Tyrosine residues vertebrates protein residues. Medical search. Frequent questions

Homeodomain-interacting protein kinases (HIPKs) belong to the CMGC kinase family and are closely related to dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs). (nature.com)
Homeodomain-interacting protein kinases (HIPKs) are an evolutionarily conserved kinase family comprising the members HIPK1, HIPK2, and HIPK3 in vertebrates, and, additionally, HIPK4 in mammals. (nature.com)
HIPKs belong to the CMGC group of serine/threonine kinases and are part of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. (nature.com)
Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases. (umbc.edu)
The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). (umbc.edu)
Vertebrate protein kinases LIMK-1 and LIMK-2. (embl.de)
Here, we show that the non-receptor Src family tyrosine kinases, SRC64B and SRC42A, are involved in WNT5-mediated signaling through Derailed in the Drosophila embryonic central nervous system. (biologists.com)
In contrast, classical immune (type I/ II) cytokine receptors do not have intrinsic protein kinase activity but associate with the Janus family of kinases (JAKs). (openrheumatologyjournal.com)
In recent years, the search for intracellular signaling integrator downstream of receptor tyrosine kinases provided valuable novel substrates. (springer.com)
These data demonstrate that the src family tyrosine kinases are direct effectors of g proteins. (anthonyvandarakis.org)
Src family belongs to nonreceptor tyrosine kinases. (anthonyvandarakis.org)
The FH1 domain is also a binding site for diverse SH3-domain containing proteins like Src-like non-receptor tyrosine kinases, WISH (WASP-interacting SH3 protein) and IRSp53 (insulin receptor substrate) in mammals, and Hof1p in yeast [ 6 ]. (biomedcentral.com)
AKT/PI3K forms a key component of many signalling pathways that involve the binding of membrane-bound ligands such as receptor tyrosine kinases, G-protein coupled receptors, and integrin-linked kinase. (senescence.info)
Key components supplier CX-4945 of these paths are protein kinases that are critical for the appropriate time of each cell cycle stage. (smadpathway.com)
Preeminent among these proteins are the cyclin dependent kinases, which upon binding to cyclins, phosphorylate numerous targets to trigger cell cycle progression. (smadpathway.com)
These proteins, including Aurora A and B, are serine/threonine kinases that are essential for cell division activities such as spindle construction, chromosome segregation, and cytokinesis. (smadpathway.com)
Shortly before birth, BDNF activates NF-κB by an atypical mechanism that involves tyrosine phosphorylation of IκBα by Src family kinases, and dephosphorylates p65 at serine 536. (silverchair.com)

Mammalian cysteine-rich intestinal protein (CRIP), a small protein which seems to have a role in zinc absorption and may function as an intracellular zinc transport protein. (embl.de)
Patient mutations function a high tyrosine of next N-glycans with an part of negative intracellular impacts, although the synapse cancer followed multi-step. (evakoch.com)
instead cytokines function through binding to a cognate receptor proteins, which trigger phosphorylation and activation of intracellular signaling proteins. (openrheumatologyjournal.com)
specifically acted, the FGFR preventing download manual of structural kinesiology 2011 traffics found by intracellular intracellular matrix proteins. (erik-mill.de)
To assess a hypothesis that the intracellular tyrosine kinase src may play a role in modulation by tyrosine phosphorylation of i f, we cotransfected hek293. (anthonyvandarakis.org)

DYRKs are named after their characteristic dual-specificity, as they auto-phosphorylate a conserved tyrosine in their activation loop, but phosphorylate substrates on serine and threonine residues 2 . (nature.com)
PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. (umbc.edu)
methylation at certain residues of histones can regulate gene expression [ 4 ], and glycosylation is responsible for targeting substrates and changing protein half-life [ 2 ]. (hindawi.com)

Src (src proto-oncogene, non-receptor tyrosine kinase) is a protein coding gene. (anthonyvandarakis.org)
Src is a proto-oncogene encoding a non-receptor tyrosine kinase, similar to the v-src gene of the rous sarcoma virus (14), which was initially. (anthonyvandarakis.org)
It binds to the common neurotrophin receptor p75 NTR and the TrkB receptor tyrosine kinase that are expressed by subsets of developing neurons, including the sensory neurons of the nodose ganglion ( Reichardt, 2006 ). (silverchair.com)

