Via positional cloning, we show that mutations in a zebrafish LTCC encoding gene, cav1.3a , underlie the auditory-vestibular defects of gemini ( gem ) circler mutants. (jneurosci.org)
Tissues2
It is also found in LUNG, TESTIS, OVARY, KIDNEY, and BREAST, and is expressed in many tumor types found in these tissues. (lookformedical.com)
APCDD1 inhibits BMP signaling in cells and tissues. (xenbase.org)
Epidermal1
BMP4 is a factor which induces the ectoderm into epidermal cells. (justia.com)
Extracellular1
gem homozygous receptor mutant HCs display normal cell viability, afferent synaptogenesis, and peripheral innervation, yet exhibit strongly reduced extracellular potentials (∼50% of wild-type potentials). (jneurosci.org)
Lymphocytes2
Using this approach, we have cloned a novel apoptotic gene from human Jurkat T lymphocytes. (deathbase.org)
Mch2 beta, 1.4 kb) were detected in Jurkat T lymphocytes and other cell lines. (deathbase.org)
Differentiate2
Rather than proliferating, activated Casp6 KO B cells preferentially differentiate into syndecan-1(+) plasma cells and produce Abs. (deathbase.org)
When BMP4 is activated, cells differentiate into the epidermis. (justia.com)
Embryos1
Embryos were injected at the 4-cell stage dorsally (A-C, double in situ hybridization for chordin and LacZ RNA as injection marker, in red), or 1 cell stage (D-R). Control embryos were injected solely with LacZ RNA (1 ng). (xenbase.org)
Mammalian3
L-type Ca 2+ channels (LTCCs) drive the bulk of voltage-gated Ca 2+ entry in vertebrate inner ear hair cells (HCs) and are essential for mammalian auditory processing. (jneurosci.org)
The new gene encodes a approximately 34-kilodalton protein that is highly homologous to human CPP32, Caenorhabditis elegans cell death protein CED-3, mammalian Ich-1 (Nedd2), and mammalian interleukin-1 beta converting enzyme. (deathbase.org)
Our data suggest that Mch2 is a Ced-3/interleukin-1 beta converting enzyme-like cysteine protease and could be another important mediator of apoptosis in mammalian cells. (deathbase.org)
Differentiation4
Caspase 6 regulates B cell activation and differentiation into plasma cells. (deathbase.org)
In this study, we show that Casp6 regulates B cell activation and differentiation into plasma cells by modifying cell cycle entry. (deathbase.org)
Casp6 may regulate both B cell activation and differentiation by modifying requirements for G(0) B cells to enter G(1). (deathbase.org)
This early process includes occurrence of neural precursor cells, pattern formation of the nervous system, and proliferation and differentiation of neural precursor cells. (justia.com)
Induces1
In addition, overexpression of recombinant Mch2 alpha, but not Mch2 beta, induces apoptosis in Sf9 insect cells. (deathbase.org)
Neurons2
Clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons. (lookformedical.com)
DR6 is broadly expressed by developing neurons, and is required for normal cell body death and axonal pruning both in vivo and after trophic-factor deprivation in vitro. (deathbase.org)
Pathways1
A-B. The activation of BMP and Wnt pathways was measured at single-cell level, using NIH 3T3 mouse fibroblast cells cultured in the presence of BMP and Wnt ligands. (xenbase.org)
Neural6
Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing. (academicinfluence.com)
Kinetics of homophilic binding by embryonic and adult forms of the neural cell adhesion molecule. (academicinfluence.com)
Chemical characterization of a neural cell adhesion molecule purified from embryonic brain membranes. (academicinfluence.com)
Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein. (academicinfluence.com)
Sensory1
Sensory ganglia may also have intrinsic interneurons and non-neuronal supporting cells. (lookformedical.com)
Developmental1
To take human organ generation via BC and transplantation to the next step, we reviewed current emerging organ generation technologies and the associated efficiency of chimera formation in human cells from the standpoint of developmental biology. (frontiersin.org)
Proliferation1
Even so, S phase entry and proliferation are not increased in Casp6 KO B cells. (deathbase.org)
Regulation1
Cell adhesion molecules in the regulation of animal form and tissue pattern. (academicinfluence.com)
Genes2
We have developed a PCR approach to clone new apoptotic Ced-3/Ice-like cysteine protease genes. (deathbase.org)
In particular, the present invention provides neurogenesis inducing genes coding for Zic proteins, vectors containing such genes, host cells containing such vectors, proteins produced by such host cells, antibodies raised to such proteins, and therapeutic agents or agents for gene therapy for nervous diseases. (justia.com)
Wild-type1
B cells from Casp6 knockout (Casp6 KO) mice examined ex vivo have more cells in G(1) than wild-type B cells, and mitogen-induced G(1) entry of Casp6 KO B cells is much faster than that of wild-type B cells. (deathbase.org)
Show1
Unlike neuronal cell body apoptosis, which requires caspase 3, we show that axonal degeneration requires caspase 6, which is activated in a punctate pattern that parallels the pattern of axonal fragmentation. (deathbase.org)
Host cells1
However, though BC is emerging as a potential organ transplant option, challenges regarding organ size scalability, immune system incompatibilities, long-term maintenance, potential evolutionary distance, or unveiled mechanisms between donor and host cells remain. (frontiersin.org)
Maternal expression at 8 cell stage (A, B) is localized in the animal pole and is frequently unevenly distributed. (xenbase.org)
The type I target gene folded gastrulation is activated only in response to peak levels of the Dl gradient, so that expression is restricted to a subdomain of the presumptive mesoderm. (sdbonline.org)
Volume1
The number of CELLS of a specific kind, usually measured per unit volume or area of sample. (lookformedical.com)