• however, the underlying mechanisms are unclear. (nature.com)
  • In totality, this work has made significant contributions in bioink development, specifically regarding printability assessment techniques, the underlying mechanisms impacting printability, and the bioactivity of tissue-specific bioinks. (wfu.edu)
  • Mechanisms underlying clinical efficacy of Angiotensin II type 2 receptor (AT2R) antagonist EMA401 in neuropathic pain: clinical tissue and in vitro studies. (ox.ac.uk)
  • To gain insight into the molecular mechanisms and determinants of gene expression evolution in natural populations, we analyzed the transcriptome from multiple tissues of two recently diverged Ficedula flycatcher species and their naturally occurring F 1 hybrids. (hal.science)
  • determine method of activation in underlying mechanisms by which this occurs. (usda.gov)
  • A detailed study of the underlying mechanisms may therefore help to identify novel therapeutic targets for future clinical use. (springer.com)
  • This simplified approach towards understanding the essence of the mechanisms, underlying the processes determining life and death of a cell has undoubtedly provided scientists with enormous amount of knowledge. (intechopen.com)
  • OBJECTIVE: Sex steroids exert important biological functions within the central nervous system (CNS), but the underlying mechanisms are poorly understood. (lu.se)
  • My focus is on studying mechanisms underlying metabolic disturbances in Huntington's disease, where I'm particularly interested in the crosstalk between brain and periphery. (lu.se)
  • Mechanisms underlying metabolic alterations in Huntington's disease. (lu.se)
  • In mammals, two types of adipose tissue have been observed: White Adipose Tissue, (WAT), which stores excess energy as triglycerides, and Brown Adipose Tissue (BAT), which dissipates stored energy as heat. (news-medical.net)
  • The only EXPAREL-related effect seen was minimal to mild granulomatous inflammation of adipose tissue around nerve roots (8 of 24 rabbits and 7 of 24 dogs) in the brachial plexus sites. (hindawi.com)
  • [ 1 ] Compression of underlying nerves, major blood vessels, and the trachea during the expansion process has not proven to be a significant problem. (medscape.com)
  • Erosion of the tumor into blood vessels in adjacent tissues, or areas of necrosis within the tumor, can lead to hyphema or vitreous hemorrhage. (medscape.com)
  • The tissues that support the underlying blood vessels have become more fragile. (webmd.com)
  • Structures such as blood vessels, nerves, and the spinal cord can become compressed due to the tissue overgrowth. (msdmanuals.com)
  • 1000 volts) exposure may, in regulating body temperature, fluid and however, cause damage to deeper tissues electrolytes. (who.int)
  • Complicated SSTIs involve the invasion of deeper tissues and typically require significant surgical intervention. (medscape.com)
  • Perform serologic testing to exclude connective-tissue disease. (medscape.com)
  • PAH associated with drugs/toxins) and connective tissue disease (CTD)-associated PAH, thus excluding other causes of WHO group 1 PAH, such as portopulmonary hypertension, haemoglobinopathies or HIV. (ersjournals.com)
  • We will analyze how the early exposure to protein sources and fruits normally consumed by infants and children prevents the initiation of and protects against development of chronic diseases by altering tissue differentiation, inflammation, and/or oxidative status. (usda.gov)
  • Thus, motor declines were associated earlier with tissue inflammation but later with tendon degenerative changes. (cdc.gov)
  • The inflammation of the deep fascia causes thrombosis of the dermal vessels, and it is this thrombosis that is responsible for the secondary necrosis of the overlying subcutaneous tissue and skin. (medscape.com)
  • Here, the authors show that IL-12-sensing neurons mediate IL-12-induced neuroprotective tissue adaptation in autoimmune conditions of the CNS. (nature.com)
  • In 2015, the European Respiratory Society and American Thoracic Society released a joint consensus statement proposing the term interstitial pneumonia with autoimmune features (IPAF) be used for idiopathic interstitial pneumonia (IIP) with clinical features that suggest an underlying autoimmune process. (medscape.com)
  • Scar tissue in the affected areas can lead to long-term problems with breathing, swallowing, and digestion. (medlineplus.gov)
  • Scar adherent to underlying tissue. (cornell.edu)
