Types 1 carboxyglutamic acid. Medical search. Frequent questions

carboxyglutamic acid residues, for the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, neuroprotective agents or analgesic agents. (justia.com)
The NH2-terminal region contains 12 g-carboxyglutamic acid (gla) residues, which facilitate the calcium dependent binding of factor IX to negatively charged phospholipid surfaces. (prottech.com.cn)
The only known biological function of vitamin K is to serve as a co-factor for the γ-glutamyl carboxylase (GGCX), an enzyme responsible for the conversion of glutamic acid residues (GLU) into γ-carboxyglutamic acid (GLA) residues in specific secreted proteins. (umontreal.ca)
The resulting HPlm contains a heavy chain of 561 amino acid residues, originating from the N-terminus of HPlg, doubly disulfide-linked to a light chain of 230 amino acid residues. (embl.de)
The heavy chain of HPlm consists of five repeating triple-disulfide-linked peptide regions, c. 80 amino acid residues in length, termed kringles (K), that are responsible for interactions of HPlg and HPlm with substrates, inhibitors and regulators of HPlg activation. (embl.de)
The amino acid residues important in these kringle/ligand binding interactions have been proposed by structural determinations, and their relative importance quantified by site-directed mutagenesis experimentation. (embl.de)
3. Kalafatis, M., Takahashi, Y., Girma, J.P., and Meyer, D. Localization of a collagen interactive domain of human von Willebrand Factor between amino acid residues Gly 911 and Glu 1365. (csuohio.edu)
Human osteocalcin is a highly conserved, 46-50 amino acid, single chain protein that contains three vitamin K-dependent g-carboxyglutamic acid residues. (joplink.net)
A sequence of about forty amino-acid residues found in epidermal growth factor (EGF) has been shown [ ( PUBMED:2288911 ) ( PUBMED:6334307 ) ( PUBMED:3534958 ) ( PUBMED:6607417 ) ( PUBMED:3282918 ) ] to be present in a large number of membrane-bound and extracellular, mostly animal, proteins. (embl.de)

Vitamin K helps to maintain bone health, partly via the activation of gamma-carboxyglutamic acid (GLA) proteins involved in skeletal mineralization, such as matrix Gla protein (MGP) and osteocalcin.8,9 Low vitamin K status may impair the function of Gla proteins involved in regulation of bone mineralization. (healthyplanetcanada.com)
it is needed for the conversion of 10-12 glutamic acid residue on the NH2 -terminal of precursor coagulation proteins into the action form of gamma-carboxyglutamic acid (which occurs via VK-dependent gamma-glutamyl carboxylase). (medscape.com)
They are found in a varying number of copies in some plasma proteins including prothrombin and urokinase-type plasminogen activator, which are serine proteases belonging to MEROPS peptidase family S1A. (embl.de)

APC Resistance is an autosomal dominant hereditary defect mainly due to a point mutation resulting in an amino acid change in the FV gene (Ag506 to Gln mutation, or Factor V Leiden mutation). (diapharma.com)
We have identified the molecular defect in factor V Leiden and we have delineated specific amino acid regions on the factor V/Va molecule that are crucial for their functions. (csuohio.edu)
C': cysteine, involved in disulphide bond 'x': any amino acid. (embl.de)

Vitamin K 1 Injection (Phytonadione Injectable Emulsion, USP) is indicated in the following coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity. (pfizermedicalinformation.com)
Empiric administration of vitamin K 1 should not replace proper laboratory evaluation of the coagulation mechanism. (pfizermedicalinformation.com)
A prompt response (shortening of the prothrombin time in 2 to 4 hours) following administration of vitamin K 1 is usually diagnostic of hemorrhagic disease of the newborn, and failure to respond indicates another diagnosis or coagulation disorder. (pfizermedicalinformation.com)
[ 1 ] is a rare syndrome of intravascular thrombosis and hemorrhagic infarction of the skin that is rapidly progressive and is accompanied by vascular collapse and disseminated intravascular coagulation (DIC). (medscape.com)

