AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureInformation ScienceNamed GroupsHealth Care
Stem CellsHematopoietic Stem CellsStem Cell TransplantationEmbryonic Stem CellsAdult Stem CellsPluripotent Stem CellsHematopoietic Stem Cell TransplantationStem Cell NicheNeural Stem CellsInduced Pluripotent Stem CellsCell DifferentiationMultipotent Stem CellsMesenchymal Stem Cell TransplantationStem Cell FactorMesenchymal Stromal CellsCell LineageStem Cell ResearchPlant StemsFetal Stem CellsCell ProliferationCells, CulturedHematopoietic Stem Cell MobilizationNeoplastic Stem CellsBone Marrow CellsRegenerationOctamer Transcription Factor-3Cell Culture TechniquesRegenerative MedicineCell SeparationTransplantation, AutologousHematopoiesisPeripheral Blood Stem Cell TransplantationTotipotent Stem CellsAntigens, CD34Transplantation, HomologousFlow CytometryMice, Inbred C57BLEmbryo, MammalianSOXB1 Transcription FactorsSpermatogoniaSignal TransductionColony-Forming Units AssayCell- and Tissue-Based TherapyMice, SCIDTissue EngineeringGene Expression Regulation, DevelopmentalProto-Oncogene Proteins c-kitCord Blood Stem Cell TransplantationNestinCell LineReverse Transcriptase Polymerase Chain ReactionGene Expression ProfilingGerm CellsHomeodomain ProteinsHair FollicleBrain StemEmbryo ResearchPhenotypeCell SurvivalBiological MarkersCoculture TechniquesMice, TransgenicBone Marrow TransplantationNeuronsCell DivisionCell DedifferentiationModels, BiologicalFetal BloodImmunohistochemistryTranscription FactorsGreen Fluorescent ProteinsTransplantation ConditioningBone MarrowTeratomaAntigens, CDGene Expression RegulationEmbryoid BodiesNuclear ReprogrammingSpheroids, CellularCell TransplantationNeurogenesisTime FactorsChondrogenesisLentivirusGraft vs Host DiseaseCell MovementMice, Inbred NODCell TrackingGranulocyte Colony-Stimulating FactorAntigens, CD24Tissue ScaffoldsDental PulpTransplantation, HeterologousLimbus CorneaeEmbryonal Carcinoma Stem CellsGene ExpressionCell CountStage-Specific Embryonic AntigensAdipogenesisHematologic Neoplasms
TransplantationDifferentiationStromal cellsBiologyTransplantsAdultDerived from pluripotent stemHematopoietic Stem Cell TransplantRegenerativeDonor stem cellsChemotherapyMesenchymal stem2023Epithelial CellsPeripheralMSCsAutologousTherapyAmniotic fluid stem202210.1016SomaticTermed induced pluri2021TherapeuticLund Stem Cell CenterEmbryoSelf-renewalProgenitorsNeuralTherapiesTreatmentsDiabetesDifferentiateHematopoiesisClinicalProliferationMarrow cellResearchPopulationsRegenerationFetalHumanImmunePluripotencyAcuteIPSCESCsDonor'sExpansionLeukemiaUmbilicalExtracellular
Transplantation38
Differentiation14
  • Abstract Background Cardiac differentiation of human-induced pluripotent stem (hiPS) cells consistently produces a mixed population of cardiomyocytes and non-cardiac cell types, even when using well-characterized protocols. (figshare.com)
  • We sought to determine whether different cell types might result from intrinsic differences in hiPS cells prior to the onset of differentiation. (figshare.com)
  • Additionally, we found that substantial cell death occurs during differentiation in a manner that suggested all cells were equally likely to survive or die, suggesting that there is no intrinsic selection bias for cells descended from particular hiPS cell progenitors. (figshare.com)
  • We thus wondered how cells grow spatially during differentiation, so we labeled cells by expression of marker genes and found that cells expressing the same marker tended to occur in patches. (figshare.com)
  • instead, factors specifying the various cell types likely act during a window that begins shortly after the seeding of hiPS cells for differentiation. (figshare.com)
  • Strengths of the experimental protocol include ease of fabrication and maintenance (gravity driven), good cell performance (viability/differentiation), as well as the possibility of exposing the culture to heterogeneous laminar flow for experimental purposes. (rsc.org)
  • The hallmark of embryonic stem (ES) cells is their ability for self-renewal (capability of unlimited cell division without the loss of pluripotency) as well as for differentiation into all cell types of the adult organism. (uni-muenchen.de)
  • A high expression of Pes1, Bop1 and WDR12 was observed in ES cells, which strongly decreased during in vitro differentiation. (uni-muenchen.de)
  • Accordingly, in various biological contexts, EVs are reported to engage in immune modulation, senescence, and cell proliferation and differentiation. (wjgnet.com)
  • Although some adult stem cells do have differentiation capacity, it is often limited in nature, which results in fewer options for use. (prnewswire.com)
  • reseeded for the progenitor expansion phase at D12 and D19 in neural stem cell culture media with EGF and bFGF, and finally at D26 for neural differentiation with neurogenic/neurotrophic factors BDNF, GDNF, NT3, and cAMP. (nih.gov)
  • Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. (lu.se)
  • A key challenge is to understand how state, but must also afford flexibility in cell-fate choice to permit the different cell-fate options confronting stem and progenitor cell-type diversification and differentiation in response to cells are selected and coordinated such that adoption of a given intrinsic cues or extrinsic signals. (lu.se)
  • Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)
Stromal cells3
  • Adipose tissue (AT) represents a commonly used source of mesenchymal stem/stromal cells (MSCs) whose proregenerative potential has been widely investigated in multiple clinical trials worldwide. (mdpi.com)
  • Mesenchymal stem/stromal cells as adjuvant therapy in COVID-19-associated acute lung injury and cytokine storm: Importance of cell identification. (wjgnet.com)
  • Mesenchymal stem/stromal cells (MSCs) obtained from pluripotent stem cells (PSCs) constitute an interesting alternative to classical MSCs in regenerative medicine. (unlp.edu.ar)
Biology3
  • Detailed characterization of cell type transitions is essential for cell biology in general and particularly for the development of stem cell-based therapies in regenerative medicine. (nature.com)
  • Understanding transitions from one cell type or state to another is in the focus of modern molecular biology. (nature.com)
  • Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. (lu.se)
Transplants8
  • Adult stem cells capable of forming blood, and derived from bone marrow, have been used in transplants for over 30 years. (cellmedicine.com)
  • Stem cell transplants have many benefits, but they also have risks. (cdc.gov)
  • Because stem cell transplants destroy and rebuild your immune system, they increase your risk for fungal infections. (cdc.gov)
  • Treatments for leukemia include chemotherapy, radiation therapy, and stem cell transplants. (medicalnewstoday.com)
  • Learn more about stem cell transplants here. (medicalnewstoday.com)
  • A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy. (genomeweb.com)
  • Mason endured more than 9 months of chemotherapy and stem cell transplants. (cdc.gov)
  • Haematopoietic stem cell transplants have been performed in more than 1 500 000 patients (both autologous and allogeneic) to date.1 Although haematological cancers remain the main indication, haematopoietic stem cell transplants are increasingly considered in the treatment of non-malignant disorders and genetic diseases such as haemoglobinopathies (sickle cell anaemia, thalassaemia) that can benefit greatly from this type of transplant. (who.int)
Adult22
Derived from pluripotent stem1
  • To deliver on that promise, our laboratory is collaborating with the laboratories of Markus Grompe, M.D., OHSU, and Gordon Keller, Ph.D., University Health Network, Toronto, Canada, in the development and characterization of monoclonal antibodies directed against cell surface molecules expressed by pancreatic cell subsets as well as pancreatic progenitor cells derived from pluripotent stem cells. (ohsu.edu)
Hematopoietic Stem Cell Transplant1
  • Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. (cdc.gov)
Regenerative4
  • The Studer laboratory investigates human stem cells as tools to understand normal and pathological development in the nervous system and to develop cell-based strategies for regenerative medicine. (uctv.tv)
  • The intricate molecular mechanisms involved in the regenerative process of the normal intestine and the identity of putative somatic intestinal stem cells have become clear. (mdpi.com)
  • Stem Health offers regenerative medicine services, mainly stem cell therapy, based on scientific research that seeks therapeutic solutions and personalized medical care. (placidway.com)
  • It includes the possible stem cell therapy mechanisms involved and outcomes recorded so far, the limitations of using these regenerative medicines, and the progressive improvement in stem cell therapy by adopting approaches like PiggyBac, Sleeping Beauty, and the Sendai virus. (biomedcentral.com)
Donor stem cells2
Chemotherapy10
  • Chemotherapy, radiation therapy, targeted therapy, and stem cell or bone marrow transplant are common treatment options for leukemia. (medicalnewstoday.com)
  • Chemotherapy uses drugs to kill cancer cells and slow or stop their growth. (medicalnewstoday.com)
  • Some supportive therapies, such as anti-nausea medications or growth factors to boost blood cell production, may help manage side effects and improve quality of life during chemotherapy. (medicalnewstoday.com)
  • Doctors transplant the donor's stem cells into the individual after chemotherapy or radiation therapy to replace their diseased or damaged stem cells. (medicalnewstoday.com)
  • The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)
  • In this study published in the journal Cell Stem Cell , a team led by researchers at Baylor College of Medicine and MD Anderson Cancer Center combined clinical and laboratory studies to show that a gene called PPM1D, whose function in blood production was unknown, can confer blood cells exposed to the chemotherapy agent cisplatin a survival advantage that might favor the development of leukemia years later. (medicalxpress.com)
  • However, following exposure to cisplatin and some other chemotherapy drugs, the researchers observed that PPM1D mutants dramatically outcompeted normal cells. (medicalxpress.com)