  • If the condition could have resulted from scar tissue or surgical intervention, the doctor will also check the surrounding tissue and the inside of the eyelids. (medicalnewstoday.com)
  • The topics are discussed in a form of review articles, written by leading researchers who study the mechanosensitivity process at the molecular, cellular, tissue and whole organ levels. (springer.com)
  • In addition, a discussion of the clinical implications, as a result of the latest developments in research in tissue and organ mechanosensitivity will provide valuable insights for clinicians, whilst pharmacological and pharmacokinetics focused reviews, will be of particular interest to researchers, searching for targets for new drugs and therapies. (springer.com)
  • The risk for infections caused by pathogens transmitted through solid organ or tissue transplants, referred to here as donor-derived or transplant-transmitted infections, has been recognized for decades and remains a worldwide public health problem. (cdc.gov)
  • For these infections, the initial link to the transplanted organ was made by histopathologic evaluation and immunohistochemical testing of tissue from an organ recipient who died 4 weeks after undergoing transplantation. (cdc.gov)
  • Treatment of necrotizing fasciitis involves early recognition and surgical debridement of necrotic tissue, combined with high-dose broad-spectrum intravenous antibiotics. (aafp.org)
  • Any ulcer covered with dead and necrotic tissue must be debrided to promote growth of healthy granulation tissue and healing. (medscape.com)
  • De- cidual cells promote hemostasis through enhanced expression of tissue factor (TF), the primary initiator of hemostasis via thrombin generation, and plasminogen activator inhibitor-1, which inactivates tissue type plasminogen activator, the primary fibrinolytic agent. (scirp.org)
  • and those with underlying unstable comorbid illnesses or signs of systemic sepsis. (aafp.org)
  • This study delineates the clinical presentation in an extended cohort and investigates the molecular mechanism underlying the disorder in a Cux1 +/− mouse model. (nature.com)
  • Quantitative approaches for decoding molecular and microenvironmental factors underlying tissue architecture. (warwick.ac.uk)
  • Although, the non-muscle myosin II holoenzyme (myosin) is a molecular motor that powers contraction of actin cytoskeleton networks, recent studies have questioned the importance of myosin motor activity cell and tissue shape changes. (elifesciences.org)
  • In the area of the common digital extensor tendon and sheath, there is moderate focal thickening of the soft tissues (short arrows), and the thickening parallels the underlying bone proliferation. (avma.org)
  • Early attempts to expand living tissues first were performed by orthopaedic surgeons in the early 1900s, but the first clinical experience with tissue expansion was not described until 1957, when Neumann related the use of a rubber balloon placed subcutaneously in the postauricular region. (medscape.com)
  • While previous studies have shown that AT2R is expressed by nociceptors in human DRG (hDRG), and that EMA401 inhibits capsaicin responses in cultured hDRG neurons, the expression and levels of its endogenous ligands AngII and AngIII in clinical neuropathic pain tissues, and their signalling pathways, require investigation. (ox.ac.uk)
  • The clinical domain includes specific features suggestive of an underlying CTD. (medscape.com)
  • Leveraging multidisciplinary collaborations between fetal therapists, tissue engineers, stem cell biologists and other experts, our team is working to develop creative solutions to the current challenges in prenatal surgical repair of MMC and to design clinical studies that compare the new technique to the established standard of open fetal surgical repair. (chop.edu)
  • If such interaction patterns can be measured for various kinds of tissues and the corresponding data can be interpreted, potential clinical benefits are obvious and novel tools for diagnostics, identification of candidate drug targets, and predictions of drug effectiveness for e.g. cancer diseases will emerge. (lu.se)
  • In clinical applications, which is of most relevance here, each slide corresponds to a tissue or blood sample, e.g. a biopsy. (lu.se)
  • Skin and soft tissue infections (SSTIs), which include infections of skin, subcutaneous tissue, fascia, and muscle, encompass a wide spectrum of clinical presentations, ranging from simple cellulitis to rapidly progressive necrotizing fasciitis. (medscape.com)
