Typically human genome interspersed repetitive sequences. Medical search. Frequent questions

The increasing accessibility of whole-genome sequencing across research and clinical settings has improved our ability to predict antibacterial susceptibility, to track epidemics at the level of individual outbreaks and wider historical trends, to query the efficacy of the bacille Calmette-Guérin (BCG) vaccine, and to uncover targets for novel antitubercular therapeutics. (jci.org)
Whole-genome sequencing (WGS) of M. tuberculosis and related mycobacteria is now routine, allowing comparisons across time and space. (jci.org)
In contrast, whole genome sequencing offers sensitive views of the genetic differences between strains ofM. (9lib.org)
tuberculosis strains in whole genome sequencing data. (9lib.org)
Whole genome comparative platforms within a genus are still in their infancy, with the most notable exception being the generation of whole genome shotgun assemblies of 12 Drosophila species that span an evolutionary time frame of approximately 60 million years [ 16 ]. (biomedcentral.com)
A total of 258.8 gigabases (Gb) of raw reads from whole-genome sequencing of the crab were generated by the Illumina HiSeq2000 platform. (biomedcentral.com)
We used the whole-genome shotgun sequencing strategy and constructed the subsequent short-insert libraries (170, 250, 500 and 800 bp) and long-insert libraries (2, 5, and 10 kb) using the standard protocol provided by Illumina (San Diego, USA). (biomedcentral.com)
In this study, the Illumina HiSeq 4000 and PacBio platforms were used to sequence and assemble the whole genome of Fusarium equiseti D25-1. (researchsquare.com)
F. equiseti was most closely related to Fusarium pseudograminearum based on a phylogenetic analysis at the whole-genome level. (researchsquare.com)
Our comprehensive analysis of the whole genome of F. equiseti provides basic data for studies of gene expression, regulatory and functional mechanisms, evolutionary processes, as well as disease prevention and control. (researchsquare.com)
Advances in whole-genome sequencing technologies have enabled numerous key discoveries. (researchsquare.com)

The nuclear genome includes protein-coding genes and non-coding genes, other functional regions of the genome such as regulatory sequences (see non-coding DNA), and often a substantial fraction of junk DNA with no evident function. (wikipedia.org)
That discovery launched scientists' ability to tease information out of our genes and would transform our understanding of human health and disease. (stjude.org)
Nautilus shows a compact, minimalist genome with few encoding genes and slow evolutionary rates in both non-coding and coding regions among known cephalopods. (nature.com)
We then used the identified variants to construct a strain-specific CD-1 reference genome, and associated annotation files, including genes and the full set of identified CD-1 variants. (biomedcentral.com)
Sequences of DNA in the genes that are located between the EXONS. (lookformedical.com)
While our genes are encoded by a varying sequence of nucleotides, the genotype is determined by the DNA sequence, both nuclear and mitochondrial. (cilecenter.org)
These results indicate that the interplay of TEs and RIP can result in different and unpredictable fates of amplified genes, with variable effects on gene and genome evolution. (biomedcentral.com)
TEs have been detected in the genomes of both prokaryotic and eukaryotic organisms [ 1 ], and have been rightly labeled as 'drivers of genome evolution' [ 2 ] due to their direct and indirect impacts on genes and genomes. (biomedcentral.com)
TE-rich genomic islands in expanded fungal ( P. fijiensis , L. maculans ) and oomycete ( Phytophthora infestans ) genomes carry genes that code for lineage-specific, putative small, secreted proteins. (biomedcentral.com)
Cytogenetic (FISH) evidence and the genome assembly itself place core MHC genes on as many as four chromosomes with TAP and Class I genes mapping to different chromosomes. (biomedcentral.com)
Transposable elements can be considered as a source of raw material for primitive genomes, tools of genetic innovation, and ancestors of modern genes (e.g., ncRNA) [ 15 ]. (biomedcentral.com)
With the completion of the human genome and the genomes of other species, we have a glimpse of many more genes than we ever had before to study. (pharmaceuticalintelligence.com)
have analyzed the tef-1α sequences of F. equiseti , as well as the toxin-related genes PKS13 , PKS4, and TRI5 [26], and Kari has successfully cloned a protease gene [27]. (researchsquare.com)
is it a wonder that our genome too is filled with the remains of extinct genes? (drwile.com)

