• In a benign tumor, the proliferated cells stay in one location where they do not impact or spread to other surrounding tissues. (wikipedia.org)
  • E-cadherin helps neighboring cells stick to one another (cell adhesion) to form organized tissues. (medlineplus.gov)
  • A lack of E-cadherin also impairs cell adhesion, increasing the likelihood that cancer cells will not come together to form a tumor but will invade the stomach wall and metastasize as small clusters of cancer cells into nearby tissues. (medlineplus.gov)
  • It is unclear why CDH1 gene mutations primarily occur in the stomach lining and these other tissues. (medlineplus.gov)
  • The NCI-60 cell lines represent the most common tumor diseases in nine tissues (such as brain, breast, bowel, skin, and blood tissue). (genengnews.com)
  • However, the researchers also found some clearly distinguishable protein profiles between the tumor cells of different tissues. (genengnews.com)
  • However, MSCs need to be expanded in vitro in order to obtain sufficient cells for clinical trials since they are extremely rare in various tissues. (hindawi.com)
  • Metastasis means that cells spread through the tissue fluid's circulation called the lymphatic system or through the bloodstream where they can then stop off in other tissues or organs where they may grow as metastases or metastatic deposits and can become destructive in these new locations. (emedicinehealth.com)
  • Increased levels of POGLUT2 were found in multiple types of cancer tissues and cell lines. (frontiersin.org)
  • C. Peterson, M. Ringne´r / Artificial Intelligence in Medicine 28 (2003) 59-74 structure and function, cellular metabolism, development of cells and tissues, and response of organisms to their environments. (lu.se)
  • Since genes are composed of a given alphabet (A, T, C, G) with fixed pairing properties A-T and C-G, probes can be constructed that attract gene transcripts extracted from cell tissues and cultures. (lu.se)
  • genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)
  • Given these findings, AFM24 is now being evaluated in a phase 1/2 trial (NCT04259450) in patients with advanced EGFR -positive solid tumors. (onclive.com)
  • Enforced expression of the transcription factors PU.1, IRF8, and BATF3 (PIB) was sufficient to induce the cDC1 phenotype in 36 cell lines derived from human and mouse hematological and solid tumors. (lu.se)
  • This study indicates that treatment with the highly diluted homeopathic remedies does not alter the gene expression in primary prostate tumors or in lung metastasis. (nih.gov)
  • This process is called metastasis, and is a hallmark of cancerous tumors. (wikipedia.org)
  • Ma Z, Gibson SL, Byrne MA, Zhang J, White MF and Shaw LM (2006) Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis. (scielo.br)
  • Finally, this study for the first time provided evidence that cetuximab may block metastasis-facilitating epithelial-mesenchymal-transition (EMT) in an epithelial cell line. (uni-muenchen.de)
  • N-809 was well-tolerated and reduced 4T1 lung metastasis, decreased MC38 tumor burden and increased survival versus N-803+αPD-L1. (bmj.com)
  • Exosomal release of beta-catenin and inhibition of Wnt signaling may explain why CD82 and CD9 suppress tumor metastasis. (eurekalert.org)
  • Researchers reveal a new way in which cells restrain beta-catenin and potentially suppress tumor metastasis: the protein can be ejected from cells in small vesicles called exosomes. (eurekalert.org)
  • CD82 and CD9 are both suppressors of metastasis whose expression is lost in several types of late stage tumor. (eurekalert.org)
  • The cancerous cells are capable of spreading to other areas of the body through the process of metastasis . (emedicinehealth.com)
  • Malignant tumors, on the other hand, are capable of spreading throughout the entire body, causing new tumors to appear. (wikipedia.org)
  • Benign adenomas or papillomas are exceedingly rare in comparison with malignant tumors. (medscape.com)
  • Hepatocellular carcinoma remains one of the most common malignant tumors in the world. (usda.gov)
  • Malignant tumors of the salivary glands are rare, comprising from 1 to 6% of all head and neck tumors and the parotid is most commonly affected, accounting for 70% of the lesions 1 . (bvsalud.org)
  • The presence of painful symptoms is more common in cases of lesions with malignant characteristic, but asymptomatic malignant tumors of minor salivary glands are not uncommon either 7 . (bvsalud.org)
  • Many malignant tumors of salivary glands are characterized by abundant secretion of mucin. (bvsalud.org)
  • Mucinous tumor is a common type of ovarian epithelial tumors. (hindawi.com)
  • Epithelial cell tumors- the most common type of ovarian cancer tumor. (mountsinai.org)
  • Metastatic bone tumors of the skeleton are caused when cancer from another part of the body spreads to the bones. (massgeneral.org)
  • The most common kinds of metastatic bone tumors of the skeleton begin with prostate, breast, thyroid, lung, or kidney cancer. (massgeneral.org)
  • In children, metastatic skeletal tumors are usually due to neuroblastoma, leukemia or Ewing's sarcoma. (massgeneral.org)
  • Metastatic tumors from the kidney or thyroid are usually very vascular (made of blood vessels) whereas tumors from prostate, breast and lung are less so. (massgeneral.org)
  • Caplan and colleagues blocked Wnt signaling in a metastatic cell line after restoring CD82 expression. (eurekalert.org)
  • If a bladder cancer cell metastasizes -- that is, spreads to the lungs through the bloodstream it is still called and is treated as metastatic bladder cancer, not as lung cancer . (emedicinehealth.com)
  • Another known fact for metastatic tumor cells is that they tend to be softer than their normal or non-metastatic counterparts. (umd.edu)
  • In addition, we show that MDA-MB-231 cells and MDA-MB-436 cells which are both epithelial breast cancer cell lines with a mesenchymal-like phenotype derived from metastatic cancers are mechanically more different from each other than from non-malignant epithelial MCF-10A cells. (umd.edu)
  • Since stiffness of tumor cells can be an indicator of metastatic potential, this result suggests that metastatic abilities could vary within the same monoclonal tumor cell line. (umd.edu)
  • Plain radiography: Radiography of the primary site and of the chest is helpful in determining the presence of calcifications and bone involvement of the primary tumor and to search for metastatic lung lesions. (medscape.com)
  • Obtain a CT scan of the liver in patients with abdominal or pelvic primary tumors to assess for metastatic spread. (medscape.com)
  • Recent studies suggested that strategies to reduce immunosuppressive cells, promote systemic T-cell responses and lymphocyte trafficking to the tumor microenvironment (TME) may improve efficacy. (bmj.com)
  • 1 This is due to multiple factors, including tumor heterogeneity, the immunosuppressive nature of the tumor microenvironment (TME) and innate or acquired resistance to treatment. (bmj.com)
  • Immune infiltration and tumor microenvironment evaluations were assessed by ImmuneScore, ImmuCellAI, and TIMER databases. (frontiersin.org)
  • POGLUT2 was mainly expressed in stromal cells as verified by StromalScore, ESTIMATEScore, ImmuneScore, and Tumor purity, and POGLUT2 was positively correlated with cancer-associated fibroblasts, macrophages, monocytes, and neutrophils in the tumor microenvironment. (frontiersin.org)
