Tyrosine kinase dna activated protein kinase. Medical search. Frequent questions

Kinases are enzymes that catalyze reactions of phosphorylation. (wikipedia.org)
Unlike other cyclin-dependent kinases, CDK5 does not also require phosphorylation on the T loop. (wikipedia.org)
In the present study, we examined the role of protein tyrosine phosphorylation and the mitogen-activated protein kinases, ERK1/2,in mediating BK-induced AP-1 and DNA replication in cultured rat mesangial cells. (nih.gov)
BK (10(-9) to 10(-7) M) stimulated a rapid increase in tyrosine phosphorylation of multiple proteins with an estimated molecular mass of 120-130, 90-95, and 44-42 kDa. (nih.gov)
Genistein, a specific tyrosine kinase inhibitor, prevented the phosphorylation of ERK2 by BK. (nih.gov)
AP-1 pathway and that BK mitogenic signaling is critically dependent on protein tyrosine phosphorylation. (nih.gov)
Furthermore, by adding various kinase inhibitors, we confirmed that the phosphorylation status of rpS3 was regulated by both Lyn and doxorubicin, and the phosphorylation of rpS3 by Lyn increased drug resistance in cells by upregulating p-glycoprotein translation. (bmbreports.org)
A 45-kilodalton protein heregulin-alpha (HRG-alpha) that specifically induced phosphorylation of p185erbB2 was purified from the conditioned medium of a human breast tumor cell line. (embl.de)
Raf family members will activate MEK1/2 followed by phosphorylation of ERK1/2 which acts on a large variety of targets. (springer.com)
Expression levels of PER2, a clock protein, were elevated in Sik3 -knockdown cells but down-regulated in Sik3 -overexpressing cells, which could be attributed to a phosphorylation-dependent decrease in PER2 protein stability. (elifesciences.org)
Phosphorylation of tyrosine residue 342 in the PTK6 activation loop corresponds with its activation. (oncotarget.com)
Similar to findings in the prostate, we detect nuclear and cytoplasmic PTK6 in normal mammary gland epithelial cells, but no phosphorylation of tyrosine residue 342. (oncotarget.com)
However, in human breast tumors, striking PTK6 expression and phosphorylation of tyrosine 342 is observed at the plasma membrane. (oncotarget.com)
These proteins are latent in the cytoplasm and become activated through tyrosine phosphorylation which typically occurs through cytokine receptor associated kinases (JAKs) or growth factor receptor tyrosine kinases. (nih.gov)
Recently a number of non-receptor tyrosine kinases (for example src and abl) have been found to cause STAT phosphorylation. (nih.gov)
Intersecting analysis, molecular docking, and pathway validation analysis showed that risperidone influences the adipocytokine signaling pathway by targeting MAPK14 (mitogen-activated protein kinase 14), MAPK8 (mitogen-activated protein kinase 8), and RXRA (retinoic acid receptor RXR-alpha), thereby inhibiting long-chain fatty acid β-oxidation by decreasing STAT3 (signal transducer and activator of transcription 3) expression and phosphorylation. (frontiersin.org)
L ike protein phosphorylation by kinases, protein ubiquitylation regulates many aspects of cell function and provides a wealth of drug target opportunities across many therapeutic areas including cancer, cardiovascular, metabolism, inflammation, neurodegeneration and infectious diseases. (ddw-online.com)

A chemical or drug that inhibits the mitogen-activated protein kinase kinase enzymes MEK1 and/or MEK2. (mek-inhibitors.com)
The byg mutation is an A to T transversion causing a premature stop codon in the gene encoding MAP3K4 (also known as MEKK4), a mitogen-activated protein kinase kinase kinase. (plos.org)

In vitro studies have shown that EGFR tyrosine kinase inhibitors (TKIs) greatly inhibit cellular growth and induced apoptosis in the ATC cell lines, while somatic mutations in the tyrosine kinase domain or an increased gene copy number are associated with increased sensitivity to TKIs in non-small cell lung cancer. (bmj.com)
Among them are the Sprouty proteins which mainly act as inhibitors of growth factor-dependent neuronal and glial signaling pathways. (springer.com)
Meanwhile, ECs iso lated from HCC tissue enhance the angiogenesis exercise with larger resistance selelck kinase inhibitor to chemotherapeutic agents and inhibitors of angiogenesis,and are connected with a high chance for metastasis. (fak-signal.com)