The 3' end of this protein is highly conserved and contains domains crucial for protein function. (wikipedia.org)
This residue is highly conserved among orthologs. (wikipedia.org)
The first position of the yeast motif is highly conserved, tolerating solely tyrosine. (eu.org)
The highly conserved family of Wnt proteins represents important regulators of cell behaviour, tissue development and homeostasis by inducing responses in a concentration-dependent manner. (exeter.ac.uk)

The caveolin gene family has three members in vertebrates: caveolin-1, caveolin-2, and caveolin-3. (biomedcentral.com)
Later genomic duplication events led to the appearance of four family members in vertebrates: tenascin-C, tenascin-R, tenascin-W and tenascin-X. (biomedcentral.com)

The CCDC109B protein contains several likely phosphorylation sites on serine, threonine, and tyrosine residues. (wikipedia.org)
In addition to the tyrosine phosphorylation, phosphorylation of threonine and serine residues has been demonstrated. (openrheumatologyjournal.com)
This gene encodes one of the three members of the human AKT serine-threonine protein kinase family which are often referred to as protein kinase B alpha, beta, and gamma. (senescence.info)
These highly similar AKT proteins all have an N-terminal pleckstrin homology domain, a serine/threonine-specific kinase domain and a C-terminal regulatory domain. (senescence.info)
Subsequent phosphorylation of both threonine residue 308 and serine residue 473 is required for full activation of the AKT1 protein encoded by this gene. (senescence.info)

The table below shows CCDC109B conservation among vertebrate organisms: CCDC109B has a single paralog in the human genome. (wikipedia.org)
The p.Asn173His mutation affects a residue in the forkhead domain that is 100% conserved among vertebrate orthologs and is predicted to participate in protein-protein interactions. (molvis.org)

This domain occurred 367 times on human genes ( 852 proteins). (umbc.edu)
This domain occurred 304 times on human genes ( 713 proteins). (umbc.edu)
Rhombotin 1 (RBTN1 or TTG-1) and rhombotin-2 (RBTN2 or TTG-2) are proteins of about 160 amino acids whose genes are disrupted by chromosomal translocations in T-cell leukemia. (embl.de)
Sequence and organization of coelacanth neurohypophysial hormone genes: evolutionary history of the vertebrate neurohypophysial hormone gene locus. (xenbase.org)
We have sequenced a coelacanth (Latimeria menadoensis) BAC clone encompassing the neurohypophysial hormone genes and investigated the evolutionary history of the vertebrate neurohypophysial hormone gene locus within a comparative genomics framework. (xenbase.org)
The two genes of each Ca2+ of insulin-like residues believe together excessive responses. (familie-vos.de)
The differentially expressed genes included those functioning in some important immune reaction and iron metabolism pathways, such as pattern recognition receptors, regulators of the JNK pathway, components of the phagosome pathway, regulators of the melanization response, activators of complement reactions, insulin signaling cascade members, oxidative stress and detoxification proteins. (biomedcentral.com)
In order to learn more about their origins and relationships to each other, as well as to clarify the nomenclature used to describe them, the tenascin genes of the urochordate Ciona intestinalis , the pufferfish Tetraodon nigroviridis and Takifugu rubripes and the frog Xenopus tropicalis were identified and their gene organization and predicted protein products compared with the previously characterized tenascins of amniotes. (biomedcentral.com)
As opposed to other styles of muscles dystrophy, where mutations take place in genes encoding structural protein, calpainopathy was the initial reported kind of dystrophy predetermined by mutations within a gene encoding a proteolytic enzyme. (exposed-skin-care.net)
The number of mitochondrial protein genes is believed to vary from 3 to 67, while the tRNA gene content varies from 0 to 27 [ 2 ]. (biomedcentral.com)
Typical triploblastic animal mtDNAs contain genes that encode the large and small subunit ribosomal RNAs, 22 transfer RNAs (tRNAs), and 13 proteins that are all components of the oxidative phosphorylation process: ATPase subunits 6 and 8 (ATP6 and 8), cytochrome b (Cyt b), cytochrome c oxidase subunits 1-3 (Cox1-3) and NADH dehydrogenase subunits 1-6 and 4L (ND1-6 and 4L). (biomedcentral.com)

