• Serial femtosecond crystallography was initially developed for room-temperature X-ray diffraction studies of macromolecules at X-ray free electron lasers. (lu.se)
  • Liquid microjets are a common means of delivering protein crystals to the focus of X-ray free-electron lasers (FELs) for serial femtosecond crystallography measurements. (iucr.org)
  • At the European XFEL, up to 27 000 pulses s −1 will be delivered to an experimental endstation, which is over 200 times more than the 120 Hz of the Linac Coherent Light Source (LCLS), where many serial femtosecond crystallography experiments have been conducted. (iucr.org)
  • Serial femtosecond crystallography is a promising new technique for protein structure determination, where a liquid stream containing protein crystals is intersected with a high-intensity X-ray free electron laser beam that is 109 times brighter than traditional synchrotron X-ray sources. (spectroscopyonline.com)
  • How did the combination of serial femtosecond crystallography and high-intensity X-ray free electron laser take place? (spectroscopyonline.com)
  • The facility provides instrumentation and expertise for collecting and processing x-ray diffraction data from macromolecular single crystals and is available to all the research groups inside and outside the campus. (umms.org)
  • Specialist in Research 1991-1998 Macromolecular Crystallography, Massachusetts Institute of Technology. (uvm.edu)
  • In a collaborative effort, the Lund Protein Production Platform (LP3) , the FragMAX platform at the BioMAX beamline of the MAX IV laboratory, the Deuteration and Macromolecular Crystallization (DEMAX) of the European Spallation Source ESS and the group of Professor F. Kozielski at University College London published new results on non-structural protein from SARS-CoV-2. (lu.se)
  • The purpose is to make neutron macromolecular crystallography at ESS world leading and available to the biotechnological and pharmaceutical industry in Sweden. (lu.se)
  • However, neutron macromolecular crystallography is still in its infancy with "only" 170 of the total 200 000 structures in the Protein Data Bank determined by this technique. (lu.se)
  • Moreover, the software required for getting from raw data to scientific results is inadequate and often tedious to work with, which is a major hindrance for the wider use of neutron macromolecular crystallography, particular for the life science community that does not have a tradition of developing software. (lu.se)
  • It is this latter aspect that is addressed in this proposal for the NMX (neutron macromolecular crystallography) instrument at ESS, which, combined with the high flux at ESS, will make NMX a truly world leading instrument attractive for industrial and academic research. (lu.se)
  • In crystallography, crystals are isomorphous if they have identical symmetry and if the atomic positions can be described with a set of parameters (unit cell dimensions and fractional coordinates) whose numerical values differ only slightly. (wikipedia.org)
  • Room-temperature X-ray crystallography provides unique insights into protein conformational heterogeneity, but obtaining sufficiently large protein crystals is a common hurdle. (iucr.org)
  • Serial synchrotron crystallography (SSX) helps to address this hurdle by allowing the use of many medium- to small-sized crystals. (iucr.org)
  • While the crystals diffract and immediately after are destroyed by the intense X-ray free electron lasers (XFELs) beam, the resulting diffraction patterns can be recorded with state-of-the-art detectors. (spectroscopyonline.com)
  • The technique is able to yield high-resolution structural information from small micro- or nanocrystals, thus reducing the contribution of crystal defects and avoiding tedious (if not impossible) growth of large crystals as is required in traditional synchrotron based crystallography. (spectroscopyonline.com)
  • Over his long career, he authored and co-authored many textbooks, including Practical Radiochemistry and Crystals and Structure Determination by X-Ray Crystallography . (surrey.ac.uk)
  • The reason for this is the limited flux at neutron sources, which therefore require very long exposure times (weeks) and very large crystals compared to X-ray crystallography. (lu.se)
  • In chemistry, isomorphism has meanings both at the level of crystallography and at a molecular level. (wikipedia.org)
  • 1996.) A History of Chemistry, Harvard University Press, p. 122. (wikipedia.org)
  • The multi-user protein crystallography facility at the Department of Chemistry and Biochemistry provides the instrumentation and expertise from X-ray diffraction data collection and processing to structure solution and refinement. (contractresearchmap.com)
