea" by people in this website by year, and whether "Hydroxyurea" was a major or minor topic of these publications. (ctsicn.org)
Active1
- The proximity of urea to active groups in the active site along with the correct orientation of urea allow hydrolysis to occur rapidly. (wikipedia.org)
Doses of hydroxyurea2
- While some patients show an increase in HbF levels and an ameliorated clinical condition under low doses of hydroxyurea, other patients present a poor effect or even develop toxicity. (nih.gov)
- Serum aminotransferase and bilirubin elevations occur in a small proportion of patients on conventional doses of hydroxyurea and a greater proportion at higher doses. (nih.gov)
WARNINGS AND PRECAUTIONS1
- What Are Warnings and Precautions for Hydroxyurea? (rxlist.com)
Sickle8
- Do Genetic Polymorphisms Affect Fetal Hemoglobin (HbF) Levels in Patients With Sickle Cell Anemia Treated With Hydroxyurea? (nih.gov)
- Hydroxyurea has long been used for the treatment of sickle cell anemia (SCA), and its clinical effectiveness is related to the induction of fetal hemoglobin (HbF), a major modifier of SCA phenotypes. (nih.gov)
- Hydroxyurea is an antimetabolite that is used in the treatment of cancer and to stimulate fetal hemoglobin production in sickle cell disease. (nih.gov)
- Hydroxyurea also increases the production of fetal hemoglobin, via an unknown mechanism of action, which increases overall hemoglobin levels and decreases sickling in patients with sickle cell anemia. (nih.gov)
- In controlled clinical trials, hydroxyurea has been shown to increase hemoglobin concentrations, decrease transfusion requirements and lessen painful crises in patients with sickle cell disease. (nih.gov)
- Since the beneficial effects of hydroxyurea are thought to depend on continuing administration, sickle cell anemia patients may be taking hydroxyurea for more than three years. (nih.gov)
- Observation of an adequate number of sickle cell anemia patients with more than three years of exposure to hydroxyurea will be necessary to obtain information on the occurrence of infrequent adverse outcomes. (nih.gov)
- He also worked closely with the Sickle Cell Disease Branch of the National Heart Lung and Blood Institute, serving on many panels including the Data Safety and Monitoring Board for the pivotal trial of hydroxyurea in babies (Baby HUG). (kidneyfund.org)
Antineoplastic3
- Hydroxyurea is an antineoplastic agent used to treat melanoma, leukemias, and other neoplasms. (infantrisk.com)
- Hydroxyurea is an antineoplastic (anti-cancer) agent used to treat melanoma , resistant chronic myelocytic leukemia , and recurrent , metastatic, or inoperable carcinoma of the ovary and primary squamous cell (epidermoid) carcinomas of the head and neck. (rxlist.com)
- Hydroxyurea was first approved for use in the United States in 1967 as an antineoplastic agent for therapy of melanoma, chronic myelogenous leukemia, ovarian carcinoma, and head and neck cancers. (nih.gov)
Bacterial1
- 16S rRNA was used to detect composition changes in the intestinal bacterial community of animals after treatment with hydroxyurea. (thno.org)
Efficacy3
- The efficacy and mechanism of hydroxyurea in the treatment of atherosclerosis have rarely been reported. (thno.org)
- The goal of this study was to investigate the efficacy of hydroxyurea in high-fat diet-fed ApoE -/- mice against atherosclerosis and examine the possible mechanism underlying treatment outcomes. (thno.org)
- We showed that aortic root HE staining and oil red O staining determined the therapeutic efficacy of hydroxyurea in the treatment of atherosclerosis in high-fat diet-fed ApoE -/- mice. (thno.org)
Acute1
- Hydroxyurea is associated with a low rate of transient serum enzyme and bilirubin elevations during therapy, and has been implicated in rare cases of clinically apparent acute liver injury with jaundice. (nih.gov)
Antimetabolite1
- Hydroxyurea (hye drox" ee ure ee' a) is a hydroxylated analogue of urea and an antimetabolite which inhibits the enzyme ribonucleotide reductase, which is necessary for DNA synthesis and cell cycle replication. (nih.gov)
