• Two proteins, THO complex subunit 1 (THOC1) and THO complex subunit 7 (THOC7) were found to interact with C15orf52 using anti-tag coimmunoprecipitation. (wikipedia.org)
  • Ring finger protein 2 (RNF2) and SUZ12 polycomb repressive complex 2 subunit (SUZ12) were also indicated as interacting proteins. (wikipedia.org)
  • This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. (nih.gov)
  • A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). (nih.gov)
  • The c-Cbl tyrosine kinase binding domain (Cbl-TKB), essentially an 'embedded' SH2 domain, has a critical role in targeting proteins for ubiquitination. (rcsb.org)
  • cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. (nih.gov)
  • A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfiler TM service. (guidetomalariapharmacology.org)
  • A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase Hotspot SM platform. (guidetomalariapharmacology.org)
  • Chromosome 15 open reading frame 52 is a human protein encoded by the C15orf52 gene, its function is poorly understood. (wikipedia.org)
  • Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. (thebiogrid.org)
  • Identification, tissue expression, and chromosomal position of a novel gene encoding human ubiquitin-conjugating enzyme E2-230k. (univ-amu.fr)
  • Mutations in this gene cause Carney complex (CNC). (nih.gov)
  • RNF2 is part of a polycomb group of proteins that are important for transcription repression of various genes. (wikipedia.org)
  • SUZ12 is also a polycomb group protein and part of a complex that methylates lysines of histones and also is involved with repression of genes. (wikipedia.org)
  • This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. (nih.gov)
  • In the largest E3 ligase subfamily, Cul3 binds a BTB domain, and an associated protein-interaction domain such as MATH recruits substrates for ubiquitination. (rcsb.org)
  • The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. (ucsc.edu)
  • Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome. (ucsc.edu)
  • protein ubiquitination. (ucsc.edu)
  • 16678110 ). It is also part of a SWI/SNF chromatin remodelling complex that consists of BAF250, elongin C (Elo C) and cullin 2 (Cul2) and mediates H2B lysine 120 ubiquitination. (iiserpune.ac.in)
  • Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex (PubMed:20595234). (univ-amu.fr)
  • Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). (univ-amu.fr)
  • Contributes to ubiquitin-protein transferase activity. (nih.gov)
  • Mechanistically, we found that Rab40c binds the protein phosphatase 6 (PP6) complex and ubiquitylates one of its subunits, ankyrin repeat domain 28 (ANKRD28), thus leading to its lysosomal degradation. (life-science-alliance.org)
  • GDF15 promotes the generation of peripherally derived inducible Treg (iTreg) cells and enhances the suppressive function of natural Treg (nTreg) cells by interacting with a previously unrecognized receptor CD48 on T cells and thus downregulates STUB1, an E3 ligase that mediates forkhead box P3 (FOXP3) protein degradation. (bmj.com)
  • During assem bly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. (univ-amu.fr)
  • E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). (univ-amu.fr)
  • Hjc_15-6 was heterologously produced in Escherichia coli and high yields of soluble and biologically active recombinant enzyme were obtained in both complex and defined media. (iucr.org)
  • this may enable the selective sequestration of c-Cbl from other target proteins. (rcsb.org)
  • posttranslational modifications, amino acid variations, computational mutation analysis, protein PTM predictor, network biology Introduction Protein PTMs are biochemical alterations of amino acids that change the physicochemical properties of target proteins, leading to structural changes and therefore regulating protein-protein interactions and cellular signal transduction in developmental and cancer pathways [1]. (deepdyve.com)
  • PMID:14996496, table 1 provides links to papers that describe subcellular location of many pro- and anti-apoptotic proteins. (geneontology.org)
  • BCL2 proteins are described as 'crucial regulators of apoptosis' (PMID:15868100)and the intrinsic apoptosis pathway is initiated by the release of mitochondrial cytochrome c into the cytoplasm, which results in the activation of caspases (15102863) - help in generating a defintion for intrinsic apoptosis? (geneontology.org)
  • Binding of the CCAAT-displacement protein/Cux to the untranslated exon 1 sequence. (nih.gov)
  • Download DNA or protein sequence, view genomic context and coordinates. (yeastgenome.org)
  • Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. (yeastgenome.org)
  • Click "Protein Details" for further information about the protein such as half-life, abundance, domains, domains shared with other proteins, protein sequence retrieval for various strains, physico-chemical properties, protein modification sites, and external identifiers for the protein. (yeastgenome.org)
  • Rab40c is a SOCS box-containing protein which binds Cullin5 to form a ubiquitin E3 ligase complex (Rab40c/CRL5) to regulate protein ubiquitylation. (life-science-alliance.org)
  • There is a homologous domain found in Coiled Coil Domain Containing Protein 9 (CCDC9) that is paralogous to the C15orf52 protein from amino acid 9 to 55 of CCDC9. (wikipedia.org)
  • Phenylalanine, Tyrosine, and Asparagine were all found in lower frequencies than other proteins in humans. (wikipedia.org)
  • The XAB2 complex, which contains PRPF19, is also involved in pre-mRNA splicing, transcription and transcription-coupled repair (PubMed:17981804). (univ-amu.fr)