Mammalian host protein Syntenin has the LYPxL motif. (eu.org)
Mammalian LH-2, a transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types. (embl.de)
Mammalian and avian cysteine-rich protein (CRP), a 192 amino-acid protein of unknown function. (embl.de)
Astacin, a digestive zinc-endopeptidase from the crayfish Astacus astacus L., is the prototype for the 'astacin family', which includes mammalian metallo-endopeptidases and developmentally regulated proteins of man, fruitfly, frog and sea urchin. (rcsb.org)
AKT proteins also participate in the mammalian target of rapamycin (mTOR) signalling pathway which controls the assembly of the eukaryotic translation initiation factor 4F (eIF4E) complex and this pathway, in addition to responding to extracellular signals from growth factors and cytokines, is disregulated in many cancers. (senescence.info)

The acetylcholinesterase found in the venom of Bungarus fasciatus (BfAChE) is produced as a soluble, non-amphiphilic monomer with a canonical catalytic domain but a distinct C terminus compared with the other vertebrate enzymes. (rcsb.org)
A family of protein-deglutamylating enzymes associated with neurodegeneration. (sysy.com)

When translated, the CCDC109B protein is composed of 336 amino acids and has a molecular weight of 39.1 kDa. (wikipedia.org)
The DIME motif is a sequence of 23 amino acids that has the sequence: QxGxLAxLTWWxYSWDIMEPVTYF, where letters correspond to actual amino acid residue and "x" represents amino acids that are not conserved within this sequence. (wikipedia.org)
Throughout the entire CCDC109B protein there are no other conserved amino acid sequences that are greater than three amino acids in length. (wikipedia.org)
Either at genomic or at proteomic level, mutations have significant impact on normal gene or protein function, and human diseases could be associated with mutations like nonsynonymous single-nucleotide variations (nsSNVs) on amino acids. (hindawi.com)
The length of the deduced protein is approximately 100 amino acids. (biomedcentral.com)

Any member of the group of ENDOPEPTIDASES containing at the active site a serine residue involved in catalysis. (lookformedical.com)

H2O2 can cross cell membranes and inactivate tyrosine phosphatases through oxidation of the catalytic cysteine7-11. (cancerhugs.com)
There cause two catalytic proteins of each of the three Drosophila cascades, whose acids contain partially developed: cycle of scalable times vertebrates occur homodimers. (familie-vos.de)

Nuclear positioning is mediated by a conserved network of nuclear envelope proteins that interacts with force generators in the cytoskeleton. (ucdavis.edu)

PTMs are involved in many protein activities and cellular processes, such as protein folding, stability, conformation, and some significant regulatory mechanisms [ 1 ]. (hindawi.com)
New regulatory targets were discovered and novel functions of known proteins were uncovered. (janechin.net)
The CPC includes, as well as Aurora B, three regulatory subunits: the inner centromeric protein, Survivin, and Borealin/Dasra W. Beginning in prophase, the CPC localizes to condensing chromosomes and steadily concentrates at the internal centromere where one function would be to correct poor Infectious causes of cancer spindle kinetochore devices. (smadpathway.com)

Present in proteasome subunit S5a and other ubiquitin-associated proteins. (embl.de)
Equally represented open and closed states of a back door channel, associated with alternate positions of a tyrosine phenol ring at the active site base, coexist in each subunit. (rcsb.org)

One of the most phosphorylate intermediate mutations is such Other protein group( VEGF). (erik-mill.de)
Yet how gene mutations affect protein activities through posttranslational modification sites have not been widely studied. (hindawi.com)
Furthermore, the deleterious aftereffect of missense mutations can occur not merely from immediate disruption of CAPN3 function(s), but additionally from disruption from the protein's structural integrity, that could affect its intra or intermolecular protein lead and interactions to decreased stability or altered localization. (exposed-skin-care.net)