  • Taking the results all together, our findings suggest that chemotherapy acts as an evolutionary selection pressure that favors the survival of PPM1D mutant cells because they have better fitness than normal cells and 'win' under this specific type of stress," said Joanne Hsu, a student in the Medical Scientist Training Program (MD/Ph.D.) at Baylor and a member of the Goodell lab. (medicalxpress.com)
  • So, when a patient receives cisplatin-based chemotherapy, stem cells carrying PPM1D mutations survive better. (medicalxpress.com)
  • Joanne I. Hsu et al, PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy, Cell Stem Cell (2018). (medicalxpress.com)
Mesenchymal stem2
20232
  • June 27, 2023 Scientists have created a stem cell-derived model of the human embryo in the lab by reprogramming human stem cells. (sciencedaily.com)
  • 2023) Organization of self-advantageous niche by neural stem/progenitor cells during development via autocrine VEGF-A under hypoxia. (news-medical.net)
Epithelial Cells3
  • The majority of epithelial cells are therefore short-lived, in contrast to a limited number of long-lived stem cells in the base of the crypts. (nature.com)
  • The corneal epithelium is composed of stratified squamous epithelial cells on the outer surface of the eye, which acts as a protective barrier and is critical for clear and stable vision. (wjgnet.com)
  • We demonstrated the induction of CSC-like cells, a potential driving force of tumor initiation and progression, from human lung epithelial cells by chronic exposure to SWCNT, as evaluated by tumor spheres side population. (cdc.gov)
Peripheral5
  • Peripheral blood stem cell collection. (medlineplus.gov)
  • OUTLINE: Conditioning: Patients undergo low dose total body irradiation followed by infusion of allogeneic peripheral blood stem cells (PBSC) on day 0. (knowcancer.com)
  • The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
  • ImmunoCult™-XF T Cell Expansion Medium is a serum-free and xeno-free medium optimized for the in vitro culture and expansion of human T cells isolated from peripheral blood. (stemcell.com)
  • T cells were isolated from human peripheral blood samples using the EasySep™ Human T Cell Isolation Kit (Catalog #17951), stimulated with ImmunoCult™ Human CD3/CD28/CD2 T Cell Activator (Catalog #10970), and cultured in ImmunoCult™-XF T Cell Expansion Medium supplemented with rhIL-2. (stemcell.com)
MSCs9
  • This study demonstrates the use of a microfluidic platform for long-term cultivation (3 weeks) of human mesenchymal stem-like cells (MSCs), a cell population of high interest for tissue engineering. (rsc.org)
  • The typical high motility of the MSCs required a strategy for preventing cells from inhabiting the feeding channels and thus interfere with a steady perfusion of medium to the cell cultivation chamber. (rsc.org)
  • Recently, mesenchymal stem cells (MSCs) have been suggested for use in the cell-based treatment of cartilage lesions. (researchgate.net)
  • Mesenchymal stem cells (MSCs) have been studied for their potential benefits in treating acute respiratory distress syndrome (ARDS) and have reported mild effects when trialed within human clinical trials. (lu.se)
  • We hypothesized that integrin α10β1 selected-MSCs can be used to treat a sepsis-induced ARDS in a porcine model when administering cells after established injury rather than simultaneously. (lu.se)
  • 6 cells/kg integrin α10β1-selected MSCs and both groups were followed for 12 h. (lu.se)
  • Among their many mechanisms of action, MSC extracellular vesicles (EVs) are a potential suitable substitute for MSCs in future cell-free-based therapeutic approaches. (unlp.edu.ar)
  • Thus, this study aims to evaluate the effectiveness of the bone marrow -derived mesenchymal stem cells (BM-MSCs) and hesperetin in the treatment of a T1DM rat model. (bvsalud.org)
  • BM-MSCs (injected intravenously at a dose of 1 × 106 cells / rat /week), and their combination (hesperetin and BM-MSCs). (bvsalud.org)
Autologous4
  • Stem cells from your own body (also called an autologous transplant). (cdc.gov)
  • Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
  • Allogeneic and autologous HSCT recipients were matched to recipients of the same type. (cdc.gov)
  • What's the difference between allogeneic and autologous stem cell transplantations? (clevelandclinic.org)
Therapy22
  • Further work will be needed to translate stem/progenitor cell therapy for the lung. (nih.gov)
  • For this reason, the topic of embryonic stem cell therapy is often a sensitive one, with ethically and politically charged implications. (cellmedicine.com)
  • However, the standardization of the manufacturing process of MSC-based cell therapy medicinal products in compliance with the requirements of the local authorities is obligatory and will allow us to obtain the necessary permits for product administration according to its intended use. (mdpi.com)
  • Radiation therapy is a cancer treatment that uses high-energy radiation to destroy cancer cells. (medicalnewstoday.com)
  • External radiation therapy involves delivering radiation to the cancer cells from outside the body using a linear accelerator. (medicalnewstoday.com)