  • The isoelectric point of the protein is 9.457, indicating a basic protein at a normal physiological pH of 7.4. (wikipedia.org)
  • Macromolecular complex annotations are imported from the Complex Portal . (yeastgenome.org)
  • hNMP 200: a novel human common nuclear matrix protein combining structural and regulatory functions. (univ-amu.fr)
  • However, the exact functions of Rab40c remain to be determined, and what proteins are the targets of Rab40c-Cullin5-mediated ubiquitylation in mammalian cells are unknown. (life-science-alliance.org)
  • It is known to function in a complex with CUL4 and DDB1. (iiserpune.ac.in)
  • The protein contains a domain of unknown function (DUF4594 from amino acid 185 to 350). (wikipedia.org)
  • OCP1 is equivalent to the F-box protein known as Fbs1, Fbx2, or NFB42 - previously shown to bind N-glycosylated proteins and believed to function in the retrieval and recycling of misfolded proteins. (protabank.org)
  • The high concentrations of OCP1 and OCP2 in the cochlea suggest that the OCP1-OCP2 heterodimer may serve an additional function independent of its role in a canonical SCF complex. (protabank.org)
  • Consequently, amino acid variations through changing the type of residues of the target sites or key flanking residues could directly or indirectly influence PTM of protein and bring about a detrimental effect on protein function. (deepdyve.com)
  • 7] analyzed amino acid variations of 15 different PTMs and indicated that about 4.5% of amino acid variations may affect protein function through disruption of PTMs, and the mutation of 238 PTMs sites in human proteins was causative of disease. (deepdyve.com)
  • Most PTMs are catalyzed by highly specific protein modifying enzymes, which have some specific recognition motif. (deepdyve.com)
  • The protein, C15orf52, is a 534 amino acid long protein weighing 57.325 kDa found in Homo sapiens. (wikipedia.org)
  • Comparison of the amino acid composition to "Homo sapiens" revealed certain amino acids with differing frequencies than other proteins in humans. (wikipedia.org)
  • Homo sapiens BUB3 mitotic checkpoint protein (BUB3), transcript variant 2, mRNA. (dbcls.jp)
  • Homo sapiens CGG triplet repeat binding protein 1 (CGGBP1), transcript variant 1, mRNA. (dbcls.jp)
  • THOC1 is a component of the THO subcomplex of the TREX complex that is thought to couple mRNA transcription, processing and nuclear export. (wikipedia.org)
  • Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. (univ-amu.fr)
  • Beside its role in pre-mRNA splicing PRPF19, as part of the PRP19-CDC5L complex, plays a role in the DNA damage response/DDR. (univ-amu.fr)
  • It also possess ubiquitin ligase activity. (wikipedia.org)
  • Enables identical protein binding activity and small GTPase binding activity. (nih.gov)
  • Predicted to enable ubiquitin protein ligase activity. (nih.gov)
  • Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. (univ-amu.fr)
  • Here we use massively parallel assays to measure the effects of nearly 2000 missense substitutions in the RING domain of BRCA1 on its E3 ubiquitin ligase activity and its binding to the BARD1 RING domain. (protabank.org)
  • In this regard, comprehensive studies of the impact of amino acid variation on protein PTMs will be helpful for further understanding of how genetic polymorphisms are involved in regulating biological and pathological processes and providing instructive information for drug development of various related diseases. (deepdyve.com)
  • To increase the utilization of current computational resources, we 﫿rst provide an overview of computational prediction of amino acid variations that influence protein PTMs and their functional analysis. (deepdyve.com)
  • Proteomic analysis and prediction of amino acid variations that influence protein. (deepdyve.com)
  • However, it often requires extensive laboratory work and considerable expense to make thousands of variant proteins and select amino acid variations that influence PTM sites. (deepdyve.com)
  • Reassembling proteins and chaperones in human nuclear matrix protein fractions. (univ-amu.fr)
  • For instance, the SwissVariant database (http://swissvar.expasy.org/) contained 76 613 variants in 20 244 human proteins on 10 January 2018. (deepdyve.com)
  • Human liver protein map: a reference database established by microsequencing and gel comparison. (drugbank.com)
  • Glycine and Arginine were found at higher frequencies than other proteins in humans. (wikipedia.org)
  • For instance, the Type I protein arginine methyltransferases are known to methylate a number of proteins that contain an arginine glycine glycine (RGG)-motif [6]. (deepdyve.com)
  • Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. (gliome.org)
  • Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. (ucsc.edu)
  • These studies provide a molecular understanding of how MATH-BTB proteins recruit substrates to Cul3 and how their dimerization and conformational variability may facilitate avid interactions with diverse substrates. (rcsb.org)
  • Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (univ-amu.fr)
  • Violin plots show distribution of expression levels for WD_REPEATS_REGION domain-containing protein (SMED30005158) in cells (dots) of each of the 12 neoblast clusters. (stowers.org)
  • Expression of WD_REPEATS_REGION domain-containing protein (SMED30005158) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells. (stowers.org)
  • Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). (univ-amu.fr)
  • C15orf52 is also predicted to be a non-cytoplasmic soluble protein likely to be found as a nuclear protein. (wikipedia.org)