• The purpose of this study is to demonstrate the application of ultrahigh-resolution Spectral Domain Optical Coherence Tomography (SD-OCT) for non contact in vivo imaging of the retina of birds of prey, which to the best of our knowledge has never been attempted. (spie.org)
  • Ultra-high isotropic resolution imaging of retinal structures was made possible with an adaptive optics system using dual deformable mirrors and a Fourier-domain optical coherence tomography (Fd-OCT) system with correction for longitudinal chromatic aberration. (spie.org)
  • Advances in Fourier-domain optical coherence tomography (Fd-OCT) permit visualization of three-dimensional morphology of in-vivo retinal structures in a way that promises to revolutionize clinical and experimental imaging of the retina. (spie.org)
  • In this case report, we describe the occurrence of multiple RPE tears with the use of intravitreal bevacizumab and also correlate the preservation of visual acuity with features seen on spectral domain optical coherence tomography. (ijo.in)
  • B. Grajciar, M. Pircher, A. F. Fercher, R. A. Leitgeb, "Parallel Fourier domain optical coherence tomography for in vivo measurement of the human eye", Opt. (photonics.pl)
  • B. Grajciar, Y. Lehareinger, A.F. Fercher, R.A. Leitgeb, "High sensitivity phase mapping with parallel Fourier domain optical coherence tomography at 512 000 A-scan/s", Opt. (photonics.pl)
  • 1 Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation In OCT, dispersion compensation is usually performed by matching the optical materials and path lengths in the two interferometer arms. (cx0512.com)
  • The aim was to determine the precise localisation of these flecks within the retinal layers using Stratus optical coherence tomography (OCT). (bmj.com)
  • The retinal disease screening study: prospective comparison of nonmydriatic fundus photography and optical coherence tomography for detection of retinal irregularities. (cns.org)
  • S. Makita, T. Fabritius and Y. Yasuno, "Quantitative Retinal-Blood Flow Measurement with Three-Dimen- sional Vessel Geometry Determination Using Ultrahigh- Resolution Doppler Optical Coherence Angiography," Optics Letters, Vol. 33, No. 8, 2008, pp. 836-838. (scirp.org)
  • Via WWC, we reconstruct visible light OCT human retinal images with 1.3-μm depth resolution in water. (escholarship.org)
  • Podoleanu and R. B. Rosen, " Combinations of techniques in imaging the retina with high resolution ," Progress in Retinal and Eye Research 27 , 464-499 (2008). (kent.ac.uk)
  • however, higher order aberrations interfere with high-resolution retinal imaging. (touchophthalmology.com)
  • The ultra-high speed and high resolution features enable the FD-OCT to visualize the retinal tissue with ultra-high clarity in a fraction of seconds. (digitaleyecenter.com)
  • We demonstrate a swept-source optical coherence tomography system, including a broadband frequency sweeping light source with the central wavelength around 1250 nm, to achieve an axial resolution of 2.4 microns in tissue. (researchwithrutgers.com)
  • S. K. Dubey, D. S. Mehta, A. Anand and C. Shakher, "Simultaneous Topography and Tomography of Latent Fingerprints Using Full-Field Swept-Source Optical Coherence Tomography," Journal of Optics A: Pure and Applied Optics, Vol. 10, No. 1, 2008, Article ID: 015307. (scirp.org)
  • Articles reporting different imaging modalities for diagnosing or monitoring treatment responses of ocular tumors were extracted using various combinations of the following keywords: ocular neoplasia, positron emission tomography or PET, single-photon emission computed tomography or SPECT, optical coherence tomography or OCT, OCT angiography or OCTA, computed tomography or CT, ultrasonography or US, ultrasound biomicroscopy or UBM, and magnetic resonance imaging or MRI. (mehdijournal.com)
  • Combined Optical Coherence Tomograph and Scanning Laser Ophthalmoscope , A. Gh. (kent.ac.uk)
  • Spectral-domain OCT (SD-OCT), a novel imaging technology provides high-resolution cross-sectional images of the retina with high point to point correlation with the fundus picture. (ijo.in)
  • On account of the output spectral characteristics for imaging, the team did not require additional optical filtering to shape the spectrum. (phys.org)
  • The acronym OCT/SLO lives on, referring to spectral domain OCT which is now so fast that an en face fundus image can be created in real time from the OCT volume. (kent.ac.uk)
  • The delay and magnitude of the optical reflections from the sample can be detected by Fourier transforming the spectral interference signal. (cx0512.com)