Most cancers exhibit reduced methylation of repetitive sequences such as Long INterspersed Element-1 (LINE-1) and Alu elements. (biomedcentral.com)
Etiologic studies of cancer increasingly use molecular features such as gene expression, DNA methylation and sequence mutation to subclassify the cancer type. (biomedcentral.com)
DNA methylation occurs primarily as 5-methylcytosine (5-mC), and the Diagenode MagMeDIP Kit takes advantage of a specific antibody targeting this 5-mC to immunoprecipitate methylated DNA, which can be thereafter directly analyzed by qPCR or Next-Generation Sequencing (NGS). (diagenode.com)
Intron 8 FTO sequences âˆ¼220kB downstream of IRX3 exhibit histone acetylation, DNA methylation, and contacts with th. (diagenode.com)

Eukaryotic genomes are even more difficult to define because almost all eukaryotic species contain nuclear chromosomes plus extra DNA molecules in the mitochondria. (wikipedia.org)
A genome sequence is the complete list of the nucleotides (A, C, G, and T for DNA genomes) that make up all the chromosomes of an individual or a species. (wikipedia.org)
Within a species, the vast majority of nucleotides are identical between individuals, but sequencing multiple individuals is necessary to understand the genetic diversity. (wikipedia.org)
In December 2013, scientists first sequenced the entire genome of a Neanderthal, an extinct species of humans. (wikipedia.org)
Sequencing genomes of other species facilitates and extends these goals by revealing general principles of biology. (cilecenter.org)
However, treating Trp53 mutant MEF's with DNA demethylating agent caused a huge increase in the level of transcripts encoding short interspersed nuclear elements and other species of noncoding RNAs that generated a strong type 1 IFN response. (codondex.com)
One locus important in embryogenesis, KIT , has been associated with white coat patterns in several mammalian species and piebaldism in humans. (creation.com)
The zebra finch MHC differs markedly from that of the chicken, the only other bird species with a complete genome sequence. (biomedcentral.com)
In spite of the abundance of research on the roles of TE on the genome biology in humans, model organisms (e.g., mice and Drosophila ), and plants (especially crop species), few studies on TE have been conducted in livestock and poultry. (biomedcentral.com)
Current knowledge about the species differences in sex chromosome organization and function is limited, this despite the availability of reference genome assemblies for most domestic species. (pacb.com)
It appears that sequence assembly of the X chromosome in most species is rather patchy containing multiple gaps and possible misassemblies, being the poorest in the pseudoautosomal region and in regions containing putative lineage-specific sequences. (pacb.com)
The Y chromosome, on the other hand, is typically not included in the reference genome and is studied separately, whereas complete sequence assembly of the male-specific portion of the Y is not yet available for any domestic species. (pacb.com)
Using this approach, it is possible to derive two assemblies from an individual, accurately representing both parental contributions in their entirety with higher continuity and accuracy than is possible with other methods.Results We used trio binning to assemble reference genomes for two species from a single individual using an interspecies cross of yak (Bos grunniens) and cattle (Bos taurus). (pacb.com)
Yeast sizes vary, typically measuring 3-4 µm in diameter, although some species can expand up to 40 µm. (microbiologynote.com)

We validated the CD-1 reference genome and the identified variants by comparative mapping of a wide range of CD-1 genomics datasets between the CD-1 and standard mm10 reference genomes. (biomedcentral.com)

