• Apical constriction is widely studied and the molecular underpinnings quite well understood. (news-medical.net)
  • Here, combining the biochemical analysis of enzymatic and motile properties for purified myosin mutants with in vivo measurements of apical constriction for the same mutants, we show that in vivo constriction rate scales with myosin motor activity. (elifesciences.org)
  • In the Drosophila embryo, apical constriction in a strip of epithelial cells along the ventral midline results in the folding of the tissue and the internalization of ventral cells, forming a ventral furrow (VF). (nature.com)
  • This has enabled us to better understand the apical constriction involved in early development and further analyze mechanisms governing cellular movements during tissue structure modification. (jove.com)
  • We used interference reflection microscopy to monitor deformations of the membrane surface and found that both modes of fusion involve the tightly coupled dilation and constriction of the vesicle. (rupress.org)
  • This group displayed an enhanced U46619 constriction and attenuated iloprost-induced dilation. (cdc.gov)
  • however, the biological effects of nanoparticle inhalation are poorly understood. (cdc.gov)
  • Whether this responsiveness to external force and geometry is important to orient force generation during the development of a tissue is poorly understood. (nature.com)
  • How cigarette smoking relates to thromboangiitis obliterans is poorly understood, and what causes the disease is unknown. (msdmanuals.com)
  • In contrast, functional consequences of injury to the thalamus are poorly understood but may be crucially important. (cdc.gov)
  • Their findings, published in the November/December issue of Mechanisms of Development, reveal a process called "basal constriction" during which cells of the neural tube's epithelium constrict on the outside to actively shape a conserved and crucial early fold in the brain. (news-medical.net)
  • Inflammation of the mucous membrane that gets inflamed and enlarged and also adds to the constriction in the airways. (yogawiz.com)
  • Blast your way to understanding shotgun choke constrictions in this quick and easy guide! (shotgunlife.com)
  • While rifle shooters are generally concerned about such things as velocity and bullet type, the shotgunner must think in terms of pattern density, shot size, what material the shot is comprised of and how hard it is, shotshell length, shot string, velocities, choke constriction and how all those things combine to affect shotgun performance. (ssaa.org.au)
  • Regardless of whether your shotgun comes from the factory pre-choked or has interchangeable choke tubes, usually they've been imprinted with a word or measurement describing the constriction. (ssaa.org.au)
  • The distance at which you pattern your loads at will be dependent on typical length of your shots and choke constriction you're using, but commonly 40 yards is used. (ssaa.org.au)
  • But, the researchers found that basal constriction takes place even in zebrafish mutants that fial to inflate their cavities, so that folding of the tissue is actively controlled, at least in part, from the basal surface. (news-medical.net)
  • Together, our in vivo and in silico data provide a framework for understanding how cells orient force generation, establishing a role for geometrical and mechanical patterning of force production in tissues. (nature.com)
  • Rat snakes are non-venomous snakes that kill pray (rats) by constriction and are generally not dangerous to humans. (yahoo.com)
  • Returning the light to the (relatively) normal right eye results in constriction of both pupils again. (cehjournal.org)
  • In other words, a bright light shone into one eye leads to an equal constriction of both pupils. (cehjournal.org)
  • To understand how the pupils react to light, it is important to understand the light reflex pathway (Figure 1). (cehjournal.org)
  • symptoms of poisoning include headache, dizziness, ยท Agricultural workers and exterminators who weakness, feelings of anxiety, constriction of the pupils, come in contact with diazinon should remove and blurred vision. (cdc.gov)
  • A dual-constriction biological nanopore resolves homonucleotide sequences with high fidelity. (cdc.gov)
  • The dynamics of the processes that alter the shape of the vesicle during regulated secretion are not understood, and we have little understanding of their molecular basis. (rupress.org)
  • A deeper understanding of the molecular processes that lead to cardiac hypertrophy offers hope for millions of individuals worldwide. (adinstruments.com)
  • A fundamental problem in the effective treatment of cardiac hypertrophy is our limited understanding of the key molecular processes involved in the development of the disease. (adinstruments.com)
  • However, the supporting mechanisms of this process are not fully understood. (sdbonline.org)
