• Protective Effects of Lithospermic Acid B on Diabetic Nephropathy in OLETF Rats Comparing with Amlodipine and Losartan. (e-dmj.org)
  • We examined the effects of LAB on the prevention of diabetic nephropathy compared with amlodipine, a calcium channel blocker, and losartan, an angiotensin receptor blocker, in Otsuka Long-Evans-Tokushima Fatty (OLETF) rats, an animal model of type 2 diabetes. (e-dmj.org)
  • CONCLUSION: These results suggest that LAB has beneficial effects on the diabetic nephropathy in OLETF rats by decreasing oxidative stress and inflammation as potent as losartan. (e-dmj.org)
  • Activation of NF-kappaB and AP-1 in Peripheral Blood Mononuclear Cells Isolated from Patients with Diabetic Nephropathy. (e-dmj.org)
  • Diabetic neuropathy and diabetic angiopathy lead to serious infectious complications which are very difficult to combat and may finally lead to the amputation of a lower limb. (bvsalud.org)
  • The aim of the study was to evaluate the quality of life, the level of acceptance of the illness and the nutritional status of patients after lower limb amputation due to diabetes. (bvsalud.org)
  • They had all undergone lower limb amputation due to diabetic foot and were treated in the Department of General and Oncological Surgery. (bvsalud.org)
  • RR = 4.56, 95% CI: 2.41-8.64) than patients with trauma-related amputation. (who.int)
  • IC à 95 % : 2,41-8,64) que les patients ayant eu une amputation suite à un traumatisme. (who.int)
  • In Lebanon, the preva- could be achieved in order to support main indication was recorded for each lence of type 2 diabetes was 13.1% for the development of programmes for patient from either trauma, diabetes, those aged 30+ years in 1994-95 [2] amputation prevention and care. (who.int)
  • Lower-limb infections, gangrene, and diabetic foot ulcers were the most common precipitating medical events leading to the need for an amputation. (janssencarepath.com)
  • The risk of amputation was highest in patients with a baseline history of prior amputation, peripheral vascular disease, and neuropathy. (janssencarepath.com)
  • Produced in high levels during periods of stress, infection, etc possibly leading to diabetic ketoacidosis, a very serious condition. (wikipedia.org)
  • It can sometimes be smelled on the breath of those in, or about to enter diabetic ketoacidosis as a fruity (nail polish remover, or lacquer thinner) sort of smell. (wikipedia.org)
  • It can lead to diabetic ketoacidosis, a medical emergency. (wikipedia.org)
  • It is not unusual for patients with type 1 diabetes to present with diabetic ketoacidosis (DKA). (medscape.com)
  • In patients with type 1 diabetes mellitus, INVOKANA ® significantly increases the risk of diabetic ketoacidosis, a life-threatening event, beyond the background rate. (janssencarepath.com)
  • Precipitating conditions for diabetic ketoacidosis or other ketoacidosis include acute febrile illness, reduced caloric intake, ketogenic diet, surgery, insulin dose reduction, volume depletion, and alcohol abuse. (janssencarepath.com)
  • Blood glucose levels at presentation may be below those typically expected for diabetic ketoacidosis (eg, less than 250 mg/dL). (janssencarepath.com)
  • Consider ketone monitoring in patients at risk for ketoacidosis if indicated by the clinical situation. (janssencarepath.com)
  • Assess for ketoacidosis regardless of presenting blood glucose levels in patients who present with signs and symptoms consistent with severe metabolic acidosis. (janssencarepath.com)
  • Withhold INVOKANA ® , if possible, in temporary clinical situations that could predispose patients to ketoacidosis. (janssencarepath.com)
  • Amyotrophy A type of diabetic neuropathy that causes muscle weakness and wasting. (wikipedia.org)
  • Foot anthropometrics (foot length, foot width and maximum toe height) was measured in 164 patients with diabetes, with and without neuropathy (n = 102 and n = 62 respectively). (faoj.org)
  • Age, gender and BMI influence the foot anthropometrics, however, when adjusting for theses variables the index foot length/width was lower (2.58) in patients with diabetes without neuropathy vs. controls (2.63), p = 0.018. (faoj.org)
  • Moreover, patients with diabetes with neuropathy had wider feet (98.6 mm) compared with the controls (97.0 mm), p = 0.047. (faoj.org)
  • In vivo corneal confocal microscopy (IVCCM) is being recognized as a non-invasive, early diagnostic tool for diabetic neuropathy, for it provides a clear image of corneal subbasal nerve plexus in detail. (e-dmj.org)
  • Nerve growth factors (NGF) are believed to regulate peripheral and central nervous system, neuronal differentiation, and regeneration of damaged nerves, and their role in diabetic neuropathy is being emphasized these days. (e-dmj.org)