  • Learn more about the various types of radiation therapy. (medicalnewstoday.com)
  • Experience cutting-edge stem cell therapy at ITC in Tijuana, Mexico. (placidway.com)
  • The UC Davis Alpha Stem Cell Clinic has improved operations and streamlined processes for conducting stem cell and gene therapy clinical trials. (ca.gov)
  • The UC Davis Alpha Stem Cell Clinic (ASCC) recognizes the importance of a multi-targeted approach to bring new and innovative cell and gene therapy clinical trials, improve patient recruitment from a diverse population to these trials and decrease the cost of the ultimate product. (ca.gov)
  • Increasing awareness of cell and gene therapy trials in the underserved medical communities is one of the targets of our program to ensure all Californians with an unmet medical need can be served. (ca.gov)
  • As my condition is deteriorating, I asked for some alternate recommendation to treat my condition and my doctor recommended to take stem cell therapy and I contacted Viezec for the same. (viezec.com)
  • And I am looking forward in approaching months to get more advantage from stem cell therapy. (viezec.com)
  • As the results of stem cell therapy for multiple diseases can vary depending on person to person and their condition because everyone knows that every individual has their own internal mechanism. (viezec.com)
  • Somatic cell nuclear transfer is a cloning method that can be used to create a cloned embryo for the use of its embryonic stem cells in stem cell therapy. (wikipedia.org)
  • The first therapy using stem cells was a bone marrow transplant performed by French oncologist Georges Mathé in 1958 on five workers at the Vinča Nuclear Institute in Yugoslavia who had been affected by a criticality accident. (wikipedia.org)
  • Therefore, EVs could be key elements for potential off-the-shelf cell-free therapy. (wjgnet.com)
  • Dorobantu M, Popa-Fotea NM, Popa M, Rusu I, Micheu MM. Pursuing meaningful end-points for stem cell therapy assessment in ischemic cardiac disease. (wjgnet.com)
  • The possibilities arising from these characteristics have resulted in great commercial interest, with potential applications ranging from the use of stem cells in reversal and treatment of disease, to targeted cell therapy, tissue regeneration, pharmacological testing on cell-specific tissues, and more. (prnewswire.com)
  • Cellular replacement therapy using islets has been shown to be partially effective in the treatment of type I diabetes. (ohsu.edu)
  • However, the supply of donor-derived islets will never meet the needs of the large number of patients who could potentially benefit from this cell-based therapy. (ohsu.edu)
  • Nowadays, therapy with stem cells is one of the most promising future treatments . (bvsalud.org)
  • These results provide novel insights into the role of IL1RAP in CML and a strong rationale for the development of an IL1RAP antibody therapy to target residual CML stem cells. (lu.se)
Amniotic fluid stem1
  • Sources of exogenous stem/progenitor cells that are currently under evaluation in the context of acute lung injury repair include embryonic stem cells, bone marrow- or fat-derived mesenchymal stem cells, circulating endothelial progenitors, and, recently, amniotic fluid stem/progenitor cells. (nih.gov)
20221
  • Feb. 24, 2022 Researchers have discovered a new type of stem cell that resembles cells in the early human embryo during the transition of 'genomic power' from mother to embryo. (sciencedaily.com)
10.10161
  • doi: 10.1016/j.stem.2008.07.026. (nih.gov)
Somatic1
  • In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)
Termed induced pluri1
20212
  • May 5, 2021 Stem cells have the ability to turn into different types of cell. (sciencedaily.com)
  • In a study published on June 7, 2021, in the journal Nature Communications , the investigators reported that they have developed a new way to create beta cells that is much more efficient than previous methods. (sciencedaily.com)
Therapeutic3
  • In order to find more promising treatments to stimulate renal repair, stem cell-based technology has been proposed as a potentially therapeutic option. (biomedcentral.com)
  • So as a new therapeutic approach, stem cells are under research with a focus on reducing the burden of several kidney diseases. (biomedcentral.com)
  • In vivo administration of IL1RAP antibodies in mice transplanted with chronic and blast phase CML cells resulted in therapeutic effects mediated by murine effector cells. (lu.se)
Lund Stem Cell Center1
  • Lund Stem Cell Center members have full access to the following services and methods. (lu.se)
Embryo9
  • Vincent Pasque's team at KU Leuven has developed the first model for a specific type of human embryo cells, extraembryonic mesoderm cells. (sciencedaily.com)
  • Professor Pasque: "These cells generate the first blood in an embryo, help to attach the embryo to the future placenta, and play a role in forming the primitive umbilical cord. (sciencedaily.com)
  • The researchers made their model cells from human stem cells that can still develop into all cell types of an embryo. (sciencedaily.com)