  • By varying the frequency separation of the two spectral components of the probe pulse, we determine the populations and coherences of the density matrix. (lu.se)
  • It is based on the next generation Fourier-Domain Optical Coherence technology just emerging from clinical research in the last two years. (digitaleyecenter.com)
  • The diagnosis of KC is mainly focused on two aspects: corneal biomechanics and corneal imaging systems including topography and tomography. (biomedcentral.com)
  • Consequently, the correlations between corneal biomechanics and corneal topography and tomography characteristics have aroused intensive research interests. (biomedcentral.com)
  • We demonstrate a high-speed parallel line field optical coherence microscopy (OCM) system that exhibits intrinsically high phase stability even with lateral scanning. (photonics.pl)
  • The microscopy system is shown to resolve the smallest elements of the USAF resolution test target (Group 7, Element 6), indicating the transverse (Y- non-scanning parallel direction)) resolution and resolution in X (scanning) direction less than 2.2 µm. (photonics.pl)
  • It allows clinicians to simultaneously visualise microscopy images of the retina alongside depth resolve optical coherence tomography images. (kent.ac.uk)
  • Optical super-resolution microscopy of molecular mechanisms of disease. (lu.se)
  • We discuss possible ways to enlarge the size of high-resolution area (isoplanatic patch) in fundus imagers equipped with adaptive optics. (spie.org)
  • The improved resolution and contrast enhanced visualization of morphological structures in the retina can be clearly seen. (spie.org)
  • I am most fortunate to benefit from an incredible technology called optical coherence tomography (OCT) - ultra high-resolution three-dimensional imaging of the retina and optic nerve, captured non-invasively within seconds. (le.ac.uk)
  • Podoleanu " Multidimensional en-Face OCT imaging of the retina ," Opt. (kent.ac.uk)
  • A. Rogers, J. Pedro, R. B. Rosen, " Combined confocal scanning ophthalmoscopy/en face T-scan based ultrahigh resolution OCT of the human retina in vivo ," Opt. (kent.ac.uk)
  • Adaptive optics-based technologies offer non-invasive, cellular resolution views of the living retina, and bring with them several exciting clinical applications. (touchophthalmology.com)
  • The Optovue RTVue is an ultra-high speed, high resolution optical coherence tomography (OCT) retina scanner used for retina imaging and analysis. (digitaleyecenter.com)
  • Supercontinuum sources for optical coherence tomography are of great interest since they provide a broad bandwidth for high resolution and high-power imaging sensitivity. (phys.org)
  • For commercial fiber-based supercontinuum systems, researchers use high pump powers to generate a broad bandwidth and customized optical filters to modulate the spectra. (phys.org)
  • As a result of high optical confinement and intrinsic nonlinearity in silicon nitride, the waveguide showed a nonlinearity parameter approximately 100 times larger than that of highly nonlinear fibers used in commercial supercontinuum systems. (phys.org)
  • The combined OCT/SLO (optical coherence tomography and scanning laser ophthalmoscope) instrument for imaging the eye was invented at Kent in 1998 by Adrian Podoleanu and David Jackson. (kent.ac.uk)
  • Ophthalmic adaptive optics systems are designed to measure and correct for these higher-order aberrations, and can provide image resolution that is limited only by the pupil diameter of the eye, the axial length of the eye, and the wavelength of light. (touchophthalmology.com)
  • To evaluate the frequency and characteristics of sub-clinical ocular surface squamous neoplasia (OSSN) detected by high-resolution anterior segment tomography (HR- OCT) in patients with clinically unapparent disease following topical treatment. (biomedcentral.com)
  • An OCT probe can be passed through the accessory channel of an endoscope and can be kept in contact with the mucosa of interest which allows for a resolution of 7-10 micrometers and an imaging depth of 2-3 mm depending on the wavelength of light used and the type of tissue being imaged [ 6 , 7 ]. (hindawi.com)
  • HALE G M, QUERRY M R. Optical constants of water in the 200-nm to 200-μm wavelength region [J]. Appl. (lightpublishing.cn)
  • Optimal wavelength for ultrahigh-resolution optical coherence tomography [J]. Opt. (lightpublishing.cn)
  • In the rapidly evolving field of endoscopic gastrointestinal imaging, Optical Coherence Tomography (OCT) has found many diverse applications. (hindawi.com)
