AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Cord Blood Stem Cell TransplantationFetal BloodHematopoietic Stem Cell TransplantationPeripheral Blood Stem Cell TransplantationMonocrotophosTransplantation, AutologousTransplantation, HomologousUmbilical CordStem Cell TransplantationPenile ImplantationStem CellsBlood BanksHematopoietic Stem CellsTransplantation ConditioningGraft vs Host DiseaseAntigens, CD34Hematologic NeoplasmsHematopoietic Stem Cell MobilizationGraft SurvivalBone Marrow TransplantationCell DifferentiationGranulocyte Colony-Stimulating FactorTransplantation ChimeraMelphalanTreatment OutcomeLeukapheresisMyeloablative AgonistsCombined Modality TherapyTissue DonorsCells, CulturedBusulfanMice, SCIDHistocompatibility TestingSpinal CordMultiple MyelomaRecurrenceCyclophosphamideBlood Component RemovalHistocompatibilityWhole-Body IrradiationRemission InductionAntineoplastic Combined Chemotherapy ProtocolsLeukemiaInfant, NewbornLiver TransplantationHematopoiesisUmbilical VeinsMesenchymal Stem Cell TransplantationVidarabineRetrospective StudiesImmunosuppressive AgentsTime FactorsGraft vs Leukemia EffectDisease-Free SurvivalHematologic DiseasesUmbilical ArteriesSpinal Cord InjuriesLymphoma, Non-HodgkinBlood CellsAntineoplastic Agents, AlkylatingPregnancyCell TransplantationMice, Inbred NODSurvival RateMesenchymal Stromal CellsInfectionSurvival AnalysisEtoposideLeukemia, Myeloid, AcuteThiotepaHLA AntigensEmbryonic Stem CellsSalvage TherapyCell SeparationTransplantation, IsogeneicImmunophenotypingAnemia, AplasticAntigens, CDKidney TransplantationBlood Cell CountPOEMS SyndromeBone Marrow CellsFlow CytometryAmyloidosisUnrelated DonorsColony-Forming Units AssayCytomegalovirus InfectionsBlood DonorsCell Culture TechniquesHodgkin DiseaseDonor SelectionFollow-Up StudiesMyelodysplastic SyndromesCell LineageAdult Stem CellsPrecursor Cell Lymphoblastic Leukemia-LymphomaCytarabineChimerismVincristineFatal Outcome
Graft-versus-HSCTTransplant2019Donor stem cellsPlacenta and umbilical cordHaematopoietic stem cell transplantClinicalAmniotic fluidInclude bone marrowBaby's umbilicalAllogeneic stemLeukemiaTherapiesMarrow transplantationConditioning regimensAutologous transplantationSource of hematopoieticParent's Guide to Cord Blood FoundationEmbryonicMononuclear cellsTransplantsProgenitor cellCharacterizationMSCsGVHDAdultChemotherapyTissueTissuesMalignanciesHuman leukocyAdultsPluripotent stemPediatric patientsTherapeuticPatientsTreatmentsDiseasesAutismRemissionNewborn'sUnderwentComplicationsCurative treatmentTreatAntigen-preseImmune systemChronic
Graft-versus-4
  • Therefore, for any specific patient, the transplant physician may be faced with a myriad of potential choices, including decisions concerning which donor to prioritize where there is more than one, the optimal selection of specific umbilical cord blood units and which conditioning and graft-versus-host disease prophylactic schedule to use. (nih.gov)
  • She suffered many complications from graft versus host disease (GVHD), a condition in which the donated stem cells view the recipient's body as foreign, and attack. (blood.ca)
  • The most common adverse event following allogeneic hematopoietic stem cell transplantation (HSCT) is graft-versus-host disease (GVHD), which can increase morbidity and mortality in HSCT patients. (oncologynurseadvisor.com)
  • 1,2 Two of the most frequent complications of stem cell transplantation are transplant rejection and graft versus host disease, or GvHD. (lifebankusa.com)
HSCT10
  • Hematopoietic stem cell transplantation (HSCT) results in the alteration of several components of the immune system. (medscape.com)
  • Patients who undergo HSCT experience a sequential suppression of host defenses, resulting in varying infectious risk at different phases of the transplantation process. (medscape.com)
  • Body iron disorders have been reported after myeloablative conditioning in patients undergoing hematopoietic stem cell transplantation (HSCT). (karger.com)
  • For pre-symptomatic infants and older individuals with mild symptoms, hematopoietic stem cell transplantation (HSCT) with cord blood is beneficial over symptomatic treatment only. (disabled-world.com)
  • CONTEXT: Omidubicel is an ex vivo expanded stem cell product derived from umbilical cord blood (UCB) for allogeneic hematopoietic stem cell transplantation (allo-HSCT). (duke.edu)
  • For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
  • Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
  • are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
  • Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (yashfiin.com)
  • Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (yashfiin.com)
Transplant21
  • A savior baby or savior sibling is a child who is conceived in order to provide a stem cell transplant to a sibling that is affected with a fatal disease, such as cancer or Fanconi anemia, that can best be treated by hematopoietic stem cell transplantation. (wikipedia.org)
  • Risks of infection also vary with the type of transplant, the indication for transplantation, and other host factors. (medscape.com)
  • The transplant procedure requires the harvesting of hematopoietic stem cells from a donor. (medscape.com)
  • Bone marrow/stem cell transplantation , including traditional and reduced-intensity transplant, using related, unrelated or umbilical cord blood cells for transplant. (dana-farber.org)
  • Blood and Marrow Transplant Research [CIBMTR] in 2004), the European Research Project on Cord Blood Transplantation (Eurocord) in 1993, and the Japanese Cord Blood Banking Network in 1996-expedited the clinical evaluation of the efficacy and safety of transplantation of cord blood from unrelated donors. (nationalacademies.org)
  • The chemotherapy she endured put her cancer in remission, but when it came back the following year, her best hope was a stem cell transplant. (blood.ca)
  • Not only does cord blood widen the pool of potential donations, it also requires a less precise match than a transplant using adult donor stem cells. (blood.ca)
  • By donating cord blood or joining the stem cell registry, donors help transplant centres provide better matches for patients - and help reduce their risk of life-threatening complications. (blood.ca)
  • IU researchers aided doctors in France in the first cord blood transplant in 1989. (ibj.com)
  • A cord blood transplant in the future might be indicated, so we're going to save the blood just in case," said Dr. Scott Goebel, who is part of the pediatric stem cell transplantation program at the children's hospital. (ibj.com)
  • Stem cells found in your baby's umbilical cord are less likely than other stem cells, including those from bone marrow, to lead to complications following transplant. (lifebankusa.com)
  • And many studies have shown that using a higher number of stem cells may help improve survival in transplant patients. (lifebankusa.com)
  • Stem Cell or Bone Marrow Transplant. (lifebankusa.com)
  • Available at https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/stem-cell-transplant.html. (lifebankusa.com)
  • Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)
  • She could not receive a bone marrow transplant operation owing to a lack of related bone marrow stem cells. (china.org.cn)
  • When needed for a transplant, the cord blood unit can be shipped to the transplant center. (schoolandyouth.org)
  • BMT InfoNet is dedicated to providing transplant patients, survivors and their loved ones with emotional support and high quality, easy-to-understand information about bone marrow, peripheral blood stem cell and cord blood transplants. (schoolandyouth.org)
  • Provides free cord blood banking for a full family member with a need for transplant. (schoolandyouth.org)
  • Donor Killer Cell Immunoglobulin-Like Receptor Genotype Does Not Improve Graft-versus-Leukemia Responses in Chronic Lymphocytic Leukemia after Unrelated Donor Transplant: A Center for International Blood and Marrow Transplant Research Analysis. (anthonynolan.org)
  • Abbey Jenkins, president and CEO of Gamida, called the approval "a major advancement in the treatment of patients with hematologic malignancies that we believe may increase access to stem cell transplant and help improve patient outcomes. (medscape.com)
20191
Donor stem cells2
Placenta and umbilical cord2
Haematopoietic stem cell transplant1
Clinical14
  • Adult tissue-derived mesenchymal stromal cells (MSCs) are showing promise in clinical trials for systemic lupus erythematosus (SLE). (nature.com)
  • However, the inability to manufacture large quantities of functional cells from a single donor as well as donor-dependent variability in quality limits their clinical utility. (nature.com)
  • In preclinical and clinical studies, progenitor cell therapy (cord blood and mesenchymal stem cells) has shown promise in reversing the underlying pathology of SNHL, the loss of cochlear sensory hair cells. (intechopen.com)
  • We will present a summary of the effect of hearing loss on auditory development, existing preclinical and clinical data on progenitor cell therapy, and its potential role in the (re)habilitation of non-genetic SNHL. (intechopen.com)
