• During mid gestation to late term the fetal brain is undergoing increasingly complex progressive growth of first the mid-brain and then development of the cortex and "higher" centers. (wikipedia.org)
  • Accumulating evidence suggests that pre-eclampsia is the product of abnormal spiral artery development leading to placental hypoxia, triggering the release of fetal-derived molecules that increase maternal blood pressure and perfusion of the placenta but result in diffuse endothelial dysfunction in the mother [ 4 ]. (biomedcentral.com)
  • Semin Fetal Neonatal Med 18(4):185-191, 2013. (msdmanuals.com)
  • @laina Four factors in maternal trauma or surgery predict fetal morbidity and mortality-hypoxia, infection, drug effects, and preterm delivery. (reanfoundation.org)
  • Fetal death can occur at any gestational age and usually results from fetal hypoxia. (reanfoundation.org)
  • 90%) results in fetal hypoxia, acidosis, and compromise. (reanfoundation.org)
  • Thus, we review the fetal, neonatal and long-term consequences of preeclampsia exposure, discuss differing ways to measure infant growth and developmental outcomes, and review studies of infant growth and psychomotor development associated with preeclampsia exposure. (biomedcentral.com)
  • Fudono A, Imai C, Takimoto H, Tarui I, Aoyama T, Yago S, Okamitsu M, Muramatsu M, Sato N and Miyasaka N. Trimester-specific associations between extracellular vesicle microRNAs and fetal growth JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE. (tmd.ac.jp)
  • Methods and Results-In vitro, neonatal rat cardiomyocytes were subjected to hypoxia-reoxygenation in the absence or presence of eEPCs with or without Tβ4 short hairpin RNA (shRNA) transfection. (elsevierpure.com)
  • We have reported that retrograde application of embryonic endothelial progenitor cells (eEPCs) provides rapid paracrine protection against ischemia-reperfusion injury. (elsevierpure.com)
  • Heusch G: Myocardial ischaemia-reperfusion injury and cardioprotection in perspective. (spandidos-publications.com)
  • Meng X, Zhang L, Han B and Zhang Z: PHLDA3 inhibition protects against myocardial ischemia/reperfusion injury by alleviating oxidative stress and inflammatory response via the Akt/Nrf2 axis. (spandidos-publications.com)
  • The results demonstrated that SA inhibited apoptosis signaling in H9c2 cardiomyocytes via downregulation of p38 mitogen-activated protein kinase (p38MAPK) and c-Jun N-terminal kinase (JNK) signaling pathways following hypoxia/reoxygenation (H/R) injury. (spandidos-publications.com)
  • Cardiomyocytes were isolated and subjected to 6 h hypoxia followed by 18 h reperfusion. (biomedcentral.com)
  • Neonatal rat cardiomyocytes were also used to evaluate the protective effect of GRh2 on hypoxia/reoxygenation (H/R)‑induced myocardial injury in vitro. (spandidos-publications.com)
  • Sun W, Wang Z, Sun M, Huang W and Wang Y and Wang Y: Aloin antagonizes stimulated ischemia/reperfusion-induced damage and inflammatory response in cardiomyocytes by activating the Nrf2/HO-1 defense pathway. (spandidos-publications.com)
  • However, the molecular pathway involved in myocardial neovascularisation after ischemia remains unknown. (elifesciences.org)
  • In this review, we discuss the consequences of hypoxia, as well as the molecular and physiological processes that occur in subjects exposed to HBOT. (mdpi.com)
  • Searching for molecular hypoxia sensors among oxygen-dependent enzymes. (ucsf.edu)
  • OBJECTIVES@#To study the effect of ligustrazine injection on mitophagy in neonatal rats with hypoxic-ischemic encephalopathy (HIE) and its molecular mechanism. (bvsalud.org)
  • cerebral ischemia decreased the extent KU 0060648 of neutrophil emigration and macrophage/activated microglial infiltration 48 hours later and only in the ischemic hemisphere (41). (techuniq.com)
  • In adult rat melatonin given after focal cerebral ischemia improves short term evaluations of infarct size and neurobehavioral outcomes (41) suggesting that melatonin treatment may be applicable to global brain ischemia in the neonate. (techuniq.com)
  • In vivo, pigs (n=9 per group) underwent percutaneous left anterior descending artery occlusion for 60 minutes on day 1. (elsevierpure.com)
  • Some neonates undergoing electroencephalography (EEG) to assess seizures or other symptoms of encephalopathy (eg, hypoactivity, decreased responsiveness) are found to have clinically silent seizures (≥ 20 seconds of rhythmic epileptiform electrical activity during an EEG but without any clinically visible seizure activity). (msdmanuals.com)
