This study presents genetic evidence suggesting an important role of both isoforms of 5alpha-reductase in the pathogenesis of PCOS. (bicnirrh.res.in)
SRD5A24
The SRD5A1, SRD5A2, and SRD5A3 genes in humans all encode 5α-reductase isozymes. (wikipedia.org)
Progression to castration-resistant prostate cancer (CRPC) is accompanied by increased expression of SRD5A1 over SRD5A2, which is otherwise the dominant isoenzyme expressed in the prostate. (wikipedia.org)
The human genome contains two genes encoding different isoforms of 5-alpha reductase: SRD5A1 and SRD5A2. (lab24.pl)
Mutations in the SRD5A2 gene cause pseudovaginal perineoscrotal hypospadias (a boy's genitals at birth develop according to the female type), since dihydrotestosterone affects the formation of the embryo's genitals. (lab24.pl)
Enzyme6
3-Oxo-5α-steroid 4-dehydrogenase 1 is an enzyme that in humans is encoded by the SRD5A1 gene. (wikipedia.org)
The 3-oxo-5α-steroid 4-dehydrogenase 1 enzyme is involved in bile acid biosynthesis, androgen and estrogen metabolism. (wikipedia.org)
For instance, the enzyme catalyzes the conversion of testosterone into the more potent androgen, 5α-dihydrotestosterone. (wikipedia.org)
It is formed from testosterone only with the help of a special enzyme - 5-alpha-reductase. (lab24.pl)
Finasteride is a synthetic 4-azasteroid compound 13 and specific inhibitor of steroid Type II 5α-reductase, which is an intracellular enzyme that converts the androgen testosterone into 5α-dihydrotestosterone (DHT). (drugbank.com)
It is one of three forms of steroid 5α-reductase. (wikipedia.org)
Steroid 5α-reductase (EC 1.3.99.5) catalyzes, among other reactions, the conversion of testosterone into the more potent androgen, 5α-dihydrotestosterone (DHT). (wikipedia.org)
This chemical reaction is called 5α-reduction, i.e. the reduction of the Δ5-4 double bond in steroids by catalyzing direct hydride transfer from NADPH to the carbon 5 position of the steroid substrate. (wikipedia.org)
Hyperinsulinemia acutely enhances ACTH effects on both the androgen and glucocorticoid pathways leading to changes in steroid metabolites molar ratios that suggest insulin stimulation of 5α-reductase activity. (wikipedia.org)
Androgens3
Insulin increases the expression of 5α-reductase type 1 mRNA via Akt signalling suggest that elevated levels of 5α-reduced androgens seen in hyperinsulinemic conditions might be explained on the basis of a stimulatory effect of insulin on 5α-reductase in granulosa cells leading to impaired follicle growth and ovulation. (wikipedia.org)
Morris syndrome (one of the forms of testicular feminization), which develops due to insensitivity to androgens, congenital disorder of 5-alpha-reductase synthesis. (lab24.pl)
Aldo-keto reductases interconvert weak androgens, estrogens, progestins, mineralocorticoids and glucocorticoids to their more potent counterparts by catalyzing the reduction and oxidation of keto- and hydroxysteroids, respectively, thereby regulating a wide range of physiological processes involved in development, homeostasis and reproduction [ 16 ]. (biomedcentral.com)
Isozyme1
In humans, the protein isozyme encoded by the SRD5A1 gene is expressed in esophagus, liver, skin and 24 other tissues. (wikipedia.org)
Testosterone8
The dominant route of DHT synthesis in human CRPC bypasses testosterone, and instead requires 5α-reduction of androstenedione by SRD5A1 to 5α-androstanedione, which is then converted to DHT fuelling cancer growth. (wikipedia.org)
In case of men up to 70% of DHT is formed in peripheral tissues from free testosterone under the action of 5-alpha-reductase, the rest - directly in the testicles. (lab24.pl)
For example, DHT stimulates the proliferation of prostate cells much more strongly than testosterone, which is one of the main reasons for the development of prostate hyperplasia (which is why 5-alpha-reductase inhibitors are currently successfully used to treat it). (lab24.pl)
A decrease in the secretion of DHT, associated with insufficient synthesis of both testosterone (for example, in hypogonadism) and 5-alpha-reductase, leads to disorders of sexual development in boys: to the absence of hair on the face, pubic hair, under the armpits, to reduced sizes of the genitals penis and testicles, anomalies of the structure of the penis, insufficient muscle mass. (lab24.pl)
13 In a single man receiving a single oral dose of 5 mg finasteride for up to 4 years, there was a reduction in the serum DHT concentrations by approximately 70% and the median circulating level of testosterone increased by approximately 10-20% within the physiologic range. (drugbank.com)
