Uptake inhibitor. Medical search. Frequent questions

Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. (mcw.edu)

Many nuts contain phytic acid and enzyme inhibitors. (tastingtable.com)

Anorectic activities of serotonin uptake inhibitors: correlation with their potencies at inhibiting serotonin uptake in vivo and 3 H-mazindol binding in vitro. (springer.com)
Seasonal variation of serotonin uptake in normal controls and depressed patients. (springer.com)
The serotonin uptake inhibitor citalopram reduces acute cardiovascular. (erowid.org)
Antidepressants, such as serotonin uptake inhibitors, address this problem by cutting off water flow. (dictionary.com)
The first highly specific serotonin uptake inhibitor. (curehunter.com)
Use of fluoxitine, a selective serotonin uptake inhibitor, in the treatmente of obesity: A dose-response study. (bvsalud.org)

Selective serotonin re-uptake inhibitors (SSRIs), which are most commonly used as antidepressants are being used to treat this condition. (cochrane.org)
Pimozide is often coprescribed with serotonin reuptake inhibitor (SSRI) antidepressants to treat depression in patients with Tourette's syndrome. (nih.gov)

This study aimed to determine whether I3C or DIM could increase glucose uptake via enhanced insulin sensitivity in 3T3‐L1 adipocytes, as well as the mechanism involved. (researchgate.net)
DIM also enhanced glucose uptake by increasing expression of glucose transporter 4 in adipocytes. (researchgate.net)
Conclusions Our findings suggest that DIM may improve insulin sensitivity through the activation of the insulin signaling pathway, leading to enhanced glucose uptake. (researchgate.net)
Previous studies have found that DIM can improve type 2 diabetes by enhancing glucose uptake through the activation of insulin signaling in 3T3-L1 cells, and by lowering the plasma glucose levels in high-fat-diet-fed obese mice [13, 14]. (researchgate.net)
DIM, a major metabolite of indole-3-carbinol, which is naturally produced in broccoli and cabbage, enhances glucose uptake through the improvement of insulin sensitivity in 3T3-L1 cells [13] . (researchgate.net)
3,3′-diindolylmethane (DIM)-a natural compound produced from indole-3-carbinol, found in cruciferous vegetables-enhances glucose uptake by increasing the activation of the insulin signaling pathway in 3T3-L1 adipocytes. (researchgate.net)
abstract = 'Conventional (c) protein kinase C (PKC) activity has been shown to increase with skeletal muscle contraction, and numerous studies using primarily pharmacological inhibitors have implicated cPKCs in contraction-stimulated glucose uptake. (ku.dk)
Here, to confirm that cPKC activity is required for contraction-stimulated glucose uptake in mouse muscles, contraction-stimulated glucose uptake ex vivo was first evaluated in the presence of three commonly used cPKC inhibitors (calphostin C, G{\'o}-6976, and G{\'o}-6983) in incubated mouse soleus and extensor digitorum longus (EDL) muscles. (ku.dk)
All potently inhibited contraction-stimulated glucose uptake by 50-100%, whereas both G{\'o} compounds, but not calphostin C, inhibited insulin-stimulated glucose uptake modestly. (ku.dk)
However, in muscles from PKCalpha knockout (KO) mice, neither contraction- nor phorbol ester-stimulated glucose uptake ex vivo differed compared with the wild type. (ku.dk)
Furthermore, the effects of calphostin C and G{\'o}-6983 on contraction-induced glucose uptake were similar in muscles lacking PKCalpha and in the wild type. (ku.dk)
It can be concluded that PKCalpha, representing approximately 97% of cPKC in skeletal muscle, is not required for contraction-stimulated glucose uptake. (ku.dk)
Thus the effect of the PKC blockers on glucose uptake is either nonspecific working on other parts of contraction-induced signaling or the remaining cPKC isoforms are sufficient for stimulating glucose uptake during contractions. (ku.dk)
It reduces hepatic glucose output, may decrease intestinal absorption of glucose, and may increase glucose uptake in peripheral tissues. (medscape.com)

We wanted to find out if medicines called selective serotonin re-uptake inhibitors (SSRIs), which are used mostly to treat depression, can help men that ejaculate faster than they want, to slow down. (cochrane.org)
Regulator of calcineurin 1 modulates expression of innate anxiety and anxiogenic responses to selective serotonin reuptake inhibitor treatment. (colorado.edu)
Prozac is an SSRI, or a selective serotonin re-uptake inhibitor. (escapistmagazine.com)
The selective serotonin reuptake inhibitor parox. (tocris.com)

