Tyrosine phosphorylation src homology 3 domain. Medical search. Frequent questions

Like the other Vav proteins, Vav3 is phosphorylated (activated) following ligand binding to a variety of receptor tyrosine kinases (TKs), including EGF receptor, PDGF receptor, insulin receptor, and insulin-like growth factor I receptor. (cytoskeleton.com)
Binding of IL-10 to the extracellular domain of IL-10R1 activates phosphorylation of the receptor-associated Janus tyrosine kinases, JAK1 and Tyk2. (nih.gov)
These kinases then phosphorylate specific tyrosine residues (Y446 and Y496) on the intracellular domain of the IL-10R1 chain. (nih.gov)
The Crk family of adaptor proteins (Crk I, Crk II and CrkL) are Src Homology 2 (SH2) and Src Homology 3 (SH3) domain-containing proteins that form protein complexes important for transmiting signals downstream of tyrosine kinases. (ecmbio.com)
The Abl family kinases are nonreceptor tyrosine kinases which regular a variety of cellular activities such as cytoskeleton organization and adhesion. (yale.edu)
This study gives insight into the interactions between PDGFRβ and Abl2 in the context of Abl2 regulation, and also provide a framework to better understand how growth factor receptors can engage with and regulate Abl family kinases through multistep phosphorylation events. (yale.edu)
Canonically, the binding of ligands to their cognate receptors leads to the recruitment and phosphorylation of tyrosine kinases, which in turn recruit and phosphorylate STAT3 at Tyr705 (4). (abwizbio.com)
Since PKB activation is PI′-3-kinase dependent, the persistent activation of certain protein tyrosine kinases, such as IGF−1 receptor, EGF receptor, PDGF receptor, pp60c-Src, and the like, leads to the persistent activation of PKB which is indeed encountered in many tumors. (justia.com)
Outcomes Inhibitions of PDGF receptor kinase, the docking proteins element Src-family kinases, as well as the success component PI3K all eradicated PDGF-stimulated ROS creation and corroborated using the suppressed cell development. (thetechnoant.info)
signaling in the zoom lens epithelial cells, where concerted efforts from the upstream the different parts of PDGF receptor kinase, Src-family kinases, PI3K, Rac, and Ras protein are needed. (thetechnoant.info)
Among the goals for ROS in vivo may be the reversible oxidation of phosphatases, which as well as proteins tyrosine kinases are in charge of maintaining a standard proteins tyrosine phosphorylation-dephosphorylation homeostasis in cell signaling in vivo [5,14]. (thetechnoant.info)
Each isoform serves via two receptor tyrosine kinases of PDGFR and PDGFR inducing dimerization of receptors and autophosphorylation of distinct tyrosines in the intracellular domains from the receptor. (thetechnoant.info)
Included in these are Src family members kinases, phosphatidylinositol-3-kinase (PI3K), phospholipase C (PLC) and little GTP-binding proteins Ras [34-36]. (thetechnoant.info)
The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). (umbc.edu)
Jak1 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) tyr kinases containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase domain. (umbc.edu)
The role of protein tyrosine kinases (PTKs) has been widely studied but less is known on the protein tyrosine phosphatases (PTPs) responsible for immunoregulation [ 3 ]. (biomedcentral.com)
Introduction The Src family kinases (SFKs) are a family of non-receptor tyrosine kinases, which are involved in a wide variety of essential functions to sustain cellular homeostasis, where they regulate cell cycle progression, motility, proliferation, differentiation and survival, among other cellular processes [1]. (niepokorny.org)
The phosphorylation of this residue stabilizes the kinases in an active conformation accessible to ATP and substrates. (niepokorny.org)
Src is usually a central signaling hub that can be activated by many factors, including immune-response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors and cytokine receptors [5]. (niepokorny.org)
The search for small molecules with an inhibitory activity toward Src kinases constitutes a growing field of study. (niepokorny.org)
However, dasatinib is known to inhibit over 40 kinases, while bosutinib inhibits over 45 kinases, making it impossible to use these compounds as selective mechanistic probes for Src-dependent pharmacology [17,18]. (niepokorny.org)