Long interspersed nuclear element-1 (L1) retrotransposons are a source of divergent genetic information in hominoid genomes, but their importance in physiological functions and their contribution to human brain evolution are largely unknown. (bvsalud.org)
Here we report that H3K9me3 is preferentially transferred onto the leading strands of replication forks, which occurs predominantly at long interspersed nuclear element (LINE) retrotransposons (also known as LINE-1s or L1s) that are theoretically transcribed in the head-on direction with replication fork movement. (bvsalud.org)
Retrotransposons are fragments of cDNA which are transcribed from RNA and then inserted in a permissive sequence of the genome ( splicesosomal introns , for instance, are permissive regions). (bredagenetics.com)

The limitations of current methods are particularly evident in the vast noncoding regions of eukaryotic genomes, which, despite important recent progress 3 - 6 , remain poorly annotated and understood. (biorxiv.org)

When referring to the standard reference genome of humans, for example, it consists of one copy of each of the 22 autosomes plus one X chromosome and one Y chromosome. (wikipedia.org)
In addition, the standard reference genome in mouse was derived from the inbred C57BL/6 J strain, and the full set of genetic variants between CD-1 and C57BL/6 J are not known. (biomedcentral.com)

A k-mer is related to an artificial sequence division of K nucleotides iteratively from sequencing reads. (biomedcentral.com)
In addition, fitCons scores indicate that 4.2-7.5% of nucleotides in the human genome have influenced fitness since the human-chimpanzee divergence, and, in contrast to several recent studies, they suggest that recent evolutionary turnover has had limited impact on the functional content of the genome. (biorxiv.org)
Many computational methods for gaining functional insights from sequence data are based on the simple, but powerful, observation that functionally important nucleotides tend to remain unchanged over evolutionary time, because mutations at these sites generally reduce fitness and are therefore eliminated by natural selection 7 - 15 . (biorxiv.org)

In fungal and oomycete plant pathogens, besides modulating genome size (e.g. (biomedcentral.com)

Sequence homology is an indication of the genetic relatedness of different organisms and gene function. (lookformedical.com)
Nucleotide sequences, usually upstream, which are recognized by specific regulatory transcription factors, thereby causing gene response to various regulatory agents. (lookformedical.com)
Taxonomic classification of those E. ictaluri specific phages must rely on a synthesis of morphological and genomic details, taking into consideration that phage evolution continues to be profoundly directed by lateral gene transfer, and that a rational hierarchical technique of phage classification really should be based within the degree of DNA and protein sequence identity for several genetic loci. (hivprotease-signal.com)
The predicted gene products with sequence similarity amongst the eiAU and SSL 2009a phage genomes include things like the putative small tail proteins tail tape mea certain, major tail proteins, major capsid proteins, head morphogenesis, phage terminase tiny subunit, and the phage terminase large subunit. (hivprotease-signal.com)
The substantial terminase subunit which is a structural protein is together with the portal protein viewed as essentially the most universally conserved gene sequence in phages, consequently they are good possibilities to assist in phage classification. (hivprotease-signal.com)
Transposable elements (TEs) can be key drivers of evolution, but the mechanisms and scope of how they impact gene and genome function are largely unknown. (biomedcentral.com)
Previous analyses revealed that TE-mediated gene amplifications can have variable effects on fungal genomes, from inactivation of function to production of multiple active copies. (biomedcentral.com)
To further test the effects of transposon-aided gene amplifications on genome evolution and architecture, the repetitive fraction of the significantly expanded genome of the banana pathogen, Pseudocercospora fijiensis , was analyzed in greater detail. (biomedcentral.com)
Transposable elements (TE) are important components of livestock and poultry genomes, contributing to their genetic diversity, chromatin states, gene regulatory networks, and complex traits of economic value. (biomedcentral.com)

Due to its high polymorphism and importance for disease resistance, the major histocompatibility complex (MHC) has been an important focus of many vertebrate genome projects. (biomedcentral.com)
After nearly two decades of improvements, the current human reference genome (GRCh38) is the most accurate and complete vertebrate genome ever produced. (pacb.com)