Xylamine (N-2'-chloroethyl-N-ethyl-2-methylbenzylamine), a nitrogen mustard that irreversibly inhibits norepinephrine uptake, cyclizes in solution to form an aziridinium ion. (aspetjournals.org)

SSRIs inhibit central nervous system (CNS) neuronal uptake of serotonin (5HT). (medscape.com)

Pretreatment with the rho kinase inhibitor, fasudil, was able to prevent brain fluorescein uptake and neuroinflammation. (cdc.gov)
Many studies have proposed multi-objective molecular generation methods and demonstrated their superiority using the public benchmark dataset for kinase inhibitor generation tasks. (bvsalud.org)

On the other hand, triple re-uptake inhibitor supplements simultaneously target three crucial neurotransmitters: serotonin, dopamine, and norepinephrine. (ceoreviewmagazine.com)
Pharmacological activity of the species derived from this irreversible norepinephrine uptake inhibitor. (aspetjournals.org)
The aziridinium ion, its hydrolysis product, and the dimer were synthesized to evaluate directly their effects on norepinephrine uptake in rabbit thoracic aorta. (aspetjournals.org)
The dimer was a weak competitive inhibitor of norepinephrine uptake, with an IC50 of about 10 microM. (aspetjournals.org)

It is a nonsteroidal competitive inhibitor of the aromatase enzyme system. (medscape.com)

Synthesis, Fluorine-18 Radiolabeling, and Biological Evaluation of N-((E)-4-Fluorobut-2-en-1-yl)-2β-carbomethoxy-3β-(4′-halophenyl)nortropanes: Candidate Radioligands for In Vivo Imaging of the Brain Dopamine Transporter with Positron Emission Tomography. (acs.org)
1994. Gas uptake studies of deuterium isotope effects on dichloromethane metabolism in female B6C3F1 mice in vivo . (cdc.gov)

It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor. (bvsalud.org)

Before they reach this phase, a growth inhibitor called phytic acid keeps vitamins, fiber, and other crucial nutrients locked within their shells, preventing us from absorbing them. (dictionary.com)

The aziridinium ion was as potent as xylamine as an irreversible uptake inhibitor, and the effects of both compounds were sodium-dependent. (aspetjournals.org)
Soaking nuts helps eliminate these compounds, increasing digestion and nutrition uptake. (tastingtable.com)

Inhibitors of arachidonic acid metabolism: effects on rat striatal dopamine release and uptake. (aspetjournals.org)

These total results preclude the chance of dLop accumulation in mitochondria or mobile accumulation through uptake transporters. (biosemiotics2013.org)
On the other side of the synapse are transporters, which re-uptake the dopamine so that it doesn't continue to just sit around the synapse, stimulating neurons endlessly. (escapistmagazine.com)

However, the results also suggest that certain inhibitors of arachidonic acid metabolism are relatively potent DA uptake blockers/releasers and that this action is unrelated to their inhibition of enzymes in the arachidonic acid cascade. (aspetjournals.org)
The inhibition of ('3)H-tdr uptake was favored over that of ('3)H-udr or ('3)H-adr, and this effect was reversible. (etsu.edu)
Inhibition constants (K(i) values) were estimated from Dixon plots (three HLMs for each inhibitor) using the appropriate enzyme inhibition model by nonlinear regression. (nih.gov)

The main groups include sodium channel blockers, calcium current inhibitors, gamma-aminobutyric acid (GABA) enhancers, glutamate blockers, carbonic anhydrase inhibitors, hormones, and drugs with unknown mechanisms of action (see the image below). (medscape.com)

Which medications in the drug class Antineoplastic Agents, mTOR Kinase Inhibitors are used in the treatment of Non-Hodgkin Lymphoma (NHL)? (medscape.com)

Pores formed upon USMB treatment are rapidly resealed, suggesting that other processes such as enhanced endocytosis may contribute to the enhanced material uptake by cells upon USMB treatment. (plos.org)
Fekri F, Delos Santos RC, Karshafian R, Antonescu CN (2016) Ultrasound Microbubble Treatment Enhances Clathrin-Mediated Endocytosis and Fluid-Phase Uptake through Distinct Mechanisms. (plos.org)

Chloroquine is an autophagy inhibitor that appears to induce the death of TSC2-deficient cells when given in combination with sirolimus and is being tested in an ongoing clinical trial. (medscape.com)

Paroxetine maleate is a highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (K i = 0.05 nM). (tocris.com)