  • OBJECTIVE: To verify the potential of hypothermic hypoxic-ischemic encephalopathy (HIE) therapy in neonatal asphyxia, based on literature data, comparing the benefits between selective head cooling (SHC) and whole-body cooling (WBC), see that the use of TH as a standard treatment in newborns with moderate or severe HIE has been adopted. (bvsalud.org)
  • Early postnatal microglia are endogenously activated and may therefore express an increased sensitivity to neonatal hypoxia-ischemia (HI). (unibas.ch)
  • Microglia are an inherent cellular component of the early postnatal SVZ and undergo specific developmental changes that are disrupted by neonatal HI injury. (unibas.ch)
  • We recently reported that neonatal ischemia induces microglia/macrophage activation three days post- ischemia . (nih.gov)
  • Neonatal seizures are abnormal electrical discharges in the central nervous system of neonates and usually manifest as stereotyped muscular activity or autonomic changes. (msdmanuals.com)
  • Seizures may be related to a serious neonatal problem and require immediate evaluation. (msdmanuals.com)
  • Most neonatal seizures are focal, probably because generalization of electrical activity is impeded in neonates by lack of myelination and incomplete formation of dendrites and synapses in the brain. (msdmanuals.com)
  • Epidemiology and aetiology of neonatal seizures. (msdmanuals.com)
  • When neonatal hypoxia is treated with therapeutic hypothermia (usually whole-body cooling), seizures may be less severe but may recur during rewarming. (msdmanuals.com)
  • Birth asphyxia causes 840,000 or 23% of all neonatal deaths worldwide. (medscape.com)
  • However, harmful stimuli (such as ischemia-reperfusion, oxidative stress, and toxic chemicals) can change the direction and efficiency of intercellular mitochondrial transfer. (frontiersin.org)
  • At 48 h after the injections, hypoxic-ischemic (HI) injury was induced by unilateral carotid artery ligation followed by hypoxia for 65 min. (biomedcentral.com)
  • Hypoxic ischemia and aggressive enteral feedings are also associated with the pathogenesis of NEC. (medscape.com)
  • The uncoupling of glycolysis and glucose oxidation induces lactate accumulation during myocardial ischemia/reperfusion (I/R) injury. (biomedcentral.com)
  • A randomized double-blind placebo phase I study evaluating the effect of melatonin on infants undergoing hypothermia as treatment for HI brain injury is planned to begin in late 2013 (48). (techuniq.com)
  • Neonatal trials following HI brain injury have been limited. (techuniq.com)
  • In fact in a randomized double blind placebo-controlled study of 53 pregnant women whose fetuses demonstrated evidence of hypoxia arterial cord blood from infants of allopurinol-treated mothers exhibited lower levels of S-100B a marker of brain injury KU 0060648 a very short-term outcome. (techuniq.com)
  • The study examined the expression of Neuroglobin (Ngb) and Hypoxia-inducible factor-1α (Hif-1α) in adult and young yak brain tissues, and provided researchers with meaningful insight into the anatomy, physiology, and biochemistry of this mammal. (scielo.br)
  • This study provides meaningful data to understand the adaptive mechanism to hypoxia and recommended researchers to expand on the adaptive mechanism and brain tissues that are not recorded. (scielo.br)
  • Those insults to the brain occurred during the foetal, neonatal or early post-neonatal periods, and although the specific mechanisms are complex and vary, all are related to cerebral hypoxia and ischemia, and reperfusion (Hilario E. Current Pediatr Review 2006;2:131). (redsamid.net)
  • Taken together, these results indicate the TLRs play an important role in ischemia-induced injury in the adult brain. (biomedcentral.com)
  • Global hypoxia-ischemia interrupts oxygen delivery and blood flow to the entire brain. (cdc.gov)
  • Previous studies of global brain hypoxia ischemia have primarily focused on injury to the cerebral cortex and to the hippocampus. (cdc.gov)
  • We therefore investigated the impact of global brain hypoxia-ischemia on the thalamic circuit function in the somatosensory system of young rats. (cdc.gov)
  • Global brain hypoxia-ischemia during cardiac arrest has a long-term impact on processing and transfer of sensory information by thalamic circuitry. (cdc.gov)
  • Bernholm KF, Meyhoff CS, Bickler P. Association between tissue oxygenation and myocardial injury in patients undergoing major spine surgery: a prospective cohort study. (ucsf.edu)
  • Methods : We retrospectively reviewed the medical records of 100 neonates who underwent endotracheal intubation and mechanical ventilation. (e-cep.org)
