• Tachyphylaxis and phosphodiesterase type 5 inhibitors. (wikipedia.org)
  • In some cases, a medical professional may prescribe sildenafil off-label to treat FSIAD if it stems from the use of antidepressants, such as selective serotonin reuptake inhibitors or serotonin-norepinephrine reuptake inhibitors. (medicalnewstoday.com)
  • Computational methods have suggested that a class of existing drugs called phosphodiesterase-5 (PDE5) inhibitors might be used to treat AD. (worldhealth.net)
  • The results do not support the use of PDE5 inhibitors such as sildenafil for AD treatment. (worldhealth.net)
  • The active ingredient in Sildenafil Teva, sildenafil, belongs to a group of medicines called phosphodiesterase-type-5 (PDE5) inhibitors. (europa.eu)
  • It is one of several products belonging to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors. (baldtruthtalk.com)
  • Viagra should not be used with revatio or with other PAH treatments containing sildenafil or any other PDE5 inhibitors such as Adcirca tadalafil. (njacs.org)
  • Ryder JE' cialis is one of a class of drugs known as PDE5 Phosphodiesterase type 5 inhibitors. (njacs.org)
  • It is classified among the class of medications recognized as phosphodiesterase type 5 (PDE 5) or phosphodiesterase 5 inhibitors. (emailwire.com)
  • Phosphodiesterase type-5 (PDE-5) or phosphodiesterase 5 inhibitors are a novel class of vasoactive medications that have been established for the treatment of erectile dysfunction (ED). The technique of activity includes active inhibition of the PDE-5 enzyme and consequent boost in cyclic guanosine monophosphate (cGMP) and effortless muscle relaxation in the penis. (emailwire.com)
  • The soaring initiatives adopted by the government and non-governmental organizations to boost awareness of erectile dysfunction including phosphodiesterase 5 inhibitors like Sildenafil Citrate is set to propel the growth of the Sildenafil Citrate Market during the forecast period 2022-2027. (emailwire.com)
  • This growth is owing to the expanding predominance of erectile dysfunction among men worldwide resulting in the soaring application of phosphodiesterase 5 inhibitors like Sildenafil Citrate. (emailwire.com)
  • The soaring novel R&D initiatives associated with the establishment of new drug molecules, the great demand for erectile dysfunction medications like phosphodiesterase 5 inhibitors including Sildenafil Citrate, and the existence of key players like Torrent Pharma Inc., in the region, are propelling the growth of the Sildenafil Citrate Market in the North American region. (emailwire.com)
  • FDA confirmed through laboratory analysis that samples of your products, Etumax Royal Honey for Him and Dose Vital Honey for Men, contain the undeclared active pharmaceutical ingredient tadalafil, and your product, Secret Miracle Royal Honey for Her, contains the undeclared active pharmaceutical ingredient sildenafil, both of which are phosphodiesterase type-5 (PDE-5) inhibitors. (fda.gov)
  • Drugs such as tadalafil, sildenafil, and vardenafil are phosphodiesterase type 5 inhibitors (PDE-5is) commonly used to treat ED. Since PDE-5is were first introduced in 1998, their durability, safety, and efficacy for treating ED have been clearly demonstrated. (eurekalert.org)
  • For the treatment of erectile dysfunction, phosphodiesterase 5 (PDE 5) inhibitors, orally administered sildenafil, tadalafil and vardenafil are typically used. (selfgrowth.com)
  • Selective phosphodiesterase (PDE) inhibitors improve the formation of hippocampus-dependent memories in several rodent models of cognition. (springer.com)
  • 2005 ). cAMP and cGMP are hydrolyzed by phosphodiesterase (PDE) enzymes, and inhibitors of PDEs (PDE-Is) produce cognition-enhancing effects in animal models of cognition. (springer.com)
  • These drugs are phosphodiesterase type 5 inhibitors (i.e. (brupharmacy.com)
  • Vigora contains the active ingredient sildenafil citrate, which belongs to a class of medications known as phosphodiesterase type 5 (PDE5) inhibitors. (webreseau.com)
  • Eligible studies evaluated efficacy and/or harms of one alpha blocker (AB) (silodosin), several antimuscarinics (tolterodine, solifenacin, fesoterodine), one beta-3 adrenoceptor agonist (mirabegron), and several phosphodiesterase type 5 (PDE-5) inhibitors (tadalafil, sildenafil) or combination therapy with one of these medications. (ahrq.gov)
