• In this study, we hypothesized that adaptive immunity reaction(s), particularly T-helper type 1 (Th1) responses, will be dominant in any metal-reactivity responses of patients with total joint replacements (TJAs). (biomedcentral.com)
  • Lymphocytes from young healthy individuals without an implant or a history of metal allergy (Group 1: n = 8) were used to assess lymphocyte responses to metal challenge agents. (biomedcentral.com)
  • These results suggest systematically coordinated, yet cell type-specific responses to factors and pathways contribute to telomere length regulation. (hindawi.com)
  • Innate type-2 lymphoid cells (ILC2s) function in immune responses against helminth parasites and are implicated in allergic inflammation and asthma. (omicsdi.org)
  • We propose that Gfi1 functions as a shared determinant within innate and adaptive immune cells to specify type-2 responses, while actively repressing the IL-17 effector state. (omicsdi.org)
  • We are interested in investigating the role of the transcription factor Gfi1 in ILC2s, which appear to be a prominent source of IL-5 and IL-13 during type-2 immune responses. (omicsdi.org)
  • Type-2 innate lymphoid cells (ILC2s) promote anti-helminth responses and contribute to allergies. (omicsdi.org)
  • Conclusions These results suggest that exendin-4 might downregulate pro-inflammatory responses and reduce oxidative stress by suppressing MAPK signaling pathways in type 2 diabetes. (ovid.com)
  • Cytotoxic T-lymphocyte (CTL) responses to E6 and E7 were previously shown to be more commonly detectable in human papillomavirus type 16 (HPV-16)-positive women without squamous intraepithelial neoplasia (SIL) than in HPV-16-positive women with SIL (M. Nakagawa, D. P. Stites, S. Farhat, J. R. Sisler, B. Moss, F. Kong, A. B. Moscicki, and J. M. Palefsky, J. Infect. (asm.org)
  • Our results suggest that both CD4 and CD8 T lymphocytes contribute to HPV-16 E6- and E7-specific CTL responses although their relative contributions vary from individual to individual. (asm.org)
  • In a previous study ( 13 ), we showed that cytotoxic T-lymphocyte (CTL) responses to HPV type 16 (HPV-16) E6 and E7 proteins appear to be important in the prevention of SIL in that responses to both E6 and E7 proteins were more commonly found in HPV-16-positive women without SIL than in HPV-16-positive women with SIL. (asm.org)
  • Interactions between brain endothelial cells and human T-cell leukemia virus type 1-infected lymphocytes: mechanisms of viral entry into the central nervous system. (semanticscholar.org)
  • The viral infectivity factor gene vif of human immunodeficiency virus type 1 has been shown to affect the infectivity but not the production of virus particles. (asm.org)
  • T lymphocytes play a primary role in recovery from viral infections and in antiviral immunity. (rupress.org)
  • Although viral-specific CD8+ and CD4+ T cells have been shown to be able to lyse virally infected targets in vitro and promote recovery from lethal infection in vivo, the role of CD4+ T lymphocytes and their mechanism(s) of action in viral immunity are not well understood. (rupress.org)
  • Although γδ T lymphocytes can target a diversity of tumor cell types, their clinical manipulation is hampered by our limited knowledge of the molecular cues that determine γδ T cell migration toward tumors in vivo. (jimmunol.org)
  • Enteropathy-type intestinal T cell lymphoma (EITCL) is a complication of longstanding and untreated coeliac disease. (bmj.com)
  • Macrophages are the major inflammatory cell type in the glucose-utilizing tissues such as adipose tissue and liver. (hindawi.com)
  • We hypothesize that GLP-1 receptor agonist, exendin-4, might reduce inflammatory response in type 2 diabetes. (ovid.com)
  • Elevated proliferation and production of IFN-gamma to metals in hip arthroplasty subjects' lymphocytes indicates that a Th1 (vs. Th2) type response is likely associated with any metal induced reactivity. (biomedcentral.com)
  • To investigate the pathogenetic role of human T-lymphocyte virus type I (HTLV-I) in central nervous system disease, a rat model for HTLV-I-associated myelopathy/tropical spastic paraparesis, designated as HAM rat disease, was examined with regard to chronological neuropathology, from early asymptomatic phase to late disease. (ingentaconnect.com)
  • Human T-cell leukemia virus type 1 (HTLV-1) is associated with a variety of clinical manifestations, including tropical spastic paraparesis or HTLV-1-associated myelopathy (TSP/HAM). (semanticscholar.org)
  • Role of vif in replication of human immunodeficiency virus type 1 in CD4+ T lymphocytes. (asm.org)
  • Additionally, Bcl11b-/- ILC2s de-repressed Rorγt, Ahr and IL-23 receptor, normally expressed in type-3 ILCs (ILC3s). (omicsdi.org)