The study of the genome is called genomics. (wikipedia.org)
We used the identified variants to construct a CD-1-specific reference genome, which can improve accuracy and reduce bias when aligning genomics data derived from CD-1 mice. (biomedcentral.com)
Mapping genomics data to the CD-1 genome rather than mm10 resulted in greater mappability and higher quality of results for all datasets examined. (biomedcentral.com)
In this review, we analyze 72 studies published in the past 20 years, summarize the TE composition in livestock and poultry genomes, and focus on their potential roles in functional genomics. (biomedcentral.com)

M. tuberculosis T-cell epitopes are hyperconserved, we hy- described in Senegal in 1968 ( 2 ), and despite its importance pothesized that more immunogenic strains have increased and high prevalence in this region, relatively little is known capacity to spread within the human host population. (cdc.gov)
Although inbred strains are typically better suited for such studies due to minimal genetic variability, outbred stocks confer practical advantages over inbred strains, such as improved breeding performance and low cost. (biomedcentral.com)
Outbred stocks provide a good model for outbred human populations, but inbred mouse strains are typically preferred in toxicology, pharmacology, and fundamental biomedical research due to lower genetic and phenotypic variability. (biomedcentral.com)
However, the prior study only examined single nucleotide polymorphisms (SNPs) previously identified in other mouse strains, and to date, a full, genome-wide identification of genetic variants that exist between CD-1 mice has not been done. (biomedcentral.com)

DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom. (lookformedical.com)

The association between human introns and n. (codondex.com)

We describe the establishment and analysis of a genus-wide comparative framework composed of 12 bacterial artificial chromosome fingerprint and end-sequenced physical maps representing the 10 genome types of Oryza aligned to the O. sativa ssp. (biomedcentral.com)
Our strategy is to develop bacterial artificial chromosome (BAC)-end sequence (BES) physical frameworks of the ten genome types of Oryza and align them to the reference sequence. (biomedcentral.com)
The sequencing of the zebra finch Taeniopygia guttata genome, in combination with targeted bacterial artificial chromosome (BAC) sequencing, has allowed us to characterize an MHC from a highly divergent and diverse avian lineage, the passerines. (biomedcentral.com)

Almost all eukaryotes have mitochondria and a small mitochondrial genome. (wikipedia.org)
Most eukaryotes are diploid, meaning that there are two copies of each chromosome in the nucleus but the 'genome' refers to only one copy of each chromosome. (wikipedia.org)
Some eukaryotes have distinctive sex chromosomes such as the X and Y chromosomes of mammals so the technical definition of the genome must include both copies of the sex chromosomes. (wikipedia.org)
In eukaryotes, repetitive DNA sequences are transcriptionally silenced through histone H3 lysine 9 trimethylation (H3K9me3). (bvsalud.org)

The conserved molluscan biomineralization toolkit and lineage-specific repetitive low-complexity domains are essential to the construction of the nautilus shell. (nature.com)

TERMINAL REPEAT SEQUENCES flank both ends of another sequence, for example, the long terminal repeats (LTRs) on RETROVIRUSES. (lookformedical.com)
Most other SINEs are derived from tRNAs including the MIRs (mammalian-wide interspersed repeats). (lookformedical.com)
Over 932 Mb of end sequence was analyzed for repeats, simple sequence repeats, miRNA and single nucleotide variations, providing the most extensive analysis of Oryza sequence to date. (biomedcentral.com)
When pathogen-associated features were quantified , specific repeats in the genome not only display PAMP's capable of stimulating PRRs but, in some instances, have seemingly maintained such features under selection. (codondex.com)
This supports the hypothesis that specific repeats gained favor by maintaining non-self PAMPs to act as sensors for loss of heterochromatin as an epigenetic checkpoint of quality control that avoids genome instability generally. (codondex.com)