c-Src tyrosine kinase plays an important role in signal transduction pathways, where its activity is regulated by phosphorylation of the two tyrosine residues. (intechopen.com)
To investigate the conformational change of c-Src tyrosine kinase, we applied network analysis to time series of correlation among residues. (intechopen.com)
With centrality measures such as betweenness centrality, degree centrality, and closeness centrality, we observed a few important residues that significantly contribute to the conformational change of c-Src tyrosine kinase for the different time steps. (intechopen.com)
Once phosphorylated, these tyrosine residues (and their flanking peptide sequences) serve as temporary docking sites for the latent transcription factor, STAT3 (signal transducer and activator of transcription-3). (nih.gov)
PKB activation involves phosphorylation of two amino acid residues, Ser473 and Thr308. (justia.com)
The SH2 domain binds to phosphotyrosine residues in RTKs such as PDGF and EGF, non-RTKs such as Bcr/Abl and FAK, and docking proteins such as FRS-2 and Gab1. (rndsystems.com)
It had been soon found that many PTB domains bind to tyrosine residues irrespective of their phosphorylation position. (researchensemble.com)
2003 As opposed to PTB domains SH2 domains recognize an important phosphotyrosine and adjacent C-terminal residues. (researchensemble.com)
PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. (umbc.edu)
The unique domain is included in the N-terminal segment of the proteins, together with SH4, and is composed of 50C70 residues. (niepokorny.org)

PTPH1 overexpression in Jurkat T cells reduces indirectly the TCR-induced serine phosphorylation of Mek, Erk, Jnk and AP-1 leading to a decreased IL-2 gene activation [ 13 ]. (biomedcentral.com)

GRB2 (growth factor receptor-bound protein 2), an adaptor protein involved in signal transduction, contains a central SH2 domain flanked by two SH3 domains. (rndsystems.com)
SHP-2 can hamper the TRIF (TIR-domain-containing adapter-inducing interferon-β) adaptor protein-dependent TLR4 and TLR3 signal transduction with a consequent block of the pro-inflammatory cytokine production [ 7 ]. (biomedcentral.com)

IRS then binds to the regulatory subunit of PI3K through its Src homology domains, and this interaction activates the catalytic unit. (diabetesjournals.org)
STAT3 binds to these sites via its SH2 (Src homology 2) domain, and is, in turn, tyrosine-phosphorylated by the receptor-associated JAKs. (nih.gov)
the preferred GFRα coreceptor for GDNF is GFRα1, although GDNF also weakly binds to GFRα2 and GFRα3 [ 3 ]. (medsci.org)
We report that cten binds to another tumor suppressor, deleted in liver cancer 1 (DLC-1), and the SH2 domain of cten is responsible for the interaction. (rupress.org)
PIP3 binds to the pleckstrin homology (PH) domains of PKB, recruits it to the membrane where it is phosphorylated and converted to its activated form. (justia.com)

The SH3-SH2-SH3 C-terminal domains bind directly with the auto-phosphorylated cytoplasmic tails of the receptor TKs while the B- and T-cell receptors activate cytosolic TKs. (cytoskeleton.com)
Direct Phosphorylation of SRC Homology 3 Domains by Tyrosine Kinase Receptors Disassembles Ligand-Induced Signaling Networks Molecular Cell , vol. 70 , nº 6. (inrs.ca)
What are physical characteristics found in all tyrosine kinase receptors? (flashcardmachine.com)