Maprotiline is a strong inhibitor of noradrenaline re-uptake in the brain and peripheral tissues, however it is worthy to note that it is a weak inhibitor of serotonergic uptake. (pharmacycode.com)

USMB treatment elicits enhanced cellular uptake of materials such as drugs, in part as a result of sheer stress and formation of transient membrane pores. (plos.org)

An attractive method to enhance the safety and efficiency of drug treatment in cancer is to supplement conventional administration methods with targeted drug delivery strategies in order to enhance drug uptake within tumour tissues while limiting their action within healthy cells [ 3 , 4 ]. (plos.org)

HPLC-purified SMAL at relatively low doses inhibited the uptake and phosphorylation of ('3)H-tdr, without significant effect on cell proliferation. (etsu.edu)

US EPA], 1994), but there is currently no information on the with uptake efficiencies (flow 150 ml/min) of 56, 40, 34, and 28% nasal dosimetry of naphthalene. (cdc.gov)

By assessing exposure to each of the three physiologically relevant NIS-inhibitors, the relative impact of each chemical on thyroid function can be estimated and appropriate regulatory action taken if exposures are negatively impacting thyroid hormone levels. (cdc.gov)
These results physiologically based pharmacokinetic (PBPK) models for provide evidence that nasal CYP metabolism of naphthalene contributes to URT scrubbing of this vapor and is also involved in nasal vapor uptake and disposition have been developed but the concentration dependence of uptake that is observed. (cdc.gov)

In this review, we critically discuss the different models of endocannabinoid trafficking, focusing on AEA cellular uptake which is best studied. (nih.gov)
First we discovered that preincubating cells with three fragile bases or an inhibitor from the v-ATPase reduced the cellular build up of [3H]dLop. (biosemiotics2013.org)

U-73122 (10 microM), another phospholipase A2 inhibitor, decreased evoked overflow of DA, did not affect the action of N-0437 but also increased spontaneous outflow of DA. (aspetjournals.org)

Uptake of radioactivity assessed over 60 min in organs of P-gp KO mice after pretreatment with four medicines and shot of [11C]dLop Lysosomal competition in the brains of P-gp KO mice had not been detected by using PET as mind radioactivity didn't significantly change in virtually any treatment condition (Desk 1). (biosemiotics2013.org)
Uptake of radioactivity assessed from 5 to 120 min in organs of healthful human beings after pretreatment with tariquidar and shot of [11C]dLop Dialogue Lysosomal Trapping of the P-gp Substrate. (biosemiotics2013.org)
A relatively large naphthalene was significantly reduced by inhibitor pretreatment database exists on nasal uptake efficiencies of vapors (e.g., with the effect being greater at the lower inspired concentrations. (cdc.gov)
Similarly, uptake was virtually abolished by PP pretreatment. (cdc.gov)

In the presence of the concentrated culture supernatant the proliferative response of PBL, to con A, as measured by the uptake of ('3)H-tdr, was significantly reduced. (etsu.edu)

The present study examined the mechanisms by which 3,4- methylenedioxymethamphetamine (MDMA) produces long-term neurotoxicity of striatal dopamine neurones in mice and the protective action of the dopamine uptake inhibitor GBR 12909. (erowid.org)
uptake in chloroquine-treated mice reduced by 20% the modification had not been significant probably as the low quality of your pet images managed to get challenging to discern the spleen through the kidney. (biosemiotics2013.org)
Uptake didn't reduction in paclitaxel-treated mice significantly. (biosemiotics2013.org)

The utilization of BRCA testing increased significantly over the study years (37% to 68% for breast cancer, 23% to 53% for ovarian cancer), with acceleration of genetic testing in patients with ovarian cancer after the approval of PARP inhibitors. (cdc.gov)

Finally the radioactivity assessed in muscle tissue (we.e. adverse control) didn't display any significant variations in uptake among the treatment organizations (Desk 1). (biosemiotics2013.org)

The mechanism(s) responsible for the toxicity, carcinogenesis, cytochrome P450 (CYP) metabolism, groups of rats were pre- and the gender differences in these responses are not fully treated with the CYP inhibitor 5-phenyl-1-pentyne (PP) (100 mg/ understood. (cdc.gov)

In a U.S. cohort study reported in JAMA Oncology , Voruganti et al found that the uptake of immune checkpoint inhibitor therapy for patients with advanced non-small cell lung cancer (NSCLC) has been associated with "modest" improvements in overall survival, particularly among older patients. (ascopost.com)