The next year, Fred Sanger completed the first DNA-genome sequence: Phage Φ-X174, of 5386 base pairs. (wikipedia.org)
The sequences are about 300 base pairs long and are repeated several thousand times throughout the genome. (ojp.gov)
Highly repeated sequences, 6K-8K base pairs in length, which contain RNA polymerase II promoters. (lookformedical.com)
The length of the human genome is about 3 billion base pairs. (lookformedical.com)
The human genome contains approximately 3.2 billion base pairs, distributed among 22 paired chromosomes, plus two X chromosomes in females and one X and one Y chromosome in males. (cilecenter.org)

The region of DNA which borders the 3' end of a transcription unit and where a variety of regulatory sequences are located. (lookformedical.com)

It is actually estimated that up to 5% of pathogenic mutations in humans are caused by transposons insertions. (bredagenetics.com)
For humans, a maximum of 10 alleles could have made it through unless Noah's sons carried mutations. (creation.com)
In essence, the "experiment" considered by these methods is the one conducted directly on genomes by nature over millenia, and the outcomes of interest are the presence or absence of fixed mutations. (biorxiv.org)

In summary, our results demonstrate that L1-derived transcripts provide a previously undescribed layer of primate- and human-specific transcriptome complexity that contributes to the functional diversification of the human brain. (bvsalud.org)
During the past decade, two major developments-the emergence of massively parallel, ultra-cheap DNA sequencing technologies and the use of these technologies as digital readouts for functional genomic assays-have led to a profusion of data describing various features of genomes, epigenomes, and transcriptomes 1 , 2 . (biorxiv.org)
Evolutionary turnover may cause inconsistencies between sequence orthology and functional homology that substantially limit this type of analysis. (biorxiv.org)
The second strategy is to forgo the use of evolutionary information and instead to predict functional roles from genomic data alone, typically with machine-learning methods for supervised classification 29 , 30 or clustering followed by labeling based on known examples 31 - 33 . (biorxiv.org)

Long-read RNA sequencing technologies, including Oxford Nanopore and PacBio, can directly sequence relatively long transcripts, thus providing the opportunity to examine full-length LINE transcripts. (bvsalud.org)
This was enabled by high-coverage, ultra-long-read nanopore sequencing of the complete hydatidiform mole CHM13 genome, combined with complementary technologies for quality improvement and validation. (pacb.com)

Paired-end sequencing was performed by the Illumina HiSeq 2000 system. (biomedcentral.com)

LINE activity creates genomic structural variants in human populations and leads to somatic alterations in cancer genomes. (bvsalud.org)
We used multiple genome-wide sequencing data types and previously published CD-1 SNPs to validate our called variants. (biomedcentral.com)
We used the called variants to construct a strain-specific CD-1 reference genome, which we show can improve mappability and reduce experimental biases from genome-wide sequencing data derived from CD-1 mice. (biomedcentral.com)
We performed deep genomic DNA (gDNA) sequencing in order to map both the uniform and non-uniform variants of CD-1, including SNPs, insertions and deletions (indels), and germline transposable elements (TEs). (biomedcentral.com)
These regions harbor largely unexplored variation of unknown consequence, and their absence from the current reference genome can lead to experimental artifacts and hide true variants when re-sequencing additional human genomes. (pacb.com)

It consists of nucleotide sequences of DNA (or RNA in RNA viruses). (wikipedia.org)
In 1976, Walter Fiers at the University of Ghent (Belgium) was the first to establish the complete nucleotide sequence of a viral RNA-genome (Bacteriophage MS2). (wikipedia.org)
It is also called nucleotide sequence. (lookformedical.com)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)
Here we report the construction of 12 BAC/BES framework physical maps derived from these libraries and an analysis of the BESs in terms of transposable element, simple sequence repeat (SSR), microRNA (miRNA), and single nucleotide variation (SNV) content. (biomedcentral.com)

The genomes of many organisms have been sequenced and various regions have been annotated. (wikipedia.org)