  • An embryonic stem cell is derived from a group of cells called the inner cell mass, which is part of the early (4 to 5 day old) embryo called the blastocyst. (cellmedicine.com)
  • In order to create an embryonic stem cell line, the destruction of the embryo is required. (cellmedicine.com)
  • Unlike with embryonic stem cells, the destruction of an embryo is not involved in the gathering of placental and umbilical cord stem cells, yet the placental and umbilical cord stem cells exhibit the same pluripotency as do embryonic stem cells. (cellmedicine.com)
  • Management of what is called the 'national embryo supply' in the UK involves new forms of governance at the 'IVF-Stem cell Interface', where questions about the provenance of donated embryos, including the ethics of their sourcing, are at a premium. (lse.ac.uk)
  • This article explores the question of embryo donation to stem cell research from the perspective of the increasing proximity of IVF and hES cell derivation, using a model of 'double reproductive value' to explore what forms of exchange and flow are occurring, and how these are defined and negotiated in the context of a national hES cell coordination network of practitioners. (lse.ac.uk)
  • The process of isolating these cells has been controversial, because it typically results in the destruction of the embryo. (wikipedia.org)
Self-renewal7
  • Rspo proteins are secreted and can stabilize the effects of Wnt ligands by preventing ubiquitination and turnover of the Wnt receptor frizzled 9 , thereby dictating the size of the Lgr5 + stem cell pool by regulating self-renewal of Lgr5 + cells 10 . (nature.com)
  • In that same year, Siminovitch was a lead investigator for studies that found colony-forming cells were capable of self-renewal, which is a key defining property of stem cells that Till and McCulloch had theorized. (wikipedia.org)
  • Oct-4 (POU5F1) is a transcription factor that is critically involved in the self-renewal of pluripotent stem cells, and its expression is commonly used as a marker for pluripotency. (stemcell.com)
  • One factor supposed to be involved in self-renewal is the rapid proliferation rate of ES cells, which is coupled to an unusual cell cycle distribution with the majority of cells in S-phase and a very short G1-phase. (uni-muenchen.de)
  • Thus, the PeBoW-complex seems to be an essential factor for the rapid proliferation of ES cells and might therefore also be involved in self-renewal. (uni-muenchen.de)
  • The self-renewal and proliferative nature of stem cells raised the hope to fight against various diseases. (biomedcentral.com)
  • To varying degrees, these fates also extend to the Such state stability is required in stem and progenitor cells to immediate progeny of stem cells, known as progenitor or support self-renewal and maintenance of the uncommitted transit-amplifying cells. (lu.se)
Progenitors3
  • Strategies to enhance endogenous alveolar epithelial repair could include protection of epithelial progenitors from injury and/or stimulation of endogenous progenitor cell function. (nih.gov)
  • This has been studied mainly in the small intestine, where different cell types such as enterocyte progenitors 4 , more differentiated secretory Bmi1 + cells 3 , or even fully differentiated Paneth cells can repopulate crypts upon injury. (nature.com)
  • 02:14 progenitors that make red blood cells. (yale.edu)
Neural6
  • Now, researchers in Japan have shed new insight into the dynamics of the neural stem cell niche, the home of stem cells in the brain. (news-medical.net)
  • In a new study published in Inflammation and Regeneration , researchers from Tokyo Medical and Dental University (TMDU) investigated the effects of hypoxic (low oxygen) conditions on the neural stem cell niche during development. (news-medical.net)
  • Neural stem and progenitor cells (NPSCs) give rise to the cells of the brain and nervous system. (news-medical.net)
  • The TMDU-led research team set out to investigate the effects of low oxygen conditions within the neural stem cell niche using a cell culture model of NSPCs isolated from the forebrains of embryonic mice. (news-medical.net)
  • While other factors may also contribute to NSPC maintenance, these results shed new light on the composition of the neural stem cell niche during development, and may serve as a foundation for further studies of self-organization of the hypoxic niche. (news-medical.net)
  • In the hepatocyte, the glycogen catabolic machinery normally responds to stimuli caused by hypoglycemia (eg, neural, hormonal), ending in a flood of glucose-6-phosphate that cannot be released from the cell. (medscape.com)
Therapies4
  • Stem cells are an extremely promising approach for developing many cell therapies, including better treatments for type 1 diabetes," says Salk Professor Juan Carlos Izpisua Belmonte, the paper's senior author. (sciencedaily.com)
  • Embryonic and fetal stem cells are known to be pluripotent, which makes them attractive candidates for use in medical therapies. (cellmedicine.com)
  • Areas of research focus are beta cell replacement therapies for the treatment of diabetes, the identification of lung progenitor cell populations involved in lung repair, and in the diagnosis of pancreatic cancer. (ohsu.edu)