  • Increased levels of POGLUT2 could result in the dysregulated immune cell infiltration and tumor microenvironment and showed a significant regulatory effect on the progression of breast cancer through Notch-related signaling. (frontiersin.org)
  • Primary brain tumor initiating cell lines from IDH-wild type GBM stably expressing H2B-Dendra2 were implanted orthotopically in the brains of SCID mice. (nature.com)
  • The issue of whether brain tumor rates are static or rising is more complicated than Kolata would have us believe. (microwavenews.com)
  • It's based on brain tumor data from The Netherlands . (microwavenews.com)
  • With advances in molecular and genetic profiling of tumors, researchers and providers found that the combination of CNS tumor biodiversity and their unique molecular markers really define brain tumor types. (labroots.com)
  • An "integrated diagnosis", based on the new edition of WHO brain tumor classifications will be more precise and include: histological diagnosis, WHO histological grade, and molecular information. (labroots.com)
  • Data on brain and central nervous system primary malignant and non-malignant ependymal tumours from the Central Brain Tumor Registry of the United States analytic data set and primary malignant ependymal tumours from the SEER 13 registries research data file were used to evaluate incidence and survival, respectively. (cdc.gov)
  • The data source for incidence was the Central Brain Tumor Registry of the United States (CBTRUS) analytic file, 1995-2009. (cdc.gov)
  • Combination therapies with anti-PD-1 treatment in TNBC-bearing mice reduced tumor growth in multi-drug cohorts. (bmj.com)
  • Our data indicate that certain GSL antigens, especially SGGLs, GD3, and OAc-GD3, are expressed in neural tumor cells and may be considered as tumor-associated antigens that represent important biomarkers for neural tumors. (karger.com)
  • Forinstance, we may find that dendritic cells use this network todistribute antigens to other cells and it may be conceivable to followthe entire pathway by tracing the network of tunneling nanotubules,"said Dr. Salter. (sciencedaily.com)
  • ICE is a bispecific engager of CD16A+ natural killer (NK) cells and macrophages and tumor antigens. (onclive.com)
  • Our approach serves as a platform for the development of immunotherapies that endow cancer cells with the capability to process and present endogenous tumor antigens. (lu.se)
  • Injection of in vitro generated melanoma-derived tumor-APCs into subcutaneous melanoma tumors delayed tumor growth and increased survival in mice. (lu.se)
  • Malignant melanoma is a highly aggressive tumor type, in which Wnt signaling is essential. (lu.se)
  • Using melanocyte and malignant melanoma cell lines, we demonstrate that the down-regulation is due to methylation. (lu.se)
  • Furthermore, by analyzing the effects of Wnt5a on the malignant melanoma proteome, we provide evidence for a cell context dependent reprogramming of cellular metabolism induced by Wnt5a. (lu.se)
  • Activation of Wnt5a signaling in melanoma cell lines resulted in a pro-tumorigenic effect by favoring aerobic glycolysis. (lu.se)
  • In abnormal cells, however, acquired mutations allow the cells to bypass these checkpoints by deregulating the cyclins and CDKs, even if there have been significant errors. (wikipedia.org)
  • Mutations in any of these cell types can begin the process of uncontrolled cell proliferation, ultimately leading to the formation of a tumor. (wikipedia.org)
  • People with HDGC caused by CDH1 gene mutations are born with one mutated copy of the gene in each cell. (medlineplus.gov)
  • 2004) Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. (scielo.br)
  • Yet, cells expressing EGFR kinase domain mutations tended to generally respond better to treatments with gefitinib compared to those with wild-type EGFR. (uni-muenchen.de)
  • The researchers based their work on the premise that it is proteins, and not mutations in DNA per se, that are ultimately responsible for changing somatic cells into cancerous ones. (genengnews.com)
  • Mutations in tumor-promoting genes (oncogenes), tumor suppressor genes, and microenvironmental cues cause esophageal cancers. (nyp.org)
  • Now this genetic knowledge is being used to direct drug development by testing specific compounds on 1,000 cancer cell lines that incorporate many of these mutations. (technologyreview.com)
  • Collectively, the cells possess about 70 cancer-linked genetic mutations, about 50 to 80 percent of the mutations that have been uncovered to date. (technologyreview.com)
  • In this analysis, investigators evaluated the ability of AFM24 to elicit antibody-dependent cellular phagocytosis in solid tumor cell lines expressing EGFR wild-type or EGFR signaling pathway mutations. (onclive.com)
  • In addition, though statistically questionable, several biologically interesting genes that are possibly involved in determining in vitro response of NSCLC cells to cetuximab have been postulated. (uni-muenchen.de)
  • On the other hand long-term exposure of A431 cells to cetuximab did not render cells resistant to neither the antibody nor gefitinib in regard to in vitro growth-inhibition. (uni-muenchen.de)
  • CRCs have marked benefits over traditional immortalized cell lines as they are generated using special in vitro conditions that permit cells to pharmacologically bypass replicative senescence without any detectable cell crisis. (sbir.gov)
  • Unlike embryonic stem cells, adult stem cells (MSCs) have a limited lifespan and stop proliferating during in vitro culture due to replicative senescence [ 8 ]. (hindawi.com)
  • Furthermore, POGLUT2 knockdown of breast cancer cells was established, followed by in vitro biological function assays and in vivo tumor growth study. (frontiersin.org)
  • In vitro and in vivo results showed that POGLUT2 knockdown could delay tumor growth and progression. (frontiersin.org)
  • In addition to acquiring improved antigen presentation, tumor-APCs had impaired tumorigenicity in vitro and in vivo. (lu.se)
  • These in vitro, and their expression in these human tumour virus. (who.int)
  • Certain types of these rare tumors can be effectively addressed through endoscopic endonasal surgery. (apollohospitals.com)
  • There are other types of very rare tumors of the esophagus. (cancer.net)
  • These abnormal cells can eventually form cancerous tumors. (nyp.org)
  • Both types of tumors share a number of general characteristics, the broadest being that they are an abnormal proliferation of cells. (wikipedia.org)
  • The first error is unscheduled proliferation, essentially refers to the cell continuing to grow and divide without the proper signaling from mitosis. (wikipedia.org)
  • Also, our mutants induced proliferation, glucose uptake, inhibited the migration of 293T cells and affected the responsiveness of the cells to cisplatin and radiation. (scielo.br)
  • The purpose of this report is to describe the features of angiosarcoma arising in mucinous tumor that was misinterpreted as a benign vascular proliferation during the intraoperative consultation. (hindawi.com)
  • Beta-catenin is a central component of the Wnt signaling pathway that controls cell proliferation and differentiation. (eurekalert.org)
  • In addition, their osteogenic differentiation potential was increased, and genes involved in cell adhesion, FGF-2 signalling, cell cycle, stemness, cell differentiation, and cell proliferation were upregulated, compared to that of the MSCs cultured on uncoated plates. (hindawi.com)
  • Proliferation of the cancer cells was significantly increased through the steroid sulfatase pathway, which metabolizes androgens, estrone sulfate, and estradiol sulfate as its substrates. (scirp.org)