Siklos1
- I would kindly like to request information regarding the use of the drug Siklos, which contains hydroxyurea, in terms of its administration to breastfeeding mothers. (infantrisk.com)
Malignancies1
- Malignancies: Hydroxyurea is carcinogenic. (globalrph.com)
Serum2
- Serological tests verified the ability of hydroxyurea to lower total serum cholesterol and LDL cholesterol. (thno.org)
- In high-fat diet-fed ApoE -/- mice, hydroxyurea effectively treated atherosclerosis, lowered serum cholesterol, modulated the gut microbiota at multiple levels and affected cholesterol absorption by reducing NPC1L1 in small intestinal epithelial cells. (thno.org)
Patients8
- In patients who have demonstrated a previous hypersensitivity to hydroxyurea or any other component of its formulation. (nih.gov)
- However, there is substantial variability in response to hydroxyurea among patients with SCA. (nih.gov)
- Drug fever occurs in up to 1% of patients treated with hydroxyurea, typically arising within 1 to 3 weeks of starting and presenting with high fevers and mild constitutional symptoms of fatigue and nausea (Case 1 below). (nih.gov)
- Expected bone marrow suppression was observed among 79% patients assigned to hydroxyurea. (nih.gov)
- An increased number of patients assigned to hydroxyurea compared to MSH patients assigned to placebo (13 versus 4) were reported at routine six-month visits to have complaints of bruising and bleeding. (nih.gov)
- repeat reports of these complaints (i.e., complaints at more than one six-month visit) were made by only three patients assigned to hydroxyurea and two patients assigned to placebo. (nih.gov)
- The only well documented causes of bleeding were reported for patients assigned to hydroxyurea -- menometrorrhagia in two patients and an anal fissure in one patient. (nih.gov)
- Other than bone marrow suppression, the MSH patients reported the effects of hydroxy-urea listed in the product package insert (i.e., hair loss, skin rash, etc.) with similar frequencies among patients assigned to placebo and patients assigned to hydroxyurea. (nih.gov)
Liver2
- It is well absorbed orally and rapidly metabolized to urea by the liver. (infantrisk.com)
- Cases of clinically apparent liver injury attributed to hydroxyurea have been reported, but are rare. (nih.gov)
Gastric1
- It plays an essential function for survival, neutralizing gastric acid by allowing urea to enter into periplasm via a proton-gated urea channel. (wikipedia.org)
Rapidly1
- The proximity of urea to active groups in the active site along with the correct orientation of urea allow hydrolysis to occur rapidly. (wikipedia.org)
Drugs3
- What Other Drugs Interact with Hydroxyurea? (rxlist.com)
- Hydroxyurea has moderate interactions with at least 115 different drugs. (rxlist.com)
- Hydroxyurea has no known mild interactions with other drugs. (rxlist.com)
Protein1
- Further histological and ELISAs verified that the protein responsible for intestinal absorption of cholesterol in mice, NPC1L1, was significantly reduced after hydroxyurea treatment. (thno.org)
Treatment1
- Hydroxyurea is used in the treatment of solid tumors and myeloproliferative diseases, the latter because of its effects in reducing excessive production of red blood cells (polycythemia vera), white blood cells (chronic myelogenous leukemia) or platelets (essential thrombocythemia). (nih.gov)
Oral2
- La ingesta de L-arginina por vía oral o intravenosa durante un máximo de 8 semanas aumenta el flujo sanguíneo en personas con esta afección. (medlineplus.gov)
- La ingesta de L-arginina por vía oral o intravenosa no mejora la función renal en la mayoría de las personas con ERC. (medlineplus.gov)
High1
- ApoE -/- mice were fed a high-fat diet for 1 month and then administered hydroxyurea by gavage continuously for 2 months. (thno.org)
Greater1
- The kcat/Km of urease in the processing of urea is 1014 times greater than the rate of the uncatalyzed elimination reaction of urea. (wikipedia.org)
Important1
- Urea is an important part of healthy young skin's natural moisturizing system. (dermaltherapy.com)