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  • inhibit
  • The present invention relates to compounds of the Formula I, the pharmaceutically acceptable salts and stereoisomers thereof, which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent. (google.com)
  • The development of the so-called "targeted therapies", particularly those drugs that inhibit the activity of tyrosine kinases, has become a remarkable progress in the treatment of neoplastic diseases. (rti.org)
  • Compounds have been developed to selectively inhibit the tyrosine kinase. (wikipedia.org)
  • Due to increasing resistance and intolerance to imatinib efforts were made to develop new drugs that could inhibit the Bcr-Abl tyrosine kinase. (wikipedia.org)
  • 1993
  • HM71224 for autoimmune diseases, under development by Hanmi Pharmaceutical and Lilly as of 2015 Bruton's tyrosine kinase was discovered in 1993 and is named for Ogden Bruton, who first described XLA in 1952. (wikipedia.org)
  • regulation
  • QIAGEN provides a broad range of assay technologies for tyrosine kinase research that enable analysis of gene expression and regulation, epigenetic modification, and signal transduction pathway activation. (qiagen.com)
  • Studying tyrosine kinase expression and regulation in an experimental model system can yield new insights into their role in normal biological and pathophysiological processes. (qiagen.com)
  • Novel regulation and function of Src tyrosine kinase. (uniprot.org)
  • Non-receptor tyrosine kinases regulate cell growth, proliferation, differentiation, adhesion, migration and apoptosis, and they are critical components in the regulation of the immune system. (wikipedia.org)
  • KTIMs are speculated to play a regulatory role in the negative regulation of many kinases in addition to IRAK-1, and can thus represent a novel regulatory mechanism in a wide range of cellular kinases. (wikipedia.org)
  • This Non-receptor tyrosine-protein kinase plays an important role in the regulation of cell growth, differentiation, migration and immune response. (wikipedia.org)
  • c-Src stands for "cellular Src kinase" and should not be confused with "C-terminal Src kinase" (CSK) which is an enzyme which phosphorylates c-Src at its C-terminus and provides negative regulation of Src's enzymatic activity. (wikipedia.org)
  • molecule
  • An isolated nucleic acid molecule encoding a novel human receptor type tyrosine kinase gene, KDR, is disclosed. (google.es)
  • The term kinase describes a large family of enzymes that are responsible for catalyzing the transfer of a phosphoryl group from a nucleoside triphosphate donor, such as ATP, to an acceptor molecule. (wikipedia.org)
  • Association of 75/80-kDa phosphoproteins and the tyrosine kinases Lyn, Fyn, and Lck with the B cell molecule CD20. (wikipedia.org)
  • FMS-like tyrosine kinase 3 ligand (FLT3L) is an endogenous small molecule that functions as a cytokine and growth factor that increases the number of immune cells (lymphocytes (B cells and T cells)) by activating the hematopoietic progenitors. (wikipedia.org)
  • enzymes
  • The enzymes fall into two broad classes, characterised with respect to substrate specificity: serine/threonine-specific, and tyrosine-specific (the subject of this article). (wikipedia.org)
  • binds
  • DASATINIB: binds both the open and closed configuration of BCR-ABL kinase. (slideshare.net)
  • Since then crystallographic studies have revealed that imatinib binds to the kinase domain of Abl only when the domain adopts the inactive or "closed" conformation. (wikipedia.org)
  • sFlt-1 (soluble fms-like tyrosine kinase-1 - also known as soluble VEGF receptor-1) binds and reduces free circulating levels of the proangiogenic factors VEGF (vascular endothelial growth factor) and PlGF (placental growth factor). (wikipedia.org)
  • ligand
  • These isoforms vary in their ligand binding properties and kinase domains, however all share a common extracellular region composed of three immunoglobulin (Ig) like domains (D1-D3), and thus belong to the immunoglobulin superfamily . (wikidoc.org)
  • homologous kinase
  • Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation. (nih.gov)
  • Csk homologous kinase (CHK), unlike Csk, enhances MAPK activation via Ras-mediated signaling in a Src-independent manner. (nih.gov)
  • Differential expression of Csk homologous kinase (CHK) in normal brain and brain tumors. (nih.gov)
  • inhibitory
  • The term Kinase tyrosine-based inhibitory motif (KTIM) was coined by a group of immunology researchers from McGill University, Montreal, Quebec, Canada in 2008 to represent any immunoreceptor tyrosine-based inhibitory-like sequence motif, with the consensus sequence I/V/L/SxYxxL/V, found in a kinase and regulating its activity. (wikipedia.org)