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  • infectious
  • The antigen causing the formation of a granuloma is most often an infectious pathogen or a substance foreign to the body, but sometimes the offending antigen is unknown (as in sarcoidosis ). (wikipedia.org)
  • Granulomas are seen in a wide variety of diseases, both infectious and non-infectious. (wikipedia.org)
  • fibrosis
  • Scleroderma is a disease of unknown origin that affects the microvasculature and loose connective tissues of the body and is characterized by fibrosis and obliteration of vessels in the skin, lungs, gut, kidneys and heart. (drlarryjaeger.com)
  • reaction
  • foreign-body granuloma a localized histiocytic reaction to a foreign body in the tissue. (thefreedictionary.com)
  • giant cell reparative granuloma, central a lesion of the jaws composed of a spindle cell stroma punctuated by multinucleate giant cells, considered by most to be a central lesion of the bone of the jaws, presenting an inflammatory reaction to injury or hemorrhage. (thefreedictionary.com)
  • However
  • However, granuloma annulare would not label for cytokeratins, and the surrounding cells would be histocytes with delicate nuclei and minimal mitotic activity. (jhu.edu)