  • A variety of oral erectogenic agents are available or are in late-phase development, including centrally active dopamine agonists (e.g., sublingual apomorphine), peripheral nonselective alpha-blockers (e.g., oral phentolamine), and other phosphodiesterase type-5 inhibitors (e.g., vardenafil). (biopsychiatry.com)
  • Treatment for ED can include medication, such as phosphodiesterase type 5 inhibitors (PDE5 inhibitors), which work by increasing blood flow to the penis. (wsscheduler.com)
  • Phosphodiesterase type 5 inhibitors (PDE5 inhibitors) such as sildenafil (Viagra), tadalafil (Cialis), vardenafil (Levitra). (wsscheduler.com)
  • Despite previous research demonstrating that the use of phosphodiesterase type 5 (PDE-5) inhibitors such as sildenafil, tadalafil, and vardenafil may reduce the risk for developing prostate cancer, a new study published in the Journal of Urology suggests that these agents do not prevent prostate cancer. (oncologynurseadvisor.com)
  • Pills like sildenafil are called phosphodiesterase inhibitors. (msdmanuals.com)
  • It is in the phosphodiesterase-5 inhibitor (PDE5-I) class of medications. (nih.gov)
  • Sildenafil was the first phosphodiesterase-5 (PDE5) inhibitor approved for use, receiving US Food and Drug Administration approval for use in erectile dysfunction on March 27, 1998. (nih.gov)
  • This similarity protects cGMP from degradation because sildenafil can bind to the catalytic site to act as a competitive inhibitor of cGMP-specific PDE-5, the enzyme that normally catalyzes the breakdown of vasodilatory cGMP. (nih.gov)
  • This substance is a type of phosphodiesterase selective inhibitor. (imedix.com)
  • Sildenafil citrate (Viagra) is a powerful and discriminatory PDE-5 inhibitor, which is the earliest medication in this class to be endorsed for the treatment of ED. Sildenafil citrate (Viagra) is a novel oral medicine that restricts phosphodiesterase 5 (PDE5) in the corpus cavernosum to expedite penile erection for the treatment of male impotence. (emailwire.com)
  • This growth is owing to the surging application of sildenafil citrate as a phosphodiesterase 5 inhibitor in the treatment of ailments like erectile dysfunction and pulmonary arterial hypertension. (emailwire.com)
  • Furthermore, the Medical Uses segment is estimated to grow with the fastest CAGR of 6.2% during the forecast period 2022-2027 owing to the heightening application of Viagra (Sildenafil) being a phosphodiesterase 5 inhibitor for the treatment of conditions like mountain sickness, Raynaud s phenomenon and may help patients with congestive heart failure or diastolic dysfunction based on investigations. (emailwire.com)
  • Furthermore, the Pulmonary Hypertension segment is estimated to grow with the fastest CAGR of 6.3% during the forecast period 2022-2027 owing to the extensive application of Sildenafil Citrate in the treatment of pulmonary arterial hypertension wherein Sildenafil is a phosphodiesterase 5 inhibitor that brings about pulmonary arterial vasodilation and minimization in pulmonary artery pressures based on investigations conducted on dogs. (emailwire.com)
  • Gameapos, rifabutin, sildenafil Viagra a potent and selective inhibitor of Type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunctio' Results of drug interaction studies with an organic nitrate and http://www.bdslist.org/cheapest-viagra-online/ a calcium antagonis' If your rheumatoid arthritis symptoms do not improve. (bellx1.com)
  • An orally active type 5 cyclic GMPspecific phosphodiesterase inhibitor for the treatment of penile erectile dysfunctio'00 X, its likely, sildenafil Viagra a potent and selective inhibitor of Type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunctio' Diabetes. (bellx1.com)
  • Explain that erectile dysfunction and phosphodiesterase V inhibitor drug sildenafil (Viagra) may also help treat Raynaud's phenomenon -- one of the most common complications of limited cutaneous systemic sclerosis -- according to results of a small clinical trial. (medpagetoday.com)
  • Sildenafil -- a phosphodiesterase type V inhibitor -- produces smooth muscle relaxation in blood vessels, which accounts for its effects in many cases of erectile dysfunction and also in pulmonary arterial hypertension. (medpagetoday.com)
