Tauroursodeoxycholic acid is a naturally occurring hydrophilic bile acid which is the taurine conjugated form of ursodeoxycholic acid (UDCA). (wikipedia.org)
Humans have only trace amounts of tauroursodeoxycholic acid but bears have large amounts of tauroursodeoxycholic acid and ursodeoxycholic acid in their bile. (wikipedia.org)
Ursodeoxycholic acid and tauroursodeoxycholic acid were first chemically synthesized in 1954 in Japan. (wikipedia.org)
Ursodeoxycholic acid is produced in several countries for the treatment of gallstones and primary biliary cholangitis. (wikipedia.org)
The results showed that the addition of capsaicin further decreased the fasting blood glucose and insulin, and increased beta-muricholic acid, deoxycholic acid, chenodeoxycholic acid, and 3 beta-ursodeoxycholic acid when compared to only high fiber diet. (ijpsonline.com)
Celecoxib and Tauro-Ursodeoxycholic Acid Co-Treatment Inhibits Cell Growth in Familial Adenomatous Polyposis Derived LT97 Colon Adenoma Cells. (fapvoice.com)
We investigated the in vitro effects on cell proliferation, apoptosis, and COX-2 expression of the potential chemopreventives celecoxib and tauro-ursodeoxycholic acid (UDCA). (fapvoice.com)
Interestingly, these are also the bile acids significantly decreased by ursodeoxycholic acid (UCDA), which is currently the main pharmacological treatment. (medscape.com)
Chenodeoxycholic acid1
HT-29 colon cancer cells and LT97 colorectal micro-adenoma cells derived from a patient with FAP, were exposed to low dose celecoxib and UDCA alone or in combination with tauro-cholic acid (CA) and tauro-chenodeoxycholic acid (CDCA), mimicking bile of FAP patients treated with UDCA. (fapvoice.com)
Bile acid7
Plasma parameters, gut microbiota, bile acid and short-chain fatty acids were analyzed to detect the improved effects and possible mechanisms. (ijpsonline.com)
Results from our study indicated that the addition of capsaicin have better effects to reduce the weight, insulin and fasting blood glucose, and the possibly mechanism can be due to the changes in bile acid composition, microbial abundance and shortchain fatty acids. (ijpsonline.com)
The results of metagenomic sequencing and targeted metabolome analysis together revealed that secondary bile acid (SBA) biosynthesis was significantly activated in the cows with excessive lipolysis. (biomedcentral.com)
Tauroursodeoxycholic acid (TUDCA) is an amphiphilic bile acid. (fruiterco.com)
Sodium ursodeoxycholate is a natural bile acid isolated from bear bile. (fruiterco.com)
It is a hydrophilic bile acid and a cholesterol gallstone. (fruiterco.com)
Up to 10 different MDR3 mutations have been identified and any one of these mutations may result in loss of function and, therefore, raise bile acid levels. (medscape.com)
Fatty acids3
and increased the short-chain fatty acids, especially acetic acid and butyric acid. (ijpsonline.com)
In addition, dietary fiber can be fermented by gut microbes into Short-Chain Fatty Acids (SCFAs), which have beneficial effects on the gut barrier and can mitigate obesity by regulating the endocrine activity[ 8 ]. (ijpsonline.com)
Yet, it remains largely unknown how these diverse metabolic pathways, including isovaleric acid, cholesterol, fatty acids, and phospholipids, specifically modulate gastric carcinogenesis or affect the host's serum metabolism, consequently leading to the development of metabolic-associated diseases. (bvsalud.org)
Tauroursodeoxycholic acid9
Ursodoxicoltaurine is the international nonproprietary name (INN) for the pharmaceutical form of tauroursodeoxycholic acid (TUDCA). (wikipedia.org)
Tauroursodeoxycholic acid prevents apoptosis with its role in the BAX pathway. (wikipedia.org)
Tauroursodeoxycholic acid prevents BAX from being transported to the mitochondria which protects the mitochondria from perturbation and the activation of caspases. (wikipedia.org)
Many effects of tauroursodeoxycholic acid appear to be dependent on the activation of the cell membrane receptors TGR5, S1PR2 and α5β1-Integrin. (wikipedia.org)
Tauroursodeoxycholic acid also acts as a chemical chaperone to help maintain the stability and correct folding of proteins. (wikipedia.org)
Studies have shown that tauroursodeoxycholic acid has neuroprotective actions based on its potent ability to inhibit apoptosis, attenuate oxidative stress, and reduce endoplasmic reticulum stress in different experimental models of these illnesses. (wikipedia.org)
Studies have shown protective effects of tauroursodeoxycholic acid in eye diseases. (wikipedia.org)
A study examined the effects of tauroursodeoxycholic acid on cones, in relation to retinitis pigmentosa (RP), a disease in which retinal rods and cones undergo apoptosis. (wikipedia.org)
