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Disease
Disease4
  • F-fluoride was injected into mice before disease onset and at various time points of progressing experimental arthritis. (biomedcentral.com)
  • Here, we found, in the Cln7 ∆ex2 mouse model of CLN7 disease, that failure in autophagy causes accumulation of structurally and bioenergetically impaired neuronal mitochondria. (nature.com)
  • Administration of the highly selective PFKFB3 inhibitor AZ67 in Cln7 ∆ex2 mouse brain in vivo and in CLN7 patients-derived cells rectifies key disease hallmarks. (nature.com)
  • Here, using the Cln7 ∆ex2 mouse model of CLN7 disease, we found an aberrant upregulation of pro-glycolytic enzyme PFKFB3 in neurons that may contribute to CLN7 pathogenesis. (nature.com)