  • The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
  • Although these initial results suggest that Modulatist TM transplantation is a promising therapy, more clinical studies in COPD patients are warranted to evaluate efficacy. (vinastemcelllab.com)
  • In addition to these already established stem cell therapies, there is ongoing research and development of new stem cell therapies, which are currently being investigated in clinical trials involving people. (centenary.org.au)
  • However, despite having the promising outcome of preclinical studies, the clinical application of stem cell therapy remained elusive due to little or no progress in clinical trials. (hindawi.com)
  • The objective of this study was to provide a generalized critique for the role of mesenchymal stem cell therapy in ischemic stroke injury, its underlying mechanisms, and constraints on its preclinical and clinical applications. (hindawi.com)
  • Thus, we attempted to present an overview of previously published reports to evaluate the progress and provide molecular basis of mesenchymal stem cells (MSCs) therapy and its application in preclinical and clinical settings, which could aid in designing an effective regenerative therapeutic strategy in the future. (hindawi.com)
  • However, effective dose and appropriate time of MSCs delivery are the main challenges in the clinical translation of stem cell therapy. (hindawi.com)
  • We aim to provide the basis for establishing a future study to promote the clinical translation of stem cell therapy in ischemic brain diseases. (hindawi.com)
  • To advance the clinical application of newborn stem cells by partnering with leading research institutions to establish FDA-regulated clinical trials, exclusive to CBR families, for conditions that have no cure today. (schoolandyouth.org)
  • Mast Cell Leukemia: Clinical and Molecular Features and Survival Outcomes of Patients in the ECNM Registry. (cdc.gov)
Amniotic fluid2
  • Using a needle, the doctor can withdraw amniotic fluid surrounding the fetus, and then the cells in this fluid can be examined in the lab. (disabled-world.com)
  • This requires obtaining fetal cells by chorionic villus sampling or culturing amniotic fluid cells obtained by amniocentesis. (disabled-world.com)
Include bone marrow1
Baby's umbilical1
Allogeneic stem16
Leukemia11
Therapies6
  • Considerable time and effort has been spent in developing targeted therapies to fight SLE, yet only one therapy, belimumab (Benlysta), a monoclonal antibody targeting B cell-activating factor, or BAFF, has been approved for the treatment of SLE in the last half-century 16 . (nature.com)
  • Dr. Kurtzberg is an internationally renowned expert in pediatric hematology/oncology, pediatric blood and marrow transplantation, umbilical cord blood banking and transplantation, and novel applications of cord blood and birthing tissues in the emerging fields of cellular therapies and regenerative medicine. (duke.edu)
  • Cord blood banking is a service that allows you to collect and preserve your newborn's cord blood stem cells for use in stem cell transplantation today and for cellular therapies that may be developed in the future. (lifebankusa.com)
  • Recently, a growing number of studies are focusing on mesenchymal stem cell-based therapies for neurodegenerative disorders. (hindawi.com)
  • Objective(s) Human umbilical cord blood (HUCB) is now considered as a valuable source for stem cell-based therapies. (virascience.com)
  • The EBMT Handbook: Hematopoietic Stem Cell Transplantation and Cellular Therapies Eds. (anthonynolan.org)
Marrow transplantation6
Conditioning regimens2
Autologous transplantation3
  • In autologous transplantation, the donor and recipient is the same individual. (medscape.com)
  • Autologous transplantation is feasible when the patient's bone marrow is normal and there are no relevant genetic conditions. (medscape.com)
  • GVHD has been reported after syngeneic and autologous transplantation but is rare. (medscape.com)
Source of hematopoietic1
  • BACKGROUND:Umbilical cord blood has become an important source of hematopoietic stem and progenitor cells for therapeutic applications. (duke.edu)
Parent's Guide to Cord Blood Foundation2
Embryonic6
  • Human embryonic stem cell (hESC)-derived MSCs are an alternative to adult MSCs that can circumvent issues regarding scalability and consistent quality due to their derivation from a renewable starting material. (nature.com)
  • With controversy over embryonic stem cell research not expected to lessen anytime soon, Genesis President and CEO Erik Woods expects the use of cord blood stem cells to increase. (ibj.com)