  • He was the head of the Laboratory of X-ray Structure Analysis and Organic Crystal Chemistry. (iucr.org)
  • He was trained in organic and medicinal chemistry, enzymology and X-ray crystallography. (degruyter.com)
  • Dominique Mengin-Lecreulx was trained in biochemistry, enzymology, molecular biology and organic chemistry and obtained his PhD degree at the University Paris-Sud in 1987. (degruyter.com)
  • Stanislav Gobec is professor of medicinal chemistry at the Faculty of Pharmacy, University of Ljubljana. (degruyter.com)
  • He graduated in pharmacy and received his PhD degree in medicinal chemistry from the University of Ljubljana in 1999. (degruyter.com)
  • He was trained in organic chemistry, biochemistry and enzymology, and received his PhD degree in natural sciences from the University Paris-Sud in 1979. (degruyter.com)
  • The perfect addition to any synthetic chemistry laboratory, the XtaLAB mini II single crystal X-ray diffractometer will enhance research productivity by offering affordable structure analysis capability without the necessity of relying on a departmental facility. (rigaku.com)
  • A degree in Chemistry from the University of Waikato means you'll gain an excellent grasp of Chemistry theory, supported by a strong emphasis on practical expertise. (waikato.ac.nz)
  • In 2009, he became Assistant Professor of Chemistry at the University of Pennsylvania, and Associate Professor of Chemistry in 2015. (cdc.gov)
  • At ActiveSight we have built a technology platform that combines high-throughput X-ray structure determination, combinatorial chemistry automated FBS and chemi-informatics approaches to rapidly invent new and novel inhibitors. (parc.com)
  • The new home for the Department of Chemistry and Chemical Biology at Rutgers University-New Brunswick , which provides expanded teaching, laboratory and support space, is open for classes and research. (rutgers.edu)
  • Dr. Beth Mundy is a recent PhD in chemistry from the Cossairt lab at the University of Washington in Seattle, Washington. (rsc.org)
  • Alushin's writerly ambitions gave way to a different passion when he took an organic chemistry class in his first undergraduate year at Columbia University. (rockefeller.edu)
  • Anna is a Professor at the Division of Physical Chemistry at Lund University specializing on biocolloids studied by scattering techniques. (lu.se)
  • The project is a collaboration between Prof. Ulf Ryde at the Division of Theoretical Chemistry, Lund University and Drs. Esko Oskanen and Thomas Rod at ESS. (lu.se)
  • A project within the LJH group will allow a researcher to become experienced in air-sensitive techniques, multinuclear nmr analysis, Infra Red Spectroscopy, High Resolution Mass Spectrometry and X-ray crystallographic data interpretation. (ncl.ac.uk)
  • Neutron and x-ray diffraction, Mossbauer spectroscopy. (edu.au)
  • The building includes a microscopy suite and optical spectroscopy, nuclear magnetic resonance spectroscopy and X-ray crystallography laboratories. (rutgers.edu)
  • Mark's long association with the University of Surrey goes back to the 1950s, when he joined Battersea Polytechnic's Chemical Physics and Spectroscopy section. (surrey.ac.uk)
  • Students joining our group will build expertise in X-ray crystallography and multinuclear NMR spectroscopy, as well as IR and UV-vis spectroscopies. (lu.se)
  • Structures of a significant number of SH2 domains both in isolation and bound to various target molecules have been determined by X-ray crystallography and NMR spectroscopy. (lu.se)
  • She was trained in biochemistry and microbiology, and received her PhD degree in biochemistry from the University Picardie Jules-Verne, Amiens, in 2004. (degruyter.com)
  • Ulf Ryde was born in 1963 and obtained a PhD in biochemistry methods and their possible combination with quantum chemical (enzyme kinetics and control theory) at Lund University, Sweden, methods, including a number of typical applications. (lu.se)
  • We also provide services and training in every stage of structure determination process for non-crystallography groups who are interested in solving the structures of their favorite proteins. (contractresearchmap.com)
  • Overall, our results illustrate the promise of serial methods for room-temperature crystallography, as well as future avant-garde crystallography experiments, for PTP1B and other proteins. (iucr.org)
  • We cause the proteins to form into lattices, fire X-rays at them and get information from those X-ray diffraction patterns to see what the molecule looks like. (newscientist.com)