Signaling through the phosphatidylinositol 3′-kinase (PI3K) pathway is crucial for metabolic responses to insulin, and defects in PI3K signaling have been demonstrated in type 2 diabetes. (diabetesjournals.org)
PTEN (MMAC1) is a lipid/protein phosphatase that can negatively regulate the PI3K pathway by dephosphorylating phosphatidylinositol (3,4,5)-triphosphate, but it is unclear whether PTEN is physiologically relevant to insulin signaling in vivo. (diabetesjournals.org)
Upon leptin stimulation the phosphorylation of STAT3 is one of the key events in JAK2-STAT3 pathway, followed by the dimerization and nuclear translocation of this molecule. (biomedcentral.com)
us pharmacological inhibitors such as Picroto in GABAA receptor antagonist, Pertussis to in Gi protein coupled receptor pathway inhibitor, Herbimycin A tyrosine kinase inhibitor, Chelerythrine chloride protein kinase C inhibitor, not Wortmannin A phosphoinositide 3 kinase inhibitor, H 89 cAMP dependent protein kinase A inhibitor for 1 hr at 37 C with 5% CO2 in humidified air prior to the addition of human SIZP. (vegfr-3inhibitor.com)
and transmembrane receptor protein tyrosine kinase signaling pathway. (nih.gov)

Proteins tyrosine phosphatase 1B (PTP1B) can be an established therapeutic focus on for type 2 diabetes mellitus (T2DM) and weight problems. (gasyblog.com)
Recombinant proteins including the catalytic domains of proteins tyrosine phosphatase 1B (PTP1B), T cell proteins tyrosine phosphatase (TCPTP), Src homology 848942-61-0 manufacture 2 (SH2) domain-containing tyrosine phosphatase 1 (SHP1), Src homology 2 (SH2) domain-containing tyrosine phosphatase 2 (SHP2), and hematopoietic proteins tyrosine phosphatase (HePTP) had been purified as previously referred to [15C18]. (gasyblog.com)

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1. (umbc.edu)

Inhibition is removed by tyrosine kinase (TK)-mediated phosphorylation of the conserved Tyr174 residue (on Vav3, Tyr173 corresponds to Vav1 Tyr174 based on Vav1 amino acid numbering) in the AC helix. (cytoskeleton.com)
Phosphorylation of tyrosine 705 residue induced by epidermal growth factor (EGF) or interleukins can activate STAT-3 in cells [ 4 ]. (biomedcentral.com)
B) Cten appearance is certainly induced by many growth elements and cytokines (shown in vibrant) through Ras-Mek-MAPK … Framework Human cten is certainly a 715-residue polypeptide which includes two conserved domains: the SH2 area and PTB area (Lo and Lo 2002 1 Both had been originally defined as binding modules for phosphotyrosine-containing peptides. (researchensemble.com)
The C-terminal lobe is usually larger, comprises an activation loop that contains a tyrosine residue that can be autophosphorylated (Tyr419 in human c-Src) and is the positive regulatory site responsible for maximizing kinase activity. (niepokorny.org)
On the contrary, when another tyrosine residue located in the C-terminal lobe tail (Tyr530 in human c-Src) is usually phosphorylated, a closed conformation is usually induced [3]. (niepokorny.org)

Vav3 contains a calponin homology (CH) domain, an acidic domain (AC), the Dbl homology (DH) and pleckstrin homology (PH) domains which are common to all Rho GEFs, an atypical cysteine-rich zinc finger (C1) domain, a proline rich domain, a Src homology-2 (SH2) domain, and two Src homology-3 (SH3) domains flanking the single SH2 region. (cytoskeleton.com)

In addition, B-cell and/or T-cell receptor stimulation also results in phosphorylation of Vav3. (cytoskeleton.com)
EGF stimulation induces phosphorylation of Tyr-251, which increases binding of Crk to the SH2 domain of Abl, and promotes transactivation of Abl. (ecmbio.com)
In response to insulin stimulation, this complex bound to tyrosine-phosphorylated IRS-1 (insulin receptor substrate-1) and Shc. (nih.gov)

How is the insulin tyrosine kinase receptor unusual? (flashcardmachine.com)
How is a tyrosine kinase receptor activated? (flashcardmachine.com)
Nearly 60% of genetic alterations have been found in AML patients involve in signaling pathways including signaling of tyrosine kinase receptor FLT3. (lu.se)