So far, most caveolin-related research has been conducted in mammals, but the proteins have also been found in other animals, including Xenopus laevis, Fugu rubripes , and Caenorhabditis elegans . (biomedcentral.com)
Since the sequencing of other vertebrate genomes has been completed, we also know now that there are indeed only four JAKs in mammals, birds and fish. (openrheumatologyjournal.com)

Wnt proteins regulate developmental processes, tissue regeneration and stem cell maintenance. (exeter.ac.uk)
These AKT proteins therefore regulate a wide variety of cellular functions including cell proliferation, survival, metabolism, and angiogenesis in both normal and malignant cells. (senescence.info)

Vertebrates have ten EphA and six EhpB receptors, which display promiscuous ligand interactions within each class. (umbc.edu)
There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands. (umbc.edu)
events have receptors stimulated with students( GAGs), unregulated chains docking of a inactive actin, all of an been protein respiration cell a considerable subunits. (evakoch.com)
Factors mandating cellular consequence include cell surface-receptors, cytoplasmic proteins, and nuclear proteins. (janechin.net)
M1, M3, M5 receptors are coupled with G q proteins, while M2 and M4 receptors are coupled with G i/o proteins. (proteopedia.org)
The adrenergic receptors are metabolic G protein-coupled receptors. (proteopedia.org)
Dopamine receptors are a class of metabotropic G protein-coupled receptors that are important in the central nervous system. (proteopedia.org)

In our research, we use the zebrafish embryo to investigate how intercellular Wnt protein transport is regulated and how signals are subsequently delivered to the target cell in a living vertebrate organism. (exeter.ac.uk)
We used zebrafish which are a powerful system to study vertebrate immunity6 16 to identify a mechanism by which neutrophils detect wound-induced H2O2. (cancerhugs.com)

Receptor dimerization and autophosphorylation attracts proteins containing Src homology 2 (SH2) or phosphotyrosine binding (PTB) domains including adaptor proteins like FRS2 and GRB2. (springer.com)
The linker of the nucleoskeleton and cytoskeleton (LINC) complex is formed by the conserved interactions between Sad-1 and UNC-84 (SUN) and Klarsicht, ANC-1, SYNE homology (KASH) domain proteins, providing a physical coupling between the nucleoskeleton and cytoskeleton that mediates the transfer of physical forces across the nuclear envelope. (ucdavis.edu)
Formins are multidomain proteins defined by a conserved FH2 (formin homology 2) domain with actin nucleation activity preceded by a proline-rich FH1 (formin homology 1) domain. (biomedcentral.com)

It was isolated as one of several proteins that became phosphorylated on tyrosine residues in chicken embryo fibroblasts transformed with the v-Src oncogene [ 4 ]. (biomedcentral.com)

Formins are multidomain proteins conserved from plants to fungi and vertebrates. (biomedcentral.com)

Protein phosphatases act as negative regulators of AKT proteins by dephosphorylating AKT or PIP3. (senescence.info)

Among them are the Sprouty proteins which mainly act as inhibitors of growth factor-dependent neuronal and glial signaling pathways. (springer.com)

Avian EAST (epidermal growth factor receptor-associated protein with SH3 and TAM domains), which colocalizes with clathrin in vesicular structure. (expasy.org)
Growth factors that signal through tyrosine-kinase receptor families include the epidermal growth factor (EGF), platelet-derived growth factor (PDGF) and transforming-growth factor-α (TGF-α). (janechin.net)
Phosphorylation of additional residues also occurs, for example, in response to insulin growth factor-1 and epidermal growth factor. (senescence.info)

Zinc binding to the peptide replica and analogs to residues 93-115 of horse liver alcohol dehydrogenase (ADH) was examined by competition of the peptides and the chromophoric chelator 4-(2- pyridylazo)resorcinol for zinc and X-ray absorption fine structure analysis of the zinc ligands. (researchgate.net)

DUF607 is conserved in orthologs and is located closer to the 3' end of this protein, even though DUF607 is present for most of the protein's length. (wikipedia.org)
DIME Motif: This motif is a completely conserved region found in all orthologs of this protein and is found within DUF607 and between the transmembrane domains. (wikipedia.org)
The orthologs found in non-vertebrate organisms may also actually be the paralog of CCDC109B which is still producing some identity to CCDC109B. (wikipedia.org)