  • This is the ultimate alternative to embryonic stem cells," Woods said. (ibj.com)
  • An induced pluripotent stem cell (iPSC), is an adult stem cell which has been altered in a lab to behave more like embryonic stem cells. (centenary.org.au)
  • Skoglund G, Lainé J, Darabi R , Fournier E, Perlingeiro R, Tabti N. Physiological and ultrastructural features of human induced pluripotent and embryonic stem cell-derived skeletal myocytes in vitro. (uh.edu)
  • Assessment of the myogenic stem cell compartment following transplantation of pax3/pax7-induced embryonic stem cell-derived progenitors. (uh.edu)
Mononuclear cells2
  • Suspension culture of human mast cells/basophils from umbilical cord blood mononuclear cells. (virascience.com)
  • In the present study, we hypothesize transplanted HUCB derived mononuclear cells (UC-MCs) can decrease injur. (virascience.com)
Transplants10
  • Transplants from HLA-matched siblings are associated with a lower risk of GVHD and faster recovery of the recipient's immune system following transplantation. (medscape.com)
  • With more than 6,000 transplants of cord blood from related and unrelated donors performed thus far, cord blood has emerged as an acceptable, alternative source of HPCs that has some advantages over adult sources of HPCs and the availability of which represents an important development in the field. (nationalacademies.org)
  • In total there are four transplantation centers in the state, however, during all the time of independence, no transplants from an unrelated donor have been performed. (parentsguidecordblood.org)
  • Although liver failure can be treated via hepatocyte transplantation, it also faces multiple problems comprising the shortage of high-quality hepatocytes sources, rejection of allogeneic transplants, difficulty to expand, and losing hepatic characteristics in vitro [ 7 , 8 ]. (springer.com)
  • Gluckman E, Rocha V. Donor selection for unrelated cord blood transplants. (lifebankusa.com)
  • To investigate cord blood as a possible solution to a critical public health need: finding appropriate hematopoietic transplants for patients who have no matched bone marrow donors. (schoolandyouth.org)
  • Website provides basic information about cord blood transplants. (schoolandyouth.org)
  • Balassa K, Danby R, Rocha V. Haematopoietic stem cell transplants: principles and indications. (anthonynolan.org)
  • The US Food and Drug Administration (FDA) approved omidubicel-onlv (Omisirge) for reducing infections and hastening neutrophil recovery for blood cancer patients aged 12 years and older who are undergoing allogeneic umbilical cord blood stem cell transplants. (medscape.com)
  • The FDA approval was based on phase 3 testing that pitted the use of omidubicel in 62 patients against standard unmanipulated cord blood transplants in 63 patients following myeloablative conditioning. (medscape.com)
Progenitor cell2
  • Progenitor cell therapy may also allow functional reorganization of the auditory pathways including primary auditory cortex (Heschl's gyrus). (intechopen.com)
  • STUDY DESIGN AND METHODS: The hematopoietic progenitor cell (HPC) and lymphocyte subset (LS) content of approximately 8000 CB units were characterized, and these results were correlated with donor ethnicity, birth weight, gestational age, sex, and type of delivery. (emmes.com)
Characterization2
  • Isolation, expansion, and characterization of natural killer cells and their precursors as a tool to study cancer immunosurveillance. (springer.com)
  • Wu J, Hunt SD, Xue H, Liu Y, Darabi R . Generation and Characterization of a MYF5 Reporter Human iPS Cell Line Using CRISPR/Cas9 Mediated Homologous Recombination. (uh.edu)
MSCs8
  • Mechanistically, in vitro data support these findings, as co-culture of hESC-MSCs with lipopolysaccharide (LPS)-stimulated BWF1 lymphocytes decreased lymphocyte secretion of TNFα and IL-6 and enhanced the percentage of putative regulatory T cells. (nature.com)
  • Evidence shows that MSCs home to sites of inflammation where they inhibit immune and inflammatory responses by influencing the behavior of local innate and adaptive immune cells (reviewed in 20 ). (nature.com)
  • Differences in expression of some cell surface and cytoplasm specific markers were evident between UCM-MSCs and BM-MSCs. (cryo-cell.com)
  • MSCs have the capacity of multiple differentiations and self-renewal and have been proven to be able to differentiate into a series of cell lineages, such as adipocytes, osteoblasts, chondroblasts, and hepatocyte-like cells (HLCs). (springer.com)