  • There are indeed other approaches to reducing sample waste, which all come at a price, such as either being too slow for very high XFEL repetition rates, not being compatible with time-resolved crystallography, not being compatible with many classes of proteins, or introducing large background. (spectroscopyonline.com)
  • But trying to capture the conformations of proteins using X-ray crystallography, which was the standard methodology back then, frustrated him. (rockefeller.edu)
  • Below you can see some examples of the infrastructure for proteins, available for researchers at Lund University. (lu.se)
  • Neutron crystallography is emerging as a unique and highly promising technique for structural biology because, unlike other techniques, it can probe the locations of protons (or more specifically the heavier isotope deuterium) which are paramount for understanding biochemical processes, e.g. the hydrogen-bond pattern, the charge and tautomeric states, as well as the interactions with the surrounding solvent. (lu.se)
  • We focus on using scattering techniques to look at the structure and dynamics associated with these strong electron corrrelations, particularly neutron and X-ray methods. (lu.se)
  • X-ray free electron lasers (XFELs) are pulsed and since the protein suspensions are typically injected in a continuous flow, sample injected in-between the XFEL's pulses is wasted. (spectroscopyonline.com)
  • 300 East University Drive Tempe, AZ, 85281 United States Department: School of Molecular Sciences (SOMS) College/Unit: COLLEGE OF LIBERAL ARTS AND SCIENCES Description: X-ray crystallography is one of the most powerful techniques to study the three-dimensional structures of biological macromolecules. (contractresearchmap.com)
  • The purpose of the X-ray Crystallography Shared Service is to provide equipment, training, assistance, and technological innovations for determining three-dimensional structures of protein and other macromolecules to understand the structural basis for biological function and dynamics. (umms.org)
  • When combined with tools that initiate biological reactions within microcrystals, time-resolved serial crystallography allows the study of structural changes that occur during an enzyme catalytic reaction. (lu.se)
  • Our method thus requires little to no adjustment compared to non-droplet approaches for the crystallographer and additionally can be adapted to time-resolved crystallography techniques, where sample requirements is a limiting factor. (spectroscopyonline.com)
  • Serial synchrotron X-ray crystallography (SSX), which extends serial crystallography methods to synchrotron radiation sources, is expanding the scientific community using serial diffraction methods. (lu.se)
  • Therefore, having a reliable cascade of screening methods to be used as pre-screens prior to labor-intensive X-ray crystallography would be extremely beneficial. (uni-marburg.de)
  • One of the experimental methods that we use is X-ray crystallography," says Higgins. (newscientist.com)
  • The most common strong alternative and complement to experimental methods to methods to obtain protein structures are X-ray crystallography obtain insight in biochemical processes. (lu.se)
  • This will be pursued by the development of sophisticated analysis software and by integrating methods from a Swedish expert research group in computational methods for crystallography into the pipeline. (lu.se)
  • The main role of MicLU is to provide planning for good access at Lund University to advanced equipment and methods in microscopy and microscopic analysis. (lu.se)
  • Three-dimensional structures of the complexes that form between these molecules and the receptor were then determined experimentally with X-ray crystallography. (sciencedaily.com)
  • Roman Šink is a post-doctoral researcher at the Faculty of Pharmacy of the University of Ljubljana. (degruyter.com)
  • She has been a visiting Professor at NIEHS and USEPA and a full professor at State University of Campinas - Faculty of Technology -UNICAMP. (cdc.gov)
  • Professor placed at the Medical Faculty of Lund University in a tri-faculty appointment together with the Faculties of Science and Engineering. (lu.se)
  • Jörgen Larsson is a professor and the head of the division for Atomic Physics at the Dept. of Physics at the Faculty of Engineering (LTH) at Lund University. (lu.se)
  • Emanuel works as a Researcher at the Department of Experimental Medical Science at the Faculty of Medicine, Lund University. (lu.se)
  • He also works as a Lund University Node Coordinator for InfraVis - a new Swedish National Research Infrastructure for Data Visualization with 9 Swedish partner universities, and as Coordinator and Application expert at CIPA - a cross faculty infrastructure for image processing and analysis at Lund University. (lu.se)