  • Fildena CT 100 is a medication containing sildenafil citrate, a phosphodiesterase type 5 (PDE5) inhibitor, used to treat erectile dysfunction (ED) in men. (fantasyplanet.cz)
  • This contains sildenafil citrate, a phosphodiesterase type 5 (PDE5) inhibitor. (carforums.com)
  • Viagra sildenafil as citrate is a phosphodiesterase type 5 inhibitor used to treat erectile dysfunction. (beltstl.com)
  • The present study investigates the effect of the PDE4 inhibitor rolipram and the PDE5 inhibitor sildenafil on object retrieval performance. (springer.com)
  • Cenforce 100 mg is the entry point for many seeking relief from ED. Embedded with 100 mg of Sildenafil Citrate, it acts as a phosphodiesterase type 5 inhibitor. (elitefitness.com)
  • Viagra is a phosphodiesterase type 5 (PDE5) inhibitor. (novalarpharm.com)
  • you take another PDE5 inhibitor (eg, tadalafil, vardenafil) or another medicine that contains sildenafil. (novalarpharm.com)
  • Sildenafil citrate (SC) is a phosphodiesterase-5 (PDE-5) inhibitor. (karger.com)
  • Besides, this effective drug falls under the family of phosphodiesterase type-5-inhibitor drugs. (arrowmeds.com)
  • These drugs include sildenafil (Viagra) and tadalafil (Cialis). (worldhealth.net)
  • The researchers compared the incidence of AD and related dementias among those treated for the condition with sildenafil or tadalafil versus those treated with a different class of drugs. (worldhealth.net)
  • Tadalafil and sildenafil are the active ingredients in the FDA-approved prescription drugs Cialis and Viagra, respectively, used to treat erectile dysfunction (ED). These undeclared ingredients may interact with nitrates found in some prescription drugs such as nitroglycerin and may lower blood pressure to dangerous levels. (fda.gov)
  • Based on available evidence, FDA has concluded that the prohibition in section 301(ll) applies to sildenafil and tadalafil. (fda.gov)
  • 1 FDA is not aware of any evidence that would call into question its conclusion that section 301(ll) of the FD&C Act prohibits the introduction into interstate commerce of any food to which sildenafil or tadalafil has been added. (fda.gov)
  • Your Etumax Royal Honey for Him, Dose Vital Honey for Men, and Secret Miracle Royal Honey for Her products are foods to which sildenafil or tadalafil has been added. (fda.gov)
  • Sildenafil, do not take tadalafil more often than once daily. (bellx1.com)
  • These medications consist of sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra). (wsscheduler.com)
  • In addition, symptoms, sildenafil citrate which inhibits the PDE5 enzyme for a period of time. (njacs.org)
  • The cGMP-selective PDE5-I sildenafil has been shown to enhance performance in the object recognition task, in the T-maze, and spatial plus maze (Devan et al. (springer.com)
  • We identified trials testing other drugs (mirabegron, oxybutynin, darifenacin, sildenafil, and vardenafil) but found the evidence insufficient to draw conclusions about efficacy, comparative effectiveness, or adverse effects. (ahrq.gov)
  • Sildenafil (Viagra) has been proved effective in the therapy for erectile dysfunction. (nih.gov)
  • Viagra, whose active ingredient is Sildenafil, is a widely trusted medication for the treatment of erectile dysfunction (ED). It's designed to assist those who struggle with achieving an erection by significantly improving blood flow to the penile area. (rolypoly.com)
  • The recommended starting dose for Viagra (Sildenafil) is often 50 mg, but depending on the individual's response and tolerance, the dosage may be adjusted by healthcare professionals up to 100 mg. (rolypoly.com)
  • Beyond the primary function of treating ED, Viagra (Sildenafil) can also be used to treat other conditions, such as pulmonary arterial hypertension, under the guidance of a doctor. (rolypoly.com)
  • By doing so, you can enjoy the benefits of Viagra (Sildenafil) with peace of mind. (rolypoly.com)
  • It is thought that Viagra works by inhibiting the enzymes type 5 and 6. (rolypoly.com)
  • Sildenafil (Viagra) treats erectile dysfunction in males. (medicalnewstoday.com)
  • Viagra is the trade name of a drug called sildenafil, which treats erectile dysfunction in males. (medicalnewstoday.com)
  • The active ingredient in Viagra is sildenafil. (medicalnewstoday.com)