Drosophila melanogaster (Fruit fly) protein apterous, required for the normal development of the wing and halter imaginal discs. (embl.de)

Coiled-coil domain containing 109B (CCDC109B) is a potential calcium uniporter protein found in the membrane of human cells and is encoded by the CCDC109B gene. (wikipedia.org)
While CCDC109B is a transmembrane protein it is unclear if it is located within the cell membrane or mitochondrial membrane. (wikipedia.org)
Transmembrane Region: CCDC109B contains two transmembrane regions, located within DUF607, making it a multipass membrane protein. (wikipedia.org)
Yeast VPS27 vacuolar sorting protein, which is required for membrane traffic to the vacuole. (embl.de)
Alix is associated with the ESCRT system, which is involved in endosomal sorting of membrane proteins. (eu.org)
The ESCRT system is involved in the selective trafficking of membrane proteins to the lysosome by incorporating the membrane proteins into multivesicular bodies (MVBs). (eu.org)
Short peptide sequences within viral Gag proteins (encoding the structural proteins of the virus) are required for the separation of the virus from the host cell membrane. (eu.org)
Caveolins can serve as protein markers of caveolae ('little caves'), invaginations in the plasma membrane 50-100 nanometers in diameter. (biomedcentral.com)
Interestingly, VIP21 was isolated as an integral membrane protein component of transport vesicles derived from the trans-Golgi network in Madin-Darby canine kidney (MDCK) cells, suggesting that Cav-1/VTP21 may have a role in molecular trafficking as well as oncogenesis. (biomedcentral.com)
Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction. (expasy.org)
separation of proteins by PAGE and subsequent transfer to a membrane. (sysy.com)
KASH proteins in the outer nuclear membrane comprise the cytoplasmic half of LINC complexes that connect nuclei to the cytoskeleton. (ucdavis.edu)
At the heart of this network are LINC ( li nker of n ucleoskeleton and c ytoskeleton) complexes made of SUN ( S ad1 and UN C-84) proteins at the inner nuclear membrane and KASH ( K larsicht, A NC-1, and S yne h omology) proteins in the outer nuclear membrane. (ucdavis.edu)
AKT proteins are recruited to the cell membrane by phosphatidylinositol 3,4,5-trisphosphate (PIP3) after phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) by PI3K. (senescence.info)

Anterograde IFT remains records from the normal amino along the water to the clear subunits in a polymerase that depends the adhesion was kinesin KIF3 palmitoylation tyrosine and the IFT-B degree branching, while major endoderm frequently to the first shape is on the ability flipped translation residue and the IFT-A site. (evakoch.com)
The MDR superfamily with ~350-residue subunits contains the classical liver alcohol dehydrogenase (ADH), quinone reductase, leukotriene B4 dehydrogenase and many more forms. (researchgate.net)
If viewed from the synaptic cleft, the protein will look like a pseudo-symmetrical rosette shown in the picture below composed of 10 different alpha and 4 different beta subunits. (proteopedia.org)
Serum proteins that inhibit, antagonize, or inactivate COMPLEMENT C1 or its subunits. (lookformedical.com)

In vertebrates, several stop codons have been found in the mt gau region, and potentially functional gau regions have been found in nuclear genomes. (biomedcentral.com)

A member of the serpin family of proteins that is found in plasma and urine. (lookformedical.com)
This is held in a latent form in the cytoplasm by interaction with a member of the IκB inhibitory family of proteins, of which IκBα is the most prevalent. (silverchair.com)

Vertebrate paxillin, a cytoskeletal focal adhesion protein. (embl.de)

This antibody is reactive against recombinant protein in ELISA. (novusbio.com)
In this work, we used chromatin immunoprecipitation (ChIP) with an anti-nitro-tyrosine antibody followed by mass spectrometry to identify nitrated DNA binding proteins in T. cruzi and to detect alterations in nitration levels induced upon parasite incubation with the ECM. (omicsdi.org)
Immunohistochemical analyses using an anti-Gau monoclonal antibody revealed strict co-localization of Gau proteins and a mitochondrial marker. (biomedcentral.com)

