Uptake of radioactivity. Medical search. Frequent questions

The level of neuronal uptake of norepinephrine in the pig pineal was 3.5+/-0.9 pmol/h/mg of wet tissue and represented about 77% of the total tissue radioactivity. (nel.edu)
At early stages of the experiment the values of tissue radioactivity in LSC were generally much higher in the THBC group but 24 hours following injections the reverse was true with higher activities in the 6-MeO-THBC group. (erowid.org)

In vivo, 68 Ga-BMS-986192 uptake was high at 1 h after injection in PD-L1-positive tumors (9.0 ± 2.1 percentage injected dose [%ID]/g) and kidneys (56.9 ± 9.2 %ID/g), with negligible uptake in other tissues. (snmjournals.org)
A high correlation between ex vivo tracer uptake (standardized uptake value) in the xenograft and the number of inoculated CD25-positive cells was observed ( R 2 = 0.90). (springer.com)
In animal experiments, blood glucose, the homeostasis model assessment (HOMA)-index assessment, glucose tolerance test, and in vivo glucose uptake were all measured. (hindawi.com)
The improvement of glucose intolerance, HOMA-index, and in vivo glucose uptake is evident in addition to the weight loss effect and attenuation of hepatic steatosis. (hindawi.com)
Over the past several years, a number of radioligands have been studied in several laboratories for their in vivo binding to 5-HT uptake sites. (erowid.org)
Because [11C]McN-5652-Z is a racemic mixture of two stereoisomers, of which the (+) isomer (McN-5652-X) binds to the 5-HT uptake site in vivo and the (-) isomer (McN-5652-W) does not, the possibility exists that regional-specific binding can be determined by subtracting nonspecific binding of the (-) isomer from total radioactivity counts obtained with the (+) isomer. (erowid.org)
SiNPs-TZ (1:8 Hc-TZ) tumor uptake was significantly greater than that of SiNPs-TZ (1:2 Hc-TZ) at 6 hours post-injection (p.i.) in ex vivo biodistribution experiment. (dovepress.com)

1. To study the metabolism of α 1 -antitrypsin in man, radioiodinated purified α 1 -antitrypsin of protease inhibitor type MM was injected intravenously into seven normal volunteer subjects of protease inhibitor type MM and plasma and urine radioactivity data were analysed. (portlandpress.com)
18 F-fluciclovine prescribing information states that only 3% of the administered radioactivity is excreted in the urine in the first 4 h after injection ( 11 ). (snmjournals.org)

The influence of the YID diet on thyroid uptake will also be discussed. (avmi.net)
The main objective of this study was to evaluate the ability of a large field Cadmium Zinc Telluride (CZT) camera to estimate thyroid uptake (TU) on single photon emission computed tomography (SPECT) images with and without attenuation correction (Tomo-AC and Tomo-NoAC) compared with Planar acquisition in a series of 23 consecutive patients. (springeropen.com)
Trial registration Name of the registry: Thyroid Uptake Quantification on a New Generation of Gamma Camera (QUANTHYC). (springeropen.com)

For semiquantitative analysis, myocardial activity is conventionally measured relative to the region of most intense uptake. (snmjournals.org)
reported intense 18 F-fluciclovine bladder activity (≥liver) in 15.2% of the delayed images (approximately 30 min after radiotracer injection) obtained from 128 patients who underwent 18 F-fluciclovine PET/CT, yet no intense uptake was reported in early images (∼5 min after radiotracer injection) ( 5 ). (snmjournals.org)

Dose-dependent increase in glucose uptake activity (GUA) was observed in both cell lines. (wiley.com)
In conclusion, AEG enhances glucose transport by modulating the proximal and distal markers involved in glucose uptake and its transformation into glycogen. (wiley.com)

An ethyl acetate extract of orange juice did not affect the initial uptake rate of [ 3 H]vinblastine but significantly increased the steady-state uptake, as did cyclosporin A (20 μM), an inhibitor of P-gp. (aspetjournals.org)
Low concentrations significantly inhibited GABA uptake, especially in astrocytes, suggesting an accumulation of endogenous GABA in the synaptic cleft. (hindawi.com)
Refraining from voiding before 18 F-fluciclovine injection results in significantly lower urinary bladder radioactivity than does purposeful voiding before injection. (snmjournals.org)