It is known to act through protein phosphorylation via PRKA and through the activation of guanine nucleotide exchange factors like EPAC. (plos.org)

PF cells were found to express regulatory (p85) and catalytic (p110α and p110β) subunits of phosphatidylinositol 3′-kinase (PI3′-kinase). (jneurosci.org)
c-Src tyrosine kinase consists of the N-terminal unique region, the Src homology 3 (SH3), SH2, linker, kinase domain, and the regulatory C-terminal tail. (intechopen.com)
PI3K is composed of two subunits: the p85 regulatory subunit, containing two Src homology-2 domains, and the p110 catalytic subunit ( 2 - 4 ). (diabetesjournals.org)
Altered membrane events induced selective inhibition of TCR-induced phosphorylation of regulatory P85 subunit of PI3K and AKT as well as abrogated calcium influx. (nature.com)
Crk II Tyr-221 (CrkL Tyr-207) phosphorylation is a negative regulatory site, while Crk Tyr-251 phosphorylation in the SH3 domain is a positive regulatory site. (ecmbio.com)

CagA can specifically bind to the SH2 domain of Src homology 2 (SH2)-containing protein tyrosine phosphatase (SHP-2), which induces spatial configuration change of SHP-2 and activates it [ 40 ]. (biomedcentral.com)

Binding of insulin to its receptor activates the insulin receptor tyrosine kinase, resulting in autophosphorylation and phosphorylation of several substrates, including insulin receptor substrate (IRS)-1 through -4. (diabetesjournals.org)
MB&B professors Dr. Karen Anderson and Dr. Anthony Koleske published a paper this month in the Journal of Biological Chemistry called 'Platelet-derived growth factor receptor beta activates Abl2 via direct binding and phosphorylation. (yale.edu)
After establishing the sites phosphorylated by PDGFRβ, they show in vitro that the PDGFRβ-mediated phosphorylation activates the Abl2 kinase activity. (yale.edu)
The SH3 domains associate with proline rich motifs on the guanine nucleotide releasing factor, Sos, stimulating GTP binding to Ras, which in turn activates MAPK and other signaling pathways. (rndsystems.com)

Phosphatidylinositol 3′-kinase (PI3K) is a crucial signaling enzyme whose activity is regulated by a variety of biological stimuli, including insulin ( 1 ). (diabetesjournals.org)
Activated PI3K phosphorylates the 3′-position of the ring in inositol phospholipids, generating phosphatidylinositol ( 3 , 4 ), diphosphate, and phosphatidylinositol (3,4,5)-triphosphate (PIP3). (diabetesjournals.org)
The lipid products of PI3K initiate phosphorylation and activation of Akt, which is believed to act as a downstream mediator of many of the metabolic effects of insulin ( 5 , 6 ). (diabetesjournals.org)
Thus, the expression of inactive PI3K mutants or chemical agents, such as wortmannin and LY294002 that interfere with PI3K activity, inhibit Akt phosphorylation, glucose uptake, and glycogen and lipid synthesis in vitro ( 7 , 8 ). (diabetesjournals.org)
PTEN also has phosphoinositide 3′-phosphatase activity and is therefore capable of suppressing PI3K signaling by dephosphorylating PIP3 ( 11 , 12 ). (diabetesjournals.org)

You can find over 440 noted mutations within the calpain 3 gene up to now, included in this 212 (50%) are missense mutations, a lot of which alter its catalytic activity (22). (exposed-skin-care.net)
catalytic (c) domain (repeat 2). (umbc.edu)
The SH1 domain name (also called the catalytic domain name) is composed of two subdomains (generally termed N-terminal and C-terminal lobes) separated by a cleft. (niepokorny.org)
The SH2 and SH3 domains regulate the Src catalytic activity through both intramolecular and proteinCprotein interactions. (niepokorny.org)

