• Ranitidine is a medication used to treat ulcers and gastroesophageal reflux disease (GERD). (thesaurus.net)
  • Gastroesophageal reflux disease (GERD), which is the chronic reflux of acid into the esophagus, can lead to esophagitis, esophageal ulcers, and changes in the lining of the esophagus that increase the risk of developing cancer. (managedhealthcareexecutive.com)
  • Cimetidine is an over the counter ant-acid or anti-ulcer drug otherwise known as Tagamet, and as such inhibits gastric acid secretion via histamine type (H2) receptors on parietal cells (in the stomach. (i-sis.org.uk)
  • Peptic ulcer disease in the elderly. (uc.edu)
  • Peptic ulcer disease affects 10% of men and 4% of women in the United States at some point in their lives. (managedhealthcareexecutive.com)
  • These drugs are used to treat gastric and duodenal ulcers by inhibition of gastric acid secretion stimulated by food, insulin, histamine, caffeine, and pentagastrin. (fsu.edu)
  • The principles of management of bleeding peptic ulcers outlined below are equally applicable to both gastric and duodenal ulcers. (medscape.com)
  • Over-the-counter cimetidine is used to prevent and treat symptoms of heartburn associated with acid indigestion and sour stomach. (medlineplus.gov)
  • If symptoms of heartburn, acid indigestion, or sour stomach last longer than 2 weeks, stop taking cimetidine and call your doctor. (medlineplus.gov)
  • Medicines that lower stomach acid (used to treat indigestion, heartburn or ulcers) may prevent this medicine from working properly. (cigna.com)
  • heartburn, ulcer treatment and treatment of Zollinger-Ellison syndrome. (globalchange.com)
  • Cimetidine treats acid reflux, stomach ulcers, heartburn, and other digestion problems caused by too much stomach acid. (rxwiki.com)
  • Prevention and treatment of stomach ulcers and esophageal reflux (heartburn), reduction of hyperphosphatemia (increased amount of phosphorus in the blood) in patients with kidney failure. (dogfoodadvisor.com)
  • Ranitidine , or cimetidine, is a medication that is prescribed to treat heartburn and other stomach problems. (thesaurus.net)
  • Results showed that the extract at 50, 100 and 200 mg/kg wt offered 73.87, 80.18 and 81.98% protection, respectively against ethanol-induced ulcer, whereas cimetidine (50 mg/kg) produced 72.07% ulcer protection. (academicjournals.org)
  • Omeprazole inhibited the metabolism of cisapride (Ki = 0.4 microM), glibenclamide (11.7 microM) and benidipine (6.5 microM), whereas cimetidine inhibited the metabolism of glibenclamide (11.6 microM). (nih.gov)
  • With Sir Godfrey Milton-Thompson, Roy Pounder and George Misiewicz he evaluated the first H2-receptor antagonists to be given to man, refining new techniques to assess acid secretion, and demonstrating efficacy in duodenal ulcer disease, a common cause of significant morbidity in sailors. (wikipedia.org)
  • This could be one reason for an abnormal secretion of hydrochloric acid in people with peptic ulcers. (rawfoodexplained.com)
  • In pylorus-ligated mice, cimetidine (positive control) and FRF significantly decreased gastric acid secretion, increased gastric pH and reduced the acid output when compared to the negative control. (who.int)
  • Cimetidine is also used to prevent ulcers in certain circumstances and to treat certain conditions that are associated with over secretion of acid by the stomach (i.e. (medbroadcast.com)
  • Cimetidine first came to the attention of Bourinbaiar and Jirathitikal when they observed the inhibition of human T cells leukaemia virus (HTLV-1) secretion from chronically infected cells. (i-sis.org.uk)
  • This led them to the idea that viral release is regulated in the same way as gastric acid secretion, and to discover that cimetidine has broad anti-retroviral activity. (i-sis.org.uk)
  • Common side effects of cimetidine include headaches, dizziness, and diarrhea. (rxwiki.com)
  • 1. The inhibitory effects of cimetidine, nizatidine and omeprazole on the metabolic activity of CYP2C9, 2C19, 2D6 and 3A were investigated in human liver microsomes. (nih.gov)
  • 1992. A Multicenter, double-blind, randomized, placebo-controlled, comparison of nocturnal Roxatidine in the treatment of active duodenal ulcer disease. (uc.edu)
  • These terms refer to the drug's ability to reduce the production of stomach acid, which can aggravate ulcers and cause GERD symptoms. (thesaurus.net)
  • it is characterized by febrile episodes lasting 3 to 6 days, pharyngitis, aphthous ulcers, and adenopathy. (msdmanuals.com)
  • In the ethanol-induced gastric ulcer model in rats, the lansoprazole (30 mg/kg), FRF and FDF (100 mg/kg) significantly protected the gastric mucosal of rats by 65%, 38% and 25% respectively when compared with the negative control group. (who.int)
  • METHODS: The activity was evaluated using induced gastric ulcer models (acetic acid and ethanol-induced gastric lesions in NEM or L-NAME pre-treated mice, and by ischemia/reperfusion). (bvsalud.org)