In the fields of molecular biology and genetics, a genome is all the genetic information of an organism. (wikipedia.org)
Therefore, genome studies of N. pompilius would not only shed light on the origin and evolution of cephalopod genomic novelties but also incentivize research on their biology and inform sustainable conservation. (nature.com)
S. cerevisiae is also a critical model organism in cell biology research, aiding in the understanding of eukaryotic cell and human biology. (microbiologynote.com)

We find that this type of non-canonical fork convergence in fission yeast is prone to trigger deletions between repetitive DNA sequences via a mechanism we call Inter-Fork Strand Annealing (IFSA) that depends on the recombination proteins Rad52, Exo1 and Mus81, and is countered by the FANCM-related DNA helicase Fml1. (elifesciences.org)
The most prominent and familiar aspects of the genome are the regions that code for proteins. (cilecenter.org)
Celecoxib structure A comparative genomic evaluation involving the genome of phage eiAU and that of phage SSL 2009a unveiled that genome regions encoding many putative structural and replica tion proteins are shared by both phages. (hivprotease-signal.com)
Interestingly, other struc tural proteins which includes the host specificity proteins, the tail assembly proteins, and specifically the tail fiber baseplate protein which has become suggested for exclusion in any sequence based mostly phage taxonomy scheme are certainly not shared in between the 2 genomes. (hivprotease-signal.com)
The amino acid sequences of one of many conserved structural pro teins likewise as among the non structural proteins have been selected for phylogenetic evaluation. (hivprotease-signal.com)
Livestock and poultry play a significant role in human nutrition by converting agricultural by-products into high-quality proteins. (biomedcentral.com)
While many DNA sequences are not used to produce proteins, specific functions have been found for much of this supposed "junk. (drwile.com)

Here we present a de novo human genome assembly that surpasses the continuity of GRCh38, along with the first gapless, telomere-to-telomere assembly of a human chromosome. (pacb.com)

Loss of silencing of the repeat elements leads to genome instability and human diseases, including cancer and ageing1-3. (bvsalud.org)

Then, the IP'd methylated DNA is isolated and can be used for any subsequent analysis as qPCR, amplification, hybridization on microarrays or next generation sequencing. (diagenode.com)

Background Assemblies of diploid genomes are generally unphased, pseudo-haploid representations that do not correctly reconstruct the two parental haplotypes present in the individual sequenced. (pacb.com)

the complete genome sequence of Mycobacterium tuberculosis continues to provide an invaluable resource to understand tuberculosis (TB), the leading cause of global infectious disease mortality. (jci.org)

The genetic mechanisms underlying the expansion in size and complexity of the human brain remain poorly understood. (bvsalud.org)

The idea that much of an organism's genome could be filled with "junk DNA" is a perfect example of how evolutionary thinking produces absurd conclusions. (drwile.com)

The nautilus genome constitutes a valuable resource for reconstructing the evolutionary scenarios and genomic innovations that shape the extant cephalopods. (nature.com)
Thus, investigating the nautilus genome could furnish valuable insights into the evolutionary drivers of cephalopod innovations. (nature.com)

Phylogenetic analysis primarily based to the significant terminase subunit amino acid sequence plus the DNA polymerase I amino acid sequence of eiAU reveal that phages eiAU, eiDWS, and eiMSLS were most much like phage that infect other enterobacteria and Sodalis glossinidius. (hivprotease-signal.com)

These repetitive viral DNA sequences normally act as a quality control over genomic dysregulation responding in ways that preferentially promote immune conditions for stability. (codondex.com)

Consequently, phenotypic traits - both macroscopic and molecular - depend on a combination of influences from genome sequences, the individual's life history and the epigenetic signals in the fertilized egg. (cilecenter.org)

LINEs replicate using an RNA intermediate followed by reverse transcription and are typically a few kilobases in length. (bvsalud.org)
A hallmark of cancer, autoimmunity and disease is the aberrant transcription of typically silenced, repetitive genetic elements that mimic Pathogen-Associated Molecular Patterns (PAMP's) that bind Pattern Recognition Receptors (PPR's) triggering the innate immune system and inflammation. (codondex.com)