  • We evaluated the effects of STS inhibitor and aromatase inhibitors on the proliferation of estrogen-dependent endometrial cancer cells. (scirp.org)
  • Inhibits the proliferation of a number of tumor cell lines. (joplink.net)
  • Oncostatin M inhibits proliferation of rat oval cells, OC15-5, inducing differentiation into hepatocytes. (joplink.net)
  • Nonetheless, the cellular atypia found was considered to be mild and immunohistochemical evaluation the reaction to Ki-67 was low, indicating a low rate of proliferation of the tumor. (bvsalud.org)
  • Cholangiocarcinomas , the most important primary tumors of the bile ducts, may involve either the intrahepatic or the extrahepatic biliary ducts. (medscape.com)
  • Squamous cell carcinoma. (cancer.net)
  • This type of esophageal cancer starts in squamous cells that line the esophagus. (cancer.net)
  • Black people are more likely to be diagnosed with squamous cell carcinoma. (cancer.net)
  • The lining of the esophagus is comprised of squamous cells. (nyp.org)
  • However, the normal squamous cells can be replaced by cells that resemble, in part, what is found in the small intestine. (nyp.org)
  • Squamous cell carcinoma - This form of cancer begins in the squamous cells-the flat, thin cells lining the esophagus. (nyp.org)
  • Squamous cell carcinoma is the most common type of esophageal cancer worldwide and has been linked to heavy tobacco and alcohol use, as well as deficiencies in certain vitamins and minerals. (nyp.org)
  • The innate cell engager ® (ICE) AFM24 showed greater efficacy in eliciting antibody-dependent cellular phagocytosis of EGFR wild-type and KRAS -mutant tumor cells compared with cetuximab (Erbitux), according to preclinical findings from a study presented in a poster during the 2021 SITC Annual Meeting . (onclive.com)
  • Blood-derived dendritic cells and macrophages, bothantigen-presenting cells, make use of these so-called tunnelingnanotubules to relay molecular messages, report Simon C. Watkins,Ph.D., and Russell D. Salter, Ph.D. Further research may show there areadditional cell types with these microscopic tunnel connections. (sciencedaily.com)
  • Using a custom-built, multi-camera live cell microscopicimaging system, they report that, in a matter of seconds, dendriticcells and macrophages can send waves of calcium and other smallmolecules to cells hundreds of micrometers away. (sciencedaily.com)
  • Moreover, in contrast to N-803+αPD-L1, N-809 reduced immunosuppressive regulatory T cells (T reg ), monocytic myeloid-derived suppressor cells (M-MDSC) and M2-like macrophages in the TME. (bmj.com)
  • In addition, N-809 reduces immunosuppressive and pro-tumorigenic immune cells in the TME, including T reg , M2-like macrophages and M-MDSC. (bmj.com)
  • However, AFM24 engages CD16A on NK cells and macrophages with a higher affinity than monoclonal antibodies, causing NK cell-mediated antibody-dependent cellular cytotoxicity and macrophage-mediated antibody-dependent cellular phagocytosis. (onclive.com)
  • To do so, monocyte-differentiated macrophages from healthy donor peripheral blood mononuclear cells were co-cultured for 4 hours with CMFDA-labeled, wild-type EGFR-expressing or KRAS -mutant tumor cells in the presence of 10 µg/mL of AFM24 or cetuximab. (onclive.com)
  • M0, M1, or M2 macrophages were co-cultured with CMFDA-labeled tumor cells in the presence of increasing concentrations of AFM24. (onclive.com)
  • Finally, M0 macrophages were co-cultured with pHRodo™-labeled tumor cells in the presence of 10 µg/mL of AFM24 or cetuximab. (onclive.com)
  • that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)
  • Applying subcutaneous tumor models in different experimental designs, specific correlations between measured total fluorescence intensity (FI) and the tumor volume (V) could be established. (nih.gov)
  • Herein, we sought to determine if rapamycin, an inhibitor of mTOR, could enhance erlotinib sensitivity for cell lines derived from a variety of tissue types (non-small-cell lung, pancreatic, colon, and breast). (aacrjournals.org)
  • This type begins in the glandular tissue in the lower part of the esophagus where the esophagus and the stomach come together. (cancer.net)
  • A polyp is an abnormal growth of tissue in the lining of an organ. (cdc.gov)
  • Solicited models include patient-derived cell lines, patient-derived xenograft (PDX) mouse models, and 3D human tissue model culture systems established from racially/ethnically diverse patient populations. (sbir.gov)
  • 3D human tissue model culture systems: While immortalized cell lines have been standard practice in cancer research for decades, adequate modeling of the heterogeneity of human cancer is an unmet need. (sbir.gov)
  • The frozen section diagnosis was at least mucinous borderline tumor, pending adequate tissue sampling for permanent sections to rule out mucinous adenocarcinoma. (hindawi.com)
  • More than 5,000 of the 10,000 proteins identified are present in varying abundances in tumor cell lines of all types of tissue. (genengnews.com)
  • A margin or edge of normal breast tissue around the tumor may also be removed, depending on the reason for the biopsy. (medpagetoday.com)
  • They may also develop in the tissue that lines the abdominal wall (peritoneum). (mountsinai.org)
  • The compounds to be screened in the Mass General/Wellcome study include both traditional chemotherapies, which can affect both healthy and cancerous tissue, and molecularly targeted drugs, designed to attack a particular genetic flaw specific to cancer cells. (technologyreview.com)
  • Expression, gene mutation and amplification, methylation, and copy number alteration (CNA) of POGLUT2 were evaluated using The Cancer Genome Atlas (TCGA), Cancer Cell Line Encyclopedia (CCLE), and Genotype-Tissue Expression (GTEx) databases. (frontiersin.org)
  • They wondered if the virus could attack tumor stem cells in the CNS, given its modus operandi in healthy tissue. (labroots.com)
  • TNBC cell lines or tumor tissue from established CRC PDX models were implanted into both flanks of humanized mice and treatments ensued once tumors reached a volume of ~150mm 3 . (bmj.com)
  • Recent reports have shown that the sensitivity of non-small-cell lung cancer cell lines to EGFR inhibitors such as erlotinib (Tarceva, OSI Pharmaceuticals) is dependent on inhibition of the phosphatidylinositol 3′-kinase-phosphoinositide-dependent kinase 1-Akt-mTOR pathway. (aacrjournals.org)
  • Therefore, inhibiting EGFR alone may not be sufficient for substantial inhibition of all tumor cells, highlighting the need for multipoint intervention. (aacrjournals.org)
  • Therefore, in select cell lines, inhibition of both S6 and Akt was achieved only with the combination of erlotinib and rapamycin. (aacrjournals.org)
  • We used PRISM (profiling relative inhibition simultaneously in mixtures), a molecular barcoding method, to screen drugs against cell lines in pools. (nature.com)
  • It was also shown that inhibition of the p16 tumour suppressor gene delays growth arrest and therefore senescence of MSC [ 16 ]. (hindawi.com)
  • Humanized mice treated with anti-PD-1 exhibited increased anti-tumor human T-cell responses coupled with decreased Treg and myeloid populations that correlated with tumor growth inhibition. (bmj.com)
  • Large libraries of cancer cell lines - collections of cells that represent tumor types seen in cancer patients - can yield profound insights into tumors' unique genetic features and their sensitivities to current and potential treatments. (broadinstitute.org)
