Loading...
  • mammary
  • The high levels of the erbB-2 product associated with malignant transformation of NIH/3T3 cells were observed in human mammary tumor cells that overexpressed this gene 3 . (apexbt.com)
  • Taken together, these observations suggest that activation of Akt-1 during ErbB-2-induced mammary tumorigenesis may have opposing effects on tumor growth and metastatic progression. (aacrjournals.org)
  • Importantly
  • Importantly, ErbB-2-dependent tumor progression in animals is inhibited by increased expression of Tid1 in tumor cells. (nih.gov)
  • malignant
  • 1 , 2 Bortezomib (Velcade, PS-341) is a novel therapeutic agent that has been shown to selectively induce apoptosis in malignant cells. (bloodjournal.org)
  • pathway
  • Mike Nickerson ( nickersonml@mail.nih.gov ) included negative feedback to IRS1 and 2 from the PI3 kinase pathway. (cancer.gov)
  • inhibition
  • A functional DnaJ domain of Tid1 also is required for its inhibition of ErbB-2 expression and the consequent PCD of carcinoma cells resulting from increased Tid1 expression. (nih.gov)
  • potent
  • A further five- to tenfold increase in its expression under influence of the long terminal repeat of Moloney murine leukemia virus was associated with activation of erbB-2 as a potent oncogene. (apexbt.com)
  • erbB-2 is a Potent Oncogene When Overexpressed in NIH/3T3 Cells. (apexbt.com)