Both models were injected with tauroursodeoxycholic acid every 3 days from post-natal day 6 (p6) to p30 and compared to the vehicle. (wikipedia.org)
Taurine2
Bile acids are naturally synthesized from cholesterol in the liver and are conjugated with specific amino-acids, specifically taurine. (wikipedia.org)
UDCA and its taurine conjugates comprise about 47% of the bile in American black bears and up to 76% in Asiatic bears. (wikipedia.org)
Cholesterol1
It can reduce the secretion of cholesterol in the liver, reduce the saturation of cholesterol in bile, promote the secretion of bile acids, increase the solubility of cholesterol in bile, dissolve cholesterol stones or prevent the formation of stones. (fruiterco.com)
Serum1
Affected individuals have a defect involving the excretion of bile salts, which leads to increased serum bile acids. (medscape.com)
Metabolic1
Background: Previous studies have suggested that bile acids (BAs) may participate in the development and/or progression of metabolic dysfunction-associated steatotic liver disease (MASLD). (bvsalud.org)
Sodium1
Administration of 0.05 g/kg capsaicin showed the highest of tauro-alpha-muricholic acid sodium salt and tauro-beta-muricholic acid sodium salt and 0.1 g/kg capsaicin resulted in the highest of lithocholic acid, cholic acid and hyodeoxycholic acid. (ijpsonline.com)
Plasma1
The use of an integrated analysis showed that the reduction of plasma glycolithocholic acid and taurolithocholic acid could contribute to the immunosuppression of monocytes (CD14 + MON) during excessive lipolysis by decreasing the expression of GPBAR1 . (biomedcentral.com)
Studies1
Recent studies have implemented 2 bile acids, taurocholic and taurodeoxycholic aids, as being the specific ones elevated in ICP. (medscape.com)
Effects2
A study done at the Department of Ophthalmology at Seoul National University College of Medicine examined the effects of ursodoxicoltaurine and UDCA on laser-treated choroids of rat models. (wikipedia.org)
In conclusion, co-treatment with low dose celecoxib and UDCA has growth inhibitory effects on colorectal adenoma cells derived from a patient with FAP, and further research on this combination as promising chemopreventive strategy is desired. (fapvoice.com)
Treatment1
Ursodoxicoltaurine and UDCA were injected intraperitoneally 24 hours before and daily after the laser treatment. (wikipedia.org)
Serum bile2
Higher serum bile acid levels are associated with an increased risk of cirrhosis and liver-related morbidity and mortality. (nih.gov)
Affected individuals have a defect involving the excretion of bile salts, which leads to increased serum bile acids. (medscape.com)
Bile acid metabolism1
These changes in the gut microbiota were associated with altered bile acid metabolism. (nih.gov)
Metabolism2
Overall, analysis of transcriptomes and correlation networks indicates both bacterial species-specific responses to BBR, as well as functional commonalities among species, such as up-regulation of Na + /H + antiporter, cell wall synthesis/repair, carbohydrate metabolism and amino acid metabolism. (researchsquare.com)
Bile acids (BAs) are natural end products of cholesterol metabolism (12). (pancreapedia.org)
Bacterial2
Multi-omics (bile acid metabolomics, 16S rDNA sequencing, cecal metatranscriptomics) were performed in order to provide a simple in vivo model from which to identify network-based correlations between bile acids and bacterial transcripts in the presence and absence of dietary BBR. (researchsquare.com)
Secondary bile acids such as deoxycholic acid (DCA) and lithocholic acid (LCA) are produced in the colon by bacterial dehydroxylation of the primary BAs. (pancreapedia.org)
Potent1
Studies have shown that tauroursodeoxycholic acid has neuroprotective actions based on its potent ability to inhibit apoptosis, attenuate oxidative stress, and reduce endoplasmic reticulum stress in different experimental models of these illnesses. (wikipedia.org)
Significantly1
Bile acid concentrations in the GI tract increased significantly during BBR treatment and developed extensive correlation networks with expressed genes in the B4PC2 community. (researchsquare.com)
Specific1
Recent studies have implemented 2 bile acids, taurocholic and taurodeoxycholic aids, as being the specific ones elevated in ICP. (medscape.com)
Studies1
Herein, we report secondary analyses of aldafermin, an engineered analogue of the gut hormone fibroblast growth factor 19, on the circulating bile acid profile in prospective, phase II studies in patients with metabolic or cholestatic liver disease. (nih.gov)
Control1
Fluorescein angiography showed lower leakage from the CNV in UDCA and ursodoxicoltaurine treated groups than the control group. (wikipedia.org)