Proteasome Endopeptidase ComplexUbiquitinProteasome InhibitorsUbiquitin-Protein LigasesUbiquitinsUbiquitinationCysteine EndopeptidasesMultienzyme ComplexesLeupeptinsUbiquitin ThiolesteraseProteolysisSKP Cullin F-Box Protein LigasesPolyubiquitinCysteine Proteinase InhibitorsUbiquitin-Conjugating EnzymesUbiquitinated ProteinsPyrazinesUbiquitin-Protein Ligase ComplexesBoronic AcidsUbiquitin-Activating EnzymesProtease InhibitorsF-Box ProteinsMuscular AtrophyProtein Processing, Post-TranslationalAcetylcysteineProtein BindingPeptide HydrolasesCullin ProteinsSignal TransductionCell LineAmino Acid SequenceMolecular Sequence DataLigasesMuscle ProteinsProtein Structure, TertiaryHeLa CellsMutationAutophagyProtein StabilityCell Cycle ProteinsNeurodegenerative DiseasesNuclear ProteinsProteinsAdenosine TriphosphatasesProtein FoldingInclusion BodiesMolecular ChaperonesLactonesEndosomal Sorting Complexes Required for TransportUbiquitin CEndoplasmic ReticulumModels, BiologicalCell Line, TumorCarrier ProteinsProtein TransportBlotting, WesternGene Expression RegulationImmunoprecipitationApoptosisDown-RegulationTransfectionCells, CulturedUnfolded Protein ResponseLysosomesDNA-Binding ProteinsPhosphorylationRNA, Small InterferingSaccharomyces cerevisiae ProteinsTranscription FactorsRING Finger DomainsEndopeptidasesGreen Fluorescent ProteinsNeuronsCell CycleRNA, MessengerMuscle, SkeletalSaccharomyces cerevisiaeHSP70 Heat-Shock ProteinsNerve Tissue ProteinsOxidative StressAnaphase-Promoting Complex-CyclosomeEnzyme InhibitorsTime FactorsS-Phase Kinase-Associated ProteinsTranscription, GeneticLysinePeptidesUp-RegulationHEK293 CellsProtein SubunitsCarbon-Nitrogen LyasesBrainUbiquitin-Specific ProteasesProto-Oncogene Proteins c-cblReverse Transcriptase Polymerase Chain ReactionAmino Acid MotifsSubstrate SpecificityMice, Knockoutbeta-Transducin Repeat-Containing ProteinsMice, Inbred C57BL