In humans, the CRYAA gene encodes a 173 amino acid residue protein by single copy genes located on chromosome 21. (molvis.org)
Genes whose protein products stimulate or enhance the division and viability of cells. (cancerquest.org)
Genes whose protein products can directly or indirectly prevent cell division or lead to cell death. (cancerquest.org)
There is no longer a need for signals to activate these genes. (cancerquest.org)
Dimerized STATs then translocate to the nucleus, where they bind DNA in the promoter sequences of target genes to activate transcription. (medscape.com)
As leukemic Slp65-deficient pre-B cells express the recombination activating genes (Rag)1 and Rag2, and manifest ongoing immunoglobulin (Ig) light-chain rearrangement, it has been hypothesized that deregulated recombinase activity contributes to malignant transformation. (eur.nl)
The Food and Drug Administration approved Vitrakvi in November 2018 to treat adults and children with solid tumors of any type originating anywhere in the body if the patients have fusions in one of three NTRK (neurotrophic receptor tyrosine kinase) genes. (curetoday.com)
2) a more complete definition of the sets of genes which are activated by different STATs and (3) how these sets of activated genes differ as a function of cell type. (nih.gov)
It is also related to increased adiponectin (APN) expression associated with adipocyte differentiation, as well as the expression of adipogenic genes such as peroxisome proliferator-activated receptor ( PPAR) ( 22 , 23 ). (frontiersin.org)
Here, we report that the guanine nucleotide-binding protein (G protein)-coupled receptor-activated WD-repeat Gβ interacts with the glucocorticoid receptor (GR), comigrates with it into the nucleus and suppresses GR-induced transactivation of the glucocorticoid-responsive genes. (rupress.org)
The Y-linked sex determining gene SRY regulates this process by initiating a pathway of gene and protein expression, including the expression of critical autosomal genes such as SOX9 . (plos.org)

This exceeds the minimum clinically important difference of 5 selleck kinase inhibitor points proposed by Riegel et al (2002). (tyrosinekinases.com)

The inhibitory effect of cAMP could not be reversed by inhibition of cAMP-dependent protein kinase (PKA) but was blocked by depletion of the alternative intracellular cAMP sensor exchange protein activated by cAMP 1 (Epac1), which is also required to observe SOCS-3 accumulation in response to cAMP. (gla.ac.uk)

In general, Janus family tyrosine kinases (JAKs) bind to the intracellular components of cytokine receptors, and are, in turn, bound by STATs upon cytokine signaling. (medscape.com)
In recent years, the search for intracellular signaling integrator downstream of receptor tyrosine kinases provided valuable novel substrates. (springer.com)
Increased synthesis under pathological conditions makes Sprouty2 an attractive pharmacological target to enhance intracellular signaling activities, notably the ERK pathway, in affected neurons or activated astrocytes. (springer.com)
Protein tyrosine kinase 6 (PTK6, also called BRK) is a SRC-related intracellular tyrosine kinase expressed in normal epithelia and cancer. (oncotarget.com)
Glycans, either alone or complexed with glycan-binding proteins, can deliver intracellular signals or control extracellular processes that promote initiation, execution and resolution of cell death programs. (nature.com)
Activation of dCK shifts its substrate specificity toward deoxycytidine, increases intracellular dCTP pools post IR, and enhances the rate of DNA repair. (biomasswars.com)
Introduction Intracellular concentrations of deoxyribonucleotide triphosphates (dNTPs) are tightly regulated to avoid mutagenesis during DNA replication and repair [1]. (biomasswars.com)