  • Initially described in 1999 [ 4 ], OCT has evolved over the years to allow for higher resolution and rapid imaging. (hindawi.com)
  • Enhanced depth imaging optical coherence tomography of optic nerve head drusen. (cns.org)
  • High-resolution ultrasound imaging of the eye - a review. (cns.org)
  • Aguirre AD, Chen Y, Fujimoto JG, Ruvinskaya L, Devor A, Boas DA (2006) Depth-resolved imaging of functional activation in the rat cerebral cortex using optical coherence tomography. (springer.com)
  • The new chip will facilitate portable OCTs and integrated photonics during optical imaging studies. (phys.org)
  • Optical coherence tomography (OCT) is a label-free, three-dimensional optical imaging modality of high resolution. (phys.org)
  • Optical coherence tomography (OCT) is a relatively new imaging technology which can produce high resolution images of three-dimensional structures. (scirp.org)
  • Visible light optical coherence tomography (OCT) is emerging for spectroscopic and ultrahigh resolution imaging, but challenges remain. (escholarship.org)
  • The assembly of a unique compact ophthalmological imaging system capable of en-face OCT/SLO as well as longitudinal SLO. (kent.ac.uk)
  • Podoleanu, R. G. Cucu, R. A. Rosen, G. M. Dobre, J. A. Rogers, and D.A. Jackson, " Quasi-simultaneous OCT en-face imaging with two different depth resolutions ," J. Phys. (kent.ac.uk)
  • With conventional optical imaging, the major factor limiting the achievable resolution is the eye's monochromatic aberrations, which are due to imperfections in the optics of the eye. (touchophthalmology.com)
  • The use of anterior segment high-resolution optical coherence tomography (HR-OCT) provides a non-invasive imaging modality to aid in the diagnosis and management of OSSN [ 3 ]. (biomedcentral.com)
  • However, MRI had a lower spatial resolution compared to OCT. Further development of imaging modalities and their application in drug development would improve the treatment of ocular tumors. (mehdijournal.com)
  • By providing an "optical biopsy," HR-OCT can confirm disease presence and resolution. (biomedcentral.com)
  • Akkin T, Dave DP, Milner TE, Rylander HG (2004) Detection of neural activity using phase-sensitive optical low-coherence reflectometry. (springer.com)
  • M. Nasiri-Avanaki, A. Meadway, A. Bradu, R. Khoshki, A. Hojjatoleslami and A. Podoleanu, "Anti-Spoof Reliable Biometry of Fingerprints Using En-Face Optical Coherence Tomography," Optics and Photonics Journal , Vol. 1 No. 3, 2011, pp. 91-96. (scirp.org)
  • Podoleanu, " Ultrahigh-Resolution Combined Coronal Optical Coherence Tomography Confocal Scanning Ophthalmoscope (OCT/SLO) : A pilot study ," Spektrum Augenheilkd 21 , 36-47 (2007). (kent.ac.uk)
  • Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) for neovascular age-related macular degeneration: a cross-sectional diagnostic accuracy study. (mhh.de)
  • An automatic segmentation algorithm was used to determine the optical thickness of the glass phantoms from the UHR-OCT tomograms. (arvojournals.org)
  • In this study the combination of morphological component analysis (MCA) and dynamic programming (DP) is used automatically for segmentation of optical coherence tomography (OCT) images.Methods: Data set for this study was 55 samples which were taken from normal people by Topcon OCT-1000. (ac.ir)
  • The UHR-OCT system provides resolution of 3.2µm (axial) and 10µm (lateral) in corneal tissue and image acquisition rate of 47,000 A-scan/s. (arvojournals.org)
  • To explore the relationship between corneal biomechanical parameters and corneal sublayer thickness using corneal visualization Scheimpflug technology (Corvis ST) and ultrahigh-resolution optical coherence tomography (UHR-OCT) in clinical and suspected keratoconus and normal eyes. (biomedcentral.com)
  • With newer advances in techniques for endoscopic mucosal resection (EMR) [ 11 ] and ablation (radiofrequency and cryotherapy), assessing the depth of invasion of mucosal cancers is vital, with a pivotal role for OCT. Indeed, studies have shown superiority of resolution for OCT compared to EUS specifically for visualization of the mucosa and submucosa [ 12 ]. (hindawi.com)
  • Another reason for using such OCT technology is that it is compatible with dynamic focus and therefore can provide enhanced transversal resolution and sensitivity. (scirp.org)
  • The coherence parameters of the SXR radiation allowed for the OCT measurements of a bulk multilayer structure with 10 nm period and 40% bottom layer thickness to period ratio, with an axial resolution of about 2 nm and detect multilayer interfaces up to a depth of about 100 nm. (nature.com)
