Ubiquitin-Protein LigasesUbiquitinUbiquitinationLigasesUbiquitinsUbiquitin-Conjugating EnzymesAngelman SyndromeUbiquitin-Protein Ligase ComplexesEndosomal Sorting Complexes Required for TransportProteasome Endopeptidase ComplexCullin ProteinsAnaphase-Promoting Complex-CyclosomeSKP Cullin F-Box Protein LigasesMolecular Sequence DataAmino Acid SequenceProtein BindingCarbon-Nitrogen LigasesF-Box ProteinsPolyubiquitinMutationUbiquitin-Activating EnzymesS-Phase Kinase-Associated ProteinsUbiquitin ThiolesteraseFatty Acid Synthase, Type IIProteolysisbeta-Transducin Repeat-Containing ProteinsBiotinylationSubstrate SpecificityCell LineProtein Structure, TertiaryRNA Ligase (ATP)Saccharomyces cerevisiae ProteinsCell Cycle ProteinsProtein Processing, Post-TranslationalCysteine EndopeptidasesMultienzyme ComplexesSaccharomyces cerevisiaeSequence Homology, Amino AcidPeptide SynthasesBiotinCarrier ProteinsF-Box MotifsHeLa CellsHEK293 CellsThioctic AcidRecombinant Fusion ProteinsLysineRepressor ProteinsMultiprotein ComplexesBase SequenceProtein StabilityUbiquitinated ProteinsVon Hippel-Lindau Tumor Suppressor ProteinImmunoprecipitationAcetyl-CoA CarboxylaseProto-Oncogene Proteins c-cblTranscription FactorsProteinsInhibitor of Apoptosis ProteinsAmino Acid MotifsDNA LigasesTwo-Hybrid System TechniquesHydroxyapatitesRING Finger DomainsProto-Oncogene Proteins c-mdm2Signal TransductionNuclear ProteinsDNA-Binding ProteinsProtein TransportAdenovirus E4 ProteinsPhosphorylationLeupeptinsModels, MolecularRecombinant ProteinsRNA InterferenceRNA, Small InterferingModels, BiologicalAdaptor Proteins, Signal TransducingProteasome InhibitorsCell Line, TumorPolynucleotide LigasesTransfectionIntracellular Signaling Peptides and ProteinsUbiquitin CTumor Suppressor ProteinsUbiquitin-Specific ProteasesImmunoblottingReceptors, Autocrine Motility FactorTumor Suppressor Protein p53SUMO-1 ProteinSumoylationCOS CellsDown-Regulationvif Gene Products, Human Immunodeficiency VirusBinding SitesPeptide HydrolasesCell CycleDNA DamageEscherichia coliCyclin-Dependent Kinase Inhibitor Proteins