  • Sive lab investigators looked at the midbrain-hindbrain boundary constriction in the living zebrafish brain, after labeling the membrane of each cell in the constriction with a green fluorescent protein. (news-medical.net)
  • While the exact cause is still not fully understood, scientists have identified a potential link to a compound called tyramine. (htfwines.co.uk)
  • We also use third-party cookies that help us analyze and understand how you use this website. (budapesttimes.hu)
  • Due to the efforts of numerous clinicians and basic scientists over many years, we now have a firm understanding of how the motor signal generated in the brain travels down the spinal cord, into a peripheral nerve, and interfaces with the target muscle. (medscape.com)
  • In an abnormal swinging-light test (i.e. there is a RAPD) there is less pupil constriction in the eye with the retinal or optic nerve disease (Figure 3). (cehjournal.org)
  • Animals with pain after chronic constriction injury of the infraorbital nerve (CCI-Pain) displayed higher spontaneous and evoked activity in PB neurons, and a dramatic increase in after-discharges-responses that far outlast the stimulus-compared to controls. (iasp-pain.org)
  • Hourglass-like constriction (HLC) is an uncommon spontaneous mononeuropathy that is typically characterised by a sudden onset of pain followed by palsy, affecting branches of the radial (posterior interosseous nerve) and median nerves (anterior interosseous nerve). (bvsalud.org)
  • These findings provide a framework for understanding the selectivity of GAG attachment. (rcsb.org)
  • Researchers in the lab of Whitehead Member Hazel Sive have moved one step closer to understanding how this process works in properly shaping the embryonic brain. (news-medical.net)
  • One of the first 'great bends' of the brain is called the midbrain-hindbrain boundary constriction and this is essential for normal brain structure," says Sive. (news-medical.net)
  • Researchers in the Sive lab use the zebrafish as a tool to understand human brain development, as early brain development in the fish and human are virtually indistinguishable. (news-medical.net)
  • Patients, insurers, public health agencies, and, of course, healthcare practitioners, want a better understanding of what is happening inside the brain that leads to the vast array of symptoms of migraine. (medscape.com)
  • We need to be able to listen to the brain in order to better understand how the brain works and what happens when it is affected by different conditions. (lu.se)
  • Gaining an understanding of the subtle clues your bird provides will enhance your relationship with your bird because you'll be able to earn his trust by respecting his moods and responding to his needs better. (avianenrichment.com)
  • Notes from the textbooks, class lectures and handouts act as clues to understanding the information. (collegemagazine.com)
  • At the same time, researchers are coming to understand that success in neuroscience requires requires skills that are the hallmark of a liberal-arts education: critical thinking, creativity, and teamwork. (reed.edu)
  • Researchers are still trying to understand the relationship. (preeclampsia.org)
  • Hungary-Austria border traffic on the Burgenland side has become constricted at several crossing points, Peter Szijjarto, the foreign minister, said on Monday, noting that he has talked to Burgenland governor Hans Peter Doskozil by phone with a view to lifting the constrictions so that locals can continue to enjoy normal living conditions. (budapesttimes.hu)
  • Secretion of hormones and peptides by neuroendocrine cells occurs through fast and slow modes of vesicle fusion but the mechanics of these processes are not understood. (rupress.org)
  • Our goal is to understand how this nutrient-driven mechanism regulates stem cell behavior for lifelong optimization of organ form and function. (stanford.edu)
  • The mechanism of its action in lowering high blood pressure is not well understood. (medicinenet.com)
  • These few cells cause a very dramatic shape change to form a deep constriction in the epithelium. (news-medical.net)
  • Research shows that children start to understand gender constrictions between the ages of 6 and 9 and form their self image and ambitions accordingly. (gofundme.com)
  • It can also be understood as a death sentence or the sense of constriction a condemned person lives with before he is finally gunned down. (eurotrib.com)
  • Constriction of the circular strip of muscle which surrounds the bronchus. (yogawiz.com)
  • We experimentally study the rheological responses of such flow instabilities in planar contraction-expansion microchannels differing only in the constriction length with three different polymer solutions. (aps.org)
  • Overall, mastering pronunciation requires a deep understanding of the language's phonetic system, as well as practice in accurately articulating sounds. (jkrfan.com)