A low protein C activity is expected in aprotinin treated patients because aprotinin is an inhibitor of activated protein C. Oral anticoagulant therapy interferes with the formation of g-carboxyglutamic acid moiety of the protein C molecules during biosynthesis in the liver, which results in a loss of anticoagulant activity. (diapharma.com)
Explain the types of protein C deficiency, and the clinical manifestations. (diapharma.com)
Two types of protein C deficiency states are recognized. (diapharma.com)
In type I deficiency, which is the most common type of disorder, the plasma concentration of protein C is reduced both in functional and immunological assays. (diapharma.com)
This reflects a genetic defect causing a reduced biosynthesis of protein C. Type II deficiency is characterized by normal protein C antigen levels, but with decreased functional activity. (diapharma.com)
Bone gamma-carboxyglutamic acid (Gla) protein, known as BGLAP, BGP or osteocalcin, is an abundant, non-collagenous protein component of bone that is produced by osteoblasts. (joplink.net)
The standard treatment for hemophilia (A and B type) is the intravenous infusion of an exogenous clotting protein more than once a week to prevent bleeding. (medicalbiochemist.com)

Fifty four women above 51 years old who are at least 1 year postmenopausal, underwent BMD (using DEXA examinations), BMI, and Osteocalcin. (walshmedicalmedia.com)

At the end of the study period, there was a 15.8% increase in bone formation biomarker P1NP (precollagen type 1 amino-terminal propeptide) compared to baseline measurements. (healthyplanetcanada.com)
Osteoporosis will cause mandible resorption, which in turn cause the failure of osteointegration between the implant and the jaw bone [ 1 ]. (walshmedicalmedia.com)

[ 1 ] Accordingly, they usually have either little normal prothrombin or a near-normal output of dysfunctional prothrombin. (medscape.com)
We have also recently identified specific amino acids on prothrombin that are responsible for its activity. (csuohio.edu)
Data from my laboratory strongly suggest that amino acids Leu 480 and Gln 481 from prothrombin are crucial for proper recognition of the fVa-dependent site(s) for fXa within prothrombinase, thus modulating the enzymatic activity of fXa within the prothrombinase complex. (csuohio.edu)

This occurs through the γ -carboxyglutamic acid (Gla) domain and results in simultaneous activation of protease-activated receptor-1 (PAR-1) signaling via the thrombin receptor agonist peptide (TRAP) domain [ 12 , 13 ]. (biomedcentral.com)

The questions in the NHANES 1999-2000 DSQ section are basically the same as in NHANES III (1988-94), however in NHANES 1999-2000, participants were asked about use of all types of dietary supplements, not just vitamin and mineral supplements. (cdc.gov)
Vitamin K 1 Injection (Phytonadione Injectable Emulsion, USP) is a yellow, sterile, nonpyrogenic aqueous dispersion available for injection by the intravenous, intramuscular and subcutaneous routes. (pfizermedicalinformation.com)
Whenever possible, Vitamin K 1 Injection (Phytonadione Injectable Emulsion, USP) should be given by the subcutaneous route (See Box Warning ). (pfizermedicalinformation.com)
Vitamin K 1 Injection may be diluted with 0.9% Sodium Chloride Injection, 5% Dextrose Injection, or 5% Dextrose and Sodium Chloride Injection. (pfizermedicalinformation.com)
The American Academy of Pediatrics recommends that vitamin K 1 be given to the newborn. (pfizermedicalinformation.com)
A single intramuscular dose of Vitamin K 1 Injection 0.5 to 1 mg within one hour of birth is recommended. (pfizermedicalinformation.com)
Several forms of vitamin K have been identified: VITAMIN K 1 (phytomenadione) derived from plants, VITAMIN K 2 (menaquinone) from bacteria, and synthetic naphthoquinone provitamins, VITAMIN K 3 (menadione). (lookformedical.com)

The light chain contains an N-terminal γ-carboxyglutamic acid domain (Gla domain) and two epidermal growth factor-like domains (EGF1 and EGF2). (wikipedia.org)

As an analog of dsRNA, polyinosinic-polycytidylic acid (poly(I:C)) is used to induce inflammation via the Toll-like Receptor 3 (TLR3) signaling pathway. (bvsalud.org)

In infants, its deficiency causes hemorrhagic disease of newborn, resulting in intracranial and retroperitoneal bleeding, which can occur at 1-7 days postpartum. (medscape.com)
alpha-1 antitrypsin deficiency, and others decrease the synthesis of VK-dependent factors. (medscape.com)
Tranexamic acid may be of value in patients undergoing surgery who have inherited factor IX deficiency in order to reduce the perioperative risk of bleeding. (wikidoc.org)