  • and 3) facilitate the purification of cell culture expanded cell populations for cell-based therapies. (ohsu.edu)
Treatments5
  • In order for beta cell-based treatments to eventually become a viable option for patients, it's important to make these cells easier to manufacture," says co-first author Haisong Liu, a former member of the Belmonte lab. (sciencedaily.com)
  • Refractory ALL is a more challenging form of leukemia because the cancer cells have become resistant to standard treatments. (medicalnewstoday.com)
  • Experience top stem cell treatments in Nuevo Progreso, Mexico by Dr. Omar Gonzalez Integra Medical Center. (placidway.com)
  • And at the present stage, we are not approved by FDA, and lastly, we do not utilize fetal and embryonic cells in our treatments for any condition. (viezec.com)
  • While both treatments help your bone marrow to develop new blood cells, studies show allogeneic stem cell transplantations work by causing the donor cells to attack unhealthy cells. (clevelandclinic.org)
Diabetes7
  • Scientists are developing a promising approach for treating type 1 diabetes by using stem cells to create insulin-producing cells (called beta cells) that could replace nonfunctional pancreatic cells. (sciencedaily.com)
  • Type 1 diabetes, which arises when the pancreas doesn't create enough insulin to control levels of glucose in the blood, is a disease that currently has no cure and is difficult for most patients to manage. (sciencedaily.com)
  • Additionally, when these beta cells were tested in a mouse model of type 1 diabetes, the animals' blood sugar was brought under control within about two weeks. (sciencedaily.com)
  • After the cells were created, they were transplanted into a mouse model of type 1 diabetes, The model mice had a modified immune system that would not reject transplanted human cells. (sciencedaily.com)
  • I was suffering from type 2 diabetes for the previous 8 years but with prescription medication and strict diet control I couldn't able to heal it, so I was recommended to use insulin inoculation. (viezec.com)
  • NEW YORK - A team led by researchers in Germany has identified gut microbial oscillations over the span of a single day that appear to be disrupted in individuals with type 2 diabetes (T2D) and other metabolic conditions. (genomeweb.com)
  • Efficiency of Bone Marrow-Derived Mesenchymal Stem Cells and Hesperetin in the Treatment of Streptozotocin-Induced Type 1 Diabetes in Wistar Rats. (bvsalud.org)
Differentiate8
  • Animal and human studies have demonstrated that stem cells isolated from placentas and umbilical cords may differentiate into a variety of specialized tissue, such as nerve, liver, heart, kidney, bone marrow, and cartilage cells, among many other types. (cellmedicine.com)
  • In multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can differentiate into various types of cells and proliferate indefinitely to produce more of the same stem cell. (wikipedia.org)
  • In vivo, they eventually differentiate into all of the body's cell types (making them pluripotent). (wikipedia.org)
  • They exist to replenish rapidly lost cell types and are multipotent or unipotent, meaning they only differentiate into a few cell types or one type of cell. (wikipedia.org)
  • they are vastly outnumbered by the progenitor cells and terminally differentiated cells that they differentiate into. (wikipedia.org)
  • Since 1998 however, it has been possible to culture and differentiate human embryonic stem cells (in stem-cell lines). (wikipedia.org)
  • In addition, their "unspecialized" nature allows them to differentiate into a wide variety of specialized cell types. (prnewswire.com)
  • While the appeal of embryonic cells has been their ability to differentiate into any type of cell, there has been significant ethical, moral, and spiritual controversy surrounding their use. (prnewswire.com)
Hematopoiesis1
  • Similarly, GATA-1 has been shown to induce lineage switching expression values even if, for simplicity, we assume only ``on'' of committed cells in hematopoiesis, first in cell lines (Kulessa and ``off'' states for each gene. (lu.se)
Clinical3
  • Each of those cell sources has specific advantages and disadvantages, and each has found particular clinical applications. (medscape.com)
  • Conditions such as Huntington's disease, Parkinson's disease, and spinal cord injuries are examples of clinical applications in which stem cells could offer benefits in halting or even reversing damage. (prnewswire.com)
  • The biological properties and clinical potential of stem cells elicit that are generated must not be unduly sensitive to small fluctu- continued scientific, commercial, and public interest. (lu.se)
Proliferation7
  • Cells expressing stem cell markers, including GFAP, and proliferation markers are closely apposed to the laminin-containing extracellular matrix (ECM) surrounding vascular endothelial cells. (nih.gov)
  • We found that NSPCs treated with VEGF-A showed lower rates of cell death and increased cell proliferation,' says senior author Tetsuya Taga. (news-medical.net)