  • Our laboratory has been testing and optimizing a variety of scaffolds, cells and growth factors to develop a tissue engineering construct that will ultimately be clinically applicable for prenatal closure of MMC. (chop.edu)
  • Watanabe M, Li H, Roybal J, Santore M, Radu A, Jo J, Kaneko M, Tabata Y, Flake A. A Tissue Engineering Approach for Prenatal Closure of Myelomeningocele: Comparison of Gelatin Sponge and Microsphere Scaffolds and Bioactive Protein Coatings . (chop.edu)
  • The aim of this study was to identify the genes and pathways underlying the growth of the mouse sclera during postnatal development. (molvis.org)
  • The diagnosis of neurogenic arthropathy should be considered in a patient with a predisposing neurologic disorder who develops a destructive but unexpectedly painless arthropathy, usually several years after the onset of the underlying neurologic condition. (msdmanuals.com)
  • New skin is generated during the process so that a net gain of tissue results. (medscape.com)
  • PWID also are at risk for skin, soft tissue, and vascular infections (SSTVI), and one third of PWID in the United Kingdom report symptoms of an injection-site infection within the previous year ( 2 ). (cdc.gov)
  • Data from a London hospital suggest that such skin and soft tissue infections cause 58% of hospital admissions in PWID, and treatment typically costs several times more than infections in other groups ( 5 ). (cdc.gov)
  • See related handout on skin and soft tissue infections , written by the authors of this article. (aafp.org)
  • Skin and soft tissue infections result from microbial invasion of the skin and its supporting structures. (aafp.org)
  • Skin and soft tissue infections (SSTIs) account for more than 14 million physician office visits each year in the United States, as well as emergency department visits and hospitalizations. (aafp.org)
  • Avoid antibiotics and wound cultures in emergency department patients with uncomplicated skin and soft tissue abscesses after successful incision and drainage and with adequate medical follow-up. (aafp.org)
  • Simple infections confined to the skin and underlying superficial soft tissues generally respond well to outpatient management. (aafp.org)
  • This space under the larger surface area creates a layer of skin that may "hang," because there is less tissue underneath taking up space. (lifehacker.com)
  • Maintaining or increasing muscle tissue is the key to minimizing loose skin. (lifehacker.com)
  • On the other hand, increasing lean tissue fills the area underneath the skin, keeping it taut. (lifehacker.com)
  • You'll retain much more muscle tissue, thus keeping your skin "tight. (lifehacker.com)
  • Hypertrophy training specializes in increasing the overall size and volume of your muscles, allowing your skin to cling tighter to the underlying tissue. (lifehacker.com)
  • V. vulnificus wound infections have a short incubation period and are characterized by necrotizing skin and soft tissue infection , with or without hemorrhagic bullae. (cdc.gov)
  • The fingertips had become gangrenous, and the skin and underlying tissue had turned black, and began to slough off from the healthier, surrounding skin. (cdc.gov)
  • Novel monoclonal antibodies to study tissue regeneration in planarians. (ca.gov)
  • Planarians are an attractive model organism for studying stem cell-based regeneration due to their ability to replace all of their tissues from a population of adult stem cells. (ca.gov)
  • Differential gene expression analysis revealed that the extent of differentiation between species and the set of differentially expressed genes varied across tissues. (hal.science)
  • Common to all tissues, a higher proportion of Z-linked genes than autosomal genes showed differential expression, providing evidence for a fast-Z effect. (hal.science)
  • Instead, we found evidence that cis -regulatory changes play a significant role in the evolution of gene expression in testis, which illustrates the tissue-specific nature of cis -regulatory evolution bypassing constraints associated with pleiotropic effects of genes. (hal.science)
  • Since genes are composed of a given alphabet (A, T, C, G) with fixed pairing properties A-T and C-G, probes can be constructed that attract gene transcripts extracted from cell tissues and cultures. (lu.se)
  • Necrotizing fasciitis is a progressive, rapidly spreading, inflammatory infection that is located in the deep fascia and is associated with secondary necrosis of the subcutaneous tissues. (medscape.com)
