Shortly before birth, BDNF activates NF-κB by an atypical mechanism that involves tyrosinephosphorylation of IκBα by Src family kinases, and dephosphorylates p65 at serine 536. (silverchair.com)
NGF is a neurotrophic factor critical for the survival and maintenance of sympathetic and sensory neurons, and it binds to the high-affinity tyrosine kinase receptor, TrkA, leading to its phosphorylation and the subsequent activation of PI3K/Akt/GSK3β pathways. (biomedcentral.com)
TrkA2
Expression of the GFRα3 receptor is primarily restricted to the peripheral nervous system and is found in a subpopulation of nociceptive sensory neurons of the dorsal root ganglia (DRGs) that coexpress the Ret and TrkA receptor tyrosine kinases and the thermosensitive channel TRPV1. (jneurosci.org)
Evidence suggests that nerve growth factor (NGF) induces neurite outgrowth from PC12 cells by activating the receptor tyrosine kinase, TrkA. (biomedcentral.com)
Binds5
It first binds with high affinity to specific cell-surface receptors and then induces their dimerization, which is essential for activating the tyrosine kinase in the receptor cytoplasmic domain, initiating a signal transduction that results in DNA synthesis and cell proliferation. (embl.de)
It binds to the common neurotrophin receptor p75 NTR and the TrkB receptor tyrosine kinase that are expressed by subsets of developing neurons, including the sensory neurons of the nodose ganglion ( Reichardt, 2006 ). (silverchair.com)
Artemin, a neuronal survival factor in the glial cell line-derived neurotrophic factor family, binds the glycosylphosphatidylinositol-anchored protein GFRα3 and the receptor tyrosine kinase Ret. (jneurosci.org)
Interleukin-2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to the cytokine IL-2. (transcriptionfactor.org)
The ESCRT portion tends typically human for receptor-ligand transport that is fulfilment metabolized unidirectional binds. (erik-mill.de)
Integrin5
Taxol-induced TRPV4-mediated hyperalgesia and the enhanced osmotransduction in cultured nociceptors were dependent on integrin/Src tyrosine kinase signaling. (jneurosci.org)
We also demonstrate that Taxol-induced TRPV4-mediated hyperalgesia is essentially dependent on integrin/Src tyrosine kinase signaling. (jneurosci.org)
Our results demonstrate that cytoglobin expression is correlated with a more quiescent phenotype of stellate cells in culture and that cytoglobin is regulated by the extracellular matrix through integrin signalling dependent on activation of focal adhesion kinase. (biomedcentral.com)
HSCs express numerous cell surface receptors including both discoidin domain receptors (DDRs)-which are receptors for collagen I and many of the integrin subunits, which are a major family of cell surface receptors for extracellular molecules and play a critical role in many biological functions [ 7 , 10 ]. (biomedcentral.com)
Interaction with ECM is a major driver of HSC morphology [ 11 ], and signal transduction from integrin activation occurs at least partly through aggregation and subsequent activation of focal adhesion kinases (FAKs) by autophosphorylation of tyrosine 397 (Y397). (biomedcentral.com)
Neurons1
Additionally, we detected increased levels of active glycogen synthase kinase 3 β, a physiological kinase of TAU, in neurons derived from AD iPSCs, as well as significant upregulation of amyloid precursor protein (APP) synthesis and APP carboxy-terminal fragment cleavage. (biomedcentral.com)
Overexpression2
The proto-oncogene designated erbB2 or HER2 encodes a 185-kilodalton transmembrane tyrosine kinase (p185erbB2), whose overexpression has been correlated with a poor prognosis in several human malignancies. (embl.de)
The overexpression of Human Epidermal Growth Factor Receptor 2 (HER2) is usually associated with aggressive and infiltrating breast cancer (BC) phenotype, and metastases. (dovepress.com)
Ligands1
GDNF family ligands (GFLs) activate the Ret receptor tyrosine kinase through binding of glycosylphosphatidylinositol-anchored GDNF family receptor α coreceptors (GFRα1-4) ( Sariola and Saarma, 2003 ). (jneurosci.org)
G protein-coupled receptors (GPCRs) as well as heterotrimeric G proteins are also involved in regulating neurite outgrowth. (biomedcentral.com)
Thus, Dab2 mediates the simultaneous attachment of clathrin-coated cargos containing transmembrane proteins with one or more NPXY motifs, such as the low density lipoprotein (LDL) receptor, megalin, and integrins, to the myosin motor, enabling endocytosis and directional trafficking. (biomedcentral.com)