  • RESULTS: Patients with more severe neuropathy had less corneal endothelial cells (3105 +/- 218 vs. 2537 +/- 142 vs. 2350 +/- 73/mm3 vs. 1914 +/- 465/mm3, P = 0.02), higher serum NGF (36 +/- 15 vs. 60 +/- 57.66 vs. 80 +/- 57.63 vs. 109 +/- 60.81 pg/mL, P = 0.39) and tear NGF levels (135.00 +/- 11.94 vs. 304.29 +/- 242.44 vs. 538.50 +/- 251.92 vs. 719.50 +/- 92.63 pg/mL, P = 0.01). (e-dmj.org)
  • Anti-diabetic drug A kind of medication that helps a person with diabetes control the level of glucose (sugar) in the blood so that the body works as it should. (wikipedia.org)
  • Precisely what causes it is not fully known, but diabetics have increased risk of both heart attack and stroke, so some of the tissue damage diabetes produces may be involved. (wikipedia.org)
  • The literature offers sparse information about foot anthropometrics in patients with diabetes related to foot length, foot width and toe height, although these measurements are important in shoe fitting. (faoj.org)
  • The purpose of this study was to describe the foot anthropometrics in groups of patients with diabetes, in groups representing the general population and to explore whether foot anthropometrics differ between patients with diabetes and the general population. (faoj.org)
  • Patients with diabetes seemed to have a wider forefoot width and a lower foot length to foot width ratio compared to the controls. (faoj.org)
  • This study investigated clinicians' perspectives about cognitive functioning and mental health in individuals with diabetes-related foot complications (DRFCs), and how these impact the clinicians' treatment of the patients' conditions. (bvsalud.org)
  • Psychological and cognitive impairments may be more pronounced in individuals with DRFCs compared with the general diabetes mellitus population. (bvsalud.org)
  • A fingerstick glucose test is appropriate for virtually all patients with diabetes. (medscape.com)
  • [ 2 ] However, in patients at high risk (eg, those who have first-degree relatives with type 1 diabetes), it may be appropriate to perform annual screening for anti-islet antibodies before the age of 10 years, along with 1 additional screening during adolescence. (medscape.com)
  • All patients with type 1 diabetes should learn how to self-monitor and record their blood glucose levels with home analyzers and adjust their insulin doses accordingly. (medscape.com)
  • Patients with type 1 diabetes require lifelong insulin therapy. (medscape.com)
  • INVOKANA ® is not recommended for use to improve glycemic control in patients with type 1 diabetes mellitus. (janssencarepath.com)
  • INVOKANA ® is not indicated for glycemic control in patients with type 1 diabetes mellitus. (janssencarepath.com)
  • An increased risk of lower-limb amputations associated with INVOKANA ® use versus placebo was observed in CANVAS (5.9 vs 2.8 events per 1000 patient-years) and CANVAS-R (7.5 vs 4.2 events per 1000 patient-years), two randomized, placebo-controlled trials evaluating patients with type 2 diabetes who had either established cardiovascular disease or were at risk for cardiovascular disease. (janssencarepath.com)
  • Long-term complications from high blood sugar can include heart disease , strokes , diabetic retinopathy where eyesight is affected, kidney failure which may require dialysis , and poor circulation of limbs leading to amputations . (thediabeticpharmacist.com)
  • In vivo Corneal Confocal Microscopy and Nerve Growth Factor in Diabetic Microvascular Complications. (e-dmj.org)
  • Moreover, NGFs and receptors are also expressed in retina and renal mesangial cells, suggesting their possible role in the common pathogenesis of diabetic microvascular complications. (e-dmj.org)
  • CONCLUSION: Our results provide a possibility of using novel tools, IVCCM and NGF, as common diagnostic tools for diabetic microvascular complications, but it should be followed by a large population study. (e-dmj.org)
  • Chronic wounds and ulcers are major public health threats. (mdpi.com)
  • Being a substantial burden for patients and health care systems alike, better understanding of wound pathophysiology and new avenues in the therapy of chronic wounds are urgently needed. (mdpi.com)
  • Even with these extreme measures, many patients go on to develop chronic infection or sustain disease comorbidities. (medscape.com)
  • Real-time continuous monitoring of glucose-using continuous glucose monitors (CGMs)-can help patients improve glycemic control. (medscape.com)
  • T he biomechanical interaction between the foot and the shoe, three-dimensional appearance of the foot and the relationship between foot anthropometrics and the shoe have been shown to be important in the prevention of diabetic foot ulcers (DFU) [1-3]. (faoj.org)