  • Although Viagra is not FDA approved for females, Revatio, which also contains sildenafil, is. (medicalnewstoday.com)
  • This means that Sildenafil Teva is similar to a 'reference medicine' already authorised in the European Union (EU) called Viagra. (europa.eu)
  • Because Sildenafil Teva is a generic medicine , studies in patients have been limited to tests to determine that it is bioequivalent to the reference medicine, Viagra. (europa.eu)
  • The CHMP concluded that, in accordance with EU requirements, Sildenafil Teva has been shown to have comparable quality and to be bioequivalent to Viagra. (europa.eu)
  • The active ingredient in Cenforce 130mg is sildenafil citrate, which is also found in the well-known brand Viagra. (baldtruthtalk.com)
  • The erectile dysfunction drug sildenafil (Viagra) may also help treat Raynaud's phenomenon, one of the most common complications of limited cutaneous systemic sclerosis. (medpagetoday.com)
  • Clinical studies, case reports, and commentaries and editorials concerning sildenafil published in the international literature between January 1999 and August 2000 were identified through searches of MEDLINE, PREMEDLINE, and International Pharmaceutical Abstracts, using the terms sildenafil, Viagra, and erectile dysfunction. (nih.gov)
  • Order Viagra 'Sildenafil' Online Without Prescriptions. (novalarpharm.com)
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  • The active ingredient in Vigora 50 mg is sildenafil citrate, the same active ingredient found in Viagra, a well-known medication for ED. Sildenafil citrate works by increasing blood flow to the penis when a man is sexually aroused. (webreseau.com)
  • The molecular structure of sildenafil mimics that of cyclic guanosine monophosphate (cGMP). (nih.gov)
  • It works by blocking the phosphodiesterase enzyme, which normally breaks down a substance known as cyclic guanosine monophosphate (cGMP). (europa.eu)
  • By blocking the breakdown of cGMP, Sildenafil Teva restores erectile function. (europa.eu)
  • Phosphodiesterase 5 itself is an enzyme responsible for the breakdown of cGMP and cAMP nucleotides, which are messengers in the mechanism of action of many neurohormones. (selfgrowth.com)
  • In males, an erection goes down when an enzyme called phosphodiesterase type 5 (PDE-5) breaks down. (medicalnewstoday.com)
  • The drug stops an enzyme called phosphodiesterase type. (njacs.org)
  • erectile dysfunction should be probed, including specificdegraded by the enzyme phosphodiesterase type V (PDE V). How long does sildenafil last? . (180360720.no)
  • Sildenafil may be taken with or without food, but taking it with a high-fat meal may increase the time before the medication starts working. (medbroadcast.com)
  • are taking any type of nitrate medication in any form (oral, sublingual [under the tongue], skin patch, or spray). (medbroadcast.com)
  • Sildenafil is a medication taken orally and intended to get rid of impotence. (imedix.com)
  • Sildenafil is a prescription medication utilized to treat erectile dysfunction (impotence) in men. (emailwire.com)
  • Since its approval by the US Food and Drug Administration in March 1998, sildenafil citrate has been used by millions of men for the treatment of erectile dysfunction. (nih.gov)
  • Considerable progress has been made in the development of new pharmacologic treatments since the approval of sildenafil in 1998. (biopsychiatry.com)
  • Benefits: With 50 mg more of Sildenafil Citrate than its predecessor, it gives that additional push required to achieve the desired effect, especially for those who found Cenforce 100 mg falling just short of their expectations. (elitefitness.com)
  • Sildenafil, via the vessel of Cenforce, has paved the way for many to rediscover their confidence and intimacy. (elitefitness.com)
  • Cenforce 200MG reviews are also popular as Sildenafil citrate among its lovers. (arrowmeds.com)
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  • Sildenafil exerts potent vasodilatory actions but has no direct influence on human myocardial contractility or proarrhythmic effects in vitro. (nih.gov)
  • Sildenafil Teva is used to treat adult men with erectile dysfunction (sometimes called impotence), when they cannot get or keep a hard penis (erection) sufficient for satisfactory sexual activity. (europa.eu)
