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  • tumors
  • As this tumor suppressor is commonly inactivated in epithelioid sarcoma, cell division can fail to appropriately halt, resulting in unregulated cellular growth and the formation of cancer tumors. (wikipedia.org)
  • tumor
  • In conclusion, therapies such as ZD6474 that target two distinct aspects of tumor growth, angiogenesis and tumor cell proliferation, warrant further investigation. (aacrjournals.org)
  • The selection of patients for tumor-specific therapies using molecular/biological properties of the patient's tumor has been a long tradition in breast cancer (e.g., estrogen receptor, progesterone receptor, and HER-2/ neu ) but has not been widely accepted in lung cancer therapy selection ( 1 , 2 ). (aacrjournals.org)
  • Preclinical studies showed that disruption of EGFR tyrosine kinase (EGFR-TK) activation could inhibit proliferation of tumor cells and induce apoptosis ( 2 ). (aacrjournals.org)
  • Lapatinib eliminates the growth of breast cancer stem cells that cause tumor growth. (wikipedia.org)
  • Lung cancer, also known as lung carcinoma, is a malignant lung tumor characterized by uncontrolled cell growth in tissues of the lung. (wikipedia.org)
  • NSCLC
  • Are age and co-morbidity prognostic factors in the treatment of metastatic non-small cell lung cancer (NSCLC): a review of a National Cancer Institute of Canada Clinical Trials Group (NCIC-CTG) randomized trial," Lung Cancer , vol. 49, supplement 176, p. (hindawi.com)
  • Epidermal growth factor receptor (EGFR) mutations have been detected in approximately 10 % of North American patients diagnosed with non-small cell lung cancer (NSCLC). (springer.com)
  • lung
  • This growth can spread beyond the lung by the process of metastasis into nearby tissue or other parts of the body. (wikipedia.org)
  • patients
  • JAK2V617F is a mutant of tyrosine kinase JAK2, is found in most patients with polycythemia vera (PV) and a substantial proportion of patients with idiopathic myelofibrosis or essential thrombocythemia. (wikipedia.org)