A comparative summary of the most important AEA uptake inhibitors and the studies involving their use is provided. (nih.gov)

A similar effect was observed in male rats (flow 150 at CDC Public Health Library & Information Center on July 11, 2012 molecule with a vapor pressure of 0.09 torr at 25 C, a log ml/min) with uptake efficiencies of 57, 49, 37, and 36% being observed. (cdc.gov)

Endeavor's new treatment candidate, called "taladegib," is an inhibitor that addresses what's known as the "hedgehog" pathway for IPF. (dictionary.com)
The U.S. Food and Drug Administration (FDA) has approved BRCA genetic tests as companion diagnostics to guide cancer treatment with poly adenosine diphosphate-ribose polymerase (PARP) inhibitors . (cdc.gov)

These results demonstrate that the aziridinium ion is responsible for xylamine's uptake blocking activity and that the other xylamine derivatives do not influence this action. (aspetjournals.org)

Letrozole is an aromatase inhibitor with antiestrogenic effects that is being tested in LAM. (medscape.com)

The evolution of the current knowledge obtained with different AEA transport inhibitors is reviewed and the confusions caused by the lack of their specificity discussed. (nih.gov)

When inserted into introns, for instance, they can enhance a gene's expression, or they can guide inhibitors to shut the gene down. (dictionary.com)
MWCNT exposure impaired blood brain barrier integrity, as noted by fluorescein uptake, which was associated with increased gene expression of IL-6 and CCL5 in the cortex and hippocampus. (cdc.gov)

The investigators concluded, "This cohort study found that, among patients with advanced NSCLC, the uptake of immune checkpoint inhibitors after [FDA] approval was rapid across all age groups. (ascopost.com)
This article delves into the reasons behind the rising popularity of triple re-uptake inhibitor supplements among patients. (ceoreviewmagazine.com)
Patients are drawn to triple re-uptake inhibitor supplements due to their potential impact on mood regulation. (ceoreviewmagazine.com)
Patients are intrigued by triple re-uptake inhibitor supplements' promise to enhance cognitive function across multiple domains. (ceoreviewmagazine.com)
Triple re-uptake inhibitor supplements are gaining popularity among patients seeking a natural way to boost energy and motivation. (ceoreviewmagazine.com)
Patients are drawn to triple re-uptake inhibitor supplements due to their potential to address mental health from a holistic perspective. (ceoreviewmagazine.com)
Triple re-uptake inhibitor supplements are capturing patients' attention for their potential to mitigate this concern. (ceoreviewmagazine.com)
Triple re-uptake inhibitor supplements captivate patients due to their multi-dimensional approach to neurotransmitter modulation. (ceoreviewmagazine.com)
As patients explore the evolving landscape of mental wellness, the appeal of triple re-uptake inhibitor supplements is a testament to their potential to transform how humans approach mental health. (ceoreviewmagazine.com)

Nitrate and thiocyanate are polyatomic anions that can disrupt thyroid function by competitively inhibiting iodide uptake, similar to the action of perchlorate. (cdc.gov)

Noradrenergic Uptake Inhibitors for ADHD, ClinCalc DrugStats Database, Version 2022.08. (clincalc.com)

Hence, therapeutic strategies that can enhance drug uptake into cells with improved efficiency and specificity are of high importance for drug delivery to treat localized diseases such as cancer. (plos.org)

Nevertheless whether Siglec-1 is Bopindolol malonate important in macrophage uptake of lipoprotein continues to be unclear. (techblessing.com)

Anatomy16

Organisms4

Chemicals and Drugs104

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Psychiatry and Psychology3

Phenomena and Processes18

Disciplines and Occupations1

Information Science1

Health Care1

Adrenergic uptake inh1

Enzyme Inhibitors1

Serotonin Uptake6

Antidepressants2

Glucose uptake14

Selective serotonin4

Inhibits1

SSRIs1

Kinase inhibitor2

Norepinephrine4

Competitive inhibitor1

Vivo2

Reuptake1

Phytic acid1

Compounds2

Dopamine release1

Transporters2

Inhibition3

Blockers1

MTOR1

Endocytosis2

Autophagy1

Potent1

Peripheral tissues1

Membrane1

Tissues1

Doses1

19941

Physiologically2

Cellular2

MicroM1

Pretreatment4

Significantly reduced1

Mice3

Breast Cancer1

Adverse1

Responses1

Oncology1

Summary1

Effect1

Treatment2

Activity1

Effects1

Transport1

Gene2

Patients9

Similar1

Database1

Enhance1

Important1