  • Treatment of peptic ulcers varies depending on the etiology and clinical presentation. (medscape.com)
  • The prescription form is used to treat acid reflux , conditions that cause your stomach to release too much acid, and stomach ulcers. (rxwiki.com)
  • The prescription form is used to treat acid reflux and stomach ulcers. (rxwiki.com)
  • In this exactly model other treatments as cimetidine, FRF and FDF (100 mg/kg) each caused 54%, 36% and 45% inhibition, respectively. (who.int)
  • Twice daily doses of 200mg of cimetidine will suffice to provide steady IC50 levels (concentration producing 50% inhibition) for HIV replication. (i-sis.org.uk)
  • 1 and the editorial in the same issue (June 2) 2 did not include several important aspects of cimetidine treatment. (elsevierpure.com)
  • abstract = "To the Editor: The recent report of Isenberg et al.1 and the editorial in the same issue (June 2)2 did not include several important aspects of cimetidine treatment. (elsevierpure.com)
  • Carbenoxolone (duogastrone) and cimetidine in the treatment of duodenal ulcer--a therapeutic trial. (ox.ac.uk)
  • Using the correct treatment, doctors can cure bleeding ulcers. (medicalnewstoday.com)
  • Diagnosis and treatment of bleeding ulcers typically involve an endoscopy . (medicalnewstoday.com)
  • The efficacy of esomeprazole will be compared versus cimetidine (a drug that previously demonstrated prevention of bleeding events) during treatment period in proportion of patients for the prevention of upper GI bleeding. (astrazenecaclinicaltrials.com)
  • Data from the literature suggest that stress ulcer prevention with effective acid suppressive treatment can reduce bleeding events and is thus an important therapy in high-risk patients. (astrazenecaclinicaltrials.com)
  • Modern botanical applications of the herb continue this tradition, with recommendations including the treatment of gastric ulcers, bronchitis, cough, and dyspepsia. (naturalmedicinejournal.com)
  • 4 Two years later, he published a report on the use of licorice juice in the treatment of duodenal ulcers. (naturalmedicinejournal.com)
  • This and his synthesis of cimetidine, used for the treatment of peptic ulcers, earned him the Nobel Prize in Physiology or Medicine in 1988. (webofstories.com)
  • Additionally, paying a fixed, diagnosis-based price for treatment - as Medicare began to do in the early 1980s, with private insurers following - increased the profitability of drugs that substitute for more costly treatments, like beta blockers instead of coronary bypass surgery and cimetidine instead of ulcer surgery. (theincidentaleconomist.com)
  • Many authorities recommend simple oversewing of the ulcer with treatment of the underlying H pylori infection or cessation of NSAIDs for bleeding PUD. (medscape.com)
  • The extract also inhibited aspirin-induced ulcer whereas omeprazole (20 mg/kg) significantly enhanced aspirin-induced ulcer. (academicjournals.org)
  • 1999. Use of omeprazole in the management of giant duodenal ulcer: Results of a prospective study. (uc.edu)
  • 2. Cimetidine inhibited the hydroxylation of tolbutamide but not of diclofenac, whereas omeprazole inhibited the hydroxylation of diclofenac but not that of tolbutamide. (nih.gov)
  • However, a newer review in the Asian Pacific Journal of Cancer Prevention states that ulcers without H. pylori infection or NSAID involvement are increasing. (medicalnewstoday.com)
  • [ 26 ] In one study, at least 2 risk factors (previous duodenal ulcer, H pylori infection, use of ASA/NSAID, and smoking) were present in two thirds of persons with acute gastroduodenal bleeding. (medscape.com)
  • A double-blind, double-dummy trial to compare carbenoxolone (Duogastrone) with cimetidine has been carried out in patients with duodenal ulcer. (ox.ac.uk)
  • Sixty patients completed the six week trial period, 31 patients were treated with carbenoxolone and 29 with cimetidine. (ox.ac.uk)
  • Endoscopy after six weeks of therapy showed healing in 61% of patients receiving carbenoxolone and 72% in those receiving cimetidine, a difference which is not significant. (ox.ac.uk)
  • Sign of multi PUB or concomitant other gastro bleeding from esophageal varices, reflux esophagitis, gastritis, Mallory Weiss rifts, ulcus simplex, Dieulafoy's lesion, colon, small bowel, or ulcer distal to the stom in Billroth-resected patients. (astrazenecaclinicaltrials.com)
  • Cimetidine is also helpful in treating upper gastrointestinal bleeding in critically ill patients. (fsu.edu)
  • Documentation of H pylori cure with a noninvasive test, such as the urea breath test or fecal antigen test, is appropriate in patients with complicated ulcers. (medscape.com)
  • Endoscopic evaluation of the bleeding ulcer can decrease the duration of the hospital stay by identifying patients at low risk for rebleeding. (medscape.com)
  • and there was no report of the side effects, other than diarrhea, associated with cimetidine, low-dose antacid, and placebo. (elsevierpure.com)