Recently Cdk5 has emerged as an essential kinase in sensory pathways. (wikipedia.org)
Lyn, a tyrosine kinase that is activated by double-stranded DNA-damaging agents, is involved in various signaling pathways, such as proliferation, apoptosis, and DNA repair. (bmbreports.org)
It is found in proteins involved in several biological processes as diverse as signal transduction pathways, cytoskeleton organization, membrane traffic or organelle assembly. (eu.org)
What pathways are this gene/protein implicaed in? (cancerindex.org)
chimeric protein with a constitutive tyrosine kinase activity that activates cell cycle related pathways and induces the malignant proliferation of the chronic phase of CML. (cancer-pictures.org)
These receptors are responsible for activating key pathways in cancer cells that lead to their proliferation and survival. (wisc.edu)

The proto-oncogene designated erbB2 or HER2 encodes a 185-kilodalton transmembrane tyrosine kinase (p185erbB2), whose overexpression has been correlated with a poor prognosis in several human malignancies. (embl.de)
It encodes a highly conserved nuclear protein of 324 amino acids which belongs to a family of proteins containing a putative new zinc-finger. (shengsci.com)
It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. (cancerindex.org)

3).(TIF) pone.0104125.s003.tif (337K) GUID:?72E596CD-8491-42F1-8F9C-3C721423C727 Abstract Efficient and adequate generation of deoxyribonucleotides is critical to successful DNA repair. (biomasswars.com)

We recently demonstrated that abrogating Sprouty2 function strongly inhibits intracranial tumor growth and leads to significantly prolonged survival of glioblastoma bearing mice by induction of ERK-dependent DNA replication stress. (springer.com)
Protein Tyrosine kinase 6 (PTK6/BRK) is overexpressed in the majority of human breast tumors and breast tumor cell lines. (oncotarget.com)
The protein also has a role as an acute-phase protein and is active in the control of immunologic and inflammatory processes, and as a tumor marker. (lookformedical.com)
Using [18F]-FAC, a dCK-specific positron emission tomography (PET) probe, we visualized and quantified dCK activation in tumor xenografts after IR, indicating that dCK activation could serve as a biomarker for ATM function and DNA damage response in vivo. (biomasswars.com)
These results suggest the use of cell free DNA in plasma to assess EGFR mutation status may be a feasible alternative in those patients for whom a tumor biopsy cannot be obtained. (selectbiosciences.com)
I will describe the development and application of CAPP-Seq, a deep sequencing-based method for ultra-sensitive and specific detection of circulating tumor DNA that is broadly applicable. (selectbiosciences.com)

It first binds with high affinity to specific cell-surface receptors and then induces their dimerization, which is essential for activating the tyrosine kinase in the receptor cytoplasmic domain, initiating a signal transduction that results in DNA synthesis and cell proliferation. (embl.de)
Risperidone upregulates fatty acid synthase (FASN) and sterol regulatory element-binding protein 1 (SREBP1) expression in hepatocyte cultures and mouse liver by targeting the hepatic SREBP-1c/FASN couple, which is also one of the mechanisms by which risperidone induces weight gain ( 24 ). (frontiersin.org)

The adapter protein Slp65 and Bruton's tyrosine kinase (Btk) are key components of the precursor-B (pre-B) cell receptor (pre-BCR) signaling pathway. (eur.nl)
Deoxycytidine kinase (dCK) is usually a rate-limiting enzyme in the dN salvage pathway, capable of phosphorylating deoxycytidine (dC), deoxyadenosine (dA) and deoxyguanosine (dG) [3], [4]. (biomasswars.com)
In the developing male (XY) gonad, sex-determining region of the Y (SRY) protein acts to up-regulate expression of the related gene, SOX9 , a transcriptional regulator that in turn initiates a downstream pathway of testis development, whilst also suppressing ovary development. (plos.org)
Here we report a role for the phylogenetically ancient mitogen-activated protein kinase (MAPK) signalling pathway in mouse sex determination. (plos.org)
This mutant, which we called boygirl ( byg ), was shown to contain an early stop codon that disrupts the autosomal gene encoding MAP3K4, a component of the mitogen-activated protein kinase (MAPK) signaling pathway. (plos.org)

