TryptophanDopamineHydroxylase mRNAMRNANeuronsKinaseCatecholaminesRatsSubstantiaStriatumLocusNeurotoxicityEnzymeRegulationSource:HGNC SymbolBelongsDexamethasoneInductionActivityTreatmentTryptophan 5-monooxygenaPhenylalanine-4-hydroxylaseMetabolism2023DystoniaAmino acidProteinsCatecholamineSynthesisMolecularBrainCatalyzes the conversionSpecificityInvolvementHumanSymbolMonoclonalConversionMeSHMarkerHomeobox
Tryptophan4
- Rabbit polyclonal antibody recognizes the middle region of YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide) protein. (fishersci.com)
- CRISPR KO of ywhaz (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta). (xenbase.org)
- Snow AJ, Puri P, Acker-Palmer A, Bouwmeester T, Vijayaraghavan S, Kline D. Phosphorylation-dependent interaction of tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein (YWHA) with PADI6 following oocyte maturation in mice.Biol Reprod. (kent.edu)
- The most well-established human function of tetrahydrobiopterin (BH4) is as the cofactor for phenylalanine-4-hydroxylase (PAH), tyrosine-3-hydroxylase, and tryptophan-5-hydroxylase. (medscape.com)
Dopamine2
- Effects of (R)-ketamine, (S)-ketamine, and their metabolites on MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-induced reduction of dopamine transporter (DAT) and tyrosine hydroxylase (TH) in the mouse striatum and substantia nigra (SNr) were examined. (unboundmedicine.com)
- Changes in striatal dopamine (DA) neurochemistry, tyrosine hydroxylase immunocytochemistry of DA fibers, and behavior following the combined administration of diethyldithiocarbamate (DDC) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to mice were assessed. (uky.edu)
Hydroxylase mRNA7
- cAMP-mediated stimulation of tyrosine hydroxylase mRNA translation is mediated by polypyrimidine-rich sequences within its 3'-untranslated region and poly(C)-binding protein 2. (rochester.edu)
- Induction of tyrosine hydroxylase mRNA by nicotine in rat midbrain is inhibited by mifepristone. (rochester.edu)
- Activation of tyrosine hydroxylase mRNA translation by cAMP in midbrain dopaminergic neurons. (rochester.edu)
- Evidence for regulation of tyrosine hydroxylase mRNA translation by stress in rat adrenal medulla. (rochester.edu)
- Scholars@Duke publication: Regulation of tyrosine hydroxylase mRNA by glucocorticoid and cyclic AMP in a rat pheochromocytoma cell line. (duke.edu)
- Isolation of a cDNA clone for tyrosine hydroxylase mRNA. (duke.edu)
- Treatment of a subclone of the PC12 pheochromocytoma cell line, PC8b, with either dexamethasone or 8-bromo cyclic AMP resulted in increased translational activity of tyrosine hydroxylase mRNA (mRNATH). (duke.edu)
MRNA2
- Quantitative-real time-reverse transcription PCR (Q-RT-PCR) is widely used and is a sensitive and robust technique for the detection and quantification of often rare mRNA targets [ 3 ]. (biomedcentral.com)
- DE caused upregulation (3 to 5-fold) of mRNA transcripts for matrix metalloproteinase 9 (Mmp9), claudins (Cldn1 and Cldn2), and Gfap (1.6-fold) in the OB, suggestive of altered blood-brain barrier integrity and reactive gliosis. (cdc.gov)
Neurons3
- Hence, in this study, the concentrations of tyrosine hydroxylase (TH), choline acetyl transferase (ChAT) and glutamic acid decarboxylase (GAD), the enzymes responsible for their synthesis, were immunohistochemically estimated within the neurons in locus coeruleus, laterodorsal tegmentum and pedunculopontine tegmentum and medial preoptic area in REM sleep deprived and control rats. (nih.gov)
- Chronic nicotine treatment leads to induction of tyrosine hydroxylase in locus ceruleus neurons: the role of transcriptional activation. (rochester.edu)
- Immunocytochemistry and in situ hybridization for tyrosine hydroxylase (TH) were used to study the distribution of putative catecholaminergic neurons in the basal forebrain magnocellular complex (BFMC) of monkeys and humans. (johnshopkins.edu)
Kinase2
- Other names in common use include pheochromocytoma tyrosine hydroxylase-associated kinase, STK4, and tyrosine 3-monooxygenase kinase (phosphorylating). (wikipedia.org)
- Protein regulators of this enzyme include inhibitors I2 (PPP1R2) and I3 (PPP1R11), sds22 (PPP1R7), protein 14-3-3 and a protein kinase, glycogen synthase kinase 3 (GSK-3). (kent.edu)
Catecholamines1
- To investigate origin, cellular localization, and functional significance of pineal catecholamines, we performed HPLC-analysis of catecholamines and tyrosine hydroxylase (TH) activity, as well as immunocytochemical and electrophysiological studies. (birmingham.ac.uk)
Rats1