  • He graduated from the physics department of the Lomonosov Moscow State University in 1935, and he received his Candidate's degree (PhD-equivalent) in 1939. (iucr.org)
  • We think - and this has been supported by many researchers in structural biology - that cryo-EM most likely will overtake or equal crystallography in the coming decade," says Jon Lorsch , the director of the National Institute of General Medical Sciences. (asbmb.org)
  • Cryo-EM doesn't require the protein to be forced into a crystal, which is a bottleneck in X-ray crystallography. (asbmb.org)
  • Large molecules contain more signals and so are easier to detect than small molecules, says Erhu Cao at the University of Utah, adding that "there is no upper limit" on what can be viewed by cryo-EM. (asbmb.org)
  • The results indicate the feasibility for megahertz serial crystallography measurements with hard X-rays and give guidance for the design of such experiments. (iucr.org)
  • The x-ray crystallography facility is operated jointly by the University of Maryland at Baltimore School of Pharmacy and the University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center. (umms.org)
  • metal site is extended X-ray absorption fine structure (EXAFS). (lu.se)
  • The laboratory is equipped with start-of-the-art hardware and software to facilitate crystallography groups to determine their structures. (contractresearchmap.com)
  • The chief design requirement when creating the XtaLAB mini II single crystal X-ray diffractometer was that the structures produced would be publishable in the most demanding scientific journals. (rigaku.com)
  • We discovered these enzymes are not rigid, as often seen in crystal structures, but are flexible and prone to remarkable changes in shape," said project leader Emerita Professor Maria Hrmova, from The University of Adelaide's School of Agriculture, Food and Wine, and the Waite Research Institute. (edu.au)
  • A new screening method fragment-based screening (FBS) which utilizes three-dimensional X-ray structures to find novel, custom-built inhibitors has led to several new drug candidates recently and has sparked interest in FBS throughout the industry. (parc.com)
  • The use of molecular mechanics calculations to supplement experimental data in standard X-ray crystallography and NMR refinements is discussed and it is shown that structures can be locally improved by the use of quantum chemical calculations. (lu.se)
  • I used computational modelling, X-ray crystallography and data analysis to design molecules that might become new medicines. (abpi.org.uk)
  • In a new study, scientists from Uppsala University describe how they have been able to predict how special molecules that can be used in new immunotherapy against cancer bind to these receptors. (sciencedaily.com)
  • Learnings from Comparative Analysis using SPR, NMR, & X-Ray Crystallography to Optimize Fragment Screening in Drug Discovery. (uni-marburg.de)
  • X-ray crystallography provides structural information that is crucial for fragment optimization, however there are several criteria that must be met for a successful fragment screening. (uni-marburg.de)
  • Our 96-fragment library was screened against TGT using SPR, NMR, and X-ray crystallography, as described in Chapter 2. (uni-marburg.de)
  • By fragment screening using x-ray crystallography we identified four ligands revealing ligand-binding sites in conserved interfaces between SARS-CoV-2 nsp10 and nsp14/nsp16. (lu.se)
  • Would you explain for our readers what developments make the high-intensity XFEL beam a billion times brighter than traditional synchrotron X-ray sources. (spectroscopyonline.com)
  • She received a Diplôme d'Etudes Approfondies in human genetics from the University Paris Diderot in 1999. (degruyter.com)
  • Dr. Schelter received his B.S. degree from Michigan Technological University (1999), Ph.D. from Texas A&M University, followed by postdoctoral fellowships at Los Alamos National Laboratory. (cdc.gov)
  • 2015 - Member of Dr Hough's research group, University of Essex. (essex.ac.uk)
  • Didier Blanot is director of research at CNRS and a member of the Laboratory of Bacterial Envelopes and Antibiotics, University Paris-Sud, Orsay. (degruyter.com)
  • The Rigaku XtaLAB mini II is a research-grade chemical crystallography diffractometer that sits on the benchtop. (rigaku.com)
  • Hard working and friendly undergraduate students in their second and third years are welcome to apply for Nuffield/RSC and University-sponsored Summer Studentships, and Erasmus and International students are regular members of the group - we collaborate widely with research groups in France, Germany, Italy, Japan and the US. (ncl.ac.uk)
