Uptake of dibasic amino acids and sodium dependent uptake sodium dependent amino acid transporter amino acids neutral. Medical search. Frequent questions

Arginine is a basic amino acid as its side chain contains a positively charged guanidinium group, which is highly polar, at the end of a hydrophobic¬†aliphatic¬†hydrocarbon chain. (cannabisdatabase.ca)
In 1993, Lee et al cloned a human complementary DNA, rBAT (renal basic amino acid transporter) in chromosome 2, encoding a transport protein for cystine and dibasic amino acids. (medscape.com)

Arginine or l-arginine, abbreviated Arg or R, is an essential amino acid that is physiologically active in the L-form. (cannabisdatabase.ca)
In mammals, arginine is formally classified as a semi-essential or conditionally essential amino acid, depending on the developmental stage and health status of the individual. (cannabisdatabase.ca)
L-Arginine is an amino acid that has numerous functions in the body. (cannabisdatabase.ca)
Cystinuria is an autosomal-recessive defect in reabsorptive transport of cystine and the dibasic amino acids ornithine, arginine, and lysine from the luminal fluid of the renal proximal tubule and small intestine. (medscape.com)
[ 9 ] showed abnormal excretion of the dibasic amino acids lysine, arginine, and ornithine in persons with cystinuria. (medscape.com)

Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. (wuxibiortus.com)
This sodium-independent transporter is formed when the light subunit encoded by this gene dimerizes with the heavy subunit transporter protein SLC3A2. (nih.gov)

Cystinuria is an autosomal-recessive defect in reabsorptive transport of cystine and the dibasic amino acids ornithine, arginine, and lysine from the luminal fluid of the renal proximal tubule and small intestine. (medscape.com)
[ 7 ] showed abnormal excretion of the dibasic amino acids lysine, arginine, and ornithine in persons with cystinuria. (medscape.com)

The protein encoded by this gene is the light subunit of a cationic amino acid transporter. (nih.gov)
[ 14 ] The normal SLC7A9 gene encodes a subunit of the cystine transporter called b 0,+ AT (amino acid transporter). (medscape.com)

The high-affinity system mediates uptake of 10% of L-cystine and the dibasic amino acids at the apical membrane of the straight third segment (S3) of the proximal tubule. (medscape.com)

Transport of L-cystine in the brush-border membrane vesicle is sodium-independent and electrogenic. (medscape.com)
Vesicle budding from the tER is an ATP-dependent process. (nih.gov)

In 1993, Lee et al cloned a human complementary DNA, rBAT (renal basic amino acid transporter) in chromosome 2, encoding a transport protein for cystine and dibasic amino acids. (medscape.com)
Probe Set ID Ref Seq Protein ID Signal Strength Name Gene Symbol Species Function Swiss-Prot ID Amino Acid Sequence 1367452_at NP_598278 7.9 small ubiquitin-related modifier 2 precursor Sumo2 Rattus norvegicus " Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. (nih.gov)

The gene that codes for the cystine transporter, initially termed rBAT, is now known as SLC3A1 (SLC for solute carrier) in the international Genome Database. (medscape.com)
The process of cystine uptake is activated by the SLC3A1 and SLC7A9 gene products. (medscape.com)

This transporter is found in epithelial cell membranes where it transfers cationic and large neutral amino acids from the cell to the extracellular space. (nih.gov)
Various authors have studied amino acid transport in cell membranes obtained from the proximal renal tubule of humans, rats, and rabbits. (medscape.com)