- We have investigated the effects of the supranigral administration of lipopolysaccharide on iNOS-immunoreactivity, 3-nitrotyrosine formation and tyrosine hydroxylase-immunoreactive neuronal number, and retrogradely labelled fluorogold-positive neurones in the ventral mesencephalon in male Wistar rats. (herts.ac.uk)
Substantia3
- There were also significant reductions in the number of tyrosine hydroxylase(50-60%)- and fluorogold (65-75%)-positive neurones in the substantia nigra. (herts.ac.uk)
- Similar reduction of tyrosine hydroxylase-immunoreactivity and fluorogold-labelled neurotics in the substantia nigra following lipopolysaccharide administration suggests dopaminergic cell death rather than down-regulation of tyrosine hydroxylase. (herts.ac.uk)
- Tyrosine hydroxylase immunocytochemistry revealed large deafferentation of DA terminal regions in striatum, moderate reductions in nucleus accumbens and dendritic regions of substantia nigra, and slight reductions in the number of DA cell bodies in substantia nigra. (uky.edu)
Striatum1
- AIM: To study the mechanism of K+ depolarization-induced activation of synaptosomal tyrosine 3-monooxygenase (TM) in rat striatum and the effect of (-)-stepholidine (SPD) on this activation. (chinaphar.com)
Locus1
- Induction of tyrosine hydroxylase in the locus coeruleus of transgenic mice in response to stress or nicotine treatment: lack of activation of tyrosine hydroxylase promoter activity. (rochester.edu)
Neurotoxicity1
- 3 h/d × 10 d) and humanely euthanized after 7 d for neurotoxicity assessments. (cdc.gov)
Enzyme2
- The systematic name of this enzyme class is ATP:[tyrosine-3-monoxygenase] phosphotransferase. (wikipedia.org)
- Following treatment of cells with inducers, the temporal increase in tyrosine hydroxylase enzyme activity was associated in all cases with an increase in the translational activity and relative amount of mRNATH, and the fold increase in the latter two parameters was equal to or greater than the increase in enzyme activity. (duke.edu)
Regulation1
- Post-transcriptional regulation of tyrosine hydroxylase expression in adrenal medulla and brain. (rochester.edu)
Source:HGNC Symbol2
- adducin 3 [Source:HGNC Symbol;Acc:H. (gsea-msigdb.org)
- desmocollin 3 [Source:HGNC Symbol;A. (gsea-msigdb.org)
Belongs2
- YWHAQ belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. (avivasysbio.com)
- This gene is upregulated in patients with amyotrophic lateral sclerosis.This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. (avivasysbio.com)
Dexamethasone1
- PC8b cells treated with either dexamethasone or 8-bromo cyclic AMP yielded greater mRNATH hybridization on Northern blot analysis and accumulated higher molecular weight tyrosine hydroxylase RNA species. (duke.edu)
Induction2
- We conclude that the expression of iNOS- and 3-nitrotyrosine-immunoreactivity and reduction of cell death by S-methylisothiourea suggest the effects of lipopolysaccharide may be nitric oxide-mediated, although other actions of lipopolysaccharide (independent of iNOS induction) cannot be ruled out. (herts.ac.uk)
- Regional hepatic CYP1A1 and CYP1A2 induction with 2,3,7,8-tetrachlorodibenzo- p -dioxin evaluated with a multicompartment geometric model of hepatic zonation. (cdc.gov)
Activity3
- The delayed growth of LBW piglets is mainly due to a slower development of skeletal muscle as the myogenic activity is usually impaired in these animals during the fetal and early postnatal period 3 , 4 . (nature.com)
- Changes in the activity of PP1g2 and GSK-3 are key events in sperm motility development. (kent.edu)
- 2,3,7,8-Tetrachlorodibenzo- p -dioxin as an antiestrogen: Effect on rat uterine peroxidase activity. (cdc.gov)
Treatment1
- Nicotinic and muscarinic acetylcholine receptors are essential for the long-term response of tyrosine hydroxylase gene expression to chronic nicotine treatment in rat adrenal medulla. (rochester.edu)
Tryptophan 5-monooxygena3
- Description: A sandwich quantitative ELISA assay kit for detection of Rat Tyrosine 3/Tryptophan 5 Monooxygenase Activation Protein Zeta (YWHAz) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids. (antibody-tech.com)
- Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein. (cdc.gov)
- 26. Inhibition of Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta (YWHAZ) Overcomes Drug Resistance and Tumorigenicity in Ovarian Cancer. (nih.gov)
Phenylalanine-4-hydroxylase1
- The most well-established human function of tetrahydrobiopterin (BH4) is as the cofactor for phenylalanine-4-hydroxylase (PAH), tyrosine-3-hydroxylase, and tryptophan-5-hydroxylase. (medscape.com)