The mutations are predominantly missense and in-frame deletions that lead to production of proteins with dominant negative activity. (medscape.com)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
Most of the somatic EGFR gene mutations that are associated with lung cancer delete genetic material in a part of the gene known as exon 19 or change DNA building blocks (nucleotides) in another region called exon 21. (medlineplus.gov)
Lung cancers with EGFR gene mutations tend to respond to treatments that specifically target the overactive epidermal growth factor receptor protein that allows cancer cells to constantly grow and divide. (medlineplus.gov)
Tarceva is approved for first line use in NSCLC patents whose tumors have been shown to have activating mutations in the EGFR receptor, usually assessed with FFPE samples by PCR tests like the cobas® EGFR Mutation Test. (selectbiosciences.com)

To investigate the prevalence of EGFR overexpression, gene amplification and activating mutation in the tyrosine kinase domain in patients with ATC. (bmj.com)
The EGFR gene status and protein expression were investigated by direct DNA sequencing of the hot-spot regions in exons 18, 19 and 21, fluorescence in situ hybridisation (FISH), and immunohistochemistry in tumour tissues from 23 patients with ATC. (bmj.com)
Recently, we isolated a novel negative regulator of epidermal growth factor receptor (EGFR), termed EGFR-related protein (ERRP), whose expression attenuates EGFR activation. (aacrjournals.org)
The EGFR gene provides instructions for making a receptor protein called the epidermal growth factor receptor, which spans the cell membrane so that one end of the protein remains inside the cell and the other end projects from the outer surface of the cell. (medlineplus.gov)
The EGFR family: not so prototypical receptor tyrosine kinases. (medlineplus.gov)

8, 9] STAT3 is one of 7 human STAT (signal transducer and activator of transcription) proteins, which are critical second messengers for many cytokine, hormone, and growth factor receptors. (medscape.com)
Extracellular stimuli that activate cell surface receptors modulate glucocorticoid actions via as yet unclear mechanisms. (rupress.org)

Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase. (eu.org)
The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. (cancerindex.org)
ATM is usually a member of phosphoinositide 3-kinase (PI3K)-related protein kinase family, which also includes ataxia telangiectasia and Rad3-related protein (ATR) and catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) [23]. (biomasswars.com)

On the contrary, knockdown of Sprouty proteins increases proliferation of activated astrocytes and, consequently, reduces secondary brain damage in neuronal lesion models such as kainic acid-induced epilepsy or endothelin-induced ischemia. (springer.com)

A common feature of all EGF-like domains is that they are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase). (embl.de)
Various diverse extracellular proteins possess Ca(2+)-binding epidermal growth factor (EGF)-like domains, the function of which remains uncertain. (embl.de)
EGF-like domains in extracellular matrix proteins: localized signals for growth and differentiation? (embl.de)
Multidomain proteins of the extracellular matrix (ECM) play an important role in development and maintenance of cellular organization and in tissue repair. (embl.de)
Woolson, H. D. , Thomson, V. S. , Rutherford, C. , Yarwood, S. J. and Palmer, T. M. (2009) Selective inhibition of cytokine-activated extracellular signal-regulated kinase by cyclic amp via Epac1-dependent induction of suppressor of cytokine signalling-3. (gla.ac.uk)

In order to perform, Cdk5 needs to be activated by p35 (these 3 amino acids, Asp-259, Asn-266, and Ser-270, are involved in the formation of hydrogen bonds with Cdk5) or p39 (the isoform of p35), which are two of its neuron-specific regulatory subunits. (wikipedia.org)
The active full-length CRYAA protein corresponding to amino acids 1-173 of CRYAA was recombined. (molvis.org)

The binding of a ligand to epidermal growth factor receptor allows the receptor to attach to another nearby epidermal growth factor receptor protein (dimerize), turning on (activating) the receptor complex. (medlineplus.gov)

Moreover, we describe experiments showing the presence of activated MKK4, a direct target of MAP3K4, and activated p38 in the coelomic region of the XY gonad at 11.5 d post coitum, establishing a link between MAPK signalling in proliferating gonadal somatic cells and regulation of Sry expression. (plos.org)

