• General transcription factor II-I is a protein that in humans is encoded by the GTF2I gene. (wikipedia.org)
  • A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I". Genes & Development. (wikipedia.org)
  • Direct role for Myc in transcription initiation mediated by interactions with TFII-I". Nature. (wikipedia.org)
  • Based on this role, TFII-I is called a transcription factor. (encyclopedia.pub)
  • PURPOSE: Human epidermal growth factor receptor 2 (HER2)-targeted therapies improve survival for patients with HER2-positive breast cancer but carry risks of hematologic, cardiopulmonary, gastro-hepatobiliary, and other adverse events (AEs). (bvsalud.org)
  • Bruton's tyrosine kinase (Btk), a member of the Tec family of cytosolic kinases, is essential for B cell development and function. (nih.gov)
  • Mechanism of Bruton's tyrosine kinase-mediated recruitment and regulation of TFII-I". The Journal of Biological Chemistry. (wikipedia.org)
  • BAP/TFII-I, a protein implicated in transcriptional regulation, is associated with Btk in B cells and is transiently phosphorylated on tyrosine following B cell receptor engagement. (nih.gov)
  • Residues Tyr357 and Tyr462 are contained within the loop regions of adjacent helix-loop-helix-like repeats within BAP/TFII-I. Mutation of either Tyr248, Tyr357, or Tyr462 to phenylalanine reduced transcription from a c-fos promoter relative to wild-type BAP/TFII-I in transfected COS-7 cells, consistent with the interpretation that phosphorylation at these sites contributes to transcriptional activation. (nih.gov)
  • In this study, we provide evidence of a novel CAF transcriptional axis regulating the expression of SDF1, a major driver of cancer cell migration, involving the transcription factor GLI1 and histone acetyltransferase p300. (bvsalud.org)
  • 17. itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2. (nih.gov)
  • General transcription factor II-I is a protein that in humans is encoded by the GTF2I gene. (wikipedia.org)
  • This gene encodes a multifunctional phosphoprotein, TFII-I, with roles in transcription and signal transduction. (wikipedia.org)
  • Although this paracrine function has been extensively documented, the molecular mechanisms controlling the expression of these factors remain elusive. (bvsalud.org)
  • Histone deacetylase 3 binds to and regulates the multifunctional transcription factor TFII-I". The Journal of Biological Chemistry. (wikipedia.org)
  • 16. Differential regulation of human NK cell-mediated cytotoxicity by the tyrosine kinase Itk. (nih.gov)
  • A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I". Genes & Development. (wikipedia.org)
  • In an effort to understand the physiologic consequences of BAP/TFII-I tyrosine phosphorylation following B cell receptor stimulation, site-directed mutagenesis and phosphopeptide mapping were used to locate the predominant sites of BAP/TFII-I phosphorylation by Btk in vitro. (nih.gov)
  • 11. Signaling of the ITK (interleukin 2-inducible T cell kinase)-SYK (spleen tyrosine kinase) fusion kinase is dependent on adapter SLP-76 and on the adapter function of the kinases SYK and ZAP70. (nih.gov)
  • BAP/TFII-I is a substrate for Btk in vitro and is hyperphosphorylated on tyrosine upon coexpression with Btk in mammalian cells. (nih.gov)
  • 12. Characterization of a novel interaction between transcription factor TFII-I and the inducible tyrosine kinase in T cells. (nih.gov)
  • Aberrant activation of the Hedgehog (Hh) signaling pathway, through which the GLI family of transcription factors (TF) is stimulated, is commonly observed in cancer cells. (bvsalud.org)