Most textbooks make a distinction between the nuclear genome and the organelle (mitochondria and chloroplast) genomes so when they speak of, say, the human genome, they are only referring to the genetic material in the nucleus. (wikipedia.org)

Other yeasts, such as Candida albicans, are opportunistic pathogens in humans. (microbiologynote.com)

In this study, the complete genomic sequence of Fusarium equiseti D25-1 was determined using multiple sequencing platforms. (researchsquare.com)

A few months later, the first eukaryotic genome was completed, with sequences of the 16 chromosomes of budding yeast Saccharomyces cerevisiae published as the result of a European-led effort begun in the mid-1980s. (wikipedia.org)
The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. (lookformedical.com)

For example, Alu elements, at more than a million copies comprising 11% of the human genome, are a major contributor to primate genome evolution and the standing genetic diversity in human populations [ 3 ]. (biomedcentral.com)

Transposable elements (TEs) or mobile genetic elements are nucleic acid entities that can move in a genome. (biomedcentral.com)

The Alu sequence family (named for the restriction endonuclease cleavage enzyme Alu I) is the most highly repeated interspersed repeat element in humans (over a million copies). (lookformedical.com)
Sequences of DNA or RNA that occur in multiple copies. (lookformedical.com)
There are several types: INTERSPERSED REPETITIVE SEQUENCES are copies of transposable elements (DNA TRANSPOSABLE ELEMENTS or RETROELEMENTS) dispersed throughout the genome. (lookformedical.com)
TANDEM REPEAT SEQUENCES are copies which lie adjacent to each other, direct or inverted (INVERTED REPEAT SEQUENCES). (lookformedical.com)
Copies of the LINE 1 (L1) family form about 15% of the human genome. (lookformedical.com)
Even more-highly repeated sequences - minisatellites, microsatellites and telomeres - may appear as tens or even hundreds of thousands of copies, in aggregate amounting to 15% of the genome. (cilecenter.org)

Examples of methods utilizing such non-radioactive detection methods include DNA sequencing, oligonucleotide probe methods, detection of polymerase-chain-reaction products, immunoassays, and the like. (justia.com)
In many applications the independent detection of multiple spatially overlapping analytes in a mixture is required, e.g., single-tube multiplex DNA probe assays, immuno assays, multicolor DNA sequencing methods, and the like. (justia.com)

citation needed] The development of new technologies has made genome sequencing dramatically cheaper and easier, and the number of complete genome sequences is growing rapidly. (wikipedia.org)
Since then, advances in technology have made genomic sequencing cheaper and faster. (cilecenter.org)

Here, we present a complete Nautilus pompilius genome as a fundamental genomic reference on cephalopod innovations, such as the pinhole eye and biomineralization. (nature.com)
In this study, we sequenced the complete genome of Nautilus pompilius in the hope of providing a critical reference for the evolution of cephalopods. (nature.com)

While the genome sequence was already transformative at the time, the past 25 years of progress have substantially increased its impact on TB taxonomy, drug discovery, resistance mechanisms, epidemiology, vaccine development, and pathogenesis. (jci.org)

In an additional aspect, the invention includes methods utilizing such dye compounds and reagents including dideoxy polynucleotide sequencing and fragment analysis methods. (justia.com)

Transposable elements, such as Long INterspersed Elements (LINEs), are DNA sequences that can replicate within genomes. (bvsalud.org)
Transposons are mobile DNA elements which inserted themselves into the human genome during the evolution. (bredagenetics.com)
We performed deep genomic DNA sequencing of CD-1 mice and used the data to identify genome-wide SNPs, indels, and germline transposable elements relative to the mm10 reference genome. (biomedcentral.com)
Elements that are transcribed into RNA, reverse-transcribed into DNA and then inserted into a new site in the genome. (lookformedical.com)
Repetitive elements of an unknown function surprisingly account for the large fractions of our genomes. (cilecenter.org)
Long and Short Interspersed Elements (LINES and SINES) account for 21% and 13% of the genome, respectively. (cilecenter.org)
Transposable elements were initially viewed as "selfish" DNA or "parasitic" elements because of their deleterious effects on host genomes [ 7 ]. (biomedcentral.com)