Our previous study has shown that CCAAT-enhancer binding protein β (C/EBPβ) is an important regulator in METH-induced neuronal autophagy and apoptosis. (cancerindex.org)
The importance of STAT activation to growth control in experiments using anti-sense molecules or dominant negative STAT protein encoding constructs performed in cell lines or studies in animals lacking specific STATs strongly indicate that STATs play an important role in controlling cell cycle progression and apoptosis. (nih.gov)
Moreover, transfected cells were hypersusceptible to apoptosis when activated through the T cell receptor. (uaeu.ac.ae)

Therefore, binding with the activator is sufficient to activate the kinase. (wikipedia.org)
3.0: hematopoietic cell-specific Lyn substrate 1 (HCLS1), Kelch domain-containing 6 (KLHDC6), sarcoglycan delta (SGCD), KIAA1706 protein (KIAA1706), RNA guanylyltransferase and 5′-phosphatase (RNGTT), chromosome 10 open reading frame 57 (C10orf57), chromosome 9 open reading frame 52 (C9orf52), and plasminogen activator, urokinase receptor (PLAUR). (molvis.org)
Here we demonstrate that elevation of cyclic AMP (cAMP) levels in human umbilical vein endothelial cells (HUVECs) specifically attenuates ERK1,2 activation in response to either leptin or a soluble interleukin IL-6 receptor-α/IL-6 (sIL-6R-α/IL-6) trans-signalling complex but not protein kinase C activator phorbol 12-myristate 13-acetate. (gla.ac.uk)

Each of these effects was blocked by tyrosine kinase inhibition with genistein or herbimycin A. Similarly, antisense oligodeoxynucleotide targeting of ERK1/2 mRNA inhibited BK-stimulated DNA synthesis. (nih.gov)
In contrast, protein kinase C inhibition or depletion had no effect on BK-induced c-fos mRNA, AP-1-DNA binding activity, or DNA synthesis. (nih.gov)

Finally, in the context of many cancers, where STATs are frequently persistently activated, an understanding of the mechanisms leading to their constitutive activation and defining the potential importance of persistent STAT activation in human tumorigenesis remains. (nih.gov)

Cyclin-dependent kinase 5 is a protein, and more specifically an enzyme, that is encoded by the Cdk5 gene. (wikipedia.org)
Intrinsic brain RAS is an enzyme-neuropeptide system having functional components (angiotensinogen, peptidases, angiotensin, and specific receptor proteins) with important biological and neurobiological activities in the brain. (hindawi.com)
An enzyme that catalyzes the hydrolysis of proteins, including elastin. (lookformedical.com)
The enzyme breaks down elastin, the specific protein of elastic fibers, and digests other proteins such as fibrin, hemoglobin, and albumin. (lookformedical.com)

B) dCK kinase assay using CHOC6 nuclear ABT-888 (Veliparib) and cytoplasmic fraction lysates, [3H]-dC as substrate and performed 2 hours after exposure to 3 Gy (*, P? (biomasswars.com)
D) dCK kinase assay using L1210 nuclear and cytoplasmic fraction lysates, [3H]-dC as substrate and performed 2 hours after exposure to 3 Gy (*, P? (biomasswars.com)

Cdk5 is abundant and mainly expressed in neurons, where it phosphorylates protein polymers with a high molecular weight called neurofilaments, and microtubule-associated protein tau, which are abundant in the CNS (Central Nervous System). (wikipedia.org)
An in vitro immunocomplex kinase assay indicated that the rpS3 protein acts as a substrate for Lyn, which phosphorylates the Y167 residue of rpS3. (bmbreports.org)
Specifically, ATM phosphorylates and activates deoxycytidine kinase (dCK) at serine 74 in response to ionizing radiation (IR). (biomasswars.com)

Some investigations have reported that the active states of protein kinases structurally differ from each other in order to preserve the geometry of its machinery so that catalytic output works properly. (wikipedia.org)