  • In amalgamation with than sexual stimulation, sildenafil functions by assisting the blood circulation into the penis to save and achieve an erection, throughout monster sexual intercourse. (ttlink.com)
  • Type 5 is the type of testosterone that is responsible for developing and maintaining a strong blood supply to your penis. (rolypoly.com)
  • Specifically, there is a type of surgery known as vascular surgery that can be used to treat ED and improve blood flow to the penis. (brupharmacy.com)
  • Oral sildenafil in the treatment of erectile dysfunction. (wikipedia.org)
  • Sildenafil is available as oral tablets of 25 mg, 50 mg, and 100 mg strength for erectile dysfunction (ED). Most patients receive a prescription for 50 mg of oral sildenafil, taken as needed approximately 1 hour before sexual activity. (nih.gov)
  • Oral Thrush in Children Yeast infections are caused by an overgrowth of a type of fungus called Candida. (njacs.org)
  • Since most people tend to take sildenafil for erectile dysfunction, this approach might have created differences between the people in the two groups that couldn't be corrected based on the information in medical claims. (worldhealth.net)
  • In addition, patients taking drugs that inhibit the cytochrome P450 3A4 isozyme, which metabolizes sildenafil, may experience increased drug concentrations and possible toxicity from normal doses of sildenafil. (nih.gov)
  • This activity describes the indications, actions, adverse effects, and contraindications of sildenafil as an agent in the clinical setting. (nih.gov)
  • Further note that patients taking sildenafil had more adverse events than those in the placebo group, but they were mostly mild or moderate. (medpagetoday.com)
  • This paper reviews recent studies of the efficacy of sildenafil, its adverse effects and drug interactions, and socioeconomic factors involved in its use, with a focus on specific patient populations (prostate cancer, diabetes mellitus, ischemic heart disease, spinal cord injuries, neurologic disorders). (nih.gov)
  • however, patients with moderate to severe cardiovascular disease or those taking nitrate therapy are at increased risk for potentially serious cardiovascular adverse effects with sildenafil therapy. (nih.gov)
  • Contact your doctor if you take a greater dose of sildenafil than prescribed. (medbroadcast.com)
  • The recommended dose of Sildenafil Teva is 50 mg taken as needed about one hour before sexual activity. (europa.eu)
  • Rolipram (0.003-0.03 mg/kg, intramuscular [i.m.]) and sildenafil (0.3-3 mg/kg, i.m.) dose-dependently increased correct first reaches during difficult trials, reaching significance at 0.01 and 1 mg/kg, respectively. (springer.com)
  • It's a balanced dose, perfect for those new to Sildenafil-based treatments. (elitefitness.com)
  • Designed for those requiring a robust solution, this dose packs double the Sildenafil Citrate of the 100 mg version. (elitefitness.com)
  • EMAILWIRE.COM , March 24, 2022 ) Sildenafil Citrate Market size is estimated to reach $1.91 billion by 2027, growing at a CAGR of 5.5% during the forecast period 2022-2027. (emailwire.com)
  • In most countries, Vigora, like other sildenafil-containing medications, requires a prescription from a healthcare provider. (webreseau.com)
  • Sildenafil, the major ingredient used in Kamagra was introduced as the first to treat erectile dysfunction and its affinity to type 5 phosphodiesterase is much greater than that of other isoforms. (selfgrowth.com)
  • Sildenafil can also treat pulmonary arterial hypertension in a person of any sex. (medicalnewstoday.com)
  • Sildenafil also has FDA approval for the treatment of World Health Organization Group I pulmonary hypertension (also known as pulmonary arterial hypertension (PAH)) in adults to improve exercise tolerance and delay clinical worsening. (nih.gov)
  • Sildenafil enhances exercise capability, WHO functional class, and hemodynamics in patients with symptomatic pulmonary arterial hypertension. (emailwire.com)
  • Describe the clinically important drug interactions of sildenafil. (nih.gov)
  • The main active component of the drug is Sildenafil . (imedix.com)
  • To test the issue, Herrick and colleagues gave 57 patients with the condition 100 milligrams of sildenafil once a day for three days, followed by either 200 milligrams of the drug once a day or an identical placebo for 25 days. (medpagetoday.com)