Factor VIII SQ variant gene construct used for gene therapy consisting of ApoE hepatic control region and human alpha-1 anti-trypsin promotor, leader sequence followed by B-domain deleted (BDD) factor VIII. (medicalbiochemist.com)

Notre laboratoire s'intéresse à la régulation du tissue osseux et du métabolisme énergétique par différents organes et types cellulaires, ainsi qu'aux interactions endocriniennes entre ces organes. (umontreal.ca)

Phytonadione is 2-methyl-3-phytyl-1, 4-naphthoquinone. (pfizermedicalinformation.com)

PCNs induced PAR-1/PAR-3 heterodimerization through EPCR occupation and PAR-1 activation, which resulted in Gα13-RhoA-mediated-Tie2 activation and stabilized vascular tight junctions via the Akt-FoxO3a signaling pathway. (biomedcentral.com)

Tumor-associated blood vessels exhibit prominent structural and functional abnormalities [ 1 , 2 ]. (biomedcentral.com)

The expression of LC3 and Beclin 1 in rats was investigated by immunohistochemical staining in vivo. (fluoridealert.org)

This type of defect reflects synthesis of abnormal molecules with reduced function. (diapharma.com)

The expression of LC3 and Beclin 1 were up-regulated in dose dependent manner after treatment with fluoride. (fluoridealert.org)

Activated Factor Xa and Factor Va bind to the plasma membranes of a variety of different cell types, including monocytes, platelets, and endothelial cells. (wikipedia.org)
Once bound to the plasma membrane, Factor Xa and Factor Va rapidly associate in a 1:1 stoichiometric ratio to form the prothrombinase complex. (wikipedia.org)

We have recently demonstrated convincingly in melanoma and triple negative breast cancer cell lines that recombinant (r) hTRAIL together with several natural compounds (Quercetin, Silibinin, Ursolic Acid) are efficient in inducing apoptosis in previously described TRAIL-resistant cancer cell lines. (csuohio.edu)

Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the 2-aminopentanedioic acid structure. (rush.edu)

Gly, a substitution based on the sequence in bone gamma-carboxyglutamic acid protein. (nih.gov)
1. Intermedin inhibits vascular calcification by increasing the level of matrix gamma-carboxyglutamic acid protein. (nih.gov)

Nucleic Acids Res. (nih.gov)

Identification of two novel transmembrane gamma-carboxyglutamic acid proteins expressed broadly in fetal and adult tissues. (genscript.com)
They are found in a varying number of copies in some plasma proteins including prothrombin and urokinase-type plasminogen activator, which are serine proteases belonging to MEROPS peptidase family S1A. (embl.de)
Originally identified for its role in the process of blood clot formation ("K" is derived from the Danish word "koagulation"), vitamin K is essential for the functioning of several proteins involved in physiological processes that encompass, but are not limited to, the regulation of blood clotting ( coagulation ) (1) . (oregonstate.edu)
Kudo and his co-workers show that Postn interacting through its FAS1 site with bone tissue morphogenic proteins (BMP)-1 enhances the proteolytic activation of lysyl oxidase to market collagen cross-linking [31]. (academicediting.org)
Postn can be a more lately added person in the matricellular proteins family a course of nonstructural ECM protein that also contains Tnc ��ig-h3 osteopontin secreted proteins acidic and abundant with cysteine (SPARC) thrombospondin-1 in addition to others [21]. (academicediting.org)

To define the mechanism by which the mutation resulted in warfarin sensitivity, we analyzed wild-type and mutant recombinant peptides in an in vitro carboxylation reaction. (nih.gov)
Vitamin K2 is a cofactor of γ-carboxylase, which converts the glutamic acid (Glu) residue in osteocalcin molecules to γ-carboxyglutamic acid (Gla), and is, therefore, essential for γ-carboxylation of osteocalcin. (prohealthadvisor.com)
Vitamin K functions as a cofactor for the enzyme, γ-glutamylcarboxylase, which catalyzes the carboxylation of the amino acid glutamic acid (Glu) to γ-carboxyglutamic acid (Gla). (oregonstate.edu)

Mus musculus proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane) (Prrg3), transcript variant 2, mRNA. (genscript.com)