Receptor dimerization and autophosphorylation attracts proteins containing Src homology 2 (SH2) or phosphotyrosine binding (PTB) domains including adaptor proteins like FRS2 and GRB2. (springer.com)
Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1. (eu.org)

In this report, we investigated whether Rag-induced DNA damage is involved in oncogenic transformation of Slp65-deficient B cells. (eur.nl)
When developing B cells in their bone marrow express this BCR, the V(D)J recombination machinery will be activated, allowing for secondary Ig light-chain gene rearrangements to occur. (eur.nl)
We also measured the levels of phosphorylated tuberous sclerosis complex 2 (TSC2) protein and Parkin protein level in SH-SY5Y cells. (cancerindex.org)
Monoclonal antibody therapy has been developed over the past 30 years to target receptor tyrosine kinases (RTKs), which sit on the outer membrane of cancerous cells. (wisc.edu)
A striking feature observed only in Lck- deficient T cells was the presence of a constitutively tyrosine- phosphorylated 32-kDa protein. (uaeu.ac.ae)
The transfectants were significantly larger than the parental cells and contained 4N DNA. (uaeu.ac.ae)
Both endogenous and enhanced green fluorescent protein (EGFP)-fused Gβ2 and Gγ2 proteins were detected in the nucleus at baseline, whereas a fraction of EGFP-Gβ2 and DsRed2-GR comigrated to the nucleus or the plasma membrane, depending on the exposure of cells to dexamethasone or somatostatin, respectively. (rupress.org)
Cytotoxic drugs damage DNA and kill many normal cells as well as cancer cells. (msdmanuals.com)
In contrast, other drugs (eg, DNA cross-linkers, also known as alkylating agents) have a linear dose-response relationship, killing more cancer cells at higher doses. (msdmanuals.com)

protein composed of uncontrolled TRK enzymes, which promote cancer growth. (curetoday.com)

On top of that, Cdk5 modulates actin-cytoskeleton dynamics by phosphorylating Pak1 and filamin 1 and regulates the microtubules by also phosphorylating tau, MAP1B, doublecortin, Nudel, and CRMPs, which are all microtubule-associated proteins. (wikipedia.org)

A sequence of about thirty to forty amino-acid residues long found in the sequence of epidermal growth factor (EGF) has been shown [ ( PUBMED:2288911 ) ( PUBMED:6334307 ) ( PUBMED:6607417 ) ( PUBMED:3282918 ) ] to be present, in a more or less conserved form, in a large number of other, mostly animal proteins. (embl.de)
The structure of a Ca(2+)-binding epidermal growth factor-like domain: its role in protein-protein interactions. (embl.de)
Several complementary DNA clones encoding related HRGs were identified, all of which are similar to proteins in the epidermal growth factor family. (embl.de)
Several ECM proteins such as laminin, tenascin and thrombospondin contain domains with homology to epidermal growth factor (EGF) and exhibit growth promoting activity. (embl.de)

However, over recent years, it became clear that RTKs cannot be sufficiently activated by growth factors or receptor agonists in the adult and aging brain to exert significant neuroprotective or neurorestorative effects. (springer.com)

Since the protein lacks enzymatic activities, it will be difficult to develop chemical compounds capable to directly and specifically modulate Sprouty functions. (springer.com)

2009 - 2011 Analysis of aberrantly activated receptor tyrosine kinase and development of molecular targeting therapy in small animals with malignancies. (go.jp)
In the present study, we provide evidence that this aberrantly hyperphosphorylated protein is p34(cat2) (cdc2) a key regulator of cell-cycle progression. (uaeu.ac.ae)

Tau interacts with src-family non-receptor tyrosine kinases. (eu.org)

Ribosomal protein S3 is a protein component of the ribosome, which is a cellular structure that plays a central role in protein synthesis. (bmbreports.org)
At that time, glycobiology, which is the study of carbohydrates and their recognition by motif-specific carbohydrate-binding proteins or lectins, lagged far behind the studies that defined the structural and cellular biology of cell death. (nature.com)
In contrast, in many cancerous cell lines and tumors, where growth factor dysregulation is frequently at the heart of cellular transformation, the STAT proteins (in particular Stats 1, 3 and 5) are persistently tyrosine phosphorylated or activated. (nih.gov)

