Loading...
  • aspartate
  • Mutation of S(1356)S(1360)S(1364) in SCC cells to non-phosphorylatable alanines stabilized HD-like structures and substantially reduced migration, while mutation into phosphorylation mimicking aspartate reduced HD-like structures but had no effect on migration, suggesting that serine phosphorylation function is releasing anchorage rather than promoting migration. (biomedsearch.com)
  • enzymes
  • Mitochondria are metabolic hubs that harbor enzymes responsible for several biochemical circuitries, including tricarboxylic acid (TCA) cycle, oxidative phosphorylation (OXPHOS), fatty acid oxidation (FAO), biosynthesis of amino acids, lipids and nucleotides and maintenance of homeostatic levels of Ca 2+ and of reducing equivalent carriers. (frontiersin.org)
  • Researcher D. G. Walker of the University of Birmingham determined the presence of two specific enzymes in adult guinea pig liver, both of which catalyze the phosphorylation of glucose to glucose 6 phosphate. (wikipedia.org)
  • However, prokaryotic Tyr phosphorylation is carried out by a different family of enzymes, the bacterial tyrosine kinases or BY-kinases, which do not share the structural homology with eukaryotic STYKs. (frontiersin.org)
  • amino acid
  • The phosphorylation defect could be overcome by transfection of plasmids that express wild-type F10, but not by plasmids that express F10 with single amino acid substitutions that abolished catalytic activity. (asm.org)
  • motifs
  • For example, src homology 2 (SH2) domains bind specific phosphotyrosyl residues on activated receptors (Fig. 2 A), and src homology 3 (SH3) domains bind to polyproline motifs on a separate set of target proteins (Fig. 2 D) ( 2 ). (sciencemag.org)