  • The main challenge of visible and near-infrared OCT is the difficulty of observing opaque materials and the axial resolution of typically sub-micron to a few microns. (nature.com)
  • En-Face OCT method is employed and recommended for its capability of providing not only the axial succession of layers in depth, but the en-face image that allows the traditional pattern identification. (scirp.org)
  • The microarray is the most comprehensive microorganism detection platform built to date and the first high throughput microarray that employs whole genome resolution for identifying all sequenced microbes. (llnl.gov)
  • While positron-emission tomography (PET)/computed tomography (CT) allowed the detection of metastatic lesions of choroidal melanoma by full-body scanning, single-photon emission CT was more sensitive compared to PET in detecting choroidal melanoma. (mehdijournal.com)
  • To determine the accuracy and repeatability of optical thickness measures of an ultra-high resolution optical coherence tomographer (UHR-OCT) using an appropriate refractive index phantom as a gold standard. (arvojournals.org)
  • All values of optical thickness were obtained as an average of 200 A-scans in the central section of the 2-D image. (arvojournals.org)
  • The optical and physical thickness measurements were almost perfectly correlated (Bootstrapped ρ=0.998). (arvojournals.org)
  • Accuracy The mean difference between the physical and optical thickness was -0.467±3.50µm. (arvojournals.org)
  • Deming regression optical-physical thickness slope was 0.99±0.001. (arvojournals.org)
  • Effect of different lubricant eye gels on tear film thickness as measured with ultrahigh-resolution optical coherence tomography. (theapharma.ca)
  • Group 1 included individuals whose clinical resolution of OSSN aligned with complete resolution on HR-OCT. Group 2 (sub-clinical OSSN group) included individuals with clinical OSSN resolution but with features of persistent disease on HR- OCT. Patients excluded included those treated at an outside institution and those who used topical therapy as a surgical adjunct. (biomedcentral.com)
  • In the 16 individuals, the mean time to clinical resolution was 3.6 ± 1.0 cycles for 5-FU and 4.0 ± 0.0 months for IFN. (biomedcentral.com)
  • We found that at least 17% of individuals with apparent clinical resolution of OSSN have sub-clinical disease detected on HR-OCT. This information can be used to optimize treatment and extend therapy past the point of clinical resolution. (biomedcentral.com)
  • When treating OSSN with medical therapy, most clinicians will provide topical therapy based on the clinical observation of tumor resolution. (biomedcentral.com)
  • A current gap exists if clinical resolution indeed corresponds with complete tumor resolution. (biomedcentral.com)
  • In their study using ultra-high resolution OCT, Chen and colleagues [ 16 ] demonstrated characteristic layered epithelium in a normal esophagus with normal architecture, while images of Barrett's esophagus corresponded to crypt-like glandular structures. (hindawi.com)
  • Two En-Face OCT systems are used to evaluate the need for high resolution and conclusions are drawn in terms of the most potential commercial route to ex- ploitation. (scirp.org)
  • During 3D printing, why high resolution photoresist (IP-Dip) is used for the lower part (close to the fibre end), while low resolution photoresist (IP-S) for the upper part (far from the fibre end)? (cx0512.com)
  • This methodology, coupled with 5 micron resolution SD-OCT technology, allows evaluation of post refractive patients with increased confidence. (digitaleyecenter.com)
  • In the paper, detailed information about the source, its optimization, the optical system, OCT measurements and the results are presented and discussed. (nature.com)
  • Our first OCT/SLO was an en-face system, with the OCT channel operating based on en-face time domain OCT. (kent.ac.uk)
  • The advantage of this design is its ability to compensate for chromatic dispersion and other optical aberrations. (wikipedia.org)
  • The performance of optical systems is often affected by aberrations that degrade the image resolution and contrast. (uwaterloo.ca)
  • A new algorithm for the quantum state tomography of photoelectrons, named KRAKEN, has been derived, numerically verified and experimentally implemented. (lu.se)
  • In OCT, dispersion compensation is usually performed by matching the optical materials and path lengths in the two interferometer arms. (cx0512.com)