  • These data, along with statistical models, allow us to see otherwise-hidden connections between genetic and epigenetic errors in cancer cells and changes in those cells' metabolic profiles," Li said. (broadinstitute.org)
  • One is the DepMap project, an effort being undertaken at the Broad Institute and at the Sanger Institute to systematically identify genetic dependencies (vulnerabilities that might serve as targets for designing new therapies or repurposing existing ones) across hundreds of cancer cell lines using RNA interference, CRISPR, and drug screens. (broadinstitute.org)
  • Ultimately, physicians hope to be able to screen a patient's tumor and choose the most effective drug based on its specific genetic profile. (technologyreview.com)
  • While a number of molecularly targeted cancer drugs, such as gleevec and herceptin, are already on the market, the effectiveness of most of these drugs depends on a single genetic mutation or molecular marker in the tumor. (technologyreview.com)
  • The findings may also aid development of diagnostic tests designed to capture a genetic snapshot of an individual's tumor. (technologyreview.com)
  • Confirm the presence of FGFR genetic alterations in tumor specimens prior to initiation of treatment with BALVERSA. (nih.gov)
  • Genetic and phenotypic cell-to-cell variability have been observed in numerous studies both within the same type of cancer cells and across different types of cancers. (umd.edu)
  • There must be something else that affects how the original genetic code in the DNA sequence is read and what message is sent into the cells. (lu.se)
  • Metastases after age 30 are usually adenocarcinoma (a type of cancer that involves the cells lining the walls of different organs in the body). (massgeneral.org)
  • Metz H, Busch SE, Hanke ML, Kargl J, Kim KH and Houghton M (2014) Insulin receptor substrate-1 regulates immune cell content in lung adenocarcinoma. (scielo.br)
  • Invasive mucinous adenocarcinoma is uncommon and usually arises in the background of benign or borderline tumors. (hindawi.com)
  • Adenocarcinoma - This type of cancer forms in Barrett's esophagus, typically located in the lower part of the esophagus. (nyp.org)
  • Adenocarcinoma is the most common type of esophageal cancer in the United States. (nyp.org)
  • Stably fluorescence protein (FP) expressing cell clones of colorectal carcinoma and germ cell tumor lines were generated by lentiviral transduction using the FPs eGFP, dsRed2, TurboFP635, and mPlum. (nih.gov)
  • thus, we developed a hematopoietic humanized mouse model, hu-CB-BRGS, and used it to study anti-tumor human immune responses to triple-negative breast cancer (TNBC) cell line and patient-derived colorectal cancer (CRC) xenografts (PDX). (bmj.com)
  • Finally, as observed in human colorectal patients, anti-PD-1 therapy had a strong response to a microsatellite-high CRC PDX that correlated with a higher number of human CD8+ IFNγ+ T cells in the tumor. (bmj.com)
  • Our previous study demonstrated that tumor-suppressor circular RNAs (circRNAs) can be specifically secreted outside of colorectal cancer (CRC) cells within exosomes to maintain tumor cell fitness. (bvsalud.org)
  • Tumors of the stomach are known as gastric tumors, and can be either benign or malignant (gastric cancer). (wikipedia.org)
  • Unfortunately, the early anatomical changes in the lining of the stomach that lead to cancer are rarely noticeable. (wikipedia.org)
  • The effect of p53 gene therapy on chemosensitivity and apoptotic response of PANC-1 tumor cells, which express high amount of mutant p53, to cancer chemotherapeutic agents of Etoposide and Doxorubicin was investigated. (ijbiotech.com)
  • In this form, known as diffuse gastric cancer, there is no solid tumor. (medlineplus.gov)
  • however, because this type of cancer is hidden underneath the stomach lining, it is usually not diagnosed until the cancer has become widely invasive. (medlineplus.gov)
  • Most people with HDGC have family members who have had one of the types of cancer associated with HDGC. (medlineplus.gov)
  • We sought to create a public resource containing the growth-inhibitory activity of 4,518 drugs tested across 578 human cancer cell lines. (nature.com)
  • An unexpectedly large number of non-oncology drugs selectively inhibited subsets of cancer cell lines in a manner predictable from the molecular features of the cell lines. (nature.com)
  • Fig. 2: Drug response landscape of human cancer cell lines. (nature.com)
  • Fig. 5: Multiple existing drugs selectively kill cancer cell lines by stimulating PDE3A-SLFN12 interaction. (nature.com)
  • Fig. 7: Tepoxalin is active against ABCB1-high cancer cell lines via an ABCB1-mediated mechanism. (nature.com)
  • They were so concerned about the elevated rates of two types of cancer among exposed rats that they felt an immediate public alert was warranted. (microwavenews.com)
  • Do Cell Phones Cause Cancer? (microwavenews.com)
  • One question on many people's minds was why, if cell phones cause cancer, there hasn't been an uptick in the incidence of brain tumors in the American population. (microwavenews.com)
  • In a short video accompanying the Times ' news story, Kolata said that there is "overwhelming evidence" that cell phones do not lead to cancer. (microwavenews.com)
  • Despite the explosion of cell phone use," she said, "it looks like the incidence of brain cancer has remained pretty much rock steady since 1992. (microwavenews.com)
  • The higher incidence of GBMs is being masked by the lower rates of the other types of brain cancer. (microwavenews.com)
  • The USC researchers looked at the incidence of brain tumors in three "major cancer registries" over a 15-year period (1992-2006). (microwavenews.com)
  • Bone metastases, or bone mets, occur when cancer cells from a primary tumor spread to the bone. (massgeneral.org)
  • Cancer spreading to the bones from elsewhere is much more common than cancer that begins in the bones (primary bone tumors). (massgeneral.org)
  • Cancer begins when healthy cells change and grow out of control, forming a mass called a tumor. (cancer.net)
  • Esophageal cancer, also called esophagus cancer, begins in the cells that line the esophagus. (cancer.net)
  • Treatment is similar for both of these types of esophageal cancer. (cancer.net)
  • There are different types of statistics that can help doctors evaluate a person's chance of recovery from esophageal cancer. (cancer.net)
  • Lung cancer is divided into two major groups: non small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). (scielo.br)
  • 2004) Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer. (scielo.br)
  • There are two main types of polyps: hyperplastic (minimal cancer potential) and adenomatous (approximately 90% of colon and rectal cancers arise from adenomas). (cdc.gov)
  • In this work, four cancer cell models, which are long-term exposed to gefitinib or cetuximab were established and characterized in terms of gain-of-resistance towards EGFR-targeting compounds, as well as in regard to biological and molecular alterations caused by long-term treatments. (uni-muenchen.de)
  • In addition, a candidate-based approach identified genes that are differentially expressed in cancer cells with primary or secondary resistance to gefitinib or cetuximab. (uni-muenchen.de)
  • In the United States, several racial/ethnic populations demonstrate increased incidence, mortality and/or more aggressive disease for numerous cancer types. (sbir.gov)