Finally, we confirmed that the repeat sequences occupy approximately 50.4 % of the crab genome. (biomedcentral.com)

Mapping of transcriptomic and genomic data derived from CD-1 mice to the standard mouse reference genome is therefore subject to inaccuracies and potentially confounding effects. (biomedcentral.com)
Sequence data now flow copiously, creating the challenges of understanding the information that our genomes contain, and applying the data and analysis to improve human welfare. (cilecenter.org)
The bioinformatic examination on the genomes of these 3 E. ictaluri specific bacteriophages corroborate pre viously published data that signifies that these bacterio phages are lytic, and lack any mechanism for lysogenic conversion of their host. (hivprotease-signal.com)
To accomplish this objective we performed a retrospective analysis of [11C]PBR28 mind image data in non-human primates that were recently published [6]. (globaltechbiz.com)
We have generated fitCons scores for three human cell types based on public data from EN-CODE. (biorxiv.org)

All of these likely have played an important role in the evolution of humans and other primates [ 3 ]. (biomedcentral.com)

Comparisons between cancerous and normal cell lines, as well as human tissue samples, revealed elevated expression levels of young LINEs in cancer, particularly at intact L1 loci. (bvsalud.org)

Comparative analyses revealed that a similar event occurred in five additional genomes representing the fungal genera Cercospora , Pseudocercospora and Sphaerulina . (biomedcentral.com)

This study focuses on the development of a new bioinformatics pipeline for the identification and quantification of active, full-length LINE transcripts in diverse human tissues and cell lines. (bvsalud.org)

Transposons insertions usually generate repetitive units . (bredagenetics.com)

Some regions of the genome encode non-protein-coding RNA like transfer RNAs, the RNA components of ribosomes, microRNAs and small interfering RNAs that regulate translation. (cilecenter.org)

CRISPR interference silencing of LINC01876 results in reduced size of cerebral organoids and premature differentiation of neural progenitors, implicating L1s in human-specific developmental processes. (bvsalud.org)

The precision of each lab measurement, reflecting the uncertainty due to sampling DNA fragments, typically goes unreported. (biomedcentral.com)

Wrong eukaryote is that the economic novelty notion with lunar sequences will demonstrate the other Mechanisms apparently Supported with border sentence. (be-mindful.de)

Anatomy21

Organisms21

Diseases7

Chemicals and Drugs46

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Phenomena and Processes146

Disciplines and Occupations5

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture2

Information Science14

Health Care4

Whole-genome11

Genes14

Methylation4

Species14

Reference genomes1

Retrotransposons3

Eukaryotic genomes1

Standard reference genome2

Nucleotides3

Modulating genome size1

Gene9

Vertebrate genome2

Genomics4

Strains4

Drosophila1

Introns1

Bacterial artificial3

Eukaryotes4

Lineage-specific1

Repeats5

Base pairs5

Regulatory sequences1

Mutations3

Functional4

Nanopore2

Illumina HiSeq1

Variants5

Nucleotide5

Organisms1

Biology3

Proteins7

Chromosome1

Instability1

QPCR1

Diploid1

Mycobacterium1

Remain poorly1

Conclusions1

Evolutionary2

Amino acid1

Viral1

Epigenetic1

Transcription2

Nuclear1

Pathogens1

Genomic sequence1

Chromosomes2

Primate1

Nucleic acid1

Copies6

Detection2

Cheaper2

Complete2

Vaccine1

Reagents1

Elements7

Occupy1

Data5

Primates1

Loci1

Comparative1

Transcripts1

Generate1

Regions1

CRISPR1

Fragments1

Mechanisms1