It plays a key role during sperm capacitation [ 3 - 6 ] and the acrosomal exocytosis [ 7 - 10 ], where it affects different intracellular signalling pathways. (plos.org)
Although these factors possess remarkably similar sequence homology, they do not bind FGFRs and are involved in intracellular processes unrelated to the FGFs (Olsen et al. (beauty104.com.tw)
Flow cytometric analysis of Raw264.7 cells (blue) and A20 cells (green) using CD19 (Intracellular Domain) (D4V4B) XP ® Rabbit mAb (Alexa Fluor ® 488 Conjugate) (solid lines) or a concentration-matched Rabbit (DA1E) mAb IgG XP ® Isotype Control (Alexa Fluor ® 488 Conjugate) #2975 (dashed lines). (cellsignal.jp)

This review comprehends literatures on leptin and leptin resistance and especially discusses what STAT3 phosphorylation would contribute to central leptin resistance. (biomedcentral.com)
Emerging evidence provided insight into the role of signal transducer and activator of transcription 3 (STAT3) in energy metabolism. (biomedcentral.com)
Signal transducer and activator of transcription 3 (STAT3) was initially showed to control acute-phase genes in response to interleukin-6 (IL-6) and epidermal growth factor (EGF) during inflammatory processes (1). (abwizbio.com)
Upon phosphorylation, STAT3 proteins dimerize and translocate to the nucleus where they bind to promoter elements of target genes and modulate their transcription (4). (abwizbio.com)
Ser727 phosphorylation can also stimulate mitochondrial STAT3, where it may trigger oxidative phosphorylation (9), confer stress protection by reducing reactive oxygen species (ROS) accumulation and apoptosis (10,11) and support Ras-induced malignant transformation (12). (abwizbio.com)
mutated JAK2s also mediate GH activation of transmission transducer and activator of transcription 3 (Stat3), transmission transducer and activator of transcription 5b (Stat5b) and ERK1, but at reduced levels. (biobender.com)

Both Crk II and CrkL are ubiquitously expressed and their SH domains are highly homologous, however both are required for mouse development and have distinct non-overlapping phenotypes in knockout mice. (ecmbio.com)

The power of the thiol proteinases to cleave a multitude of substrates in response to calcium mineral activation allows their involvement in a variety of cell processes offering cell motility, sign transduction, apoptosis, cell differentiation and legislation of the cytoskeleton (3). (exposed-skin-care.net)

The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. (wikipedia.org)
The ECM proteins bind to the extracellular domains of integrin heterodimers, whereas the actin stress fibers link to integrin cytoplasmic tails via large molecular complexes. (rupress.org)

Activation of Src in human cancers employs a variety of mechanisms mainly including covalent modification, allosteric regulation, gene mutation. (xcessbio.com)

Based on the amino acid sequence homology and biological activity in macrophages, Shimamoto et al ( 15 ) identified that HLP was identical to MSP ( 15 ). (spandidos-publications.com)
The aim of this study was to investigate the diversity of cagA 3′ variable region and the amino acid polymorphisms in the EPIYA segments of the CagA C-terminal region of H. pylori , and their association with gastroduodenal diseases. (biomedcentral.com)
The SH4 domain name is usually a 15-amino acid sequence whose myristoylation allows the binding of Src users to the inner surface of the plasma membrane. (niepokorny.org)

recently found a highly selective small-molecule degrader of STAT-3, i.e. (biomedcentral.com)
Ubenimex To this end, it is meaningful to find more effective and selective Src inhibitors with new chemical scaffolds. (niepokorny.org)

They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). (umbc.edu)

