• Consequently, amino acid variations through changing the type of residues of the target sites or key flanking residues could directly or indirectly influence PTM of protein and bring about a detrimental effect on protein function. (deepdyve.com)
  • A protein modification that effectively converts a source amino acid residue to L-lysine. (reactome.org)
  • Tyrosine protein kinases belonging to the Btk/Itk/Tec subfamily. (embl.de)
  • Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. (drugbank.com)
  • PAPbeta, a protein that binds to and is phosphorylated by the non-receptor tyrosine kinase PYK2, contains several modular signaling domains including a pleckstrin homology domain, an SH3 domain, ankyrin repeats and an ARF-GAP domain. (embl.de)
  • BDNF cDNA encodes a 247 amino acid residue precursor protein with a signal peptide and a proprotein that are cleaved to yield the 119 amino acid residue mature BDNF. (novusbio.com)
  • At the center of protein-protein interactions are the binding surfaces, or interfacial residues which form contacts between binding partners and stabilize protein complexes. (biomedcentral.com)
  • c-Src (cellular Src), encoded by Src gene, is a non-receptor tyrosine kinase first isolated as the normal cellular homolog to the potent avian sarcoma viral transforming oncogene v-Src [ 4 ]. (intechopen.com)
  • Here, we show that plexin-B family members stably associate with the receptor tyrosine kinase ErbB-2. (rupress.org)
  • CD79a has several cysteine residues, one of which forms covalent bonds with CD79b. (wikipedia.org)
  • All neurotrophins have six conserved cysteine residues that are involved in the formation of three disulfide bonds and all share approximately 55% sequence identity at the amino acid level. (novusbio.com)
  • The PP-fold family comprises neuropeptide Y (NPY), peptide YY (PYY), and pancreatic polypeptide (PP). They are composed of a chain of 36 amino acids residue and share amino acid homology, amidated C-terminal ends. (hindawi.com)
  • The BTK gene is large and consists of 19 exons that encode the 659 amino acids that form the Btk cytosolic tyrosine kinase. (medscape.com)
  • The CD79a ITAM tyrosines (human CD79a Tyr188 and Tyr199, mouse CD79a Tyr182 and Tyr193) phosphorylated in response to BCR crosslinking, are critical for binding of Src-homology 2 domain-containing kinases such as spleen tyrosine kinase (Syk) and signal transduction by CD79a. (wikipedia.org)
  • Bruton's tyrosine kinase (Btk) is a member of the Tec family of kinases. (medscape.com)
  • In vivo, the CD79a ITAM tyrosines synergize with the CD79b ITAM tyrosines to mediate the transition from the pro to the pre B cell stage as suggested by the analysis of mice with targeted mutations of the CD79a and CD79b ITAM. (wikipedia.org)
  • Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. (embl.de)
  • These viruses showed a specifi c effective against recent ORVs, but continuous surveillance NA mutation with a histidine-to-tyrosine substitution at the remains necessary. (cdc.gov)
  • There are no totally invariant residues within the PH domain. (embl.de)
  • An invariant arginine and several nearby hydrophobic residues are solvent exposed and are predicted to be the site of interaction with ARFs. (embl.de)
  • This disorder is now formally referred to as X-linked agammaglobulinemia (XLA), and the gene defect has been mapped to the gene that codes for Bruton tyrosine kinase (Btk) at band Xq21.3. (medscape.com)
  • The CD79a cytoplasmic domain further contains a non-ITAM tyrosine distal of the CD79a ITAM (human CD79a Tyr210, mouse CD79a Tyr204) that can bind BLNK and Nck once phosphorylated, and is critical for BCR mediated B cell proliferation and B1 cell development. (wikipedia.org)
  • With centrality measures such as betweenness centrality, degree centrality, and closeness centrality, we observed a few important residues that significantly contribute to the conformational change of c-Src tyrosine kinase for the different time steps. (intechopen.com)
  • Berlett BS, Levine RL, Stadtman ER(1996) Comparison of the effects of ozone on the modification of amino acid residues in glutamine synthetase and bovine serum albumin. (malque.pub)
  • The currently available implementation for this method initially defines interfacial residues using atomic details, and then uses positions of the Cα atoms for structural alignment and scoring, and includes a sequence-order dependent version [ 10 ] and a sequence-order independent version [ 11 ]. (biomedcentral.com)
  • Site-directed mutagenesis of these residues confirms their importance in ARF-GAP activity. (embl.de)
