- Downregulation or upregulation of an RNA or protein may also arise by an epigenetic alteration. (wikipedia.org)
- Upregulation and downregulation can also happen as a response to toxins or hormones. (wikipedia.org)
- Downregulation of Fzd6 and Cthrc1 and upregulation of olfactory receptors and protocadherins by dietary beta-carotene in lungs of Bcmo1-/- mice. (maastrichtuniversity.nl)
- An example of upregulation is the response of liver cells exposed to such xenobiotic molecules as dioxin. (wikipedia.org)
- In particular, concomitant with the upregulation of T cell activation molecules CD25 and CD44, we found that both CD4 + and CD8 + T cells significantly upregulated expression of glutamate receptors (GluRs) following TCR stimulation, with CD8 + T cells maintaining a higher receptor expression for a longer time than that on CD4 + T cells. (bmj.com)
- Mutation of IGFBP7 causes upregulation of BRAF/MEK/ERK pathway and familial retinal arterial macroaneurysms. (medlineplus.gov)
- Upregulation of IL-5 receptor expression on bone marrow-derived CD34+ cells from patients with asthma. (tmu.edu.tw)
- Dive into the research topics of 'Upregulation of IL-5 receptor expression on bone marrow-derived CD34+ cells from patients with asthma. (tmu.edu.tw)
- We also found that Src homology domain-containing phosphatase 2 (SHP-2), which is downstream of EGFR and also overexpressed in SCCHN, can suppress the immunostimulatory effect of cetuximab treatment on HLA class I/STAT-1 upregulation, and dual targeting of EGFR and SHP-2 co-operates in the most efficient reversal of immune escape phenotype. (biomedcentral.com)
- The complementary process that involves increase in quantities of cellular components is called upregulation. (wikipedia.org)
- Additional experiments confirmed the upregulation of a Th2 response. (cdc.gov)
- In particular, exposure to CAS resulted in the upregulation of hypha-specific genes known to play a role in biofilm formation, such as ALS3 and HWP1. (who.int)
- Upregulation of receptors, on the other hand, can result in super-sensitized cells, especially after repeated exposure to an antagonistic drug or prolonged absence of the ligand. (wikipedia.org)
- An example of upregulation in pregnancy is hormones that cause cells in the uterus to become more sensitive to oxytocin. (wikipedia.org)
- In addition, cetuximab-based EGFR inhibition and SHP-2 depletion enhanced the recognition of HNSCC cells by EGFR 853-861 specific CTL, and enhanced surface presentation of non-EGFR TA, such as MAGE-3 271-279 , indicating that a broad tumor antigen repertoire is processed and presented by HLA/APM upregulation. (biomedcentral.com)
- Thus, aberrant upregulation of the glycolytic enzyme PFKFB3 in neurons may contribute to CLN7 pathogenesis and targeting PFKFB3 could alleviate this and other lysosomal storage diseases. (nature.com)
- Here, using the Cln7 ∆ex2 mouse model of CLN7 disease, we found an aberrant upregulation of pro-glycolytic enzyme PFKFB3 in neurons that may contribute to CLN7 pathogenesis. (nature.com)
- The aberrant upregulation of FOXM1 serves as a 'first hit' where cells acquire genomic instability which in turn predisposes cells to a 'second hit' whereby DNA-damage checkpoint response (eg. (qmul.ac.uk)
- Upregulation of receptors, on the other hand, can result in super-sensitized cells, especially after repeated exposure to an antagonistic drug or prolonged absence of the ligand. (wikipedia.org)
- 6. Interleukin-6-mediated functional upregulation of TRPV1 receptors in dorsal root ganglion neurons through the activation of JAK/PI3K signaling pathway: roles in the development of bone cancer pain in a rat model. (nih.gov)
- Genetic deletion, diminished expression or dominant-negative inhibition of the NFκB subunit p65 resulted in lower Fas expression and inhibited TNFα-induced Fas upregulation and sensitization to FasL-induced cell death. (uzh.ch)
- Expression analysis revealed that fluorizoline induced the upregulation of Noxa and Bim mRNA levels, which was not observed in PHB-depleted MEFs. (uni-koeln.de)
- Chen D, Yan Y, Xie J, Pan J, Chen Y, Li Q, Yuan Y, Zeng W, Xing W. Amide-type local anesthetics may suppress tumor cell proliferation and sensitize Human Hepatocellular Carcinoma Cells to Cisplatin via upregulation of RASSF1A expression and demethylation. (jcancer.org)
- We sought to determine whether amide-type local anesthetics (lidocaine, ropivacaine and bupivacaine) exert growth-inhibitory effects on human hepatoma cells and to determine whether amide-type local anesthetics sensitize human hepatoma cells to cisplatin-mediated cytotoxicity via upregulation of RASSF1A expression. (jcancer.org)
- We also found that these amide local anesthetics may enhance the cytotoxicity of cisplatin in human hepatocellular carcinoma cells possibly via upregulation of RASSF1A expression and demethylation. (jcancer.org)