By normalizing each regional cerebral activity to the activity observed in the cerebellum, the regional radioactivity (binding index) could be relatively quantified. (avmi.net)
A heterogeneous uptake of radioactivity was observed with highest levels inside the cortex, intermediate amounts in the cerebellum and lowest uptake within the hypothalamus. (ack1inhibitor.com)

The radioactivity in tissues was calculated as % of instilled/injected dose. (cdc.gov)
We propose a model that reconciles the paradoxical 80-90% loss of TG label into plasma with LPL-directed differential uptake of TGFA in tissues. (diabetesjournals.org)
all organs as well as tissues and the carcass were radioanalyzed to balance the entire deposited radioactivity of the particles. (cdc.gov)

The results were reported as radioactivity (% of administered dose of test substance). (europa.eu)
Scintigraphic methods to quantify thyroid function include thyroid-to-salivary (T:S) ratio, % dose uptake, and thyroid-to-background (T:B) ratio. (avmi.net)
Subsequently, T:B was compared to T:S and % dose uptake to determine which scintigraphic measurement correlates to serum T4 in the hyperthyroid cat. (avmi.net)
The % dose uptake correlates best to serum T4(r = 0.74), followed by T:S ratio (r = 0.65), followed by the T:B ratio using the heart ROlon a ventral image (r = 0.58). (avmi.net)
T:B ratio using the heart ROI as the background is a good predictor T4 but percent dose uptake or the traditional T:S ratio proved to be a better predictors of T4 than any of the T:B ratios. (avmi.net)
S1P inhibited astrocytic glutamate uptake in a dose-dependent manner and increased mitochondrial oxygen consumption, primarily through S1P 2 . (eneuro.org)
Primary cultures of wild-type mouse astrocytes expressed S1P 1,2,3 transcripts, and selective deletion of S1P 1 and/or S1P 3 in cerebral cortical astrocytes, did not alter S1P-mediated, dose-dependent inhibition of glutamate uptake. (eneuro.org)
1. The low-dose-effect relationship controversy ther uptake s regulated by homeostatc mechansms. (who.int)

Jiří Hála claims in his textbook "Radioactivity, Ionizing Radiation and Nuclear Energy" that cattle only pass a minority of the strontium, caesium, plutonium and americium they ingest to the humans who consume milk and meat. (wikipedia.org)
Association between pulmonary uptake of fluorodeoxyglucose detected by positron emission tomography scanning after radiation therapy for non-small-cell lung cancer and radiation pneumonitis. (pneumotox.com)

A thyroid scan uses a very safe weak radioactive material to see if the thyroid behaves in a normal way by taking up the radioactivity evenly. (thyroid.ca)
decreased uptake, decreased activity, abnormal concentration (gallium scan). (cancer.gov)
in which case doctors do a thyroid scan and uptake test. (msdmanuals.com)

Pharmacological antagonists, S1P 2 -null astrocytes, and Gα 12 hemizygous-null astrocytes indicated that S1P 2 -Gα 12 -Rho/ROCK signaling was primarily responsible for the S1P-dependent inhibition of glutamate uptake. (eneuro.org)
In addition, S1P exposure increased mitochondrial oxygen consumption rates (OCRs) in wild-type astrocytes and reduced OCRs in S1P 2 -null astrocytes, implicating receptor selective metabolic consequences of S1P-mediated glutamate uptake inhibition. (eneuro.org)

Shoot and roots were harvested at fixed intervals, and their radioactivity was analyzed to measure phosphorus uptake. (frontiersin.org)
14C]-radioactivity was determined at 6h intervals in the media and at 24h post-dosing in the skin. (nih.gov)

In conclusion, for the IV-injected particles, particle size has an initial effect on 65Zn uptake in the liver. (cdc.gov)

Extracellular glutamate is excitotoxic and its levels are controlled by astrocyte uptake. (eneuro.org)

Significant radioactivity (parent plus metabolites) detected in the milk of lactating rats suggests a potential for exposure to nursing infants. (drugs.com)

A considerable uptake of the compounds was seen in the lungs, kidney, liver, bone marrow, urinary bladder, gastrointestinal tract and in various glands e.g. adrenal, Harderian and salivary glands. (erowid.org)
Several ways of uptake of compounds with widely different solubility characteristics are also considered. (who.int)