In addition to distinct cytoplasmic domains, the luminal KASH domain also varies among KASH domain proteins of distinct functions. (ucdavis.edu)

Crystallization and Structural Determination of ABLT315I:AP24534 The kinase domain of murine ABLT315I was coexpressed with YopH protein tyrosine phosphatase in E. coli as described previously and purified in the clear presence of AP24534 to near homogeneity using metal affinity, Mono Q, and measurement exclusion chroma tography. (smadpathway.com)

a protein required for the differentiation of the set of six touch receptor neurons in this nematode. (embl.de)
calcium mediates increased and cleaved into the knockout was entire differentiation proteins. (erik-mill.de)

We have recently described a significant increase in the tyrosine nitration levels of histones H2A and H4 when trypomastigotes are incubated with components of the ECM. (omicsdi.org)
This work provides the first global profile of nitrated DNA binding proteins in T. cruzi and additional evidence for modification in the nitration profile of histones upon parasite incubation with ECM. (omicsdi.org)

Although it is known that CCDC109B is a transmembrane protein the proper folding of its N-terminus and C-terminus is unclear. (wikipedia.org)
Finally, the C-terminus of HIPK1-3 comprises a region rich in serine, glutamine, and alanine (SQA) residues, which is involved in the interaction with different co-factors 14 . (nature.com)
Synthetic peptide corresponding to residues near the c-terminus of human Glu-α-tubulin. (sysy.com)
Importantly, one other individual meats directly influence Aurora T localization, and phosphorylation of conserved residues in the C terminus of INCENP greatly raises Aurora B kinase activity. (smadpathway.com)

LYPxL and PTAP are among the many short linear motifs that were first identified in viral proteins and only later in the regular cellular context. (eu.org)
Some LIM domains bind protein partners via tyrosine-containing motifs. (embl.de)
They consist of two zinc-binding motifs that resemble GATA-like Znf's, however the residues holding the zinc atom(s) are variable, involving Cys, His, Asp or Glu residues. (embl.de)
Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. (embl.de)
They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. (embl.de)
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. (lookformedical.com)

In vitro evaluation identified an individual cysteine residue C466 to be responsible for immediate oxidation-mediated activation of Lyn. (cancerhugs.com)
Cysteine oxidation also Rosuvastatin regulates protein kinases12-15. (cancerhugs.com)
TGF-β1 is a 112 amino-acid homodimer with nine cysteine residues, Figure 1-2. (janechin.net)

SEF, Sprouty and Spred proteins. (erik-mill.de)
On the contrary, knockdown of Sprouty proteins increases proliferation of activated astrocytes and, consequently, reduces secondary brain damage in neuronal lesion models such as kainic acid-induced epilepsy or endothelin-induced ischemia. (springer.com)
Since the protein lacks enzymatic activities, it will be difficult to develop chemical compounds capable to directly and specifically modulate Sprouty functions. (springer.com)

src kinase (src) is a tyrosine protein kinase that regulates cellular metabolism, survival, and proliferation. (anthonyvandarakis.org)

The yeast YPxL motif binds to a hydrophobic groove in the central V-domain of yeast proteins Bro1 and Rim20 (Alix_V domain-containing proteins), which are implicated in vacuolar transport and the pH response respectively. (eu.org)
In the motif of the yeast taxonomic grouping, the hydrophobic residue preceding the Tyrosine seems not to be strongly conserved. (eu.org)
It leans against three hydrophobic residues on the Alix surface, with the binding centered on a conserved phenylalanine in ALIX ( Baietti,2012 ). (eu.org)
The yeast short version seems to allow a flexible spacing between a hydrophobic residue and the conserved tyrosine. (eu.org)
The fourth position of the motif is most commonly represented by either leucine or isoleucine, but sequence alignments indicate other hydrophobic residues are also allowed. (eu.org)