  • She completed post-doctoral training in the Reproductive Toxicology Branch of the National Health and Environmental Effects Research Laboratory, U. S. Environmental Protection Agency and the Nicholas School of the Environment at Duke University. (cdc.gov)
  • Project leader and Emerita Professor Maria Hrmova from the University of Adelaide's School of Agriculture, Food and Wine, and the Waite Research Institute. (edu.au)
  • He received his Ph.D. from Duke University in 1984 and joined The Scripps Research Institute in La Jolla where he ran an active program in the structure and function of metalloproteins, including doing the structure of the first microsomal P450. (parc.com)
  • Research on the magnetism and crystallography of materials that contain rare-earth elements, nanocrystalline soft magnetic materials and meteorites. (edu.au)
  • Rutgers University President Robert Barchi and Rutgers-New Brunswick Interim Chancellor Christopher Molloy on Friday unveiled the building that launches a new era in research and education. (rutgers.edu)
  • The building allows the university to expand upon its tradition of collaborative research with leading academic labs, federal agencies and private companies in New Jersey and around the world. (rutgers.edu)
  • Thanks to our world-class research infrastructure, Lund University is well equipped to help lead the way towards future scientific breakthroughs. (lu.se)
  • At Lund university in different research groups as well as at infrastructurs facilities, there are many light microscopes including for live cell imaging. (lu.se)
  • This system was demonstrated by collecting SSX data at MAX IV Laboratory from microcrystals of the integral membrane protein cytochrome c oxidase from Thermus thermophilus, from which an X-ray structure was determined to 2.12 Å resolution. (lu.se)
  • Researching Cytochrome c' structure and function 2016 - p/t PhD Biological Sciences, University of Essex. (essex.ac.uk)
  • X-ray crystallography offers detailed insights into protein structure. (iucr.org)
  • The crystal and molecular structure of the title compound, C 24 H 36 CoN 10 O 4 ·2(NO 3 )·3(H 2 O)·Cl, have been determined by X-ray analysis: Cc (No: 9), a = 17.6920(4) Å, b = 11.8163(2) Å, c = 16.4752(4) Å, ß = 91.679(1)°, Z = 4. (mdpi.com)
  • we have selected this protein for structure determination by X-ray crystallography. (rcsb.org)
  • In order to identify the chemical structure of OIF, Addams and Ratto collaborated with protein chemist Louis Delbaere at the University of Saskatchewan. (the-scientist.com)
  • Matt Higgins at the University of Oxford and his colleagues were researching a protein that they believed was key to interrupting the lifecycle of the malaria parasite , but were struggling to map its structure. (newscientist.com)
  • Birney says that using X-ray crystallography to map the structure of a protein is expensive and time-consuming. (newscientist.com)
  • Fundamentals of Crystallography: the theory behind crystal structure solution. (iucr.org)
  • The x-ray photons can also interact directly with the spin of the electrons, and so they can scatter off the magnetic structure. (lu.se)
  • Researchers from the University of Adelaide have uncovered previously unknown properties in a plant enzyme that could lead to advances in cereal production, medical and pharmaceutical industries. (edu.au)
  • Structural changes of a barley enzyme, as envisaged by high-resolution X-ray crystallography and multiscale molecular modelling. (edu.au)
  • Previous work by lead author Gregg Adams at the University of Saskatchewan and colleagues also demonstrated that OIF injection altered the follicle maturation dynamics in cows-which ovulate spontaneously-suggesting crossover in function between these two types of ovulators. (the-scientist.com)
  • Hélène Barreteau is assistant professor at the University Paris-Sud, Orsay, and a member of the Laboratory of Bacterial Envelopes and Antibiotics. (degruyter.com)
  • Delphine Patin was trained in genetics and molecular biology at the University Paris Diderot, Paris. (degruyter.com)
  • Jointly with the biopharmaceutical company Sosei-Heptares, the researchers Willem Jespers, Johan Åqvist and Hugo Gutierrez-de-Terán of Uppsala University have succeeded in showing how a series of A2A antagonists bind to the receptor and inactivate it. (sciencedaily.com)
  • Materials provided by Uppsala University . (sciencedaily.com)