13 In a double-blind, placebo-controlled study, finasteride reduced intraprostatic DHT level by 91.4% but finasteride is not expected to decrease the DHT levels to castrate levels since circulating testosterone is also converted to DHT by the type 1 isoenzyme expressed in other tissues. (drugbank.com)
Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. (bicnirrh.res.in)
A decline in intratesticular testosterone levels has been highlighted in vitro in 35- to 49-day cultures of 5 d pp mouse testes, i.e. after the end of the first wave of spermatogenesis ( 9 ). (elifesciences.org)
Enhanced androgen1
PCOS is associated with enhanced androgen and cortisol metabolite excretion and increased 5α-reductase activity that cannot be explained by obesity alone. (wikipedia.org)
Androgenic alopecia2
To monitor the success of the use of 5-alpha-reductase inhibitors in BPH or androgenic alopecia. (lab24.pl)
Compared to alpha-blockers that focus on providing the rapid relief of symptoms, 5α-reductase inhibitors aim to target the underlying disease by blocking the effects of the primary androgen involved in benign prostate hyperplasia and androgenic alopecia, thus reducing the risk for secondary complications while providing symptom control. (drugbank.com)
Genes4
ETV4 family members bind to ETS DNA-binding sites and both regulate their own expression and the transcription of a subset of genes that are dependent upon testicular luminal fluid factors, including Ggt_pr4, SRD5A1, and Gpx5. (wikipedia.org)
Screening the porcine CHORI-242 BAC library with a full-length AKR1C4 cDNA identified 7 positive clones and sample sequencing of 5 BAC clones revealed 5 distinct AKR1C genes ( AKR1CL2 and AKR1C1 through 4 ), which mapped to 126-128 cM on SSC10. (biomedcentral.com)
Using the IMpRH 7000rad and IMNpRH2 12000rad radiation hybrid panels, these 5 genes mapped between microsatellite markers SWR67 and SW2067 . (biomedcentral.com)
In the human, an aldo-keto reductase (AKR) gene family (AKR1C) has been identified near the telomere on chromosome 10p15 that contains at least six aldo-keto reductase family 1, member C genes [ 11 ]. (biomedcentral.com)
Gene3
Six-month dietary vitamin E deficiency in rats resulted in a twofold increase in the mRNA level of SRD5A1 gene and a twofold decrease in the mRNA level of GCLM gene but is not directly mediated by changes in promoter DNA methylation. (wikipedia.org)
Quantitative trait loci (QTL) for age of puberty, nipple number and ovulation rate have been identified in Meishan crosses on pig chromosome 10q (SSC10) near the telomere, which is homologous to human chromosome 10p15 and contains an aldo-keto reductase (AKR) gene cluster with at least six family members. (biomedcentral.com)
Because the gene page contains a lot of information, it takes on average 3-5 seconds to load. (uth.edu)
Tissues1
It has been previously shown that supplementing organotypic culture media with retinol improves the in vitro production of spermatids and spermatozoa in prepubertal mouse testicular tissues cultured at a gas-liquid interphase ( 5 , 7 ). (elifesciences.org)
Finasteride3
Finasteride is an antiandrogenic compound that is used for the treatment of symptomatic benign prostatic hyperplasia (BPH) and male pattern hair loss in adult males by inhibiting Type II 5-alpha reductase. (drugbank.com)
12 Finasteride is commonly marketed under the brand names Propecia and Proscar to be used aloneo or in combination with doxazosin , an alpha-blocker. (drugbank.com)
The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. (bicnirrh.res.in)
Corticosterone1
It can also catalyze the conversion of progesterone, corticosterone or other steroids, to its corresponding 5α-3-oxo-steroids. (wikipedia.org)
Prostate1
2 In the treatment of benign prostate hyperplasia, alpha-blockers such as tamsulosin and terazosin are also used. (drugbank.com)
Human1
One of the QTL regions is located on the long arm of pig chromosome 10 (SSC10q) near the telomere, which is homologous to human chromosome 10p15 [ 5 , 6 ]. (biomedcentral.com)
Treatment2
When using drugs that inhibit the action of 5-alpha-reductase, in order to control the success of the treatment. (lab24.pl)
During the course of treatment with 5-alpha-reductase inhibitors, it is necessary to control the content of DHT, which is interdependent with the size of the gland. (lab24.pl)