General transcription factor II-I is a protein that in humans is encoded by the GTF2I gene. (wikipedia.org)
The GTF2I gene provides instructions for making two proteins, BAP-135 and TFII-I. BAP-135 is involved in normal immune system function. (encyclopedia.pub)
TFII-I, the other protein produced from the GTF2I gene, binds to specific areas of DNA and helps regulate the activity of other genes. (encyclopedia.pub)
Genes1
A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I". Genes & Development. (wikipedia.org)
Regulates2
Histone deacetylase 3 binds to and regulates the multifunctional transcription factor TFII-I". The Journal of Biological Chemistry. (wikipedia.org)
4. Graham PL, Yanowitz JL, Penn JK, Deshpande G, Schedl P. The translation initiation factor eIF4E regulates the sex-specific expression of the master switch gene Sxl in Drosophila melanogaster. (prolekarniky.cz)
Protein3
cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I". The Journal of Biological Chemistry. (wikipedia.org)
Studies suggest that the TFII-I protein is involved in coordinating cell growth and division, and it may also play a role in controlling the flow of calcium into cells. (encyclopedia.pub)
7. Valcárcel J, Singh R, Zamore PD, Green MR. The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA. (prolekarniky.cz)
Initiation1
Direct role for Myc in transcription initiation mediated by interactions with TFII-I". Nature. (wikipedia.org)
Gene2
This gene encodes a multifunctional phosphoprotein, TFII-I, with roles in transcription and signal transduction. (wikipedia.org)
Danoff SK, Taylor HE, Blackshaw S, Desiderio S. TFII-I, a candidate gene forWilliams syndrome cognitive profile: parallels between regional expression inmouse brain and human phenotype. (encyclopedia.pub)
Nuclear1
Bioinformatic analysis and molecular biological characterization revealed that VEGF-C is negatively regulated by an orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII). (endometriosistreatmentreport.com)
Human1
PURPOSE: Human epidermal growth factor receptor 2 (HER2)-targeted therapies improve survival for patients with HER2-positive breast cancer but carry risks of hematologic, cardiopulmonary, gastro-hepatobiliary, and other adverse events (AEs). (bvsalud.org)
Studies1
Further studies demonstrated that proinflammatory cytokines, via suppression of COUP-TFII level, induce VEGF-C overexpression. (endometriosistreatmentreport.com)
Role1
Based on this role, TFII-I is called a transcription factor. (encyclopedia.pub)
Cells1
Herein, we identified that vascular endothelial growth factor (VEGF)-C, a potent lymphangiogenic factor, is up-regulated in endometriotic cells and contributes to increased lymphangiogenesis. (endometriosistreatmentreport.com)
Bruton's2
Bruton's tyrosine kinase (Btk), a member of the Tec family of cytosolic kinases, is essential for B cell development and function. (nih.gov)
Mechanism of Bruton's tyrosine kinase-mediated recruitment and regulation of TFII-I". The Journal of Biological Chemistry. (wikipedia.org)
Phosphorylation4
In an effort to understand the physiologic consequences of BAP/TFII-I tyrosinephosphorylation following B cell receptor stimulation, site-directed mutagenesis and phosphopeptide mapping were used to locate the predominant sites of BAP/TFII-I phosphorylation by Btk in vitro. (nih.gov)
These residues, Tyr248, Tyr357, and Tyr462, were also found to be the major sites for Btk-dependent phosphorylation of BAP/TFII-I in vivo. (nih.gov)
Residues Tyr357 and Tyr462 are contained within the loop regions of adjacent helix-loop-helix-like repeats within BAP/TFII-I. Mutation of either Tyr248, Tyr357, or Tyr462 to phenylalanine reduced transcription from a c-fos promoter relative to wild-type BAP/TFII-I in transfected COS-7 cells, consistent with the interpretation that phosphorylation at these sites contributes to transcriptional activation. (nih.gov)
Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. (cusabio.com)
Transcriptional4
BAP/TFII-I, a protein implicated in transcriptional regulation, is associated with Btk in B cells and is transiently phosphorylated on tyrosine following B cell receptor engagement. (nih.gov)
cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I". The Journal of Biological Chemistry. (wikipedia.org)
The SCP is the strongest core promoter observed in vitro and in cultured cells and yields high levels of transcription in conjunction with transcriptional enhancers. (wikiversity.org)
In this study, we provide evidence of a novel CAF transcriptional axis regulating the expression of SDF1, a major driver of cancer cell migration, involving the transcription factor GLI1 and histone acetyltransferase p300. (bvsalud.org)
Binds1
Histone deacetylase 3 binds to and regulates the multifunctional transcription factor TFII-I". The Journal of Biological Chemistry. (wikipedia.org)
Proteins1
The GTF2I gene provides instructions for making two proteins, TFII-I and BAP-135. (medlineplus.gov)
Molecular1
Although this paracrine function has been extensively documented, the molecular mechanisms controlling the expression of these factors remain elusive. (bvsalud.org)
Promoter1
The core promoter includes the transcription start site(s) (TSS). (wikiversity.org)
Roles1
This gene encodes a multifunctional phosphoprotein, TFII-I, with roles in transcription and signal transduction. (wikipedia.org)
Extracellular2
of NETs Ansatrienin A is usually partially due to impaired NET clearance by extracellular DNases as DNase substitution improved NET dissolution and reduced FXII activation for articles that Pcdhb5 included the following search terms: Inflammation and thrombosis in COVID-19, NETs and COVID-19, and Factor XII and COVID-19. (exposed-skin-care.net)
Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. (cusabio.com)
Cytokines1
Secretion of cytokines and growth factors underlies the pro-tumoral effect of CAFs. (bvsalud.org)
Regulation2
16. Differential regulation of human NK cell-mediated cytotoxicity by the tyrosine kinase Itk. (nih.gov)
During early mesoderm induction, the mesoderm-associated transcription factors MESP1 and EOMES showed a transient up-regulation, which decreased later in the cardiac induction stage. (nih.gov)
Cell2
11. Signaling of the ITK (interleukin 2-inducible T cell kinase)-SYK (spleen tyrosine kinase) fusion kinase is dependent on adapter SLP-76 and on the adapter function of the kinases SYK and ZAP70. (nih.gov)
17. itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2. (nih.gov)
Regulate1
From a teleological standpoint, this arrangement [of focused promoters] is consistent with the notion that it would be easier to regulate the transcription of a gene with a single transcription start site than one with multiple start sites. (wikiversity.org)