  • Despite advances in health care, osteomyelitis remains a major clinical challenge, with recurrent and persistent infections occurring in approximately 40% of patients. (medscape.com)
  • because continued production of mature leukocytes by bone marrow and an intact antibody response are crucial to defense against infection in immunosuppressed patients, we have evaluated the effects of db on these processes as well. (liverpool.ac.uk)
  • A poorly fitted shoe is one of many contributory factors in the development of diabetic foot ulcers. (faoj.org)
  • In Sweden at the present time, foot measurements are not mandatory when patients are provided with therapeutic footwear at a department of prosthetics and orthotics (DPO). (faoj.org)
  • PURPOSE: The purpose of this study was to explore the impact of diabetic foot ulcer (DFU) on individuals' lives and daily routines. (bvsalud.org)
  • for example, the rate cases in Lebanon including the surgi- upper limb and whether it was major increased from 2.0 to 2.7 per 100 000 cal indications so that a better under- (above the ankle or above the wrist) or population in England between 1996 standing of the scope of the problem minor (hand, foot or part thereof). (who.int)
  • 21,22] More than two courses of any medication are not recommended as 80% of patients who fail two courses will fail a third, and can be a harbinger of rapidly progressive, dangerous disease. (blogspot.com)
  • 5] Upwards of 80% of patients with CIS will present with irritative voiding symptoms. (blogspot.com)
  • In patients with irritative symptoms and/or positive high-grade cytology, a number of strategies can be employed to evaluate the bladder for the presence of CIS including (1) random, cold-cup bladder biopsies or (2) fluorescence cystoscopy. (blogspot.com)
  • Lithospermic acid B (LAB), an active component isolated from Salvia miltiorrhizae, has been reported to have renoprotective effects in type 1 and type 2 diabetic animal models. (e-dmj.org)
  • Surgical bony debridement is often needed, and further surgical intervention may be warranted for high-risk patients or for those with extensive disease. (medscape.com)
  • however patients with T1 disease and concomitant CIS have a 55% risk of upstaging. (blogspot.com)
  • 95% of patients who do not respond to an induction course of BCG will progress to worse disease. (blogspot.com)
  • I am a 20-year T2D patient and I have dedicated my past 8 years to researching this disease in order to save my own life. (endocrineconferences.com)
  • clinical effects of hyperthermia in patients with carcinoma of the esophagus--a multi-institutional cooperative study]. (liverpool.ac.uk)
  • Angiopathy A process that damages the blood vessels. (wikipedia.org)
  • METHODS: Ninety-nine patients (23 men and 76 women) were enrolled into the study. (bvsalud.org)
  • Antibiotics are the primary treatment option and should be tailored based on culture results and individual patient factors. (medscape.com)
  • Approximately 50% of patients experience a durable response for 4 years or longer. (blogspot.com)
  • Approximately 30% of patients experience a response for 10 years. (blogspot.com)
  • Characterization of surface markers on extracellular vesicles isolated from lymphatic exudate from patients with breast cancer. (gu.se)
  • Of patients who undergo cystectomy for CIS alone, upwards of 20% will be found to have invasive cancer at final pathology. (blogspot.com)
  • If first-line treatment fails, especially if the first line was chemotherapy, a second course of BCG can be given as 30-50% of patients will respond to this second course. (blogspot.com)
  • The ADA recommends using patient age as one consideration in the establishment of glycemic goals, with different targets for preprandial, bedtime/overnight, and hemoglobin A 1c (HbA 1c ) levels in patients aged 0-6, 6-12, and 13-19 years. (medscape.com)
  • We plan to examine corneal structures of diabetic patients and compare IVCCM with conventional tools and analyze their serum and tear NGF levels. (e-dmj.org)
  • From IVCCM, we measured corneal nerve density, branch, and tortuosity, total corneal/epithelial thickness, and the number of endothelial/keratocyte cells, and we checked patients' biochemical profiles and serum and tear NGF levels. (e-dmj.org)
  • 20% of patients with CIS alone will die at 10 years. (blogspot.com)
  • sem studies of acellular glomerular basement membrane in human diabetic glomerulopathy. (liverpool.ac.uk)
  • Many patients with CIS will be refractory to an initial course of intravesical treatment. (blogspot.com)
  • These findings underscore the need for holistic support for patients with DFUs that simultaneously address physical, psychological, and social needs and areas of impact. (bvsalud.org)