  • Therefore, MSCs may help resolve issues restricting the application of hepatocyte transplantation. (springer.com)
  • The present study had aimed to evaluate the effect of a feeder layer of irradiated MSCs in the in vitro expansion of NK cells. (springer.com)
  • MSCs were obtained from the bone marrow (BM) cells remaining in the bag and filter used in the transplantation of hematopoietic stem cells. (springer.com)
  • NK expansion and activation were stimulated by culture with artificial antigen-presenting cells (aAPCs) and IL-2, in the presence or absence of BM-MSCs. (springer.com)
GVHD6
  • In GVHD, the donated stem cells view the recipient cells as foreign and attack recipient cells. (medscape.com)
  • An environment for GVHD is formed when antigen-presenting cells are activated by the patient's disease and the pretreatment destruction of cells caused by chemotherapy and radiotherapy. (oncologynurseadvisor.com)
  • Treatment focuses on blocking the expansion of donor T cells, as GVHD develops from the expansion of these cells. (oncologynurseadvisor.com)
  • CD20 antagonists deregulate B cells, which are believed to contribute to the pathogenesis of GVHD. (oncologynurseadvisor.com)
  • When CD20 antagonists decrease the amount of circulating B cells, the body may not produce as many cytotoxic T cells that can potentially induce GVHD. (oncologynurseadvisor.com)
  • 1,2 GvHD develops when blood cells from the donor's stem cells attack the recipient's cells and tissue. (lifebankusa.com)
Adult4
Chemotherapy2
  • For example, people who have stem cell transplantation go through intensive chemotherapy before treatment. (clevelandclinic.org)
  • Chemotherapy, radiation, or both are initiated prior to transplantation to enable engraftment of the transplanted cells, decrease tumor size, and reduce immunoreactivity of the recipient. (oncologynurseadvisor.com)
Tissue9
  • Many believe that someday they'll be able to develop stem cells into other organs, muscles and nerves and use them to rebuild cardiac tissue, repair damage caused by stroke or spinal cord injuries, and reverse the effects of diseases such as Parkinson's and multiple sclerosis. (ibj.com)
  • Extracorporeal photopheresis inactivates antigen-presenting cells and T cells, whereas TNF antagonists decrease cellular activation and local tissue damage. (oncologynurseadvisor.com)
  • Intrinsically, ischemic stroke indicates the cascade of congesting events, i.e., thrombus formation and embolism, that ultimately decreases the local blood flow and cause oxygen deprivation in affected brain tissue. (hindawi.com)
  • Newborn Possibilities Program® offers free cord blood and tissue processing and five years of storage to qualifying families in the U.S. (schoolandyouth.org)
  • Over time, excessive storage of fats can cause permanent cellular and tissue damage, particularly in the brain, peripheral nervous system (the nerves from the spinal cord to the rest of the body), liver, spleen, and bone marrow. (nih.gov)
  • Optimising tissue acquisition and the molecular testing pathway for patients with non-small cell lung cancer: A UK expert consensus statement. (cdc.gov)
  • Complementary Roles for Tissue- and Blood-Based Comprehensive Genomic Profiling for Detection of Actionable Driver Alterations in Advanced NSCLC. (cdc.gov)
  • The large proteoglycan molecules made up of protein cores, and GAG branches are secreted by cells and constitute a significant fraction of the extracellular matrix of connective tissue. (medscape.com)
  • The enzyme deficiencies lead to the accumulation of mucopolysaccharides in the lysosomes of the cells in the connective tissue and to an increase in their excretion in the urine. (medscape.com)
Tissues6
  • They create cells that range from muscle cells to brain cells and they can, in some cases, fix damaged tissues. (centenary.org.au)
  • Stem cells can develop into any type of cell in the body, making them valuable for repairing damaged tissues and organs. (centenary.org.au)
  • Lipid storage diseases (also known as lipidoses) are a group of inherited metabolic disorders in which harmful amounts of fatty materials (lipids) accumulate in various cells and tissues in the body. (nih.gov)
  • These fatty materials are stored naturally in the body's cells, organs, and tissues. (nih.gov)
  • Overview of Transplantation Transplantation is the removal of living, functioning cells, tissues, or organs from the body and then their transfer back into the same body or into a different body. (msdmanuals.com)