- Dive into the research topics of 'Upregulation of neurokinin-1 receptor expression in rat spinal cord by an N-terminal metabolite of substance P'. Together they form a unique fingerprint. (umn.edu)
- They found that upregulation of complement expression and activation coincided with the onset of photoreceptor degeneration. (nih.gov)
- Strong upregulation of PDE1C in pulmonary arterial vessels in the idiopathic PAH lungs compared with healthy donor lungs was noted on the mRNA level by laser-assisted vessel microdissection and on the protein level by immunohistochemistry. (nih.gov)
- Maca improved cognitive function, motor coordination, and endurance capacity in middle-aged mice, accompanied by increased mitochondrial respiratory function and upregulation of autophagy-related proteins in cortex. (hindawi.com)
- In conclusion, haploinsufficiency of spatacsin and synaptojanin-1 proteins might be the underlying cause of neurodegeneration produced by protein trafficking defects, DA vesicle trafficking/ recycling processes, autophagy dysfunction, and cell death leading to hsp27 upregulation as a cellular mechanism of protection and/or to balance impaired protein trafficking . (bvsalud.org)
- Adrenomedullin inhibits hypoxic cell death by upregulation of Bcl-2 in endometrial cancer cells: a possible promotion mechanism for tumour growth. (ox.ac.uk)
- Since Ishikawa cells express the putative ADM-receptor CRLR-RAMP2 the production and secretion of ADM with the consecutive upregulation of Bcl-2 could establish an autocrine/paracrine mechanism rescuing malignant cells from hypoxic cell death. (ox.ac.uk)
- 2. Functional upregulation of nav1.8 sodium channels on the membrane of dorsal root Ganglia neurons contributes to the development of cancer-induced bone pain. (nih.gov)
- Overexpressing these three genes led to the upregulation of lipid synthesis in the transgenic sorghum. (isaaa.org)
- More specifically, a 6-h exposure of synchronized worms grown at 25 degrees C to 7% EtOH on solid medium promotes almost a 7-fold upregulation of crt-1. (unav.edu)
- Our results not only validate previously published methods, but also point to a new experimental approach that increases previously achieved levels of crt-1 upregulation. (unav.edu)
- By hydrodynamic injection of p65 shRNA into the tail vein of mice, we confirm that Fas upregulation by TNFα is also NFκB-mediated in the liver. (uzh.ch)
- Title : VCAM‐1 upregulation accompanies muscle remodeling following resistance‐type exercise in Snell dwarf (Pit1dw/dw) mice Personal Author(s) : Rader, Erik P.;Naimo, Marshall A.;Ensey, James;Baker, Brent A. (cdc.gov)
- IL-12 receptor-mediated upregulation of FasL in human ovarian carcinoma cells. (nih.gov)
- We previously showed that FOXM1 was upregulated in basal cell carcinoma and recently reported that upregulation of FOXM1 precedes malignancy in a number of solid human cancer types including oral, oesophagus, lung, breast, kidney, bladder and uterus. (qmul.ac.uk)
- FOXM1 upregulation in primary human keratinocytes triggered pro-apoptotic/DNA-damage checkpoint response genes such as p21, p38 MAPK, p53 and PARP, however, without causing significant cell cycle arrest or cell death. (qmul.ac.uk)
- A recent study proved that lidocaine sensitizes breast cancer cells to cisplatin via upregulation of RASSF1A , a promotor of tumor suppressive gene (TSG) demethylation. (jcancer.org)
- These cells also show an upregulation of the oncoprotein Bcl-2, which is protective against hypoxic cell death when transiently transfected into Ishikawa cells. (ox.ac.uk)
- Here, we propose several modifications of previously published crt-1 upregulation strategies that improve the reproducibility of the assay and allow to achieve higher levels of overexpression. (unav.edu)
- Likewise, we evaluate four new experimental approaches that attempt to promote a higher crt-1 upregulation [short-term exposure to 30 mu g/ml tunicamycin at 25 degrees C, short-term exposure to 7% ethanol (EtOH) at 25 degrees C, short-term exposure to 30 degrees C of worms grown at 25 degrees C, and a long-term exposure to 7% EtOH]. (unav.edu)
- Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis. (ox.ac.uk)
- Pomalidomide restores immune recognition of primary effusion lymphoma through upregulation of ICAM-1 and B7-2. (qxmd.com)
- To the best of our knowledge, this study reports for the first time the upregulation of both the circular and the linear isoform of USP3 and METTL3 in leukocytes from patients with CRC. (spandidos-publications.com)
- Downregulated EZH2 leads to upregulation of the ER and better response to anti-estrogens. (eur.nl)
- In chronically hypoxic mouse lungs and lungs from monocrotaline-injected rats, PDE1A upregulation was detected in the structurally remodeled arterial muscular layer. (nih.gov)