Extracellular1
Analytes include soluble growth and differentiation factors, extracellular matrix components, proteases, membrane-bound receptors, and intracellular signaling molecules. (rndsystems.com)
20011
They gated mediated to facilitate a JmjC cellular debris, specifically secreted in direct receptors( Clissold & Ponting 2001). (erik-mill.de)
Protein3
HomB protein contributes to the colonization and persistence of H. pylori , and the presence of homB genes affects the number of bacteria adhering to the host cells. (nature.com)
Western blot analysis and in situ hybridization confirmed the presence of AND-34 RNA and protein in lens epithelial cells, particularly at the lens equator. (molvis.org)
Since the crystal structure confirmed the W and Y to form a hairpin agreement with their aromatic rings stacked together, we've now investigated the role of the AID tyrosine Y388 inside the role of CaVB sub-units and in G-protein modulation. (plasignaling.com)
Enzymes1
National Science Foundation, and cleaved on BBC World, Science 360, and continuous viral receptors enzymes. (erik-mill.de)
The β and γ chains of the IL-2R are members of the type I cytokine receptor family. (transcriptionfactor.org)
Tissues2
Here, we reported that mammalian target of rapamycin complex 2 (mTORC2) kinase is overexpressed in pancreatic cancer tissues and promotes pancreatic cancer cell growth and invasion. (techscience.com)
Transcriptome profiling of the early stages in Atlantic cod revealed the presence of transcripts involved in patterning and development of tissues and organs long before activation of the zygotic genome. (biomedcentral.com)
Cell2
This could be considered to be part of a feedback loop as changes in ECM composition results in changes in HSC cell surface receptors, particularly integrins indicating that the ECM should not be regarded simply as an inert physical scaffold but a dynamic structure that is able to influence the phenotype of HSCs [ 2 , 8 , 9 ]. (biomedcentral.com)
In tract, markup at cell H3 lysine-5( H3K4) and detailed( H3K36), forming glucose and potential at these receptors, is released synthesized to partially associated kinases( shown in Martin & Zhang 2005). (erik-mill.de)
Targets1
[ 1 , 2 ] Although the chief target of the autoimmune attack in most cases is the skeletal muscle nicotinic acetylcholine receptor (nAChR), other antigenic targets that are components of the neuromuscular junction (NMJ) have also been implicated. (medscape.com)
Gene1
10. A double null mutation in the gene that produces Poly-Ig-Receptor (PIgR), would cause which of the following to occur? (mockdocs.org)
Crucial1
The presence of IGF-1 is crucial for maintaining cartilage integrity. (biomedcentral.com)
Signal1
Cytokines bind to their receptors, activating signal transduction pathways such as adenylate cyclase/cAMP, phospholipase C/inositol trisphosphate, and Ca 2+ and tyrosine kinases. (biomedcentral.com)
Components2
All components of the RAS (angiotensinogen, angiotensin converting enzyme, angiotensin receptors) are expressed in many types of tumours, including endometrial cancer ( 2 , 4 ). (spandidos-publications.com)
Dab2 also modulates cellular signaling pathways by mediating the endocytosis and recycling of surface receptors and associated signaling components. (biomedcentral.com)
Activity1
Dimers of PDGFR consist of either homodimers of alpha/alpha, beta/beta, or heterodimers of alpha/beta and serve as a substrate for its kinase activity. (thermofisher.com)
Role2
Moreover, both angiotensin receptors (AT1 and AT2) are overexpressed in different types of cancers, which confirms the role of local RAS in cancer development and progression ( 3 , 5 - 8 ). (spandidos-publications.com)
Modulation of LDL receptor endocytosis by Dab2 has also been studied in cultured cells [ 36 ], though a role in vivo has not yet been established. (biomedcentral.com)
Alpha1
The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. (thermofisher.com)
Provide1
The site stabilizes vesicle of the hemoprotein loading tyrosine to provide Gag enlargement and function erythematosus. (erik-mill.de)
Levels1
TSH-receptor antibody (TRAb) levels were significantly raised in all cases, when ascertained. (thebiotechdictionary.com)
Growth1
Description: The APB5 monoclonal antibody reacts with the mouse CD140b molecule, the beta chain of the platelet derived growth factor receptor (PDGF receptor). (thermofisher.com)