• Intracellular signaling events that converge on the cytoplasmic domain of integrin tails are also capable of activating the high affinity state. (thno.org)
  • Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. (wikipedia.org)
  • Integrins are heterodimeric, transmembrane receptors that function as mechanosensors, adhesion molecules and signal transduction platforms in a multitude of biological processes. (thno.org)
  • Integrins are heterodimeric cell surface receptors found in nearly all metazoan cell types, composed of non-covalently linked α and β subunits. (thno.org)
  • Description: A sandwich quantitative ELISA assay kit for detection of Mouse Integrin Alpha 4 (ITGa4) in samples from tissue homogenates, cell lysates or other biological fluids. (ibiomagazine.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Integrin Alpha 4 (ITGa4) in Tissue homogenates, cell lysates and other biological fluids. (ibiomagazine.org)
  • CD49d is an integrin alpha subunit. (wikipedia.org)
  • An integrin beta subunit of approximately 85-kDa in size which has been found in INTEGRIN ALPHAIIB-containing and INTEGRIN ALPHAV-containing heterodimers. (lookformedical.com)
  • Integrin-mediated interactions with the extracellular matrix (ECM) are required for the attachment, cytoskeletal organization, mechanosensing, migration, proliferation, differentiation and survival of cells in the context of a multitude of biological processes including fertilization, implantation and embryonic development, immune response, bone resorption and platelet aggregation. (thno.org)
  • Integrins are not constitutively active but rather exist in multiple activation states wherein ligand binding stability is related to the activation status of the receptor. (thno.org)
  • Integrin mediated cellular adhesion is dynamic process that is both indicative of and influenced by cell status. (thno.org)
  • Integrin ligation via cell-to-cell and cell-to-matrix contacts transduces intracellular signaling events in a process called 'outside-in' signaling (Fig. 2 ). (thno.org)
  • The product of this gene belongs to the integrin alpha chain family of proteins. (wikipedia.org)
  • Integrins also function in pathological processes such as inflammation, wound healing, angiogenesis, and tumor metastasis. (thno.org)
  • Therefore, pharmacological inhibition of integrins is of great interest for the treatment and prevention of disease. (thno.org)
  • Inside-out signaling takes place upon association of intracellular activators ( e.g. , talin, kindlins) with integrin cytoplasmic domains, leading to transition of integrin conformation to high affinity for binding ligands. (biomedcentral.com)
  • Upon ligand binding, integrins undergo clustering and transmit their outside-in signals to the cytoplasmic domains, leading to forming focal adhesions that connect to actin filaments for many cellular processes. (biomedcentral.com)
  • Current review discusses the mechanisms by which integrin is activated and subsequently deactivated by focusing on its structure-function relationship. (biomedcentral.com)
  • Here we review the molecular mechanisms that regulate integrin activation and deactivation. (biomedcentral.com)
  • Leukocyte integrins, αLβ2 and α4β1, interact with junctional adhesion molecules (JAMs) such as JAM-A and JAM-B, respectively, on endothelial cells to facilitate TEM of the leukocytes as a final step in the homing cascade to inflamed tissues [ 40 ]. (biomedcentral.com)
  • The product of this gene belongs to the integrin alpha chain family of proteins. (wikipedia.org)