  • Generally, cells have to closely coordinate growth and cell cycle progression during proliferation to prevent premature division. (uni-muenchen.de)
  • Moreover, a putative crosstalk between ribosome biogenesis and proliferation of ES cells was assessed. (uni-muenchen.de)
  • Further, impaired proliferation of ES cells was observed. (uni-muenchen.de)
  • Overall, the results suggest that ES cells use different mechanisms as mature cells to coordinate their proliferation rate with ribosome biogenesis. (uni-muenchen.de)
  • Here, we show that primitive (CD34(+)CD38(-)) CML cells, in contrast to corresponding normal cells, express a functional interleukin-1 (IL-1) receptor complex and respond with NF-κB activation and marked proliferation in response to IL-1. (lu.se)
Marrow cell1
  • They hypothesized that each lump (colony) was a clone arising from a single marrow cell (stem cell). (wikipedia.org)
Research12
  • From "Stem Cells: Scientific Progress and Future Research Directions," available at http://stemcells.nih.gov). (cellmedicine.com)
  • 8 Feb, 2008 06:09 pm Six years ago, biomedical engineer Michael King was exploring the strange rolling motion of white blood cells when his research took a radical turn. (scitizen.com)
  • 27 Nov, 2007 10:41 am Tony Maciulis talks with Dr. Jon LaPook about a breakthrough in stem cell research. (scitizen.com)
  • 21 Nov, 2007 10:54 am A huge advancement in stem cell research--and a stake in the heart of human cloning--was announced yesterday. (scitizen.com)
  • 6 Sep, 2007 12:57 pm British authorities decided yesterday to permit research that uses animal eggs to create human stem cells because of the limited supply of human eggs. (scitizen.com)
  • 25 Jun, 2007 04:43 pm On June 7, the House of Representatives voted 247-176 to pass a bill (S 5) that would allow federal funding for research using stem cells derived from. (scitizen.com)
  • Human Embryonic Stem (hES) cell research has met with a mixed reception internationally, but in the UK remains a significant national priority. (lse.ac.uk)
  • Research into stem cells grew out of findings by Canadian biologists Ernest McCulloch, James Till and Andrew J. Becker at the University of Toronto and the Ontario Cancer Institute in the 1960s. (wikipedia.org)
  • Stem cell research and experimentation have been in process for well over five decades, as stem cells have the unique ability to divide and replicate repeatedly. (prnewswire.com)
  • Induced pluripotent stem cells represent one of the most promising research advances within the past decade, making this a valuable report for both executives and investors to use to optimally position themselves to sell iPSC products. (prnewswire.com)
  • A distinctive feature of this report is an end-user survey of 273 researchers (131 U.S. / 143 International) that identify as having induced pluripotent stem cells as a research focus. (prnewswire.com)
  • In 2003 he became Director of the OHSU Hematopoietic Cell Processing Laboratory, and in 2004 he became a member of the Oregon Stem Cell Center, where he is Director of the Center's monoclonal antibody and flow cytometry core facilities and conducts independent research. (ohsu.edu)
Populations3
  • At least two populations of epithelial stem/progenitor cells give rise to the lung anlage, comprising the laryngo-tracheal complex versus the distal lung below the first bronchial bifurcation. (nih.gov)
  • We identify two populations of cells with active Wnt signaling: highly proliferative Lgr5 + /Axin2 + cells, as well as secretory Lgr5 − /Axin2 + cells. (nature.com)
  • Lgr5 is a well-established marker of these basal stem cells in the gastrointestinal tract 1 and lineage tracing experiments have demonstrated that Lgr5 + cells give rise to clonal cell populations establishing entire colonic crypts 2 . (nature.com)
Regeneration7
  • Signals that regulate epithelial regeneration upon stem cell injury are largely unknown. (nature.com)
  • Upon Lgr5 + cell depletion, these cells are recruited to contribute to crypt regeneration. (nature.com)
  • Chemical injury induced by DSS leads to a loss of both Lgr5 + cells and Axin2 + cells and epithelial regeneration is driven by Axin2 − cells, including differentiated Krt20 + surface enterocytes. (nature.com)
  • Regeneration requires stromal Rspo3, which is present at increased levels upon injury and reprograms Lgr5 − but Lgr4 + differentiated cells. (nature.com)
  • Thus, we find that endogenous Rspo3 signaling is a critical determinant of cellular fate within the crypt and stimulates rapid recruitment of differentiated cells for epithelial wound healing and crypt regeneration through induction of Wnt signaling. (nature.com)
  • Little has been studied regarding EVs derived from human pluripotent stem cells (hPSC-EVs), even though hPSCs offer good opportunities for induction of tissue regeneration and unlimited proliferative ability. (wjgnet.com)
  • Our laboratory, in collaboration with the laboratory of Jeffrey Whitsett, M.D., at the Cincinnati Children's Hospital, is generating and characterizing a panel of monoclonal antibodies targeting cell-surface markers on different subsets of pulmonary cells involved in the process of pulmonary tissue regeneration. (ohsu.edu)