  • Researchers hope to use stem cells to repair or replace cells or tissues damaged or destroyed by such disorders as Parkinson disease, diabetes, and spinal injuries. (msdmanuals.com)
Malignancies1
  • There is also a small risk of infections and malignancies from donor blood. (medscape.com)
Human leukocy1
  • 2003). After the early success of transplantation of cord blood from related donors, cord blood banks were established to provide rapidly accessible, human leukocyte antigen (HLA)-typed units predominantly for transplantation of HPCs from unrelated donors. (nationalacademies.org)
Adults7
  • Older adults with cancers of the blood often have different needs from younger adults, for example, a higher risk for heart disease, diabetes, or kidney problems, which may limit treatment options. (dana-farber.org)
  • While adults in Canada donate stem cells by joining Canadian Blood Services Stem Cell Registry, umbilical cord blood is donated directly by new mothers. (blood.ca)
  • Ooi J. Cord blood transplantation in adults. (lifebankusa.com)
  • Stem cells from umbilical cords are usually used only in children because umbilical cord blood does not contain enough stem cells to use in adults. (msdmanuals.com)
  • The bone marrow and blood of children and adults contain stem cells. (msdmanuals.com)
  • These cells are taken from adults. (msdmanuals.com)
  • However, babies are small and umbilical cords even smaller, so it is very hard to get enough stem cells to treat adults with. (lu.se)
Pluripotent stem5
  • In our image, induced pluripotent stem cells can be seen, derived from patients, that replicate unique heart cell behaviours in relation to genetic heart disease. (centenary.org.au)
  • The main interest of Dr. Darabi's lab is to use pluripotent stem cells for skeletal muscle regeneration in muscular dystrophies and muscle injuries. (uh.edu)
  • During the last several years, his lab has developed novel methods for multi-lineage differentiation of pluripotent stem cells for cell therapy in mice models of muscular dystrophies and injuries. (uh.edu)
  • Derivation of Skeletal Myogenic Precursors from Human Pluripotent Stem Cells Using Conditional Expression of PAX7. (uh.edu)
  • Pluripotent" stem cells are the cells that are generated during the pregnancy process, and these are the stem cells that are capable of becoming any cell required by the DNA "blueprint" that is created at conception when an egg and sperm unite. (autism-mmc.com)
Pediatric patients1
Therapeutic1
  • The purpose of this study is to examine the therapeutic efficacy of human umbilical cord mesenchymal stem/stromal cells (UMSCs) in treating congenital and acquired corneal opacity associated with the loss of collagen V. (molvis.org)
Patients9
  • Allogeneic haemopoietic stem cell transplantation offers a potentially curative treatment option for a wide range of life-threatening malignant and non-malignant disorders of the bone marrow and immune system in patients of all ages. (nih.gov)
  • With rapidly emerging advances in the use of alternative donors, such as mismatched unrelated, cord blood and haploidentical donors, it is now possible to find a potential donor for almost all patients in whom an allograft is indicated. (nih.gov)
  • About 48% of these patients need stem cell transplantation. (parentsguidecordblood.org)
  • Two patients with late stage COPD (stage IV) were transfused with Modulatist at a dose of 10 6 cells/kg. (vinastemcelllab.com)
  • Patients were evaluated by the COPD assessment test (CAT) score as well as the Modified Medical Research Council Dyspnea Scale (mMRC) score, before and after transplantation (1, 3 and 5 months post transplantation). (vinastemcelllab.com)
  • The success of the operation, namely unrelated allogeneic allo umbilical cord stem cell transplantation (allo UCBSCT), is good news to other blood cancer patients, said professor Yu Rongxi who participated in the operation. (china.org.cn)
  • Professor Yu said that this method is more suitable for patients under the age of 14 who have more stem cells. (china.org.cn)
  • The FDA's "approval is an important advance in cell therapy treatment in patients with blood cancers. (medscape.com)
  • Cite this: FDA OKs Stem Cell Therapy to Reduce Infection Risk in Blood Cancer Patients - Medscape - Apr 18, 2023. (medscape.com)
Treatments7
  • Healthcare providers typically recommend stem cell transplantation if initial treatments don't work or if conditions have come back. (clevelandclinic.org)
  • Some medical treatments may affect transplantation. (clevelandclinic.org)