  • METHODS@#Neonatal Sprague-Dawley rats, aged 7 days, were randomly divided into a sham-operation group with 8 rats, a model group with 12 rats, and a ligustrazine group with 12 rats. (bvsalud.org)
  • Expansion of MSCs was shown to be limited to a few passages of in vitro culture and the cells underwent replicative senescence [ 11 ]. (hindawi.com)
  • However, oxygen therapy might cause the accumulation of distal bronchial viscous secretions because of positive pressure ventilation mode, and thus increase airway resistance, aggravate systemic hypoxia [15]. (researchgate.net)
  • Rat cardiomyocyte H9c2 cells underwent H/R (hypoxia for 4 h and reoxygenation for 12 h). (biomedcentral.com)
  • Background-Prolonged myocardial ischemia results in cardiomyocyte loss despite successful revascularization. (elsevierpure.com)
  • Hypoxia/reoxygenation (H/R)-induced cardiomyocyte cell apoptosis is critical in developing myocardial infarction. (biomedcentral.com)
  • We aimed to investigate the effect of PLCA on hypoxia/reoxygenation (H/R) in neonatal rat ventricular myocytes (NRVM) and on myocardial I/R in rats. (biomedcentral.com)
  • These findings suggest that BAG3 may provide a therapeutic target in patients undergoing reperfusion after myocardial infarction. (uthscsa.edu)
  • A therapeutic drug that targets ischemia reperfusion (I/R) injury is needed and has yet to be developed. (biomedcentral.com)
  • The rats in the model group and the ligustrazine group were used to establish a neonatal rat model of HIE by ligation of the left common carotid artery followed by hypoxia treatment, and blood vessels were exposed without any other treatment for the rats in the sham-operation group. (bvsalud.org)
  • For patients undergoing the Jatene arterial switch procedure, the presence of an intramural coronary artery course in patients with D-TGA may prohibit arterial repair. (medscape.com)
  • With ischemia in coronary heart disease, impairment of the oxygen supply and metabolic disorder both occur [ 2 ]. (biomedcentral.com)
  • There are several factors (low temperature, hypoxia, strong ultraviolet light, and dryness) at high altitudes that affect the survival of mammals especially deoxygenated atmosphere which leads to inadequate oxygen reaching the animal's body. (scielo.br)
  • Ngb is a neuronal hemeprotein that shares its capability for oxygen binding while Hif-1α is a transcription factor that responds to decreases in available oxygen in the cellular environment or hypoxia. (scielo.br)
  • Regarding neurodevelopment, a delay in important reflexes during the neonatal period in ZIKV animals was observed. (bvsalud.org)
  • Following induction of global ischemia in neonatal pigs melatonin combined with hypothermia decreased MR spectroscopic indices of impaired cerebral energy metabolism compared with hypothermia alone (45). (techuniq.com)
  • has been demonstrated to attenuate renal ischemia‑reperfusion (I/R) injury. (spandidos-publications.com)
  • However, reperfusion following a period of prolonged ischemia can often cause myocardial ischemia-reperfusion (I/R) injury, leading to damage of cardiac tissues ( 5 ). (spandidos-publications.com)
  • Electrocardiography (ECG) demonstrates classic findings of deep Q waves, peaked T waves, or ST segment changes consistent with ischemia, injury, or infarction. (medscape.com)
  • Abouzaki NA, Christopher S, Trankle C, Van Tassell BW, Carbone S, Mauro AG, Buckley L, Toldo S and Abbate A: Inhibiting the inflammatory injury after myocardial ischemia reperfusion with plasma-derived Alpha-1 Antitrypsin: A post hoc analysis of the VCU-α1RT study. (spandidos-publications.com)
  • We also found that female mice sustained smaller infarcts than males three months post- ischemia . (nih.gov)
  • More encouragingly melatonin provided to neonatal mice before and after severe hypoxia significantly increased hippocampal neuronal survival at 3 7 and 14 days as well as functional motor outcomes two weeks following insult (43). (techuniq.com)
  • Early Sex Differences in the Immune-Inflammatory Responses to Neonatal Ischemic Stroke. (nih.gov)
  • Multichannel video-electroencephalography (EEG) and electrocardiography were assessed at 6-72 h after birth in full-term infants with HIE, recruited prior to (pre-TH group) and following (TH group) the introduction of TH in our neonatal unit. (nature.com)
  • The HF component of HRV is increased in infants with moderate HIE undergoing TH. (nature.com)
  • We assessed two groups of infants with HIE who were (i) monitored prior to the introduction of TH in our neonatal intensive care unit (NICU) (pre-TH group) and (ii) monitored following the introduction of TH in our NICU, where all infants with moderate and severe HIE received TH (TH group). (nature.com)