Metabolism1
20231
- 242(Pt 3): 124873, 2023 Jul 01. (bvsalud.org)
Dystonia5
- Dopa-responsive dystonia (described above) is sometimes considered a mild form of tyrosine hydroxylase deficiency. (medlineplus.gov)
- Furukawa Y, Kish SJ, Fahn S. Dopa-responsive dystonia due to mild tyrosine hydroxylase deficiency. (medlineplus.gov)
- Tyrosine hydroxylase deficiency causes progressive encephalopathy and dopa-nonresponsive dystonia. (medlineplus.gov)
- A common point mutation in the tyrosine hydroxylase gene in autosomal recessive L-DOPA-responsive dystonia in the Dutch population. (drugbank.com)
- This report concerns one new mutation in the tyrosine hydroxylase (TH) gene in three patients originating from three unrelated Dutch families with autosomal recessive L-DOPA-responsive dystonia (DRD). (drugbank.com)
Amino acid1
- Phenylalanine hydroxylase is responsible for the conversion of phenylalanine to another amino acid, tyrosine. (nih.gov)
Proteins9
- The 14-3-3zeta and 14-3-3epsilon isoforms were isolated in a two-hybrid screen for proteins interacting with the N-terminal regulatory domain of MEKK3. (nih.gov)
- 14-3-3 proteins also interacted with MEKK1 and MEKK2, but not MEKK4. (nih.gov)
- MEKK1 and 14-3-3 proteins colocalized using two-color digital confocal immunofluorescence. (nih.gov)
- Binding of 14-3-3 proteins mapped to the N-terminal 393 residues of 196-kDa MEKK1. (nih.gov)
- With regard to MEKK1, -2 and -3, 14-3-3 proteins do not appear to directly influence activity, but rather function as "scaffolds" for protein-protein interactions. (nih.gov)
- 14-3-3 proteins in pineal photoneuroendocrine transduction: how many roles? (nih.gov)
- Recent studies suggest that a common theme links the diverse elements of pineal photoneuroendocrine transduction--regulation via binding to 14-3-3 proteins. (nih.gov)
- We review general aspects of 14-3-3 proteins and their biological function as binding partners, and also focus on their roles in pineal photoneuroendocrine transduction. (nih.gov)
- 14-3-3 Proteins and photoneuroendocrine transduction: role in controlling the daily rhythm in melatonin. (nih.gov)
Catecholamine1
Synthesis1
- Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis. (nih.gov)
Molecular1
- Investigate biochemistry and molecular biology of related beta-carotene monooxygenases. (nih.gov)
Brain2
- DE caused upregulation (3 to 5-fold) of mRNA transcripts for matrix metalloproteinase 9 (Mmp9), claudins (Cldn1 and Cldn2), and Gfap (1.6-fold) in the OB, suggestive of altered blood-brain barrier integrity and reactive gliosis. (cdc.gov)
- Brain , 143 (3), 960-975. (elsevierpure.com)
Catalyzes the conversion1
- Specifically, this enzyme catalyzes the conversion of SQUALENE to (S)-squalene-2,3-epoxide. (uchicago.edu)
Specificity1
- This antibody has specificity for Mouse TH/Tyrosine Hydroxylase. (thermofisher.com)
Involvement1
Human4
- Here, we present a comparative analysis of the human, mouse, rat and dog genomes to create a systematic catalogue of common regulatory motifs in promoters and 3' untranslated regions (3' UTRs). (gsea-msigdb.org)
- Recognizes human 14-3-3 beta, alpha. (monclonals.com)
- Research additional functions of -carotene monooxygenases for regulation of xanthophylls levels in the human macula.Mentor junior staff in the laboratory. (nih.gov)
- Description: A competitive ELISA for quantitative measurement of Human Mothers against decapentaplegic homolog 3(SMAD3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (antibody-tech.com)
Symbol1
- epsin 3 [Source:HGNC Symbol;Acc:HG. (gsea-msigdb.org)
Monoclonal2
- The following product was used in this experiment: Tyrosine Hydroxylase Recombinant Rabbit Monoclonal Antibody (1) from Thermo Fisher Scientific, catalog # MA5-29830, RRID AB_2785650. (thermofisher.com)
- Western Blot using Tyrosine Hydroxylase Recombinant Rabbit Monoclonal Antibody (1) (Product # MA5-29830) at 1:500 dilution. (thermofisher.com)
Conversion1
- TH is also responsible for the conversion of L-tyrosine to L-dopa. (thermofisher.com)
MeSH1
- Squalene Monooxygenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
Marker1
- CD68 and lysozyme expression (tumor tissue markers) changed from negative and weakly positive to strongly positive, AE1/3 expression (epithelial marker) changed from negative to positive, and CD34, CD4, CD43, and CD56 expression (common in naive hematopoietic cell-derived tumors) was greatly attenuated. (bvsalud.org)
Homeobox2
- zinc finger homeobox 3 [Source:HGN. (gsea-msigdb.org)
- iroquois homeobox 3, op. (gsea-msigdb.org)