Fetal1
Human15
  • Scientists have managed to generate a new type of human cell in the lab using stem cells. (sciencedaily.com)
  • The new cells closely resemble their natural counterparts in early human embryos. (sciencedaily.com)
  • Professor Vincent Pasque and his team at KU Leuven have managed to generate a new type of human cell in the lab using stem cells. (sciencedaily.com)
  • That is why scientists have already developed stem cell models for various types of embryonic and extraembryonic cells to study human development in a dish. (sciencedaily.com)
  • The new cells closely resemble their natural counterparts in human embryos and are therefore a good model for that specific cell type. (sciencedaily.com)
  • You don't make a new human cell type every day," Pasque continues. (sciencedaily.com)
  • In the current work, the investigators started with human pluripotent stem cells (hPSCs). (sciencedaily.com)
  • Growing the cells in this way creates more shared surface area between the cells and allows them to influence each other, just as they would during human development. (sciencedaily.com)
  • We apply our method to study differences between human pluripotent stem cells and several cell types including their parental cell line and differentiated progeny. (nature.com)
  • The cells or blood is then tested for special proteins, called human leukocytes antigens (HLAs). (medlineplus.gov)
  • 18 Sep, 2007 12:13 pm Rice University researchers have engineered musculoskeletal cartilages with human embryonic stem cells, with the hope of eventually using the neotissue. (scitizen.com)
  • 27 Jun, 2007 06:08 pm Stem cells have the potential to become all the cells and tissues in the human body. (scitizen.com)
  • Activation of OCT4 enhances ex vivo expansion of human cord blood hematopoietic stem and progenitor cells by regulating HOXB4 expression. (stemcell.com)
  • One recently developed reagent recognizes a molecule associated with human pancreatic cancer cells as well as precancerous lesions of the pancreas. (ohsu.edu)
  • The objective of this study was to develop an in vitro model for lung cancer risk assessment of CNT and to evaluate the in vivo tumorigenicity of chronic CNT-exposed human lung cells. (cdc.gov)
Immune2
  • This is a group of rare disorders caused by mutations in different genes involved in the development and function of infection-fighting immune cells. (clevelandclinic.org)
  • Unlike cells, EVs do not elicit acute immune rejection, and they can be produced in large quantities and stored until ready to use. (unlp.edu.ar)
Pluripotency2
  • Using our integrative proteomics approach and the web-based tool, we uncover a molecular basis for the uncoupling of robust transcription from parsimonious translation in stem cells and propose a method for maintaining pluripotency in vitro. (nature.com)
  • To get a new insight into pluripotency, we employed a plurifaceted experimental design combining expression proteomics with the proteome-wide integral solubility alteration (PISA) assay 7 to compare pluripotent cells with their isogenic progenies and parental cells as well as with allogeneic cells. (nature.com)
Acute1
  • Moreover, it was found that these two are firmly correlated, which means acute renal failure can lead to chronic type and vice versa [ 6 ]. (biomedcentral.com)
IPSC2
  • Next, we compared both datasets and found that while iPSC EVs enclose proteins that modulate RNA and microRNA stability and protein sorting, PD-MSC EVs are rich in proteins that organize extracellular matrix, regulate locomotion, and influence cell-substrate adhesion. (unlp.edu.ar)
  • Moreover, compared to their respective cells, iPSCs and iPSC EVs share a greater proportion of proteins, while the PD-MSC proteome appears to be more specific. (unlp.edu.ar)
ESCs2
Donor's1
Expansion3
  • Mediates ex vivo expansion of cord blood CD34+ hematopoietic stem and progenitor cells (Huang et al. (stemcell.com)
  • Recombinant cytokines, required for the optimal growth and expansion of T cells, have not been added to ImmunoCult™-XF T Cell Expansion Medium. (stemcell.com)
  • Effects of oxygen metabolites/chemokines on hematopoietic stem cell expansion and preservation. (rochester.edu)
Leukemia3
  • People with life-threatening cancers, such as leukemia , lymphoma , and myeloma can be treated with a bone marrow transplant or, sometimes, a stem cell transplant. (medlineplus.gov)
  • Refractory ALL is a type of leukemia characterized by the failure to achieve complete remission or the recurrence of the disease after initial treatment. (medicalnewstoday.com)
  • Chronic myeloid leukemia (CML) is currently treated with tyrosine kinase inhibitors, but these do not effectively eliminate the CML stem cells. (lu.se)
Umbilical6
Extracellular2
  • Extracellular vesicles from IFN-γ-primed mesenchymal stem cells repress atopic dermatitis in mice. (iasp-pain.org)
  • Extracellular vesicles (EVs) are nanometric particles that enclose cell-derived bioactive molecules in a lipid bilayer and serve as intercellular communication tools. (wjgnet.com)