  • Cancer cell lines: The use of immortalized cell lines in cancer research has been standard practice for decades. (sbir.gov)
  • Notably, the scientific integrity of cancer cell lines is critical for maintaining high standards in research. (sbir.gov)
  • Hepatocellular carcinoma, known as liver cancer, is the most common life-killing tumors in the world. (usda.gov)
  • Newcastle disease virus (NDV), an avian disease pathogen, has been proved to be an efficient cancer cells killing, or oncolytic, agent. (usda.gov)
  • The results showed that the NDV Anhinga strain was effective in killing liver cancer cells. (usda.gov)
  • There was no obvious difference of the growth capability between the recombinant NDV and the parental virus in the cancer cells. (usda.gov)
  • NDV/Anh-EGFP significantly inhibited liver cancer development both in cancer cell lines and in mice. (usda.gov)
  • Scientists from the Technical University of Munich (TUM) have decoded the proteome of 59 tumor cell lines and say that they have found new ways to explain why cancer drugs do not have the same effect on all patients suffering from the disease. (genengnews.com)
  • The team identified over 10,000 different proteins in cancer cells. (genengnews.com)
  • The researchers used NCI-60 tumor cell lines which came from the U.S. National Cancer Institute. (genengnews.com)
  • The TUM group also showed that the protein pattern of the cells determines the effectiveness of cancer drugs. (genengnews.com)
  • We investigated how the cell lines react to 108 different cancer drugs and found that there are indeed proteins that indicate whether a cell will respond to certain therapeutic agents, or whether it will be resistant to the drug," explains Hannes Hahne, Ph.D. a TUM expert in mass spectrometry techniques. (genengnews.com)
  • Transitional cell carcinoma, also called urothelial carcinoma, is the most common type of bladder cancer. (emedicinehealth.com)
  • Cancer occurs when normal cells undergo a degenerative, dangerous, or what is called a malignant change or transformation causing them to grow abnormally and multiply without normal controls. (emedicinehealth.com)
  • A mass of cancerous cells is called a malignant tumor or cancer . (emedicinehealth.com)
  • Cancer cells can also metastasize . (emedicinehealth.com)
  • Of the different types of cells that form the bladder, the cells lining the inside of the bladder wall are the most likely to develop cancer. (emedicinehealth.com)
  • Urothelial carcinoma (transitional cell carcinoma): This is by far the most common type of bladder cancer in the United States. (emedicinehealth.com)
  • In transitional cell carcinoma, these normal lining cells undergo changes that lead to the uncontrolled cell growth characteristic of cancer. (emedicinehealth.com)
  • Bladder cancer may develop related to changes in DNA (the material in cells that makes up genes and controls how cells work). (emedicinehealth.com)
  • If the ovaries develop abnormal cells that grow uncontrollably, it may be a type of gynecologic cancer. (mountsinai.org)
  • In this study, we aimed to evaluate the possible effects of tumor-stromal interactions on local estrogen biosynthesis in endometrial cancer. (scirp.org)
  • We isolated stromal cells from endometrial cancer patients to examine local biosynthesis of estrogens and tumor-stromal interactions. (scirp.org)
  • Next we examined the effects of steroid sulfatase inhibitor and aromatase inhibitor in monoculture of endometrial cancer cell line (Ishikawa) and in a co-culture system involving an Ishikawa cells and stromal cells. (scirp.org)
  • Estrogen receptor and steroid sulfatase mRNA levels in cancer cells were significantly higher in the co-cultures compared with the monocultures of endometrial cancer cells. (scirp.org)
  • Esophageal cancer occurs when abnormal cells, starting in the esophagus lining, divide and multiply. (nyp.org)
  • Esophageal cancer can develop in this cell type. (nyp.org)
  • Doctors define esophageal cancer types and recommend courses of treatment based on what cells were affected. (nyp.org)
  • The stage depends on the size and location of the tumor, if the lymph nodes are involved, and whether or not the cancer has spread elsewhere in the body. (nyp.org)
  • Certain habits and conditions can cause chronic irritation and changes in the esophageal cells and can increase cancer risk. (nyp.org)
  • Boxers are predisposed to cancers, including three of the most common types of cancer in dogs (hemangiosarcoma, mast cell tumors, and lymphoma). (loveyourdog.com)
  • Hemangiosarcoma is a type of skin cancer that grows in the cells that line blood vessels , commonly on a dog's spleen, skin, or heart. (loveyourdog.com)
  • Mast cell tumors are the most common type of skin cancer in dogs . (loveyourdog.com)
  • Researchers take a broad, multi-faceted look at a large collection of cancer cell lines, creating a new trove of data to explore for drug development opportunities. (broadinstitute.org)
  • Such is the case with the Cancer Cell Line Encyclopedia (CCLE) , a collection of more than 900 cell lines assembled starting in 2008 by the Broad Cancer Program in collaboration with the Novartis Institutes for BioMedical Research. (broadinstitute.org)
  • and WRN in cancer cells lacking a key DNA proofreading mechanism . (broadinstitute.org)
  • A multi-center research team has now greatly augmented this cancer research resource by incorporating new cell lines and adding new data spanning the molecular spectrum from sequence to expression to protein. (broadinstitute.org)
  • Studying the effect of novel cancer drugs on 1,000 lines of genetically diverse cancer cells will drive the development of personalized medicine. (technologyreview.com)
  • One line of cancer cells is shown here. (technologyreview.com)
  • Researchers will screen 400 compounds on 1,000 lines of cancer cells derived from a variety of types of tumors. (technologyreview.com)
  • Previous efforts to screen new drugs on cancer cell lines have focused on just tens of different lines. (technologyreview.com)
  • On April 26, 2018, a Brazilian study was published in the journal Cancer Research utilizing the Zika Virus to kill CNS tumor cells. (labroots.com)
  • Introduction Many second-line treatments for advanced non-small-cell lung cancer (NSCLC) have been assessed in randomised controlled trials, but which treatments work the best remains unclear. (bmj.com)
  • This proof-of-concept study will be the first live cumulative network meta-analysis (NMA) evaluating second-line treatments in advanced non-small-cell lung cancer (NSCLC) with wild-type or unknown status for epidermal growth factor receptor. (bmj.com)
  • Multiple myeloma (MM) is a cancer of terminally differentiated plasma B cells that originates in the hematopoietic bone marrow and accounts for 15%-20% of all hematologic malignancies ( 1 , 2 ). (snmjournals.org)
  • Background The success of agents that reverse T-cell inhibitory signals, such as anti-PD-1/PD-L1 therapies, has reinvigorated cancer immunotherapy research. (bmj.com)
  • Leiomyosarcoma (cancer of smooth muscle cells) can develop in the wall of the small intestine. (msdmanuals.com)
  • is a type of skin cancer that can affect internal organs and sometimes occurs in people with AIDS due to human immunodeficiency virus (HIV) infection. (msdmanuals.com)
  • Decreased antigen presentation contributes to the ability of cancer cells to evade the immune system. (lu.se)
  • We used the minimal gene regulatory network of type 1 conventional dendritic cells (cDC1) to reprogram cancer cells into professional antigen-presenting cells (tumor-APCs). (lu.se)