Unexpectedly, the interaction between DLC-1 and the cten SH2 domain is independent of tyrosine phosphorylation of DLC-1. (rupress.org)
Structural determinants required for the interaction between Rho GTPase and the GTPase-activating domain of p190. (embl-heidelberg.de)
We identified SLAP2 and ABL2 as potent interaction partners of FLT3 through their SH2 domain. (lu.se)

c-Src (cellular Src), encoded by Src gene, is a non-receptor tyrosine kinase first isolated as the normal cellular homolog to the potent avian sarcoma viral transforming oncogene v-Src [ 4 ]. (intechopen.com)
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. (cancerindex.org)
Thus, the ability of IL-10 to inhibit gene expression in monocytes is associated with its ability to rapidly induce synthesis of SOCS-3. (nih.gov)
This gene is highly expressed in fetal brain and encodes a protein of relative molecular mass 91K, named oligophrenin-1, which contains a domain typical of a Rho-GTPase-activating protein (rhoGAP). (embl-heidelberg.de)

24(3): 160-165, 2017 Sep. (bvsalud.org)

After dimerization, STAT-3 can transfer to the nucleus and act as a transcription activator. (biomedcentral.com)

Pure T-cell deficiencies are caused by defects in either a CD3 subunit (such as CD3 δ, CD3 ζ, CD3 ε ) or in CD45 tyrosine phosphatase, key proteins involved in pre-TCR and/or TCR signaling at the positive selection stage. (medscape.com)

This experiment revealed that mutations of four specific tyrosines in Abl2 (Y116, Y161, Y272, and Y310) compromise the PDGFRβ-mediated activation of Abl2 which suggests these sites are crucial for proper Abl2 activation. (yale.edu)
Here, we show that insulin-induced activation of ERKs was enhanced by stable overexpression of growth factor receptor-bound protein 2 (GRB2) but not by overexpression of GRB2 proteins with point mutations in the Src homology 2 and 3 domains. (nih.gov)
In addition ot Tyr705 phosphorylation, Ser727 is required for maximal activation although Tyr705 phopsohrylation plays a key activating role (7,8). (abwizbio.com)
The particularly phosphorylated tyrosine enables docking and following activation of some responding molecules filled with Src homology 2 or SH2 domains [33]. (thetechnoant.info)
Calpain 3 provides 54 and 51% series homology towards the 80 kDa subunits of - and m-calpains, respectively, and stocks similar properties with one of these ubiquitously portrayed calpains such as for example Ca2+- reliant activation and maximal activity at natural pH (1). (exposed-skin-care.net)

Hepatocyte growth factor (HGF) is produced by stromal and mesenchymal cells, and it stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its cognate receptor, Met. (spandidos-publications.com)

The signal transducer and activator of transcription-3 (STAT-3) can facilitate cancer progression and metastasis by being constitutively active via various signaling. (biomedcentral.com)
In this study we used phosphorylation of the transcription factor cAMP response element-binding protein as a functional readout to identify cells responding to EGF and FGF-2. (beauty104.com.tw)

Our research demonstrated that genipin suppresses STAT-3 phosphorylation and nuclear translocation, which may be attributed to the binding capacity of this compound to the Src homology-2 (SH2) domain of STAT-3. (biomedcentral.com)

Non-activated Abl2 are kept inactive through an autoinhibitory mechanism involving intramolecular interactions with the Src homology 3 (SH3) and Src homology 2 (SH2) domains, but it has been proposed that interactions with cellular binding partners relieve the inhibition. (yale.edu)
Orthologous to human ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase). (nih.gov)
A Role for the Non-Receptor Tyrosine Kinase Abl2/Arg in Experimental Neuroinflammation. (nih.gov)

Tyrosine phosphorylation of GRB2 SH3 domains reduces binding to Sos and negatively regulates downstream signaling pathways including Ras, JNK and MAPK. (rndsystems.com)

Two types of phosphatidylinositol 3-kinase from bovine thymus. (wikidata.org)

2007 The SH2 domain of cten interacts with phosphotyrosine-containing protein. (researchensemble.com)

Based on these results and the crystal structure of the JAK2 kinase domain name, we hypothesize that small changes in the conformation of the regions of JAK2 surrounding Tyr 868, 966, and 972 due, for example, to phosphorylation, binding to a ligand-bound cytokine receptor, and/or binding to SH2B1, may be essential for JAK2 to presume a maximally active conformation. (biobender.com)

