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  • However
  • However, the involvement of these proteins in type I IFN (IFN-I) signaling during innate immunity has not been investigated. (jimmunol.org)
  • However, the role for F-box proteins in innate immunity remain poorly studied, and thus far there is no report about involvement of F-box proteins in antiviral events through type I IFN (IFN-I) signaling. (jimmunol.org)
  • However, the transthioesterification process is very complicated, as both E1 and E2 enzymes form an intermediate complex wherein both enzymes undergo a series of conformational changes in order to bind with one another. (wikipedia.org)
  • cell
  • During studies of cell cycle regulators, the F-box motif was first found in cyclin F and was shown to interact with S-phase kinase-associated protein 1 (SKP1) ( 1 ). (jimmunol.org)
  • Many processes such as cell division, immune responses and embryonic development are also regulated by post-translational modification by ubiquitin and ubiquitin-like proteins. (wikipedia.org)
  • mass spectrometry
  • Electron Transfer Dissociation (ETD) fragmentation mass spectrometry revealed the preferential binding sites of the RAPTA complexes on the BRCA1 zinc finger RING domain at a similar short peptide stretch, Cys(24)Lys(25)Phe(26)Cys(27)Met(28)Leu(29) and Lys(35) (residues 44-49 and 55 on full length BRCA1). (epfl.ch)
  • progression
  • A potential human counterpart of GRR1, SKP2, has been identified along with hSKP1 as a Cyclin A/CDK2-associated protein that is necessary for S-phase progression ( 10 ). (pnas.org)
  • A gene on chromosome 14q24.3 that encodes a member of the WD-repeat protein family, which are involved in various cellular processes, including cell cycle progression, signal transduction, apoptosis and gene regulation. (thefreedictionary.com)
  • Moreover, it has additional shared features of cyclins, such as pEST region, protein quantity, localization, cell cycle-regulated mRNA, and ability to influence cell cycle and progression. (wikipedia.org)
  • regulatory proteins
  • This principle is clearly evident in the organization of the cell division cycle, where initiation of DNA replication, chromosome segregation, and exit from mitosis are triggered by the destruction of key regulatory proteins ( 1 - 3 ). (pnas.org)
  • cyclin
  • Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. (wikipedia.org)
  • Cyclin F is the main member of the F-box protein family, which has about 40 amino acid motif, forming the F-box. (wikipedia.org)
  • Instead, cyclin F forms part of the ubiquitin-proteosome system (UPS) and ubiquitinates or directly interacts with the target substrates through the F-box domain. (wikipedia.org)
  • Moreover, cyclin F located at the centrosomes are needed to regulate levels of CP110, a protein involved in centrosome duplication. (wikipedia.org)
  • One of the most critical CDK inhibitors involved in cancer pathogenesis is p27Kip1, which is involved primarily in inhibiting cyclin E-CDK2 complexes (and to a lesser extent cyclin D-CDK4 complexes). (wikipedia.org)
  • peptides
  • Check out links to articles that cite our custom service antibodies, peptides, and proteins in major peer-reviewed journals, organized by research category. (abgent.com)
  • Sequence
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence. (uniprot.org)
  • section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. (uniprot.org)
  • mammalian
  • This mechanism acts to create a chromatin environment at CpG islands that highlights these regulatory elements and differentiates them from non-regulatory regions in large complex mammalian genomes. (wikipedia.org)
  • interacts
  • The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. (genecards.org)
  • amino
  • The average coverage of the annotated isotigs was x40 containing 5655 unique gene IDs and 785 full-length cDNAs coding for proteins containing 58-1536 amino acids. (biomedcentral.com)
  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. (wikipedia.org)
  • This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. (wikipedia.org)
  • interaction
  • In this study, the interaction of some RAPTA compounds with the N-terminal fragment of the BRCA1 RING domain protein was investigated. (epfl.ch)
  • The SOCS box domain of SOCS3: structure and interaction with the elonginBC-cullin5 ubiquitin ligase. (nih.gov)
  • The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. (wikipedia.org)
  • inhibitor
  • In response to mitogens, PDCD4, an inhibitor of the translation initiation factor eIF4A, is rapidly degraded in a βTrCP- and S6K1-dependent manner, allowing efficient protein translation and cell growth. (wikipedia.org)
  • human
  • As part of an effort to identify components and substrates of a putative human SCF complex, we isolated hSKP1 in a two-hybrid screen with hCUL1, the closest human homologue of CDC53 . (pnas.org)
  • Taken together, these data suggest that hCUL1 functions as part of an SCF ubiquitin ligase complex in human cells. (pnas.org)
  • Further application of biochemical assays similar to those described here can now be used to identify regulators/components of hCUL1-based SCF complexes, to determine whether the hCUL2-hCUL5 proteins also are components of ubiquitin ligase complexes in human cells, and to screen for chemical compounds that modulate the activities of the hSKP1 and hCUL1 proteins. (pnas.org)
  • Human homologues of yCDC34 and ySKP1 have been reported ( 9 , 10 ), and F-box-containing proteins like CDC4 and GRR1 have been identified in many eukaryotes ( 11 ). (pnas.org)
  • We have constructed and validated for the human (M)SAC mechanism an in silico dynamical model, integrating 11 proteins and complexes. (nih.gov)
  • Human βTrCP (referred to both βTrCP1 and βTrCP2) was originally identified as a cellular ubiquitin ligase that is bound by the HIV-1 Vpu viral protein to eliminate cellular CD4 by connecting it to the proteolytic machinery. (wikipedia.org)
  • proteasome
  • Levels of p27Kip1 (like all other CKIs) rise and fall in cells as they either exit or re-enter the cell cycle, these levels are not modulated at the transcriptional level, but by the actions of the SCFSkp2 complex in recognizing p27Kip1 and tagging it for destruction in the proteasome system. (wikipedia.org)
  • Fbxs
  • The protein encoded by this gene belongs to the Fbxs class. (wikipedia.org)
  • The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. (wikipedia.org)
  • The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. (wikipedia.org)
  • The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle. (wikipedia.org)
  • The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. (wikipedia.org)
  • yeast
  • Alternative SCF complexes (SCF GRR1 ) assembled with GRR1 instead of CDC4 bind G 1 cyclins but not SIC1, suggesting that there exist multiple SCF complexes in yeast whose substrate specificities are dictated by the identity of the F-box subunit ( 7 ). (pnas.org)