  • C. Peterson, M. Ringne´r / Artificial Intelligence in Medicine 28 (2003) 59-74 structure and function, cellular metabolism, development of cells and tissues, and response of organisms to their environments. (lu.se)
  • Extreme weather events, such as coastal floods, hurricanes, and storm surges, can force coastal waters into inland areas, putting people that are exposed to these waters-especially evacuees who are older or have underlying health conditions-at increased risk for Vibrio wound infections. (cdc.gov)
  • Because of immunosuppression and underlying co-existing conditions in transplant recipients, infections can be severe and fatal. (cdc.gov)
  • They are the same in that most of the reproductive organs of both sexes develop from similar embryonic tissue, meaning they are homologous. (wikibooks.org)
  • In short, this is a known list of sex organs that evolve from the same tissues in a human life. (wikibooks.org)
  • This may ultimately influence the function of tissues and organs in health and disease. (springer.com)
  • Nobel Prize winner Alexis Carrel performed numerous experiments clearly showing that tissue explants, including connective tissue and heart tissue, could be cultured in vitro preserving their characteristics for prolonged periods of time [ 2 ] supporting the notion that entire organs could be cultured in vitro. (intechopen.com)
  • In mammals, many tissues express CUX1/Cux1 , including the developing and mature central nervous system [ 4 ]. (nature.com)
  • This article primarily addresses internal tissue expansion, although external expansion is discussed in a later section. (medscape.com)
  • SCTLD is causing extensive mortality of multiple coral species and disease signs vary among affected coral species with differences in rates of tissue loss (acute and subacute), lesion morphology (adjacent bleached zone or not) and lesion occurrence (focal and multi-focal). (frontiersin.org)
  • Montastraea cavernosa with subacute tissue loss lesions in the southeast Florida region near Fort Lauderdale was compared to corals (multiple species) with acute tissue loss lesions in the Middle Keys. (frontiersin.org)
  • Underlying soft tissue missing in an area exceeding six square inches (39 sq. cm. (cornell.edu)
  • There is no residual bony protrusion at the site from which the osteochondroma had been removed (brackets), and the soft tissue swelling has resolved. (avma.org)
  • Diagnosing the exact extent of the disease is critical for successful management of a patient of soft tissue infection. (medscape.com)
  • Burns in the airway or gastrointestinal tract can lead to tissue death. (medlineplus.gov)
  • This book series, Mechanosensitivity in Cells and Tissues, is devoted to the specific response of cells and tissues to mechanical stimulation and has been intensively studied during recent years. (springer.com)
  • This condition occurs due to a buildup of excess fluid in the tissue layers surrounding the lungs. (medicalnewstoday.com)
  • Remember, the phenomenon occurs when the underlying layers of tissue shrink under a much large surface area. (lifehacker.com)
  • However, while testis showed the highest divergence of gene expression among tissues, it showed no clear signature of misexpression in F 1 hybrids, even though these hybrids were found to be sterile. (hal.science)
  • Tilley, R. and Mackman, N. (2006) Tissue factor in hemostasis and thrombosis. (scirp.org)
  • Subsequent microscopical examination served to identify tissue samples without cell remnants. (nih.gov)
  • Realistic surgical simulation requires a combination of representative tissue geometry, accurate tissue material properties and lifelike tool-tissue interaction forces. (sbir.gov)
  • 3) Only cell-free tissue sections were subjected to detailed liver-specific morphological assessment using a histological and immunohistochemical decellularization score. (nih.gov)
  • People at higher risk for wound infection include those with underlying health conditions such as liver disease, diabetes, and immunocompromising conditions [3]. (cdc.gov)
  • No evidence of dysplasia or other abnormal cellular architecture has been demonstrated in expanded tissues. (medscape.com)
  • Failure to recognize atypical cases, in which symptoms were often masked by underlying disease, and transfer between institutions of patients during the incubation period were other factors that amplified or reignited outbreaks. (who.int)