The mature form of the zymogen, human plasminogen (HPlg), contains 791 amino acids present in a single polypeptide chain. (embl.de)
The vitamin K-dependent zymogen, protein C, is synthesized in the liver as a single chain polypeptide and is subsequently converted to a disulfide linked heterodimer, by removal of a dipeptide (Lys-146 and Arg-147) from the precursor molecule (1,2). (cellsystems.eu)

1996 Oct 1;98(7):1619-25. (nih.gov)

Measurement of C02 incorporation at a range of peptide concentrations yielded a Vmax of 343 cpm/min/reaction for the wild-type peptide, and Vmax values of 638 and 726 for A-10T and A-10G respectively, a difference of only twofold. (nih.gov)
2. C-type natriuretic peptide inhibiting vascular calcification might involve decreasing bone morphogenic protein 2 and osteopontin levels. (nih.gov)

Menaquinones differ in length from 1 to 13 repeats of 5-carbon units in the side chain of the molecules. (oregonstate.edu)

Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. (nih.gov)

17] The gene encodes a signal region, a propeptide region, a glutamic acid domain, two kringle regions, and a catalytic domain. (medscape.com)

Addition of L-ascorbic acid (50 μg/mL-25 μM) (see Note 1) to HBDCs in secondary culture (E1P1) increases proliferation, produces a sustained increase in the steady-state levels of α1 (I)-procollagen mRNA, and dramatically increases the secretion of type I collagen. (irakaufman.com)

Shape 1 additional illustrates reputation sites for the Postn molecule that permit domain-specific relationships with additional ECM protein including collagen types I BMS-708163 and V fibronectin tenascin-C (Tnc) and heparin in addition to with cell surface area receptors notably integrins and Notch1. (academicediting.org)
Postn performing via its EMI site binding collagen type I and fibronectin and its own adjacent FAS1 site binding BMS-708163 Tnc was further proven to work as a molecular bridge to aid the incorporation of Tnc in to the ECM therefore acting to create a particular hexabrachion framework that may boost and stabilize bifurcations of collagen type I and fibronectin fibrils built-into an extracellular meshwork structures [32]. (academicediting.org)

Histamine is synthesized from the amino acid L-histidine through the action of the enzyme histidine decarboxylase. (auxiliarfisioterapia.es)

12. Angiotensin-(1-7) inhibits vascular calcification in rats. (nih.gov)

There are different types of therapeutic chelation. (longevity.ca)

[ 1 ] As a major contributor to bone-mass reduction and osteoporosis, owing to long-term systemic inflammation and use of corticosteroids, RA seriously impaired patient quality of life. (medscape.com)

They are shown a hand card that lists examples of dietary supplements (Appendix 1: Handcard DSQ1). (cdc.gov)

Once bound to the plasma membrane, Factor Xa and Factor Va rapidly associate in a 1:1 stoichiometric ratio to form the prothrombinase complex. (wikipedia.org)

[ 1 ] As a result, many patients, particularly those with earlier-stage and/or serum-negative results, experience misdiagnosis or missed diagnosis. (medscape.com)
cancer in one year and approximately 7 million patients fall victim to the cancer per anno, thereof 5.4 million alone by tobacco smoke 1 . (ijpsr.com)

a Data were tested by χ 2 testing, 1-way analysis of variance (ANOVA), and posthoc least significant difference (LSD) testing, or Kruskal-Wallis and posthoc Nemenyi testing. (medscape.com)

The chelating agent, an organic molecule such as an amino acid, grabs and claws into a ring, a mineral, ion, or cation (the chelate) such as iron or calcium. (longevity.ca)

Residues9

Proteins3

Amino acid3

Coagulation4

Protein7

Osteocalcin1

Bone2

Prothrombin3

Occurs1

Vitamin7

Epidermal1

Receptor1

Deficiency3

Gene1

Interactions1

Phytonadione1

Activation1

Structural1

Vivo1

Abnormal1

Treatment1

Plasma2

Natural1

Structure1

Gamma-carboxygluta2

Nucleic Aci1

Proteins5

Carboxylation3

Proline rich1

Polypeptide2

19961

Peptide2

Molecules1

Sequence1

Kringle1

MRNA1

Fibronectin2

Enzyme1

Vascular1

Therapeutic1

Osteoporosis1

Dietary1

Rapidly1

Patients2

Data1

Mineral1