  • Postnatal-day (P)7 rats underwent sham or right-hemispheric HI surgery. (unibas.ch)
  • The rats in the ligustrazine group were intraperitoneally injected with ligustrazine (20 mg/kg) daily after hypoxia-ischemia, and those in the sham-operation group and the model group were intraperitoneally injected with an equal volume of normal saline daily. (bvsalud.org)
  • Before 23 weeks' gestation, preterm delivery uniformly results in neonatal death. (reanfoundation.org)
  • Hypothetically, manipulation of the intramural coronary artery may cause damage and resultant inflammation, kinking, thrombosis, and myocardial ischemia or infarction (see Transposition of the Great Arteries). (medscape.com)
  • For example, intravenous ritodrine poses a 5-10% risk of serious cardiopulmonary complications, such as pulmonary edema and significant subendocardial ischemia. (reanfoundation.org)
  • However, it is not easy to apply ischaemic preconditioning in a clinical setting because brief organ ischaemia should be preceded after real ischaemic time [ 8 ]. (medsci.org)
  • The application of RIPC into clinical fields is more useful than ischaemic preconditioning because it is easy to apply briefly preceding ischaemia to distant organs such as the limbs. (medsci.org)
  • Effect of lower leg compression during caesarean section on post-spinal hypotension and neonatal hemodynamic parameters: nonrandomized controlled clinical trial. (medical-online-hub.com)
  • Overview of Perinatal Respiratory Disorders Extensive physiologic changes accompany the birth process (see also Neonatal Pulmonary Function), sometimes unmasking conditions that posed no problem during intrauterine life. (msdmanuals.com)
  • Maternal spiral arteries undergo extensive remodeling during a key window of 6 to 20 weeks' gestation allowing for appropriate perfusion of the placenta [ 7 ]. (biomedcentral.com)
  • Taking into consideration the transport time, resources, and maternal condition, in-utero transport is preferable to delivery and neonatal transport in most cases. (reanfoundation.org)
  • The aim of this study was to highlight the importance of cord blood S100B protein in the diagnosis of neonatal HIE and determination of its severity. (bartleby.com)
  • Meanwhile, the organ protective effect of ischaemic preconditioning could be induced when the episodic ischaemia is at distant tissues or organs, the concept being termed remote ischaemic preconditioning (RIPC) [ 9 ]. (medsci.org)
  • Patients undergoing TKR were randomly allocated to not receive RIPC (control group) and to receive RIPC (RIPC group). (medsci.org)
  • Total knee arthroplasty (TKR) is a common major surgical procedure in the elderly, and the number of elderly patients undergoing TKR is increasing [ 1 ]. (medsci.org)
  • A novel approach for the detection of cognitive impairment and delirium risk in older patients undergoing spine surgery. (ucsf.edu)
  • Local anesthetics have been undergoing development for centuries, and, as this article illustrates, research continues to provide surgeons with pharmacologic variety and to provide patients with anesthetic agents that have superior safety and efficacy profiles. (medscape.com)
  • Chronic hypoxia in the presence of high glucose leads to progressive acidosis of cardiac myocytes in culture. (biologists.com)
  • Purpose : To evaluate the association between neonatal mortality and the initial response to surfactant replacement therapy, and to examine the correlation between the response type and other prognostic factors. (e-cep.org)
  • It is unclear whether gestational hypertension and pre-eclampsia are separate entities or represent a spectrum of disease as they share some but not all risk factors and result in varying placental pathology, with findings consistent with placental ischemia specifically associated with pre-eclampsia [ 5 ]. (biomedcentral.com)
  • After 55 minutes of ischemia, control eEPCs (5×10 6 cells) or cells transfected with Tβ4 shRNA when indicated or 15 mg Tβ4 alone were retroinfused into the anterior interventricular vein. (elsevierpure.com)
  • El uso de ecografía ha entrado en el campo de la medicina del dolor, anestesia regional y del bibliographic search, data intervencionismo analgésico durante la última década, e incluso es el estándar de la práctica, por tanto, la capacitación y analysis, writing, revision and un adecuado aprendizaje en la ecografía deben ser parte del plan de estudios de cualquier programa de anestesiología. (bvsalud.org)