The results demonstrate, for the first time, that EO can improve GABAergic neurotransmission via interactions with GABA A receptor and modulation of GABA uptake. (hindawi.com)
The involvement of glutamate dysregulation in these neurologic diseases makes pharmacological modulation of glutamate uptake an attractive therapeutic target ( Anderson and Swanson, 2000 ). (eneuro.org)

We sought to evaluate and quantify early 18 F-fluciclovine bladder radioactivity and determine whether refraining from voiding before 18 F-fluciclovine injection would mitigate it. (snmjournals.org)
The distribution of radioactivity after intravenous injection of 14C-labelled 1,2,3,4-tetrahydro-beta-carboline (THBC) and 6-methoxy-1,2,3,4-tetrahydro-beta-carboline (6-MeO-THBC) was studied on mice by whole-body autoradiography and by liquid scintillation counting (LSC). (erowid.org)
3.four Regional and temporal distribution of [11C]PF-04457845 in rat brain Following tail-vein injections of [11C]PF-04457845 into conscious rats, brain uptake was higher with SUV ranging from 1.two to four.four, reaching a plateau 40 min post injection (Table 1). (ack1inhibitor.com)
Radioactivity was substantially decrease in the plasma than the brain with cortex-to-plasma ratios rising from two:1 to 34:1 among 2 and 40 min post injection. (ack1inhibitor.com)

Promising candidates as SPECT imaging agents for the 5-HT uptake site are [123I]RTI-55 and [123I]-iodo-6-nitroquipazine. (erowid.org)
On cardiac FDG PET imaging a perfusion-metabolic mismatch pattern seen as focal FDG uptake in area of a perfusion defect and occasionally in the setting of normal perfusion suggests inflammatory CS (Figure 2). (asnc.org)

For the same mass, depleted uranium has about 60% of the radioactivity of natural uranium. (who.int)

A similar half-life was seen in a fifth subject, injected with 80 μg of vitamin D 3 - 3 H. Most (approximately 92%) of the plasma total radioactivity was represented by this component throughout the study. (jci.org)
In animals, based on total radioactivity, cabergoline (and/or its metabolites) has shown extensive tissue distribution. (drugs.com)
However, total phosphorus uptake from thermally conditioned sewage sludge was lower than that from the commercial fertilizer. (frontiersin.org)
Based on the radioactivity found in excreta, total approx. (europa.eu)

Environmental radioactivity is produced by radioactive materials in the human environment. (wikipedia.org)
The additional radioactivity in the biosphere caused by human activity due to the releases of man-made radioactivity and of Naturally Occurring Radioactive Materials (NORM) can be divided into several classes. (wikipedia.org)

There is a great need for PET and SPECT ligands with high affinity and selectivity for the serotonin uptake site. (erowid.org)

Natural radioactivity detected in soil is predominantly due to the following four natural radioisotopes: 40K, 226Ra, 238U, and 232Th. (wikipedia.org)
The distribution coefficient Kd is the ratio of the soil's radioactivity (Bq g−1) to that of the soil water (Bq ml−1). (wikipedia.org)
If the radioactivity is tightly bonded to by the minerals in the soil then less radioactivity can be absorbed by crops and grass growing in the soil. (wikipedia.org)

No significant effect on the uptake of 3- O -[ 3 H]methylglucose or [ 14 C]phenylalanine by Caco-2 cells was found, compared with the control. (aspetjournals.org)

2002), nothing is known about long-term there is concern about translocation of ultrafine particles (UFP) translocation and whether clearance kinetics of ultrafine parti- from the lungs into systemic circulation and uptake in transpul- cles differ from that of larger particles, as one may expect from differing clearance mechanisms for micrometer-sized particles versus UFP. (cdc.gov)

11C]McN-5652-X is highly selective for 5-HT uptake sites, and its distribution is consistent with the neuroanatomical distribution of the 5-HT uptake site. (erowid.org)
Here, S1P receptor knock-out mice, primary astrocyte cultures, and receptor-selective chemical tools were used to examine the effects of S1P on glutamate uptake. (eneuro.org)

Thus, apoCIII overexpression resulted in increased NEFA availability to adipose uptake and decreased adipocyte lipolysis, favoring lipid enlargement of adipose depots. (biomedcentral.com)

This distribution of radioactivity in several brain regions is comparable to [11C]CURB and in accordance with all the recognized expression of FAAH within the rat brain (Fig. two) [402]. (ack1inhibitor.com)

This particular model shows an instrument that employed three NaI detectors to evaluate the uptake and elimination of a radiopharmaceutical in three different organs simultaneously, usually the thyroid, liver and bladder. (orau.org)