LIM domains coordinate one or more zinc atoms, and are named after the three proteins (LIN-11, Isl1 and MEC-3) in which they were first found. (embl.de)
Here we report the X-ray crystal structure of astacin, which reveals a deep active-site cleft, with the zinc at its bottom ligated by three histidines, a water molecule and a more remote tyrosine. (rcsb.org)
ADH is a dimeric zinc metalloprotein and occurs as five different classes in humans, resulting from gene duplications during vertebrate evolution, the first one traced to ~500. (researchgate.net)
In the enzyme, zinc is coordinated by four Cys residues. (researchgate.net)

In vertebrate systems, the distal pocket typically contains a 'distal' histidine at position E7 and a leucine at position B10. (elsevierpure.com)
The third histidine (His 102) forms part of a consensus sequence, shared not only by the members of the astacin family, but also by otherwise sequentially unrelated proteinases, such as vertebrate collagenases. (rcsb.org)

Then are several invertebrate organisms that have hemoglobins or myoglobins that display a pattern in which residues E7 and B10 are a glutamine and tyrosine, respectively. (elsevierpure.com)
The regulation of SGG/GSK-3 represents a conserved strategy during evolution for establishing embryonic polarity of both invertebrate and vertebrates. (biomedcentral.com)

Multiple sequence alignment reveals that differences in the size of tenascin-W from various vertebrate classes can be explained by duplications of specific fibronectin type III domains. (biomedcentral.com)

We detected autophosphorylation of the activation loop tyrosine of SFKs at 30 minutes post tail transection in 3 days-post-fertilization (dpf) larvae (Fig. 1a b c). (cancerhugs.com)
SFKs maintain inhibitory intramolecular interactions in an inactive state while dephosphorylation of the C-terminal phosphotyrosine releases TNR the inhibitory configuration allowing trans-autophosphorylation of the activation loop tyrosine thereby activating SFKs20-23. (cancerhugs.com)

The size and polarity of the residues occupying the distal pocket may contribute steric and dielectric effects. (elsevierpure.com)

The membranes inhibitory for the NTs download manual of structural kinesiology 2011 of sufficient synapsis and homodimeric excitability corepressor of protein by ciliary early transporters and tails are found in this domain as six unintegrated dynamics: protein 1. (erik-mill.de)
nevertheless, recent studies have got exposed a fresh potential function for CAPN3 being a structural proteins (23,24). (exposed-skin-care.net)

Ultraviolet resonance Raman spectroscopy and visible resonance Raman spectroscopy are used to probe, respectively, the ligand-dependent hydrogen bonding pattern of the tyrosine residues and the proximal heine pocket interactions. (elsevierpure.com)
Molecular docking revealed that DnBP can affect protein molecular activity via pi-sigma, pi-alkyl, and pi-pi interactions or by forming carbon-hydrogen bonds. (bvsalud.org)
Structure of the VHS domain of human Tom1 (target of myb 1): insights into interactions with proteins and membranes. (expasy.org)

In vitro, the FH2 domain competes with barbed-end capping proteins and is necessary and sufficient to nucleate actin polymerization, but the FH1 domain, which interacts with profilin-actin, funnels actin to the nucleation vicinity and confers full activity to the molecule [ 1 ]. (biomedcentral.com)

Despite its cellular simplicity (five pairs of neurons), the MG exhibits conservation of transcription factor expression with the spinal cord of vertebrates. (biologists.com)

The proteomic analysis demonstrated that DnBP upregulated the expression of rice proteins associated with transporter activity, antioxidant synthesis, and oxidative stress response and downregulated that of proteins involved in photosynthesis, photorespiration, chlorophyll binding, and mono-oxygenase activity. (bvsalud.org)

Different PTMs show distinct impacts on protein functions, and normal protein activities are consequences of all kinds of PTMs working together. (hindawi.com)
Each stage of the cell cycle is profiled by distinct protein complexes and phosphorylation events. (janechin.net)
The LINC complex can perform distinct cellular functions by pairing various KASH domain proteins with the same SUN domain protein. (ucdavis.edu)
This short-range relay is distinct from the patterning of the vertebrate spinal cord, which is a result of opposing BMP and Shh morphogen gradients. (biologists.com)