  • BioMojo LLC and the Departments of Mathematics and Biomedical Engineering at the University of North Carolina Chapel Hill, will develop a preliminary bio mathematical model framework to represent how human tissues interact and behave at their boundaries. (sbir.gov)
  • The hallmarks of this lung disease are damage to and scarring of the lung tissue. (medicalnewstoday.com)
  • Destruction of lung tissue is thought to result from an over- exuberant immune response rather than from the direct effects of viral replication. (who.int)
  • We found that labeling efficiency for each antibody varies greatly depending on the addition or removal of tissue processing steps that are commonly used for in situ hybridization or immunolabeling techniques. (ca.gov)
  • Corals from both regions showed progressive tissue loss but the in situ rate of mortality was significantly higher in tagged colonies in the Keys. (frontiersin.org)
  • These are drugs that stop your immune system from harming healthy cells and tissues. (yahoo.com)
  • The explosion in interest in tissue expansion did not occur for another 20 years. (medscape.com)
  • multiple changes occur in the tissues overlying the expanders during the process of expansion. (medscape.com)
  • When this happens, your skin's surface area increases to accommodate the new fat tissue (which is why stretch marks sometimes occur). (lifehacker.com)
  • Neurogenic arthropathy is a rapidly destructive arthropathy due to impaired pain perception and position sense, which can result from various underlying disorders, most commonly diabetes and stroke. (msdmanuals.com)
  • As a result of tissue expansion, the treatment of alopecia has been revolutionized, and the ability to treat other cutaneous defects of the head and neck has been greatly improved. (medscape.com)
  • Levels of gene expression are measured using a preparation of fluorescently labeled tissue RNA (copies of DNA), together with reference RNA labeled with a different fluorochrome, hybridized onto the slides. (lu.se)
  • Direct contact with fluoride can result in tissue damage. (cdc.gov)
  • While a more aggressive deficit will result in faster weight loss, there's a higher risk that this weight loss will come from muscle tissue, especially when done over a prolonged period of time. (lifehacker.com)
  • Denture base adaption to the underlying mucosa is reduced as a result of this deformation, resulting in decreased denture stability and retention. (hindawi.com)
  • Increased serum TNF-alpha and matrix metalloproteinase-2 are associated with grip strength declines and tissue degeneration in a rat model of overuse. (cdc.gov)
  • Hyponatraemia and low systolic blood pressure upon admission and underlying CTD are the main prognostic factors for in-hospital mortality in patients with PAH admitted for RHF. (ersjournals.com)
  • We aimed to assess the effect of underlying malignancy on outcomes and treatment of AIS at a population level. (bmj.com)
  • To assess tissue surface adaptation, the fitting surfaces of each denture base were scanned and placed on the reference master cast. (hindawi.com)
  • 2009) Progestin and thrombin regulate tissue factor expression in human term decidual cells. (scirp.org)
  • Non-muscle cell contractility is critical for tissues to adopt shape changes. (elifesciences.org)
  • Overall, our data highlights that myosin activity is required for rapid cell contraction and tissue folding in developing Drosophila embryos. (elifesciences.org)
  • Cell shape changes and cell movements drive these tissue-scale transformations. (elifesciences.org)
  • Adequate denture tissue fit is also important for denture retention, stability, and support [ 3 ]. (hindawi.com)
  • Outbreaks of coral disease, especially tissue loss diseases (white syndromes), have damaged coral reefs worldwide, with the first outbreaks reported from the Caribbean in the 1970s ( Dustan, 1977 ). (frontiersin.org)
  • The tissue loss diseases are the most virulent (highest host mortality), and Florida's reefs have had multiple outbreaks. (frontiersin.org)
  • An outbreak of stony coral tissue loss disease (SCTLD), emerged on reefs off the coast of southeast Florida in 2014 and continues to spread throughout Florida's Reef Tract. (frontiersin.org)
  • Distribution depends largely on the underlying disease. (msdmanuals.com)
  • Mortality rates are highest in the elderly and people with underlying chronic disease. (who.int)
  • The response to therapy is often complicated by underlying disease states. (medscape.com)