  • Buy Fildena 150mg a popular brand of sildenafil citrate is a drug used mainly for the treatment of the erectile dysfunction in men. (ttlink.com)
  • Sildenafil Teva is a medicine that contains the active substance sildenafil. (europa.eu)
  • Active Ingredient: Sildenafil citrate. (novalarpharm.com)
  • Sildenafil Citrate is present in Fildena 150 as an active agent which is used to treat Erectile Dysfunction and Pulmonary Hypertension. (ttlink.com)
  • Each blue, round, diamond-shaped tablet, marked 'PFIZER' on one side and 'VGR 25' on the other side, contains sildenafil 25 mg. (medbroadcast.com)
  • Each blue, rounded diamond-shaped coated tablet with 'WPI' on one side and '3781' on the other side, contains sildenafil 25 mg. (medbroadcast.com)
  • In the United Kingdom, you can get sildenafil over the counter following a consultation with a pharmacist. (healthline.com)
  • For more information about treatment with Sildenafil Teva, read the package leaflet (also part of the EPAR) or contact your doctor or pharmacist. (europa.eu)
  • The aim of the study was to investigate effects of sildenafil on isolated human cardiovascular tissue directly. (nih.gov)
  • In precontracted arteries and veins, addition of sildenafil (0.1-10 microM) led to pronounced vasorelaxation (maximal 35.5 +/- 2.2% and 45.6 +/- 6.3%, respectively, in the presence of 10 microM sildenafil). (nih.gov)
  • Because Sildenafil Teva is a generic medicine and is bioequivalent to the reference medicine, its benefits and risks are taken as being the same as the reference medicine's. (europa.eu)
  • Generic name Sildenafil citrate 2014, and ask them to enroll you in all of the above hotel loyalty programs and jump ahead to elite hotel loyalty status. (beltstl.com)
  • Sildenafil also reduced certain molecular abnormalities associated with AD in cultured nerve cells derived from AD patients. (worldhealth.net)
  • The researchers also examined the effect of sildenafil on a range of molecular features associated with AD in cell cultures. (worldhealth.net)
  • Alcohol and grapefruit products can interact with sildenafil and may reduce its effectiveness or increase the risk of side effects. (fantasyplanet.cz)
  • Neither addition of isoprenaline (0.1 microM) nor addition of the nitric oxide donor S-nitroso-N-acetylpenicillamine (SNAP) (100 microM) affected myocardial contractility in the presence of sildenafil (10 microM). (nih.gov)
  • However, the addition of sildenafil to bosentan therapy did not result in any improvement in exercise capacity. (nih.gov)
  • For Sildenafil Teva to be effective, sexual stimulation is required. (europa.eu)
  • Some disorders unrelated to sexual dysfunction (eg, esophageal motility dysfunction) may also respond to sildenafil. (nih.gov)
  • [2] Sildenafil-induced delay in clinical worsening is demonstrated when sildenafil was used concomitantly with epoprostenol therapy. (nih.gov)
  • Type 6 is the type of testosterone which is responsible for maintaining the production of sex hormones in your body. (rolypoly.com)
  • Buy Fildena 120 mg works by impeding the catalyst phosphodiesterase in the body. (ttlink.com)
  • On average, patients in the sildenafil group had a 44% reduction in the frequency of attacks per week, compared with 18.1% for those in the placebo group. (medpagetoday.com)
  • It explains how the Committee for Medicinal Products for Human Use ( CHMP ) assessed the medicine to reach its opinion in favour of granting a marketing authorisation and its recommendations on the conditions of use for Sildenafil Teva. (europa.eu)
  • You shouldn't take these pills if you also take a certain type of heart medicine called nitrates. (msdmanuals.com)
  • This systematic review evaluates maternal tolerance and obstetric and perinatal outcomes following sildenafil citrate (SC) use in human pregnancy. (karger.com)
  • The average number of attacks also improved -- from 30.5 at baseline to 18.7 after sildenafil treatment, compared with 25 at baseline to 19.3 in the placebo group. (medpagetoday.com)
  • Summarize the role of the interprofessional healthcare team in improving care coordination and communication to improve outcomes related to sildenafil therapy. (nih.gov)
  • Sildenafil is an effective first-line therapy for erectile dysfunction in men. (nih.gov)