  • The XtaLAB mini II benchtop diffractometer provides the opportunity for students to learn single crystal X-ray analysis by actually using a fully functional diffractometer. (rigaku.com)
  • The New York University Tandon School of Engineering (commonly referred to as Tandon ) is the engineering and applied sciences school of New York University . (wikipedia.org)
  • In 1854, the University of the City of New York, now New York University , founded the School of Civil Engineering and Architecture at a time when specialized schools of engineering were uncommon in America. (wikipedia.org)
  • During this time the engineering school officially separated from the university's arts and science school then called University College. (wikipedia.org)
  • In 1894 the University of the City of New York moved its engineering school to a new campus in the Bronx . (wikipedia.org)
  • Infrastructure resources at Lund University. (lu.se)
  • Martin Stankovski is a project manager at the central Lund University Cooperation Office. (lu.se)
  • This project benefits from a close collaboration between Lund University and ESS and contributes to both focus areas of the call. (lu.se)
  • Lund university has a newly set up infrastructure for correlative image processing and analysis (CIPA). (lu.se)
  • A non-comprenhsive list of resources for microscopy at Lund University. (lu.se)
  • Examples of microscopy infrastructures at Lund University Fluorescence microscopes and live cell imaging for microbiology at Dept. of Biology. (lu.se)
  • In many universities, the departmental single crystal X-ray diffractometer is considered off limits to students because of fear the instrument might be damaged by inexperienced users. (rigaku.com)
  • The simple design of the XtaLAB mini II X-ray diffractometer minimizes the possibility of students misaligning or damaging the system. (rigaku.com)
  • X-ray source tube lifetime is extended by running a standard off-the-shelf X-ray tube at 600 W. To compensate for running at a lower power, a SHINE optic (special curved monochromator) is utilized to produce usable X-ray flux comparable to a standard X-ray diffractometer. (rigaku.com)
  • Researchers at the University of California, Davis have developed a self-assembling, fibrous photosensitizer that targets mitochondria in tumor cells for destruction via photodynamic therapy with enhanced localization and potency. (universityofcalifornia.edu)
  • Professor Min Xue and his lab at the University of California, Riverside have developed a novel hydrophilic endocytosis-promoting peptide (EPP6) rich in hydroxyl groups with no positive charge that may be used for drug delivery purposes. (universityofcalifornia.edu)
  • Researchers at the University of California, Davis have developed a customizable polysaccharide that can be added to nanoparticles to reduce their rejection by the human immune system. (universityofcalifornia.edu)
  • My PhD was gained in the X-ray crystallography department. (ed.ac.uk)
  • Mark leaves two sons, Tony, a Professor in the Chemical Engineering Department at the University of Florida, and Nick, a Church of England Minister. (surrey.ac.uk)
  • 2013 - Laboratory Technician, University of Essex. (essex.ac.uk)
  • College of Veterinary Medicine, National Reference Laboratory of Veterinary Drug Residues (SCAU), South China Agricultural University, Guangzhou 510642, People's Republic of China. (who.int)
  • [12] The new campus gave the university space to build larger science laboratories that could not be constructed at its Washington Square site. (wikipedia.org)
  • X-ray crystallography allows the detection of specific binders that may be too weak binders to be detected by SPR and even by NMR but can still provide valid structural information to support the search for appropriate starting points in lead discovery. (uni-marburg.de)
  • The theoretical and technical aspects of the study of microstructure and composition of materials, optical microscopy, electron microscopy (scanning and transmission) including electron diffraction and image analysis principles, electron microanalysis, x-ray topography, field-ion microscopy, relationship of observed microstructures to the macroscopic properties of materials. (uwindsor.ca)
  • They used synchrotron X-ray fluorescence microscopy (XFM) to probe the cellular uptake and distribution of TRIP and an iodo-derivative I-TRIP by looking at elemental signals. (rsc.org)
  • He remains an adjunct professor of Molecular Biology at Scripps and is a visiting professor of Sichuan University. (parc.com)
  • He is now the Jacobus H. van't Hoff Distinguished Professor of Molecular Sciences at University of Groeningen in the Netherlands, from where he also obtained his Ph.D. degree. (lu.se)