  • A good editor, I came to understand, is one who helps a work become the best version of itself: not imposing her own voice, but helping the writer refine their gem in the ways that will most allow it to shine. (blogs.com)
  • We have recently had some work carried out by MJG Constriction and I'm so happy with the outcome of our new patio. (fmb.org.uk)
  • Understand the sefirot in the context of the worlds. (chabad.org)
  • Similarly, in the context of this exhibition, excess is understood not as commodified luxury but as opulence against constrictions. (kim.lv)
  • In class, we generally go over examples that are very similar to the homework, so understanding class examples is the first step to a good start on homework," said the University of Missouri Assistant Professor Kateryna Holland. (collegemagazine.com)
  • This is very important in forming tubes, which are found in essentially all organs, and constrictions, which bend many organs in characteristic ways. (news-medical.net)
  • Still, the mom insists it's important for children to understand how to interact with wildlife. (yahoo.com)
  • How epithelial cells actively respond to mechanical constraints by adjusting how they generate force is important to understand tissue morphogenesis. (nature.com)
  • It is important to understand the standards and expectations in a difficult class ," said University of Missouri Associate Professor Peter Pivovarov. (collegemagazine.com)
  • It is important you understand this information because this substance may harm you. (cdc.gov)
  • Matt had a clear vision and understanding of what I was looking for and clearly delivered. (fmb.org.uk)
  • Little is understood about how the upstream contraction flow may be influenced by the high shearing flow inside the finite constriction as well as the transverse stretching and subsequent relaxation in the downstream expansion flow. (aps.org)
  • Failing to complete my double-digit subtraction homework that night years ago made the success of understanding it all the better. (kqed.org)
  • Homework provides a way for students to understand the confusing parts of a subject or class as well as the parts that make sense. (collegemagazine.com)
  • There are four cells that are pivotal at the midbrain-hindbrain boundary for basal constriction," says Sive. (news-medical.net)
  • Thus, it is critical to understand how cells orient the cytoskeleton to produce forces that deform tissues. (nature.com)
  • In addition to a better understanding of the sequence of events in the case of a heart attack, the hope is that it will be possible to use this knowledge in the future as a complement when one is unsure whether or not someone has suffered a heart attack. (lu.se)
  • In "Celebrity Training, Mon Amour: Audrey Hepburn" the deranged celebrity, not at all how we know her, eats "her entire body in hopes of better understanding her own physicality. (guernicamag.com)
  • As a non-giant who also has difficulty understanding the parameters of my own body, how can I ever hope to begin to know where my body ends and the rest of the world begins? (guernicamag.com)
  • Understanding how to correctly pronounce words is essential for effective communication. (jkrfan.com)
  • A constriction within the peptide binding cleft requires the acceptor serine to be followed by glycine or alanine. (rcsb.org)
  • In theory, I understood this idea. (kqed.org)
  • These advances in scientific understanding that have directly impacted clinical practice represent an excellent example of translational research. (medscape.com)
  • You learn how to talk to a patient about how to use a peak flow diary, how to create a PAAP, and learn to talk to patients about the pathology of asthma so they have a true understanding of the nature of their asthma. (ed.ac.uk)
  • Not only is there an abundance of information that often appears on the exams but the best way to understand the material is to learn from a profess(or)ional. (collegemagazine.com)
  • The current understanding points out an inflammatory disease that should be treated conservatively for 3-7 months. (bvsalud.org)
  • When discussing disease of the neuromuscular junction (NMJ), many physicians first think of myasthenia gravis (MG). This is entirely appropriate, as research into the pathogenesis of MG has always been at the center of our understanding of the NMJ. (medscape.com)
  • Proteomics and informatics for understanding phases and identifying biomarkers in COVID-19 disease. (cdc.gov)
  • By paying attention to the correct enunciation of sounds, stress patterns, intonation, and rhythm, we ensure that our spoken words are easy to understand. (jkrfan.com)
  • Our understanding of excess relies on the idea of existence of limits to what is acceptable - politically, culturally, in our private and public lives etc. (kim.lv)