  • Reprogramming cancer cells to antigen-presenting cells. (lu.se)
  • diagnostic prediction of small round blue cell tumors (SRBCT) of childhood and determining the estrogen receptor (ER) status of sporadic breast cancer. (lu.se)
  • One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
  • Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
  • Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)
  • The research of the past ten years has shown that changes to the epigenetic pattern can play a role in the development of diseases such as cancer and type 2 diabetes. (lu.se)
  • Epigenetic changes, for instance the number and location of methyl groups along a DNA sequence, can be both a cause and a symptom of various types of cancer. (lu.se)
  • To tailor CRC treatment, it is essential to first model this heterogeneity by defining subtypes of patients with homogeneous biological and clinical characteristics and second match these subtypes to cell lines for which extensive pharmacological data is available, thus linking targeted therapies to patients most likely to respond to treatment. (tudelft.nl)
  • PDX Mouse Models: PDX models are commonly used in many clinically relevant research applications including characterization of tumor heterogeneity, in vivo therapeutic target validation studies, therapeutic mechanism of action studies, and therapeutic sensitivity and resistance studies. (sbir.gov)
  • Cellular heterogeneity in tumor cells is a well-established phenomenon. (umd.edu)
  • However, the heterogeneity of mechanical properties in tumor cells are not widely studied. (umd.edu)
  • Here we analyzed single-cell optical stretcher data with machine learning algorithms on three different breast tumor cell lines and show that similar heterogeneity can also be seen in mechanical properties of cells both within and between breast tumor cell lines. (umd.edu)
  • This evidence reinforce the view that combining p53 gene therapy with conventional chemotherapeutic agents may yield a more beneficial response than conventional treatments alone in pancreatic tumor cells with high amount of mutant p53. (ijbiotech.com)
  • Hagi-Sharifia Taghavi, M., Mirshahi, M., Davoodi, J. Wild type p53 gene transfer increases chemosensitivity and apoptotic response of PANC-1 pancreatic tumor cell line. (ijbiotech.com)
  • involving the other copy of the CDH1 gene must occur in the cells of the stomach lining during a person's lifetime. (medlineplus.gov)
  • When both copies of the CDH1 gene are mutated in a particular cell, that cell cannot produce any functional E-cadherin. (medlineplus.gov)
  • Except for the B3B3 line that has undergone unproductive gene rearrangement, all other lines express IgH and L mRNAs but do not synthesize any Ig protein (Robert et al. (rochester.edu)
  • In line with this, we wanted determine whether the IRS1 gene was mutated in the coding regions surrounding YXXM motifs. (scielo.br)
  • Compared with N-803+αPD-L1, N-809 enhanced natural killer (NK) and CD8 + T-cell activation and function in the dLN and TME, relating to increased gene expression associated with interferon and cytokine signaling, lymphoid compartment, costimulation and cytotoxicity. (bmj.com)
  • In 2012, the CCLE collaborators took a deep dive into the genomic features and drug sensitivities of these cells, cataloging gene expression, chromosomal copy number, and targeted gene sequencing data from all 947 lines and a number of drug-response profiles. (broadinstitute.org)
  • Moreover, increased gene mutation and amplification, methylation, and CNA of POGLUT2 were found in several types of cancers. (frontiersin.org)
  • Infinium data for four matched tumor-normal pairs and a dilution series of a tumor cell line mixed with its paired normal cell line are available in NCBI's Gene Expression Omnibus with accession ​ GSE11976 . (lu.se)
  • The main emphasis is on supervised machine learning methods for classification and prediction of tumor gene expression profiles. (lu.se)
  • The gene is no longer expressed, i.e. that part of the DNA cannot be read and the information is not passed on to the cell. (lu.se)
  • We found tumor border configurations, recapitulating human tumor border morphologies. (nature.com)
  • They examined the effects of Zika on three human tumor cell lines derived from medulloblastoma and atypical teratoid/rhabdoid tumors (AT/RT). (labroots.com)
  • Often located in the central spinal cord, these tumors arise from ependymal cells lining the spinal canal. (apollohospitals.com)
  • These tumours are derived from ependymal cells that line cerebrospinal fluid (CSF)-filled ventricles, spinal canal and filum terminale ( Del Bigio, 1995 ). (cdc.gov)
  • A type of neuroglia, ependymal cells are essential for CSF production and have a cuboidal, multi-ciliated morphology ( Brody et al , 2000 ). (cdc.gov)
  • Nearly all anti-tumor drugs are targeted against cellular proteins," says Bernhard Küster, Ph.D., TUM chair of proteomics and bioanalytics. (genengnews.com)
  • However, since only a minority of patients respond to single-agent therapies, methods to test the potential anti-tumor activity of rational combination therapies are still needed. (bmj.com)
  • Tumors of the bile duct constitute about 2% of all cancers found at autopsy. (medscape.com)
  • These include small cell neuroendocrine cancers , lymphomas , and sarcoma and make up less than 1% of esophageal cancers. (cancer.net)
  • The resulting cancers are named after the cell types. (emedicinehealth.com)
  • These cancers are comprised of cells that typically form as a result of bladder inflammation or irritation that has taken place for many months or years. (emedicinehealth.com)
  • These cancers form from cells that make up glands. (emedicinehealth.com)
  • Thus, individuals with transitional cell cancers of the bladder are at risk for transitional cell cancers of the kidneys/ureter (upper urinary tract). (emedicinehealth.com)
  • These cancers are caused by stem cell DNA aberrations and affect neural progenitor cells during development and cellular maturation processes. (labroots.com)
  • The L-type amino acid transporter 1 (LAT1) is a key mediator in uptake and intracellular accumulation of melphalan and correlates with melphalan sensitivity and response in MM and other cancers ( 8 - 10 ). (snmjournals.org)
  • Cellular senescence, which is morphologically characterized by an enlarged and flattened cell shape, was first described by Hayflick [ 9 ]. (hindawi.com)
  • Cellular senescence refers to active cells that eventually enter a state of irreversible growth arrest. (hindawi.com)
  • It helps differentiate the cellular makeup of particular tumors that could not be determined prior. (labroots.com)
  • The innate cell engager AFM24 showed greater efficacy in eliciting antibody-dependent cellular phagocytosis of EGFR wild-type and KRAS-mutant tumor cells compared with cetuximab. (onclive.com)
  • AFM24 enhances macrophage-mediated antibody-dependent cellular phagocytosis of various EGFR-expressing tumor cell lines, irrespective of the EGFR signaling pathway," wrote lead study author Sheena Pinto, PhD, translational project leader at Affimed, and coauthors, in the poster. (onclive.com)
  • Additional results showed that AFM24 increased antibody-dependent cellular phagocytosis of EGFR -positive tumor cells regardless of macrophage subtype. (onclive.com)
  • WHO grade II tumours grouped as 'ependymoma' include cellular ependymoma, clear cell ependymoma, tanycytic ependymoma and papillary ependymoma. (cdc.gov)