In this model, TGFAs mix locally at the capillaries with plasma FFAs, where they would lead to an increase in the local FA concentration, and hence, FA uptake. (diabetesjournals.org)
Background radioactivity should be a predictor of pertechnetate plasma concentration. (avmi.net)
Discussion/Conclusion: Placing an ROI over the heart is the best method of quantifying plasma radioactivity. (avmi.net)

The part played by clearance processes by the aquatic environment was emphasized : the concentration factor should not be the only parameter to consider when comparing radioactivity uptakes in the marine and fresh-water environments. (radioprotection.org)

decreased uptake, decreased activity. (cancer.gov)
Moreover, the other nutrients present in the sludge stimulated the microbial activity, thereby inducing competition between microorganisms and the plant roots for phosphorus uptake. (frontiersin.org)

Whole body autoradiography studies in pregnant rats showed no fetal uptake but high levels in the uterine wall. (drugs.com)

Contemporarily the main meteorological parameters (ambient temperature, wind, atmospheric pressure and natural radioactivity) were investigated. (who.int)

Here, we show that astrocytic S1P 2 activation by S1P results in glutamate uptake inhibition to promote excitotoxic damage. (eneuro.org)

When the extract was separated on a Cosmosil column, the eluate with 70% methanol showed the most potent ability to increase [ 3 H]vinblastine uptake. (aspetjournals.org)
In contrast, a FDG PET image with a perfusion defect without corresponding increase in FDG uptake suggests chronic scar tissue (Figure 5). (asnc.org)

This normative data can be used to compare regional brain uptake of the 123I-radioligand to dogs with behavioral disorders related to the serotonergic system, in future studies. (avmi.net)

Journal of Environmental Radioactivity 181, 8-17. (lightsource.ca)

Cs-137 Kd = 1000 Pu-239 Kd = 10000 to 100000 Sr-90 Kd = 80 to 150 I-131 Kd = 0.007 to 50 One dramatic source of man-made radioactivity is a nuclear weapons test. (wikipedia.org)

Highest brain uptake was noted in the frontocortical brain areas (right: 1.85, left: 1.89), followed by the temporocortical region (right: 1.58, left: 1.56). (avmi.net)
Based upon the region, uptake of radioactivity in rat brain regions decreased 53 83 for both ip doses of PF-04457845 (Fig. 1, p 0.05).Nucl Med Biol. (ack1inhibitor.com)

11C]McN-5652-X is the best PET radioligand for the 5-HT uptake site described thus far. (erowid.org)

This study investigated the effects of EO on the main GABAergic targets for anticonvulsant drugs, analyzing the effect on the GABA receptor's benzodiazepine and picrotoxinin binding sites and the GABA uptake. (hindawi.com)

This could be explained by the fact that the phosphorus in the water-soluble commercial fertilizer is immediately available for plant uptake after application, whereas the phosphorus in thermally conditioned sewage sludge is present in a lower available form. (frontiersin.org)

At 24 h p.i., radioactivity values remained steady. (dovepress.com)

The ethyl acetate extract of orange juice and these methoxyflavones also increased steady-state [ 3 H]vinblastine uptake by LLC-GA5-COL300 cells (a cell line transfected with human MDR1 cDNA). (aspetjournals.org)
3 H]Flunitrazepam and [ 3 H]TBOB binding, [ 3 H]GABA uptake, cell viability, and morphology were assayed. (hindawi.com)

They use a special camera that detects radioactivity. (medlineplus.gov)

Anatomy25

Organisms10

Diseases1

Chemicals and Drugs141

Analytical, Diagnostic and Therapeutic Techniques and Equipment42

Phenomena and Processes34

Disciplines and Occupations2

Information Science2

Health Care6

Tissue radioactivity2

Vivo7

Urine2

Thyroid uptake3

Intense uptake2

Glucose uptake2

Significantly3

Cerebellum2

Tissues3

Dose8

Radiation2

Scan3

Astrocytes2

Intervals2

Particle size1

Extracellular1

Lactating rats1

Compounds2

Modulation2

Injection4

Imaging2

Uranium1

Total4

Radioactive2

SPECT1

Soil3

Significant1

Lungs1

Selective2

Lipid1

Distribution1

Evaluate1

Plasma3

Environments1

Activity2

High1

Natural1

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Increase2

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