These gene changes result in a receptor protein that is constantly turned on (constitutively activated), even when it is not bound to a ligand. (medlineplus.gov)

Ubiquitylation describes the covalent attachment of a small 76-amino acid protein, ubiquitin, to other proteins. (ddw-online.com)

The STAT proteins (Signal Transducers and Activators of Transcription), were identified in the last decade as transcription factors which were critical in mediating virtually all cytokine driven signaling. (nih.gov)

A member of the serpin family of proteins that is found in plasma and urine. (lookformedical.com)

Philips and Felix [ 4 ] proved the presence of Ang II-activated neurons in the brain and subfornical organs [ 4 ]. (hindawi.com)

Immunoblots using antibodies specific for ERK or tyrosine-phosphorylated ERK revealed a shifting of p42 ERK2 to a higher molecular weight that correlated temporally with an increase in tyrosine-phosphorylated ERK2. (nih.gov)
My laboratory is focused on understanding mechanisms of resistance to molecular targeting agents directed against receptor tyrosine kinases. (wisc.edu)

Ribosomal protein S3 (RpS3) is involved in protein biosynthesis as a component of the ribosome complex and possesses endonuclease activity to repair damaged DNA. (bmbreports.org)

2.5M) GUID:?208A859C-1A0A-4CCB-9C9A-37A0559DBF74 Physique S3: dCK is localized and activated after IR in the cytoplasm. (biomasswars.com)

We detected PTK6 mRNA and protein expression in the immortalized normal MCF-10A human mammary gland epithelial cell line, and examined PTK6 expression and activation in a normal human breast tissue microarray, as well as in human breast tumors. (oncotarget.com)

Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold. (eu.org)

The initial one was the immune-activating drug Keytruda (pembrolizumab), approved for patients with solid tumors characterized as microsatellite instability (MSI)-high or mismatch repair deficient. (curetoday.com)
Tumors with these genetic abnormalities have trouble repairing their own DNA when it's damaged. (curetoday.com)

Activation of rat c-raf during transfection of hepatocellular carcinoma DNA. (wikidata.org)
This activation results in either arrest of the cell cycle in phase G1 or apoptotic cell death, both of which are dependent on the kinase activity of c-Abl. (shengsci.com)
Understanding consequences of PTK6 activation at the plasma membrane may have implications for developing novel targeted therapies against this kinase. (oncotarget.com)

Serum proteins that inhibit, antagonize, or inactivate COMPLEMENT C1 or its subunits. (lookformedical.com)

Even though Cdk5 has a similar structure to other cyclin-dependent kinases, its activators are highly specific (CDK5R1 and CDK5R2). (wikipedia.org)

Functional annotation clustering showed that they belong to cell cycle, organelle or nuclear lumen, protein transport, and DNA binding and repair clusters. (molvis.org)

Anatomy17

Organisms8

Diseases1

Chemicals and Drugs174

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes38

Disciplines and Occupations1

Information Science3

Phosphorylation17

Mitogen-activa2

Inhibitors3

Genes11

Inhibitor1

CAMP-depend1

Intracellular7

Pathways6

Encodes3

Abstract1

Tumor6

Induces2

Pathway5

Mutations5

EGFR5

Receptors2

Subunit3

Proliferation1

Extracellular5

Amino acids2

Growth factor r1

MAPK1

Apoptosis3

Activator3

Inhibition2

Constitutive1

Enzyme4

Cytoplasmic2

Phosphorylates3

Catalytic1

GRB22

Cells9

Enzymes1

Regulates1

Epidermal4

RTKs1

Specifically1

Aberrantly2

Interacts1

Cellular3

Receptor protein1

Ubiquitin1

Transcription1

Family of proteins1

Neurons1

Molecular2

Biosynthesis1

Cytoplasm1

MRNA1

Actin1

Tumors2

Activation3

Inhibit1

Activators1

Nuclear1