  • A benign tumor means the tumor can grow but will not spread. (cancer.net)
  • Activation of Akt leads to the stimulation of antiapoptotic pathways, promoting cell survival. (aacrjournals.org)
  • Glioblastoma (GBM) is one of the most aggressive primary brain tumors, with a median survival time of about 14.6 months despite maximal therapy 1 . (nature.com)
  • Overall, these novel effects of N-809 promote an inflamed TME, leading to lower tumor burden and increased survival. (bmj.com)
  • In the last decade, the availability of autologous stem cell transplantation and combination therapies consisting of immunomodulatory drugs, proteasome inhibitors, and other chemotherapeutics has improved median 5-y survival from 34.6% in 2004 to 49.6% in 2013 ( 3 , 4 ). (snmjournals.org)
  • Treatment depends on the type of lymphoma and may include chemotherapy and radiation therapy to help control symptoms and sometimes lengthen survival time. (msdmanuals.com)
  • However, children and adolescents, the oldest adult age group, cases diagnosed with anaplastic ependymoma and/or tumour location in a brain site had lowest survival rates. (cdc.gov)
  • The study showed "decreased rates of primary brain tumors in all sites with the notable exception of increased incidence of GBM in the frontal lobes, temporal lobes and cerebellum. (microwavenews.com)
  • Even benign tumors tend to recur after excision and have been reported to undergo malignant change. (medscape.com)
  • Germ cell tumors tend to occur in young women or are in their reproductive years. (mountsinai.org)
  • Sex cord-stromal cell tumors tend to occur in women past menopause. (mountsinai.org)
  • Rhabdomyosarcoma cells tend to have variable differentiation along the myogenesis pathway and may appear as strap cells or myotubes that sometimes contain muscle cross-striations. (medscape.com)
  • Pharmacological response data for targeted inhibitors of SRC, WNT, GSK3b, aurora kinase, PI3 kinase, and mTOR, showed significant differences in sensitivity across cell lines assigned to different subtypes. (tudelft.nl)
  • Antitumor immunity elicited by tumor-APCs was synergistic with immune checkpoint inhibitors. (lu.se)
  • Moreover, several promising candidate genes differentially expressed in gefitinib sensitive and resistant NSCLC cell lines were revealed by a global mRNA expression analyses. (uni-muenchen.de)
  • Activation of the Wnt pathway stabilizes beta-catenin, allowing it to move into the cell nucleus and control the expression of many different genes. (eurekalert.org)
  • These changes may turn on certain genes, oncogenes, that will tell the cells to grow, divide, and stay alive, or turn off suppressor genes, genes that control the division of cells, repair of mistakes in the DNA, and death of cells. (emedicinehealth.com)
  • Here we investigated whether quantification of a xenograft tumor intrinsic fluorescence signal can be used to evaluate tumor growth and response to chemotherapy. (nih.gov)
  • In a model of visceral growing mPlum tumors, measurements of FI could be used to follow growth and response to chemotherapy. (nih.gov)
  • Agents that induce apoptosis may inhibit tumor growth and provide therapeutic benefit. (nih.gov)
  • Akt also regulates the mammalian target of rapamycin (mTOR)-S6K-S6 pathway to control cell growth in response to growth factors and nutrients. (aacrjournals.org)
  • During this time, the cell completes a series of growth, DNA replication, and more growth to ensure they are ready to divide again eventually. (wikipedia.org)
  • In the case of tumors, the cells display a level of abnormal growth. (wikipedia.org)
  • In most cases, this abnormal growth comes from an error in the cell cycle checkpoints. (wikipedia.org)
  • There are three general errors that occur within the cell cycle to cause abnormal cell growth. (wikipedia.org)
  • The loss of this protein prevents it from acting as a tumor suppressor, contributing to the uncontrollable growth and division of cells . (medlineplus.gov)
  • To further investigate the physiological processes 40 underlying GBM cell movement, this study aimed to image and analyze distinct GBM invasive growth patterns found in vivo , similar to those observed in patients. (nature.com)
  • It was found that gefitinib long-term treatment of primary sensitive A431 cells confered growth-resistance to this TKI, but not to cetuximab. (uni-muenchen.de)
  • Methods and analysis We will consider trials of second-line treatments in patients with advanced NSCLC with wild-type or unknown epidermal growth factor receptor status. (bmj.com)
  • Growing tumors exist in metabolically compromised environments that require activation of multiple pathways to scavenge nutrients to support accelerated rates of growth. (jci.org)
  • Angiosarcoma of the ovary is rare but represents an aggressive type of malignant ovarian neoplasms. (hindawi.com)
  • A 35 cm right ovarian mass submitted for intraoperative consultation was a multicystic mucinous tumor with an 8 cm area of hemorrhagic lesion between cystic locules. (hindawi.com)
  • A macroscopic hemorrhagic area in an ovarian mucinous tumor should be evaluated with care, and the possibility of angiosarcoma should be borne in mind. (hindawi.com)
  • The findings in this case may be useful for pathologists in the recognition of this uncommon type of ovarian tumors. (hindawi.com)
  • When an ovarian tumor is present, your gynecologic oncologist will need to find out the type of tumor you have. (mountsinai.org)
  • Germ cell tumors- start in the ovarian cells that form eggs. (mountsinai.org)
  • The World Health Organization (WHO) reclassified CNS tumors in 2016 based on this information. (labroots.com)
  • Mesenchymal stem cells (MSCs) possess great therapeutic potential. (hindawi.com)
  • Spinal cord tumors encompass a diverse array of growths that develop within or near the spinal cord or the spinal canal. (apollohospitals.com)
  • The cells can develop benign tumors or growths called polyps. (cdc.gov)
  • Carcinoid Tumors and Carcinoid Syndrome Carcinoid tumors are noncancerous (benign) or cancerous (malignant) growths that sometimes produce excessive amounts of hormone-like substances (such as serotonin), resulting in the carcinoid. (msdmanuals.com)
  • Unfortunately there is no effective treatment of the tumor disease. (usda.gov)
  • Celiac Disease Celiac disease is a hereditary intolerance to gluten (a protein found in wheat, barley, and rye) that causes characteristic changes in the lining of the small intestine, resulting in malabsorption. (msdmanuals.com)
  • For the treatment cutaneous T-cell lymphoma (CTCL), including mycosis fungoides. (pdr.net)
  • All sera had high titers of antibodies of the IgM isotype against SGPG (titers over 1:3,200), especially in tumors such as meningiomas, germinomas, orbital tumors, glioblastomas, medulloblastomas, and subependymomas. (karger.com)
  • Suitable for certain types of meningiomas located at the skull base, this technique ensures optimal tumor removal while preserving critical structures. (apollohospitals.com)
  • Typically, most gastric tumors are cancerous and not detected until a later stage for various reasons. (wikipedia.org)
  • Nonepithelial malignant neoplasms sometimes arise in mucinous tumors, typically as mural nodules. (hindawi.com)
  • Treatment is typically tumor removal and chemotherapy, both of which can be extremely costly. (loveyourdog.com)
  • The black segment of each column tracks the incidence of glioblastoma multiforme (GBM) , the most aggressive and deadly type of brain tumors. (microwavenews.com)
