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  • amino acid
  • Using nuclear magnetic resonance (NMR) and computer-assisted molecular modelling, they showed that NCK contains a tyrosine amino acid that is extremely important in cellular signalling. (eurekalert.org)
  • gene
  • The virus encodes a single product, the v-Abl nonreceptor protein tyrosine kinase, which contains amino-terminal sequences derived from the Moloney leukemia virus gag gene fused to sequences from the c- abl protooncogene. (asm.org)
  • Overexpression of Abl-related gene tyrosine kinase ABL2 in pro-B cell line Ba/F3 cells expressing an oncogenic mutant of FLT3 (FLT3-ITD) resulted in partial inhibition of FLT3-ITD-dependent cell proliferation. (nih.gov)
  • In gene knockout studies, SOCS-1(-/-) mice were born but failed to thrive and died within 3 weeks of age with fatty degeneration of the liver and hemopoietic infiltration of several organs. (embl-heidelberg.de)
  • The diphtheria toxin repressor (DtxR) regulates the expression of several iron-sensitive genes in Corynebacterium diphtheriae , including the iron-response protein genes ( irp ), a heme oxygenase, and the diphtheria toxin gene ( tox ) ( 1 - 3 ). (pnas.org)
  • It is closely related to Tks5 (gene symbol SH3PXD2A) and like Tks5, appears to play a role in the formation and function of podosome/invadopodia based on studies of Src-transformed fibroblasts (Buschman, 2009). (merckmillipore.com)
  • Molecular
  • On the molecular level, the Arp2/3 complex might provide the driving force for formation of membrane protrusions by nucleating actin polymerization from the sides of existing filaments. (biologists.org)
  • cytoskeleton
  • Cytoplasmic c-Abl is associated with the F-actin through the COOH-terminal actin-binding domain and may influence the cytoskeleton locally. (aacrjournals.org)
  • phosphatidylinositol
  • Binds a range of phosphoinositides including phosphatidylinositol 3,5-biphosphate and, to a lesser extent, phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate and phosphatidylinositol 5-biphosphate. (merckmillipore.com)
  • FRS2 also plays a pivotal role in FGF-induced recruitment and activation of phosphatidylinositol 3-kinase (PI3-kinase). (sdbonline.org)
  • Structural
  • Structural basis for the autoinhibition of c-Abl tyrosine kinase. (springer.com)
  • A limited number of mutations in the C-terminal domain ( 12 ) or the linker region ( 13 ) affect repressor activity, but the structural nature of this regulation by the C-terminal domain has been obscure. (pnas.org)
  • actin
  • Cortactin has a multidomain structure consisting of binding regions for the Arp2/3 (actin-related protein 2/3) complex and F-actin. (rupress.org)
  • fold
  • The SH3 domain is structured in a beta-barrel fold, which is made up of 5-6 beta strands organized in tightly packed anti-parallel beta sheets. (wikibooks.org)
  • function
  • The results of this study, combined with previous x-ray studies of intact DtxR, provide insights into a possible biological function of the C-terminal domain in regulating repressor activity. (pnas.org)
  • To obtain a more complete understanding of the function of the intact repressor protein, we are focusing on the C-terminal domain. (pnas.org)