  • However, the presence of both the CD79a and CD79b ITAM tyrosines were required for normal T cell dependent antibody responses. (wikipedia.org)
  • c-Src tyrosine kinase consists of the N-terminal unique region, the Src homology 3 (SH3), SH2, linker, kinase domain, and the regulatory C-terminal tail. (intechopen.com)
  • To investigate the conformational change of c-Src tyrosine kinase, we applied network analysis to time series of correlation among residues. (intechopen.com)
  • STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. (nih.gov)
  • While all Nek kinases strongly select for hydrophobic residues in the -3 position, the family separates into four distinct groups based on specificity for a serine versus threonine phospho-acceptor, and preference for basic or acidic residues in other positions. (creixell-lab.com)
  • Unlike Nek1-Nek9, Nek10 is a dual-specificity kinase that efficiently phosphorylates itself and peptide substrates on serine and tyrosine, and its activity is enhanced by tyrosine auto-phosphorylation. (creixell-lab.com)
  • Nek10 dual-specificity depends on residues in the HRD+2 and APE-4 positions that are uncommon in either serine/threonine or tyrosine kinases. (creixell-lab.com)
  • The most well-characterized protein kinases in the human genome are protein serine/threonine kinases and protein tyrosine kinases ( Methods Enzymol 200 (1991)">2 ). (cancerdiagnosisprognosis.org)
  • Previous studies have identified the contribution of several activated tyrosine or serine/threonine kinases to growth compensation upon PI3K inhibition ( Otorhinolaryngol Head Neck Surg 1(2) (2016)">8 - Oncogene 30(22) (2011)">10 ). (cancerdiagnosisprognosis.org)
  • An invariant arginine and several nearby hydrophobic residues are solvent exposed and are predicted to be the site of interaction with ARFs. (embl.de)
  • There is an abundance of evidence*" that sug- gests that this effect is due to hydrogen bonds between tyrosine hydroxyl groups and carboxylate groupings. (nih.gov)
  • Tyrosine sulfation, a posttranslational modification involved in the processing of secretory proteins, is the covalent attachment of sulfate to the hydroxyl group of the tyrosyl residues in peptides and proteins. (ijbs.com)
  • J Cell Biol (2000) 151 (1): 187-198. (rupress.org)
  • 2000. Monitoring methyl parathion residues in milk and yogurt, and fate of [14C] methyl parathion during milk processing. (cdc.gov)
  • The RA3-6B2 monoclonal antibody specifically binds to an epitope on the extracellular domain of the transmembrane CD45 glycoprotein which is dependent upon the expression of exon A and specific carbohydrate residues. (bdbiosciences.com)
  • The CD79a cytoplasmic domain further contains a non-ITAM tyrosine distal of the CD79a ITAM (human CD79a Tyr210, mouse CD79a Tyr204) that can bind BLNK and Nck once phosphorylated, and is critical for BCR mediated B cell proliferation and B1 cell development. (wikipedia.org)
  • However, the presence of both the CD79a and CD79b ITAM tyrosines were required for normal T cell dependent antibody responses. (wikipedia.org)
  • Rigidly folded proteins can be solved in high-resolution crystal, cryo-EM or NMR structures that can be described by a simplified hierarchy of elements of increasing length from primary structure (sequence of single amino acid) over secondary structure elements (α-helices and β strands of ~10 residues) to tertiary structure (folded domains of ~100 residues) and quaternary structures (i.e. assemblies of several folded proteins). (nature.com)
  • In vivo, the CD79a ITAM tyrosines synergize with the CD79b ITAM tyrosines to mediate the transition from the pro to the pre B cell stage as suggested by the analysis of mice with targeted mutations of the CD79a and CD79b ITAM. (wikipedia.org)
  • In M31 hybridoma cell line, tyrosine sulfation has been shown to serve as a signal for the secretion of IgG [ 13 ]. (ijbs.com)
  • FIG. 4 depicts GFP + photoreceptor cells per million retinal cells as counted by flow cytometry, following transduction by 7M8 or by 7M8 bearing 4 tyrosine mutations (7m8.4YF). (justia.com)
  • Tks5 is a substrate of the tyrosine kinase Src and is required for the organization of podosomes/invadopodia implicated in invasion of tumor cells. (biomedcentral.com)
  • Shift of ultraviolet spectrum of native ribonuclease to that of the total acid hydrolyzate, whereby the maximum of the "tyrosine" peak moves 15 A toward the ultraviolet and de- creases in extinction. (nih.gov)
  • A java script ( SecStrucComparison.jar ) was written which counts the number of matches between two sequences and the total number of residues. (tu-muenchen.de)