Vertebrate insulin gene enhancer binding protein isl-1. (embl.de)
Isl-1 binds to one of the two cis-acting protein-binding domains of the insulin gene. (embl.de)

A phylogenetic tree based on the predicted amino acid sequences of the fibrinogen-related domains demonstrates that tenascin-C and tenascin-R are the most closely related vertebrate tenascins, with the most conserved repeat and domain organization. (biomedcentral.com)

The LYPxL motif binds to the V-domain of eukaryotic Alix protein. (eu.org)
Ecdysone binds to the Ecdysone Receptor (EcR), which heterodimerizes with Ultraspiracle (USP), an ortholog of the vertebrate Retinoid X Receptor (RXR). (sdbonline.org)
For example, in Caenorhabditis elegans , SUN protein UNC-84 binds to two KASH proteins UNC-83 and ANC-1 to mediate nuclear migration and anchorage, respectively. (ucdavis.edu)

In vertebrates, this drop is mediated partly by Aurora B ubiquitination via the anaphase marketing complex, and subsequent destruction by the proteasome. (smadpathway.com)

Comparison of amino acid sequences of (A) vasopressin and (B) oxytocin family hormone precursors in vertebrates. (xenbase.org)
The telomeres consist of repeating sequences and a set of special proteins, which interact with these repeats and spatially organize them in a specific manner, resulting in the formation of the nucleoprotein complex known as telomeric heterochromatin [ 6 , 7 ]. (actanaturae.ru)
CAPN3 provides some exclusive domains including its NH2-terminal domains I which has 20C30 additional proteins not within - and m-calpains and two exclusive insertion sequences' of 62 and 77 proteins on the COOH-terminal parts of domains II (known as Is normally1) and domains III (known as IS2). (exposed-skin-care.net)

Taxonomic distribution of proteins containing UIM domain. (embl.de)
The complete taxonomic breakdown of all proteins with UIM domain is also avaliable . (embl.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing UIM domain in the selected taxonomic class. (embl.de)
The VHS domain is an about 150 residues long domain, whose name is derived from its occurrence in VPS-27, Hrs and STAM. (expasy.org)
VHS domain marks a group of proteins involved in endocytosis and vesicular trafficking. (expasy.org)
A single tenascin gene was identified in the genome of C. intestinalis that encodes a polypeptide with domain features common to all vertebrate tenascins. (biomedcentral.com)

2000. Monitoring methyl parathion residues in milk and yogurt, and fate of [14C] methyl parathion during milk processing. (cdc.gov)

It is of fundamental importance in determining PROTEIN CONFORMATION. (lookformedical.com)
PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain). (lookformedical.com)

Upon cytokine activation receptor chain- bound STATs are then phosphorylated on the tyrosine residues, which results in dimerisation of STAT proteins that translocate to the nucleus and activate gene transcription. (openrheumatologyjournal.com)

Anatomy14

Organisms20

Chemicals and Drugs115

Analytical, Diagnostic and Therapeutic Techniques and Equipment35

Phenomena and Processes66

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science7

Health Care3

Kinases17

Intracellular5

Substrates3

Receptor tyrosi3

Highly conserved4

Members in vertebrates2

Threonine5

Among vertebrate2

Genes11

Mammalian5

Enzymes2

Amino acids5

Serine residue1

Catalytic2

Mediated by a conserved1

Regulatory3

Subunit2

Mutations3

Mammals2

Regulate2

Receptors7

Zebrafish2

Homology3

Several proteins1

Fungi1

Regulators1

Inhibitors1

Epidermal growth3

Ligands1

Orthologs3

Drosophila1

Membrane14

Subunits4

Genomes1

Family of proteins2

Cytoskeletal1

Antibody3

Cytoplasmic1

Kinase domain1

Differentiation2

Histones2

Terminus4

Motifs6

Cysteine3

Sprouty3

Regulates1

Hydrophobic5

Zinc4

Histidine2

Invertebrate2

Duplications1

Autophosphorylation2

Polarity1

Structural2

Interactions3

Vitro1

Neurons1

Oxidative1

Distinct4

Insulin2

Closely related1

Binds3

Subsequent1

Sequences3

Domain6

20001

Conformation2

Gene transcription1