SH2 domains of cten and various other tensins bind towards the SIY442DNV site on DLC1 (Deleted in Liver organ Cancer tumor 1) and phosphorylation from the tyrosine is not needed (Liao et al. (researchensemble.com)

Moreover, the ability of IL-10 to induce de novo synthesis of SOCS-3 in monocytes correlates with its ability to inhibit expression of many genes in these cells, including endotoxin-inducible cytokines such as tumor necrosis factor-alpha (TNF-alpha) and IL-1. (nih.gov)
The tensin family member cten (C-terminal tensin like) is an Src homology 2 (SH2) and phosphotyrosine binding domain-containing focal adhesion molecule that may function as a tumor suppressor. (rupress.org)
These results provide a novel mechanism whereby the SH2 domain of cten-mediated focal adhesion localization of DLC-1 plays an essential role in its tumor suppression activity. (rupress.org)

One of these genes, SOCS-3 (Suppressor of Cytokine Signaling-3) is a member of a newly identified family of genes that inhibit JAK/STAT-dependent signaling. (nih.gov)

Inhibition of PTEN expression also dramatically reduced insulin concentrations in ob/ob mice, improved the performance of db/db mice during insulin tolerance tests, and increased Akt phosphorylation in liver in response to insulin. (diabetesjournals.org)

Src consists of four homology domains (SH1, SH2, SH3 and SH4) and a unique domain name (Physique 1). (niepokorny.org)

Mutational analysis revealed that only the C1 and DH domains are essential for Vav3 GEF activity with the C1 region being involved in binding with the GTPase substrate. (cytoskeleton.com)
Vav3 GEF activity is dependent upon tyrosine phosphorylation which unlocks Vav3 from its "closed" conformation. (cytoskeleton.com)
Phosphorylation may be important for regulating Crk activity. (ecmbio.com)
Coexpression with Src-homology 2B1 (SH2B1), like coexpression with GH-bound GH receptor, partially restores the activity of all three JAK2 mutants. (biobender.com)
Coexpression with Src-homology 2 (SH2)B1, like coexpression with GH-bound GH receptor, also partially restored their kinase activity. (biobender.com)
In conclusion, genipin showed therapeutic potential for HCC treatment by interacting with the SH2-STAT-3 domain and suppressing the activity of STAT-3. (biomedcentral.com)
Inhibiting of STAT-3 activity can be divided into two categories: regulating upstream genes of STAT-3 or directly binding to STAT-3 and suppressing its activity [ 7 ]. (biomedcentral.com)

tensin4 TNS4) was defined as a faraway person in the tensin focal adhesion family members (Lo and Lo 2002 It really is a much smaller sized proteins compared to various other tensins in support of stocks the SH2 (Src homology 2) and PTB (phosphotyrosine binding) domains bought at the C-terminal ends of most various other tensins (Lo 2004 (body 1). (researchensemble.com)

Anatomy24

Organisms9

Diseases1

Chemicals and Drugs149

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Phenomena and Processes53

Technology, Industry, Agriculture1

Information Science3

Kinases21

Residues10

Serine1

Signal Transduction2

Binds5

Receptors3

Pathway5

Proteins tyrosine2

Janus1

Residue5

Pleckstrin homology1

Stimulation3

Kinase receptor3

Protein phosphorylation1

Regulatory5

Induces1

Activates4

PI3K5

Catalytic4

Intracellular3

STAT36

Knockout mice1

Substrates1

Actin2

Regulation1

Amino acid3

Selective2

Autophosphorylation1

Interaction3

Gene4

20171

Dimerization1

Subunit1

Activation5

Cognate1

Transcription2

Translocation1

Abl23

Downstream1

Phosphatidylinositol-3-kina1

Interacts1

Cytokine receptor1

Bind1

Tumor3

Inhibit1

Inhibition1

Consists1

Activity7

Phosphotyrosine1