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  • UBE2L3
  • The alteration of UBE2L3 protein levels during the S-phase of the cell cycle is due to ubiquitin-dependent proteasomal degradation. (abcam.cn)
  • The role of UBE2L3 in the ubiquitination of the NF-κB precursor implicated it in various major autoimmune diseases, including rheumatoid arthritis (RA), celiac disease, Crohn's disease(CD), and systemic lupus erythematosus. (wikipedia.org)
  • Through genome-wide association studies (GWAS), UBE2L3 has been associated with several autoimmune diseases, including RA, celiac disease, CD, and SLE via the ubiquitination of the NK-κB precursor. (wikipedia.org)
  • UBE2L3 controls the protein stability of 53BP1 and determines the DNA double-strand break repair choice. (wikipedia.org)
  • Recombinant
  • Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications. (mybiosource.com)
  • vivo
  • RNA interference (RNAi) was employed in an attempt to determine the biological function of UBC-2 interacting proteins in vivo. (ubc.ca)
  • vitro
  • Since DSK-2 represented 60% of the putative interactors isolated from the screen, this project focused on the interaction of UBC-2 and DSK-2, and demonstrated a novel interaction between an E2 and an ubiquitin-domain protein (UDP) in vitro. (ubc.ca)