  • The group focused their work on embryonal CNS tumors because these are found to be aggressive and reveal themselves close to birth or in early adolescence. (labroots.com)
  • progressed during or following at least one line of prior platinum-containing chemotherapy including within 12 months of neoadjuvant or adjuvant platinum-containing chemotherapy. (nih.gov)
  • Depending on the location, definitive surgery can be postponed to allow for neoadjuvant chemotherapy to shrink the tumor. (medscape.com)
  • This protein is found within the membrane that surrounds epithelial cells, which are the cells that line the surfaces and cavities of the body. (medlineplus.gov)
  • Other particles may be engulfed by epithelial cells, primarily in the vicinity of the bronchial-alveolar duct junctions, and retained for much longer periods, with gradual removal to lymph nodes. (cdc.gov)
  • There are additional recognized entities based on variants and patterns in Glioblastomas and Ganglion Cell tumors for example. (labroots.com)
  • This study characterized a panel of NSCLC cell lines as well as a stably transfected cell model expressing wild-type and mutated EGFR variants in terms of response to the EGFR-targeting drugs, gefitinib and cetuximab. (uni-muenchen.de)
  • Furthermore, it appeared that long-term gefitinib-treated A431 cells downregulate overall EGFR levels, while long-term cetuximab exposed cells displayed decreased EGFR surface levels but constant overall expression. (uni-muenchen.de)
  • Moreover, AFM24 was superior to cetuximab in eliciting phagocytosis in EGFR -positive cells in live cell imaging analysis over 24 hours. (onclive.com)
  • These tumors originate from astrocytes and can occur anywhere along the spinal cord. (apollohospitals.com)
  • While gap junctions -- interconnecting molecular bridges thatconjoin tightly packed cells -- are known to generate calcium signalsand transport other molecules between cells, the researchers say thetunneling nanotubules are something quite different. (sciencedaily.com)
  • The researchers focused initially on Zika because it infects and destroys neural stem cells in the fetus and prevents the formation of new neurons. (labroots.com)
  • Antitumor efficacy of N-809 or N-803+αPD-L1 was evaluated in two murine carcinoma models and an extensive analysis of immune correlates was performed in the tumor and tumor-draining lymph node (dLN). (bmj.com)
  • In comparison, axillary lymphadenectomy, also called axillary lymph node dissection , is a surgical procedure where the lymph nodes are dissected out within the axilla en bloc. (medpagetoday.com)
  • A continuous monitoring of the whole tumor burden of individuals in orthotopic tumor models is a desirable aim and requires non-invasive imaging methods. (nih.gov)
  • Using high-resolution time-lapse intravital imaging, tumor cell migration in the tumor core, border and invasive front was recorded. (nature.com)
  • Two types of border configurations contributed to tumor cell spreading through distinct invasion patterns: an invasive margin that executes slow but directed invasion, and a diffuse infiltration margin with fast but less directed movement. (nature.com)
  • The frozen section diagnosis was at least mucinous borderline tumor. (hindawi.com)
  • The large majority of mucinous tumors are benign and borderline tumors. (hindawi.com)
  • Only 5 previous cases of angiosarcoma related to mucinous tumors have been reported [ 1 , 2 , 5 - 7 ]. (hindawi.com)
  • Clinical case description of a papillary mucinous cystadenocarcinoma, extremely rare malignant tumor in the salivary gland and difficult to diagnose, in geriatric patient. (bvsalud.org)
  • The antitumor efficacy of the recombinant virus on hepatoma was examined both in cell cultures and in mice. (usda.gov)
  • C57BL/KaLwRij mice were implanted subcutaneously with unilateral murine green fluorescent protein-expressing 5TGM1 tumors and divided into 3 independent groups: untreated, treated beginning week 2 after tumor implantation, and treated beginning week 3 after tumor implantation. (snmjournals.org)
  • Conclusion Hu-CB-BRGS mice represent an in vivo model to study immune checkpoint blockade to human tumors. (bmj.com)
  • Increased incidences of pulmonary bronchioloalveolar tumors have been observed in mice, but not in rats. (cdc.gov)
  • The model-based analysis suggests that humans would be expected to be 100- fold less sensitive to ST-inducted lung tumors than mice, based on pharmacokinetic differ- ences. (cdc.gov)
  • Recently the Styrene Information and Re- search Center (SIRC) conducted subchronic and chronic inhalation studies exposing both rats and mice to various concentrations of ST. No evidence of treatment-related increases in any type of tumor was observed in rats, com- pared to controls, at the end of the 2-yr inhalation study (Cruzan et al. (cdc.gov)
  • 1998). However, the chronic inhalation study with mice resulted in statisti- cally significantly increased incidences of bronchioloalveolar tumors in both male and female mice at the end of 2 yr, but not after 12 or 18 mo (Cruzan et al. (cdc.gov)
  • Cells that transform in a less dangerous fashion may still multiply and form masses or tumors. (emedicinehealth.com)
  • Immune system cells are connected to each other by an extensive network of tiny tunnels that, like a building's hidden pneumatic tube system, are used to shoot signals to distant cells. (sciencedaily.com)
  • It's one thing to find that this intricate physical networkexists but quite astonishing to learn that immune system cells areusing it to relay molecular signals to one another," said Dr. Watkins,professor and vice chair, department of cell biology and physiology,and director of the Center for Biologic Imaging, University ofPittsburgh School of Medicine. (sciencedaily.com)
  • Thus, N-809 can potentially stimulate effector immune cells through IL-15 and block immunosuppressive PD-L1. (bmj.com)
  • ICE molecules are made to boost the activity of innate antitumor immune cells. (onclive.com)
  • At end of study, immune organs and tumors were collected for immunological assessment. (bmj.com)
  • Welcome to APCC's neurosurgery website, where we describe spinal cord tumors - a complex group of conditions that demand expert diagnosis, tailored treatment, and a patient-centered approach. (apollohospitals.com)
  • Such characteristics associated with oncologists' scarce clinical experience in this type of injury complicate diagnosis and treatment, hindering the prognosis and becoming a real challenge for clinicians and pathologists 1 . (bvsalud.org)
  • It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. (joplink.net)
  • Diagnosed at an early stage, germ cell tumors are curable. (mountsinai.org)
  • To characterize biomarkers in neural tumors, we analyzed the acidic lipid fractions of 13 neural tumor cell lines using enzyme-linked immunoabsorbent assay (ELISA) and high-performance thin-layer chromatography (HPTLC) immunostaining. (karger.com)
  • The second is PRISM , a system that uses genetically-barcoded versions of the CCLE cell lines to identify biomarkers that could be used to predict tumors' responses to different drug compounds. (broadinstitute.org)
  • NDV tumor killing efficacy is not only depending on the NDV strain but also the type of tumor targeted. (usda.gov)
  • This mechanism of action may be instrumental to the efficacy of AFM24, especially in macrophage-rich tumors," wrote the study authors. (onclive.com)
  • These tumors arise from the cells of the gastric mucosa which lines the stomach. (wikipedia.org)