  • The recommended adult dose of cimetidine depends on the condition being treated. (medbroadcast.com)
  • When treating duodenal or gastric ulcers, the dose ranges from 800 mg to 1,200 mg daily, in divided doses. (medbroadcast.com)
  • To prevent recurrent ulcers , the dose ranges from 400 mg to 600 mg. (medbroadcast.com)
  • it can include glucocorticoids, such as a single dose of prednisone (1 to 2 mg/kg orally) or betamethasone (0.1 to 0.2 mg/kg), which, when given at the onset of an episode can dramatically abort fever attacks in a few hours, cimetidine (20 to 40 mg/kg orally once a day), and, rarely, tonsillectomy. (msdmanuals.com)
  • RESULTS: In chronic gastric ulcers, a single daily oral dose of Sa-FRF or Sb-FRF (100 mg/kg body wt. (bvsalud.org)
  • for 14 consecutive days accelerated ulcer healing to an extent similar to that seen with an equal dose of cimetidine. (bvsalud.org)
  • Certain drugs, such as aspirin and other nonsteroidal anti-inflammatory drugs, reserpine, and possibly corticosteroids may initiate the formation of an ulcer. (rawfoodexplained.com)
  • Cimetidine comes as a tablet and a liquid to take by mouth. (medlineplus.gov)
  • This study investigated the antiulcer activity of aqueous extract of unripe Musa paradisiacal (plantain) peels in rats using ethanol, aspirin, indomethacin and pyloric ligation-induced ulcer models. (academicjournals.org)
  • Similar to cimetidine, the extract did not inhibit indomethacin-induced ulceration. (academicjournals.org)
  • In indomethacin/bethanechol-induced gastric ulcers, cimetidine (100 mg/kg) and the EEOH (100, 250 mg/kg) inhibited gastric ulcer formation by 73%, 55% and 32% respectively. (who.int)
  • Cimetidine is both an over-the-counter and a prescription medication. (rxwiki.com)
  • Do not take this medication if you are allergic to cimetidine or any ingredients of the medication. (medbroadcast.com)
  • Peptic ulcers can be difficult to diagnose because some people never display symptoms. (medicalnewstoday.com)
  • Symptoms of ZES may be similar to those of peptic ulcers, such as dull or burning pain in the belly, and digestive problems such as diarrhea , nausea, decreased appetite, bloating, and burping. (medicalnewstoday.com)
  • Symptoms vary with the location of the ulcer and the person's age. (rawfoodexplained.com)
  • To test whether the anticonvulsant topiramate had an effect on inflammatory bowel diseases, the researchers administered the drug to rats that had bowel disease symptoms -- diarrhea and inflammation, ulcers and microscopic damage in the colon. (sciencedaily.com)
  • These ulcers tend to heal when the drug is discontinued and are unlikely to recur unless the drug is taken again. (rawfoodexplained.com)
  • To avoid drug-drug interactions, care needs to be taken to select suitable medicines for co-administration with anti-ulcer drugs. (nih.gov)
  • Butte's team chose to further investigate two such drug-disease combinations: an anti-ulcer medicine (cimetidine) that matched with lung cancer, and an anticonvulsant (topiramate) that matched with inflammatory bowel disease, which includes Crohn's disease. (sciencedaily.com)
  • In both cases, the drug slowed the growth of the cancer cells compared to the control group (cells or mice) that had not received cimetidine. (sciencedaily.com)
  • PPIs heal peptic ulcers more rapidly than H 2 -blockers or any other drug. (managedhealthcareexecutive.com)
  • Among H 2 -blockers, the low price of generic cimetidine probably does not outweigh its many adverse drug interactions,' says Dr. Abramowicz. (managedhealthcareexecutive.com)
  • Cimetidine was developed as part of a research effort led by Nobel laureate Sir James Black, and was the first H2-antagonist to receive approval from the FDA (Food and Drug Administration) in 1977. (i-sis.org.uk)
  • Endoscopy is required to document healing of gastric ulcers and to rule out gastric cancer. (medscape.com)
  • In the ethanol/HCl-induced ulcer model, lansoprazole (30 mg/kg), EEOH (50, 100, 250 mg/kg) given orally protected the gastric mucosal against injury in mice by 79%, 78%, 73%, and 64% respectively. (who.int)
  • In the same model, cimetidine, FRF and FDF (100 mg/kg) significantly protected the gastric mucosal of the mice by 60%, 51% and 47% when compared to the control group. (who.int)
  • To confirm the cimetidine-lung cancer link, the team tested cimetidine on human lung cancer cells in lab dishes and implanted in mice. (sciencedaily.com)
  • See the "Cimetidine Precautions" section. (rxwiki.com)
  • NSAIDs can also decrease the blood's clotting ability, which can make ulcers more likely to bleed. (medicalnewstoday.com)
  • Cimetidine is also used sometimes to treat stress ulcers, hives and itching, and viral warts, and to prevent aspiration pneumonia during anesthesia. (medlineplus.gov)
  • It is thus likely that cimetidine acts like an NNRTI and has the ability to treat HIV infection. (i-sis.org.uk)