  • Stem cell research is important because it has the potential to both better understand and furthermore, cure diseases and injuries that currently have no effective treatments. (centenary.org.au)
  • Although use of stem cell treatments in medicine is still in its early stages, they are currently being used to treat people with blood and immune system conditions, such as leukaemia and lymphoma. (centenary.org.au)
  • Umbilical cord blood contains powerful stem cells that can be transplanted for many potentially life-saving medical treatments for your baby and his or her siblings. (lifebankusa.com)
  • Stem cells have been discovered by medical science to be extremely valuable as a "healing factor" that can address medical conditions other treatments can't. (autism-mmc.com)
  • First Tyra explained the limited supply of blood stem cells for transplantations which are vital after some cancer treatments, for example. (lu.se)
Diseases3
  • Stem cell transplantation has been considered promising in treating problems related to several life-threatening diseases and disorders. (powershow.com)
  • This makes them beneficial for researchers wanting to learn about various human cells and diseases in the laboratory. (centenary.org.au)
  • The research community is also actively engaged in expanding our understanding of stem cells and their potential applications in overcoming various diseases. (centenary.org.au)
Autism3
  • The research groups in the Marcus Center for Cellular Cures and the Duke Center for Autism and Brain Development led by Drs. Joanne Kurtzberg and Geraldine Dawson, have been studying whether intravenous infusions of cord blood can improve the symptoms of autism in young children. (parentsguidecordblood.org)
  • They performed an initial study (Duke ABC study), published in Stem Cells Translational Medicine , for 25 children, ages 2-6 years, which demonstrated that autologous cord blood infusions were safe and that approximately 70% of children had improvement in one or more core symptom of autism. (parentsguidecordblood.org)
  • The Duke ACT study was a randomized, double blinded, placebo controlled, prospective, cross-over study testing whether cord blood infusions would improve core symptoms of autism in 180 affected children. (parentsguidecordblood.org)
Remission1
Newborn's2
  • Today, Genesis, a private cord blood bank, stores samples for about 400 clients who pay $950 to have their newborn's blood collected, tested and frozen. (ibj.com)
  • Previously discarded as medical waste, blood from your newborn's umbilical cord is now recognized as a precious source of stem cells that can be transplanted to restore blood production in the bone marrow otherwise known as hematopoiesis. (lifebankusa.com)
Underwent1
Complications1
Curative treatment1
Treat5
  • 5 however, it has been used to treat many pediatric hematologic conditions, including chronic immune thrombocytopenic purpura, posttransplant lymphoproliferative disease, juvenile rheumatoid arthritis, and other blood dyscrasias. (oncologynurseadvisor.com)
  • In recent years, a growing number of studies have shown that stem cells can effectively treat acute liver failure. (springer.com)
  • Stem cell transplantation is a new approach to treat COPD. (vinastemcelllab.com)
  • In this study we report in two cases the use of transplanted stem cells to treat COPD. (vinastemcelllab.com)
  • These include generation of knock-in reporter stem cell lines to study myogenic differentiation, CRISPR/Cas9 gene targeting methods to correct mutated genes in muscular dystrophies, and using bioscaffolds, seeded with stem cells, to treat skeletal muscle injuries. (uh.edu)
Antigen-prese2
  • 1 After transplantation, donor T cells are activated by antigen-presenting cells. (oncologynurseadvisor.com)
  • 4 One of the primary pathways in which T cells are activated is through antigen-presenting cells such as B cells. (oncologynurseadvisor.com)
Immune system2
  • It will take 6 to 12 months or more for your child's blood counts and immune system to fully recover. (medlineplus.gov)
  • We kicked off the first ScienceBrew of 2024 with two great talks, covering the expansion of blood with nanotechnology and the possible role of immune system in limb regeneration. (lu.se)
Chronic2
  • When a patient is diagnosed with a blood cancer or chronic blood condition, it is often the start of a new journey that will be the beginning of great change. (rochester.edu)
  • Trang chủ Công trình KHCN Bài báo ngoài nước Umbilical cord derived stem cell (ModulatistTM) transplantation for severe chronic obstructive pulmonary. (vinastemcelllab.com)